Rehabilitation of reproductive function in women with chronic endometritis

2015 ◽  
Vol 98 (2) ◽  
pp. 94-96
Author(s):  
V.I. Pirogova ◽  
◽  
I.V. Kozlowski ◽  
Keyword(s):  
Reproductive Function ◽  
Chronic Endometritis

Fertility and ovarian reserve (Сlinical lecture)

2018 ◽  
pp. 10-13
Author(s):  
V.I. Pyrohova ◽  
◽  
M.T. Ferents ◽  
Keyword(s):  
Key Words ◽  
Ovarian Reserve ◽  
Reproductive System ◽  
Reproductive Function ◽  
The State ◽  
Chronic Endometritis ◽  
National Medical ◽  
Medical University ◽  
The Relationship

Lviv national medical University named Danylo Galitsky The article considers the selected aspects of fertility of women in modern conditions, the relationship between the ovarian reserve, the state of the endometrium and the ability to realize the reproductive function. Key words: fertility, ovarian reserve, endometrium, chronic endometritis, reproductive system.

Clinico-immunohistochemical aspects of recovery of reproductive function of women with chronic endometritis

2014 ◽  
Vol 63 (4) ◽  
pp. 34-38 ◽  
Author(s):  
Vera Aleksandrovna Kolmyk ◽  
Ruslan Abdullayevich Nasyrov ◽  
Galiya Fettyakhovna Kutusheva
Keyword(s):  
Epstein Barr Virus ◽  
Antiviral Drug ◽  
Progesterone Receptors ◽  
Reproductive Function ◽  
Clinical Analysis ◽  
Estrogen And Progesterone Receptors ◽  
Chronic Endometritis ◽  
Barr Virus ◽  
Epstein Barr ◽  
Simplex Virus

20 female patients aged 18-40 years old with a complicated anamnesis have been examined. Besides the regular clinical analysis the Pipel-byopsy was carried out with the immunohistochemical and histological investigation of the material. The expression level of estrogen and progesterone receptors has been determined. As well as the antigens of HSV, CMV and Epstein-Barr virus. In the case when chronic endometritis was diagnosed with the appearance of any of the viruses, the immunomodulating and antiviral therapy was administered. In the treatment of chronic endometritis associated with herpes simplex virus is advisable to administer an antiviral drug cour at least 3 months.

Modern approaches to the management of patients with chronic endometritis

2016 ◽  
Vol 3 (3) ◽  
pp. 141-148
Author(s):  
Ara L. Unanyan ◽  
Yu. M Kossovich
Keyword(s):  
Reproductive Function ◽  
Successful Implementation ◽  
Chronic Endometritis

Chronic endometritis is the clinically relevant nosological form requiring the timely detection and treatment. Comprehensive stepped and pathogenetically grounded therapy for chronic endometritis in most of cases leads to the restoration of morphofunctional potential of the endometrium and as a consequence, it contributes to the successful implementation of the reproductive function.

scholarly journals ОПТИМІЗАЦІЯ ЛІКУВАННЯ ЖІНОК З ХРОНІЧНИМ ЕНДОМЕТРИТОМ ЯК РЕЗЕРВ ПІДВИЩЕННЯ ФЕРТИЛЬНОСТІ

World Science ◽  
2018 ◽  
Vol 1 (10(38)) ◽  
pp. 28-32
Author(s):  
Донська Ю. В. ◽  
Лоскутова Т. О. ◽  
Сімонова Н. В. ◽  
Петулько А. П.
Keyword(s):  
Menstrual Cycle ◽  
Reproductive Potential ◽  
Clinical Manifestations ◽  
Reproductive Function ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Demographic Situation ◽  
Chronic Endometritis ◽  
The Creation

The worsening demographic situation encourages the search for new reserves to improve reproductive potential. The maximum incidence of chronic endometritis (97.6%) is 26-35 years old - the most important in the implementation of reproductive function. The lack of a single concept for the pathogenesis of HE, the purge of clinical manifestations impedes the creation of well-grounded therapy in women of childbearing age. The aim of the study was to increase the effectiveness of treatment of patients with confirmed chronic endometritis in order to restore fertility. It is proved that the use of the scheme, which includes antibacterial (doxycycline 100 mg orally 2 times a day and metronidazole 500 mg 2 times a day for 14 days in one menstrual cycle) and cyclic progestogen (didrogesterone at a dose of 20 mg per day with 15 to 25 days of the menstrual cycle - within three months), therapy can restore the morpho-functional endometrium potential by 88% compared with the initial rates.

scholarly journals CLINICAL AND MORPHOLOGICAL FEATURES OF CHRONIC ENDOMETRITIS IN INFERTILE WOMEN

2017 ◽  
Vol 4 (4) ◽  
pp. 208-213
Author(s):  
Ara L. Unanyan ◽  
Yu. M Kossovich ◽  
T. A Demura ◽  
D. V Baburin ◽  
I. S Sidorova ◽  
...  
Keyword(s):  
Reproductive Function ◽  
Occurrence Rate ◽  
Etiologic Factor ◽  
Chronic Endometritis ◽  
Vitro Fertilization ◽  
Anaerobic Microorganisms ◽  
Steady Growth ◽  
Clinically Significant ◽  
And Function

Morphofunctional state of the endometrium is one of the key factors determining both the successful implantation and full development of the embryo, including in cycles of «in vitro fertilization» (IVF). The most common cause of the impairment of the structure and function of the endometrium being chronic endometritis (CE), the frequency of its detection in infertile patients varies between 13 and 68%, reaching its maximum in women with tubal peritoneal factor and unsuccessful attempts of IVF in the anamnesis. The increasing prevalence and steady growth of the currently occurrence rate of CE cases in infertility is promoted by an increase in the role of intrauterine contraception and intrauterine interventions, including artificial abortions. On the other hand, happened in the last decades the evolution of the etiologic factor of CE towards the predominance of associations of facultative and obligate anaerobic microorganisms and viruses in the endometrium often leads to the development of erased, sluggish and atypical forms of the disease, which significantly hamper the diagnosis of CE and significantly reduce the effectiveness of traditional schemes of its treatment. CE is a clinically significant nosological form requiring the timely detection and treatment. The complex phased and pathogenetically substantiated therapy of CE in most cases leads to the restoration of the morphofunctional potential of the endometrium and, as a consequence, promotes the successful realization of the reproductive function.

Diagnosis and clinical criteria for chronic endometritis

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 53-59
Author(s):  
K G Serebrennikova ◽  
N A Arutyunyan ◽  
A I Alekhin
Keyword(s):  
Reproductive Function ◽  
Antiviral Effect ◽  
Chronic Endometritis ◽  
Vitro Fertilization ◽  
Clinical Criteria ◽  
New Methods ◽  
And Function ◽  
Social Importance

Currently, the urgency of the problem of chronic endometritis is of medical and social importance, since it leads to impaired reproductive function. Among the risk factors there is a predominance of intrauterine devices and inflammatory complications after childbirth and abortion. Prolonged persistence of infectious agents in the endometrium in chronic endometritis leads to marked changes in the structure and function of the tissue, causes proliferative disorders, as well as disorders in cyclic transformation. Morphofunctional damage to the endometrium is not only the cause of infertility, unsuccessful attempts of in vitro fertilization (IVF) and embryo transfer (PE), miscarriage, and a decrease in the quality of life of women due to chronic pain, dyspareunia, uterine bleeding and discharge from the genital tract. Timely and accurate diagnosis is key to the success of the restoration of reproductive function. Treatment of chronic endometritis is a complex, phased process. One of the new methods is photodynamic therapy, which leads to the development of a photochemical reaction that destroys bacterial and tumor cells, and also has an antiviral effect.

Chronic endometritis in women with endometriosis-associated infertility

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (3) ◽  
pp. 15-20
Author(s):  
Mekan R. Orazov ◽  
Victor E. Radzinsky ◽  
Snezhana V. Volkova ◽  
Marina B. Khamoshina ◽  
Ludmila M. Mikhaleva ◽  
...  
Keyword(s):  
Immune Response ◽  
Bacterial Contamination ◽  
Abdominal Cavity ◽  
Reproductive Function ◽  
Endometrial Receptivity ◽  
Reproductive Disorders ◽  
Chronic Endometritis ◽  
Common Features ◽  
Adaptation Mechanisms

The article highlights modern ideas about the role of the endometrium in the genesis of reproductive failures. A crucial place of chronic endometritis in the structure of the endometrial infertility factor in endometriosis is noted. Given the frequent association of chronic endometritis and endometriosis, common features of these diseases have been identified. The characteristic of endometrial microbiota in infertility, chronic endometritis and endometriosis is given. An extremely important area of scientific research is precisely the interaction between the microbiota of the endometrium and its immunity, and not just the confirmation of the presence of microorganisms in the endometrium. The modern aspects of the etiology and pathogenesis of chronic endometritis and endometriosis are described. The main pathogenetic determinants of chronic endometritis are the failure of adaptation mechanisms to the constant effects of microbes and, as a consequence, the decrease and inferiority of the immune response and the development of autoimmune reactions. The modern paradigm for the development and progression of endometriosis involves the presence of bacterial contamination of the endometrium and the abdominal cavity, which in turn becomes a trigger for genetically-epigenetic modifications of cells, launching different cascades that underlie reproductive function disorders. The pathogenetically significant relationship between chronic endometritis and endometriosis is highlighted. It was revealed that chronic endometritis can be both a cause and a consequence of endometriosis. Disorders of the endometrial receptivity in chronic endometritis associated with endometriosis, their importance in the implementation of endometrial infertility are described. The important role of the microbiome in the formation of reproductive disorders is noted.

scholarly journals CHARACTERISTICS OF THE MICROBIOCENOSIS OF THE VAGINAL TRACT AND ITS ROLE IN INITIATING THE INFLAMMATORY PROCESS IN THE ENDOMETRIUM IN WOMEN WITH REPRODUCTIVE DISORDERS

2018 ◽  
Vol 2 (5) ◽  
pp. 15-20
Author(s):  
Ирина Данусевич ◽  
Irina Danusevich ◽  
Елена Иванова ◽  
Elena Ivanova ◽  
Исай Михалевич ◽  
...  
Keyword(s):  
Inflammatory Process ◽  
Reproductive Function ◽  
Reproductive Disorders ◽  
Secondary Immunodeficiency ◽  
Suppressor Activity ◽  
Chronic Endometritis ◽  
Significance Level ◽  
Vaginal Tract ◽  
Student’S T ◽  
Histological Confirmation

Background. Microbiological disorders in the genital tract predispose to the development of chronic pelvic diseases and subsequently worsen the prognosis for reproductive function, causing infertility, miscarriage. Aims: study of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders. Materials and methods. The study included 50 patients with reproductive disorders with histological confirmation of the diagnosis of chronic endometritis and 50 patients with reproductive disorders without chronic endometritis. Mi- crobiological studies of the biotope of the vagina were carried out according to the guidelines. The counting of immune cells was carried out in peripheral blood with flow cytofluorimeter. Methods of mathematical statistics implemented in the application package Statistica 6.1 (StatSoft Inc., USA) were used in the study. Used criteria were Student’s t-test and Fisher criterion with a significance level less than 5 % (p ≤ 0.05). Results and conclusions. Conditionally pathogenic microflora in women with chronic endometritis in the cervical ca- nal is represented by candidiasis, herpesviruses, ureaplasma and facultative-anaerobically positive microorganisms. Candida, obligate-anaerobic gram-negative, and facultative anaerobic gram-positive microorganisms predominated in the endometrium. The secondary immunodeficiency state is characterized by suppressor activity of T-lymphocytes; the decrease in mi- crobicide activity of blood, pronounced inhibition of the humoral link of the immune system. Violations of the balance of the indigenous and conditionally pathogenic microflora accompanied by a secondary immunodeficiency may be the initiator of chronic inflammation in the endometrium.

scholarly journals CHRONIC ENDOMETRITIS AS A СAUSE OF DISORDERS OF THE FEMALE REPRODUCTIVE FUNCTION

2015 ◽  
pp. 9-16
Author(s):  
Yu. A. Lyzikova
Keyword(s):  
Risk Factors ◽  
Reproductive Function ◽  
Receptor Expression ◽  
Immunohistochemical Method ◽  
Main Role ◽  
Reproductive Disorders ◽  
Local Immunity ◽  
Chronic Endometritis ◽  
Inflammatory Processes

The review deals with the main role of chronic endometritis in the genesis of disorders of the female reproductive function and reveals the etiologic risk factors for the development and starting mechanism of chronic inflammatory processes in the endometrium, features of the pathogenesis and clinical picture of chronic endometritis. The work shows the importance of diagnosis of chronic endometritis with immunohistochemical method, reasonability of immunohistochemical research for the assessment of receptor expression and expressiveness of local immunity in the endometrium, the necessity of detection of fertility alpha-2-microglobulin (AMGF) protein for prediction of reproductive disorders.

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