Active Polymer Nanoparticles: Delivery of Antibiotics

2007 ◽  
Vol 1019 ◽  
Author(s):  
Monica Rabinovich ◽  
Shankari N. Somayaji ◽  
Rajeev Raghavan Pillai ◽  
Michael C. Hudson ◽  
J. Kent Ellington ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Loading ◽  
Plga Nanoparticles ◽  
Polymer Nanoparticles ◽  
Copolymer Composition ◽  
Zns Nanoparticles ◽  
Primary Mouse ◽  
Evaporation Technique ◽  
Uv Visible ◽  
Scanning Electron

AbstractAntibiotic-encapsulated PLA and PLGA nanoparticles were prepared by the single emulsion-solvent evaporation technique. Different PLA and PLGA systems were prepared, varying the copolymer composition and the amount of the surfactant polyvinyl alcohol. Characterization and drug loading studies were performed by UV-Visible spectrophotometry, dynamic light scattering, and scanning electron microscopy (SEM).Simultaneously, in order to model the diffusion of the nanoparticles within the osteoblast, QDs such as functionalized InGaP/ZnS and polymer encapsulated InGaP/ZnS nanoparticles were added to confluent cultures of primary mouse osteoblasts. Following PreFer fixation, cultures were examined via confocal microscopy. QDs were clearly visible within osteoblasts.

Effect of Synthesis Parameters on Size of the Biodegradable Poly (L-Lactide) (PLLA) Microspheres

2013 ◽  
Vol 858 ◽  
pp. 60-66 ◽  
Author(s):  
A.A. Hawari ◽  
C.Y. Tham ◽  
Zuratul Ain Abdul Hamid
Keyword(s):  
Electron Microscopy ◽  
Volume Ratio ◽  
Water Volume ◽  
Synthesis Parameters ◽  
Weight Variation ◽  
Infra Red ◽  
Biodegradable Poly ◽  
Evaporation Technique ◽  
Molecular Weight Variation ◽  
Scanning Electron

In this work, PLLA microspheres were prepared via emulsion solvent evaporation technique. Several synthesis parameters were studied to evaluate their effect on the size of PLLA microspheres. PLLA pallets before emulsion and PLLA microspheres surface chemistry after emulsion were determined using Fourier Transform Infra-red (FTIR). Results showed that PLLA pallets and microspheres FTIR obtained an identical spectrum. Microspheres size and surface morphology were determined using Scanning Electron Microscopy (SEM). In conclusion, the parameters that significantly affect the size of PLLA microspheres were PLLA concentration, DCM to water volume ratio, PVA concentration and stirring speed. PVA molecular weight variation showed no significant change in microspheres size.

Synthesis and Characterization of Gold Nanoparticles Synthesized in Gel and Paper by Electrolysis

2019 ◽  
Vol 824 ◽  
pp. 163-167
Author(s):  
Pema Dechen ◽  
Ekasith Somsook
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Gold Nanoparticles ◽  
Room Temperature ◽  
Synthesis And Characterization ◽  
Visible Spectroscopy ◽  
Gold Leaf ◽  
Uv Visible ◽  
Scanning Electron

In this report, synthesis and characterization of gold nanoparticles (AuNPs) from gold leaf by electrolysis in two different media (gel and paper) in presence of sodium chloride (NaCl), glucose (C6H12O6) and polyvinyl pyrrolidone (PVP) at room temperature were investigated. Graphite was used as two electrodes, NaCl was used as an electrolyte, C6H12O6 was used as reducing agent and PVP was used as stabilizer to control the aggregation of the nanoparticles. UV-Visible spectroscopy (UV-Vis) and scanning electron microscopy (SEM) were used to confirm the characteristics and morphologies of the synthesized AuNPs.

scholarly journals Studies on Characterization, Optical Absorption, and Photoluminescence of Yttrium Doped ZnS Nanoparticles

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ranganaik Viswanath ◽  
Halehatty Seethya Bhojya Naik ◽  
Yashavanth Kumar Gubbihally Somalanaik ◽  
Prashanth Kumar Parlesed Neelanjeneallu ◽  
Khandugadahalli Nagarajappa Harish ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Blue Emission ◽  
Band Gap Energy ◽  
Zinc Sulphide ◽  
Infrared Spectrometry ◽  
Zns Nanoparticles ◽  
Scanning Calorimetry ◽  
Uv Visible ◽  
Coprecipitation Route ◽  
Average Size

Pure ZnS and ZnS:Y nanoparticles were synthesized by a chemical coprecipitation route using EDTA-ethylenediamine as a stabilizing agent. X-ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectrometry (FTIR), thermogravimetric-differential scanning calorimetry (TG-DSC), and UV-visible and photoluminescence (PL) spectroscopy were employed to characterize the as-synthesized ZnS and ZnS:Y nanoparticles, respectively. XRD and TEM studies show the formation of cubic ZnS:Y particles with an average size of ~4.5 nm. The doping did not alter the phase of the zinc sulphide, as a result the sample showed cubic zincblende structure. The UV-visible spectra of ZnS and ZnS:Y nanoparticles showed a band gap energy value, 3.85 eV and 3.73 eV, which corresponds to a semiconductor material. A luminescence characteristics such as strong and stable visible-light emissions in the orange region alone with the blue emission peaks were observed for doped ZnS nanoparticles at room temperature. The PL intensity of orange emission peak was found to be increased with an increase in yttrium ions concentration by suppressing blue emission peaks. These results strongly propose that yttrium doped zinc sulphide nanoparticles form a new class of luminescent material.

scholarly journals Thiol-Functional Polymer Nanoparticles via Aerosol Photopolymerization

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4363
Author(s):  
Narmin Suvarli ◽  
Iris Perner-Nochta ◽  
Jürgen Hubbuch ◽  
Michael Wörner
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Functional Groups ◽  
Residence Time ◽  
Polymer Nanoparticles ◽  
Vinyl Ethers ◽  
Sh Groups ◽  
Scanning Electron ◽  
Half Minute ◽  
Individual Polymer

Spherical, individual polymer nanoparticles with functional –SH groups were synthesized via aerosol photopolymerization (APP) employing radically initiated thiol-ene chemistry. A series of various thiol and alkene monomer combinations were investigated based on di-, tri-, and tetrafunctional thiols with difunctional allyl and vinyl ethers, and di- and trifunctional acrylates. Only thiol and alkene monomer combinations able to build cross-linked poly(thio-ether) networks were compatible with APP, which requires fast polymerization of the generated droplet aerosol during the photoreactor passage within a residence time of half-minute. Higher monomer functionalities and equal overall stoichiometry of functional groups resulted in the best nanoparticles being spherical and individual, proven by scanning electron microscopy (SEM). The presence of reactive—SH groups in the synthesized nanoparticles as a basis for post-polymerization modifications was verified by Ellman’s test.

scholarly journals Differential surface characterizations of cotton fibers coated with TiO2 and ZnO nanoparticles for nano-based analysis of fabrics

2021 ◽  
Vol 16 ◽  
pp. 155892502110438
Author(s):  
Parshuram Singh ◽  
Sapna Balayan ◽  
Rajendra Kumar Sarin ◽  
Utkarsh Jain
Keyword(s):  
Electron Microscopy ◽  
Uv Light ◽  
Natural Fibers ◽  
Vital Role ◽  
Cotton Fibers ◽  
Visible Spectroscopy ◽  
X Ray ◽  
Uv Visible ◽  
Unit Component ◽  
Scanning Electron

Fibers are the unit component for product development. They can be divided into two types: synthetic and natural fibers. Recently, emerging nanotechnology has played a vital role in advancing next-generation fabrics. The nanomaterials provide several unique properties such as higher conductivity, self-cleaning, water-resistant, and others. Owing to their advanced properties, the fabrics are being developed by coating and integrating with nanomaterials. Therefore, in the presented work two cotton samples were modified with titanium dioxide (TiO2) and zinc oxide (ZnO). These samples were further examined under various techniques including scanning electron microscopy (SEM), UV-visible spectroscopy, X-ray fluorescence (XRF), and Fourier-transform infrared spectroscopy (FTIR). Furthermore, these samples were evaluated at varying wavelengths with UV light and the obtained results demonstrated that the nano-coated fiber samples can be differentiated at 365 nm.

Characterization of Synthesized SnO2 Nanoparticles and its Application for the Photo Catalytic Degradation of Eosin Y in Aqueous Solution

2021 ◽  
Vol 43 (1) ◽  
pp. 14-14
Author(s):  
Fazal Akbar Jan Fazal Akbar Jan ◽  
Muhammad Aamir Muhammad Aamir ◽  
Naimat Ullah and Husaain Gulab Naimat Ullah and Husaain Gulab
Keyword(s):  
Electron Microscopy ◽  
Aqueous Solution ◽  
Scanning Electron Microscopy ◽  
Sno2 Nanoparticles ◽  
Catalytic Degradation ◽  
Eosin Y ◽  
X Rays ◽  
Visible Spectroscopy ◽  
Uv Visible ◽  
Scanning Electron

The synthesized oxide (SnO2) nanoparticles by sol-gel method were characterized using UV-Visible spectroscopy (UV-Vis), Fourier Transform Infrared spectroscopy (FTIR), X-rays diffraction(XRD) and Scanning electron microscopy(SEM). Using X-rays diffraction analysis different parameter were calculated such as crystallite size, d-spacing, dislocation density, number of unit cell, cell volume, morphological index, micro strain and instrumental broadening. The average particle size was 28.396 nm. Scanning electron microscopy revealed that SnO2 nanopartcles are uniformly distributed. Optical properties such as band gap (energy gap = 3.6 eV) was calculated from UV-Visible spectroscopy. The characterized particles were used as photocatalyst for the degradation of Eosin dye in aqueous solution under UV light. The effect of different parameters i.e irradiation time, initial dye concentration, pH of the medium and catalyst weight on percent degradation was also studied. Mmaximum dye degradation was found at 220 minutes time interval that was 92 % using 10 ppm solution. At pH 5 the degradation of dye was found to be 94%. The catalyst dose of 0.06 g was found to be the optimum weight for the best photo catalytic degradation of Eosin Y.

Formation and Electrical Interfacing of Nanocrystal-Molecule Nanostructures

2009 ◽  
Vol 1154 ◽  
Author(s):  
Claire Barrett ◽  
Gaëtan Lévêque ◽  
Hugh Doyle ◽  
Donocadh P Lydon ◽  
Gareth Redmond ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Electrical Characterization ◽  
Directed Assembly ◽  
Optical Response ◽  
Histogram Analysis ◽  
Top Down ◽  
Uv Visible ◽  
Absorbance Data ◽  
Scanning Electron

AbstractThe formation of nanocrystal-molecule-nanocrystal nanostructures via controlled mixing of Au nanocrystals and bifunctional Re linkers is reported. UV-visible absorbance data, coupled with histogram analysis of nanostructures measured using Scanning Electron Microscopy has shown a characteristic optical response at wavelengths close to 600 nm following formation of dimer and trimer nanostructures. Directed assembly processes based on dielectrophoretic trapping have also been developed for electrical interfacing of these nanostructures between top-down nanoelectrode pairs for electrical characterization.

Synthesis and optical properties of composites based on ZnS nanoparticles embedded in layered magadiite

Clay Minerals ◽  
2013 ◽  
Vol 48 (5) ◽  
pp. 739-748 ◽  
Author(s):  
Yufeng Chen ◽  
Gensheng Yu
Keyword(s):  
Electron Microscopy ◽  
Optical Properties ◽  
Interlayer Space ◽  
Transmission Spectra ◽  
Zns Nanoparticles ◽  
X Ray ◽  
Transmission Electron ◽  
Uv Visible ◽  
Photoluminescence Enhancement ◽  
Properties Of Composites

AbstractComposites based on ZnS nanparticles embedded in layered magadiite were synthesized via a three step process : protonation of Na-magadiite, ion exchange in order to introduce Zn(NH3)42+ in the interlayer space, and addition of Na2S to form ZnS particles in the interlayer space of magadiite. The composites obtained were characterized by X-ray power diffraction (XRD), Scanning Electron Microscopy coupled with Energy Dispersive Spectroscopy (SEM-EDS), Transmission Electron Microscopy (TEM), Raman spectroscopy, Photoluminscence spectra (PL), and UV-visible transmission spectra (UV-vis). Results indicated that ZnS nanoparticles embedded in magadiite presented different optical properties and photoluminescence enhancement properties compared with those of uncovered ZnS particles (without host magadiite).

Kinetic Evaluation of Anti-tumor Chlorambucil Release from O-stearoyl Mannose PLGA Nanoparticles

2020 ◽  
Vol 10 (1) ◽  
pp. 63-75
Author(s):  
Antonio O. Costa ◽  
Claure N. Lunardi ◽  
Anderson J. Gomes
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Light Scattering ◽  
In Vitro Release ◽  
Plga Nanoparticles ◽  
Diffusion Models ◽  
Kinetic Evaluation ◽  
First Order ◽  
Scanning Electron

Purpose: This study assesses the kinetics of the anti-tumor drug chlorambucil (CLB) incorporated into PLGA nanoparticles (NP-CLB) with and without the presence of the O-stearoyl mannose (OEM) functionalizing agent (NP-CLBMAN). Methods: OEM was synthesized and used in the NP-CLB-MAN formulation. The nanoparticles were characterized by dynamic light scattering, electrophoretic light scattering, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Results: The nanoparticles presented an encapsulation efficiency greater than 61% and a PdI between 0.186–0.217. The mean size was 185 nm for NP-CLB and 220 nm for NPCLB- MAN, and the zeta potential values were -17.7 mV for NP-CLB and -14.2 mV for NP- CLB-MAN. Scanning electron microscopy showed that NPs with OEM have a surface with a different shape, and FTIR analyses showed binding of CLB to the drug delivery system, as well as functionalization with OEM. In vitro release studies showed a biphasic release profile for both systems, and they were analyzed considering the mathematical Korsmeyer-Peppas, first-order, and Fick diffusion models, and the combination of the first-order and Fick diffusion models. Conclusion: The experimental results obtained for the release of CLB were better described using a combination of the first order and Fick diffusion mathematical models.

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