Molecularly Imprinted Polymers (MIPs) Against Uracils: Functional Monomer Design, Monomer-Template Interactions In Solution And MIP Performance In Chromatography

2002 ◽  
Vol 723 ◽  
Author(s):  
Andrew J. Hall ◽  
Panagiotis Manesiotis ◽  
Jakob T. Mossing ◽  
Börje Sellergren
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Chloroform Solution ◽  
The Novel ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
H Nmr ◽  
Recognition Elements ◽  
Substituted Uracils ◽  
Apparent Association Constants ◽  
Apparent Association

AbstractThe interaction of N1-substituted uracils (cyclohexyl (1) and benzyl (2)) with three polymerisable recognition elements, the novel monomers 9-(3/4-vinylbenzyl)adenine (3) and 2,6-diamino-9-(3/4-vinylbenzyl)purine (4) and the previously synthesised monomer 2,6-bis(acrylamido)pyridine (5), has been studied via1H NMR in deuterio-chloroform solution. MIPs against (2) have been prepared using each of the monomers and tested in the chromatographic mode. The effect of the number and type of hydrogen bonds formed between the templates and the functional monomers is reflected in the values of the apparent association constants obtained from the solution study and by the performance of the subsequently prepared MIPs in the chromatographic mode.

Novel β- Cyclodextrin Functional Monomers and its Application for Molecularly Imprinted Polymers

2015 ◽  
Vol 1101 ◽  
pp. 256-260 ◽  
Author(s):  
Feng Feng ◽  
Zhi Min Liu ◽  
Zhi Gang Xu
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Chemical Properties ◽  
Development Trend ◽  
The Novel ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Cavity Structure ◽  
Recognition Ability ◽  
Physical And Chemical

β-Cyclodextrin shows good molecular recognition ability for its unique physical and chemical properties and suitable cavity structure. The selective recognition can be further improved if β-cyclodextrin combines with molecularly imprinted technique. In this paper, the novel β-cyclodextrin functional monomers were introduced. And the preparation and application of molecularly imprinted polymers based on β-cyclodextrin functional monomers were reviewed. The development trend of β-cyclodextrin molecularly imprinted polymers were also prospected.

scholarly journals Rational Design of Molecularly Imprinted Polymers Using Quaternary Ammonium Cations for Glyphosate Detection

Sensors ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 296
Author(s):  
Mashaalah Zarejousheghani ◽  
Alaa Jaafar ◽  
Hendrik Wollmerstaedt ◽  
Parvaneh Rahimi ◽  
Helko Borsdorf ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Quaternary Ammonium ◽  
Photoelectron Spectroscopy ◽  
Rational Design ◽  
Water Soluble ◽  
Trimethylammonium Chloride ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Quaternary Ammonium Cations

Molecularly imprinted polymers have emerged as cost-effective and rugged artificial selective sorbents for combination with different sensors. In this study, quaternary ammonium cations, as functional monomers, were systematically evaluated to design imprinted polymers for glyphosate as an important model compound for electrically charged and highly water-soluble chemical compounds. To this aim, a small pool of monomers were used including (3-acrylamidopropyl)trimethylammonium chloride, [2-(acryloyloxy)ethyl]trimethylammonium chloride, and diallyldimethylammonium chloride. The simultaneous interactions between three positively charged monomers and glyphosate were preliminary evaluated using statistical design of the experiment method. Afterwards, different polymers were synthesized at the gold surface of the quartz crystal microbalance sensor using optimized and not optimized glyphosate-monomers ratios. All synthesized polymers were characterized using atomic force microscopy, contact angle, Fourier-transform infrared, and X-ray photoelectron spectroscopy. Evaluated functional monomers showed promise as highly efficient functional monomers, when they are used together and at the optimized ratio, as predicted by the statistical method. Obtained results from the modified sensors were used to develop a simple model describing the binding characteristics at the surface of the different synthesized polymers. This model helps to develop new synthesis strategies for rational design of the highly selective imprinted polymers and to use as a sensing platform for water soluble and polar targets.

scholarly journals Molecularly imprinted polymers in biological applications

BioTechniques ◽  
2020 ◽  
Vol 69 (6) ◽  
pp. 406-419
Author(s):  
Zahra El-Schich ◽  
Yuecheng Zhang ◽  
Marek Feith ◽  
Sarah Beyer ◽  
Louise Sternbæk ◽  
...  
Keyword(s):  
Amino Acids ◽  
Molecularly Imprinted Polymers ◽  
Low Cost ◽  
Cancer Diagnostics ◽  
Biological Applications ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recognition Elements ◽  
Synthesis Procedure

Molecularly imprinted polymers (MIPs) are currently widely used and further developed for biological applications. The MIP synthesis procedure is a key process, and a wide variety of protocols exist. The templates that are used for imprinting vary from the smallest glycosylated glycan structures or even amino acids to whole proteins or bacteria. The low cost, quick preparation, stability and reproducibility have been highlighted as advantages of MIPs. The biological applications utilizing MIPs discussed here include enzyme-linked assays, sensors, in vivo applications, drug delivery, cancer diagnostics and more. Indeed, there are numerous examples of how MIPs can be used as recognition elements similar to natural antibodies.

Water-compatible surface molecularly imprinted polymers with synergy of bi-functional monomers for enhanced selective adsorption of bisphenol A from aqueous solution

2016 ◽  
Vol 3 (1) ◽  
pp. 213-222 ◽  
Author(s):  
Feifei Duan ◽  
Chaoqiu Chen ◽  
Xiaofeng Zhao ◽  
Yongzhen Yang ◽  
Xuguang Liu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Bisphenol A ◽  
Molecularly Imprinted Polymers ◽  
Selective Adsorption ◽  
Aqueous Media ◽  
Selective Removal ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Adsorption Performance

Water-compatible surface molecularly imprinted polymers were synthesized via bi-functional monomers and exhibited excellent adsorption performance for the selective removal of BPA from aqueous media.

scholarly journals Phthalocyanine-Based Molecularly Imprinted Polymers as Nucleoside Receptors

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
Luigia Longo ◽  
Giuseppe Vasapollo
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Zinc Phthalocyanine ◽  
Scatchard Analysis ◽  
Binding Affinities ◽  
Imprinted Polymer ◽  
Binding Ability ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Combined Use

A molecularly imprinted polymer (MIP) for tri-O-acetyladenosine (TOAA), PPM(TOAA), was prepared by the combined use of methacrylic acid (MAA) and Zn(II)tetra(4'-methacryloxyphenoxy) phthalocyanine as functional monomers. This MIP exhibited a higher binding ability for TOAA compared to the MIP prepared using only MAA, PM(TOAA), in batch rebinding tests. Scatchard analysis gave a higher association constant of PPM(TOAA) for TOAA (2.96×104 M−1) than that of PM(TOAA) (1.48×104 M−1). The MIP prepared using only the zinc-phthalocyanine, PP(TOAA), did not show any binding capacity for TOAA. This means that the phthalocyanine in the MIP contributes to higher affinities, although it barely interacts with TOAA. Since selectivity for this kind of MIPs is more important than binding affinity, the binding of TOAA and a structurally related compound, tri-O-acetyluridine (TOAU), on the polymers was investigated. Both PPM(TOAA) and PM(TOAA) exhibited binding affinities for TOAA while they did not show any binding capacity for TOAU.

scholarly journals “Monoclonal-type” plastic antibodies for SARS-CoV-2 based on Molecularly Imprinted Polymers

2020 ◽  
Author(s):  
Ortensia Ilaria Parisi ◽  
Marco Dattilo ◽  
Francesco Patitucci ◽  
Rocco Malivindi ◽  
Vincenzo Pezzi ◽  
...  
Keyword(s):  
Light Scattering ◽  
Molecularly Imprinted Polymers ◽  
Polymeric Nanoparticles ◽  
Infection Process ◽  
Spike Protein ◽  
The Novel ◽  
Receptor Binding Domain ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Novel Coronavirus

Summary of the ideaOur idea is focused on the development of “monoclonal-type” plastic antibodies based on Molecularly Imprinted Polymers (MIPs) able to selectively bind a portion of the novel coronavirus SARS-CoV-2 spike protein to block its function and, thus, the infection process. Molecular Imprinting, indeed, represents a very promising and attractive technology for the synthesis of MIPs characterized by specific recognition abilities for a target molecule. Given these characteristics, MIPs can be considered tailor-made synthetic antibodies obtained by a templating process.In the present study, the developed imprinted polymeric nanoparticles were characterized in terms of particles size and distribution by Dynamic Light Scattering (DLS) and the imprinting effect and selectivity were investigated by performing binding experiments using the receptor-binding domain (RBD) of the novel coronavirus and the RBD of SARS-CoV spike protein, respectively. Finally, the hemocompatibility of the prepared MIP-based plastic antibodies was also evaluated.

scholarly journals Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Polymers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1173 ◽  
Author(s):  
Alberto Rico-Yuste ◽  
Sergio Carrasco
Keyword(s):  
Hybrid Materials ◽  
Optical Sensors ◽  
Materials Science ◽  
Synergetic Effect ◽  
Optical Signal ◽  
The Novel ◽  
Molecularly Imprinted ◽  
Recognition Ability ◽  
Recognition Elements ◽  
New Generation

We report on the development of new optical sensors using molecularly imprinted polymers (MIPs) combined with different materials and explore the novel strategies followed in order to overcome some of the limitations found during the last decade in terms of performance. This review pretends to offer a general overview, mainly focused on the last 3 years, on how the new fabrication procedures enable the synthesis of hybrid materials enhancing not only the recognition ability of the polymer but the optical signal. Introduction describes MIPs as biomimetic recognition elements, their properties and applications, emphasizing on each step of the fabrication/recognition procedure. The state of the art is presented and the change in the publication trend between electrochemical and optical sensor devices is thoroughly discussed according to the new fabrication and micro/nano-structuring techniques paving the way for a new generation of MIP-based optical sensors. We want to offer the reader a different perspective based on the materials science in contrast to other overviews. Different substrates for anchoring MIPs are considered and distributed in different sections according to the dimensionality and the nature of the composite, highlighting the synergetic effect obtained as a result of merging both materials to achieve the final goal.

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