Features of the clinical course of vulvar precancer and cancer in women of reproductive age

2020 ◽  
pp. 28-32
Author(s):  
T.F. Tatarchuk ◽  
◽  
V.V. Dunaevskaya ◽  
N.V. Kosei ◽  
◽  
...  
Keyword(s):  
Young Women ◽  
Vulvar Cancer ◽  
Clinical Course ◽  
Precancerous Lesions ◽  
Close Association ◽  
Gynecological Cancer ◽  
Young Patients ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Cell Hyperplasia

Continuing increase of precancer, epithelial and invasive vulvar cancer rate significantly enlarges the proportion of this group of patients. Meanwhile, all the grounds to improve the system of early diagnosis and treatment of this pathology are given nowadays. No other localization of gynecological cancer proves such a close association with postmenopause and involute atrophic processes of this period of a woman’s life. The objective: is to study the features of the clinical course of cancer and precancerous lesions of the vulva in women of reproductive age. Materials and methods. From 2017 to 2020, 150 patients with dystrophic diseases, precancerous lesions and vulvar cancer were examined in the outpatient department of the National Cancer Institute. The age of patients in the study ranged from 18 to 49 years old (32±3.5). Menstrual function was unchanged in 98 (65%) of 150 women. The age of menarche varied from 11 to 18 years old (mean age – 14.5±0.3 years). The average duration of the menstrual cycle was 28±0.4 days. The doctor performed conservative treatment of «leukoplakia and kraurosis» for many months, and sometimes years, without histological clarification of the diagnosis. More than half (n=106; 71%) of patients underwent long-term and unreasonable anti-inflammatory or hormonal therapy with unsatisfactory results without cytological and / or histological examinations. Results. In the study of vulvar biopsies, the VIN diagnosis (28%) prevailed in comparison with the invasive tumor process (12%) and was asymptomatic in more than 50% of cases. Thus, the peak level of HPV was observed in young women (80%). HPV was represented by types of high oncogenic risk (16, 18, 31, 33) in 90% of cases and it was associated with a malignant process in 100% of cases. At the same time, the background disease in young patients is squamous cell hyperplasia, where the sequence of tumor development (VIN I - VIN II – VIN III) is more clearly traced and largely resembles the development of cervical cancer. It has been noted that in young women PVI is usually temporary, there is a faster spontaneous elimination of the virus and regression of existing HPV-associated pathology compared with menopausal women. Conclusion. Vulvar neoplasia is more common in the VIN form in women of reproductive age and in all cases, it is associated with human papillomavirus (HPV) of high oncogenic risk. Multicentric lesions are more typical for young patients. Keywords: vulva, cancer, precancer, anamnesis, vulvoscopy, histological examination.

scholarly journals PREVALENCE AND CORRELATES OF BACTERIAL VAGINOSIS AMONG YOUNG WOMEN OF REPRODUCTIVE AGE IN MYSORE, INDIA

2008 ◽  
Vol 26 (2) ◽  
pp. 132-137
Author(s):  
P Madhivanan ◽  
K Krupp ◽  
V Chandrasekaran ◽  
C Karat ◽  
A Arun ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Young Women ◽  
Reproductive Age ◽  
Women Of Reproductive Age

Ovarian Reserve in Young Women of Reproductive Age with Crohnʼs Disease

2012 ◽  
Vol 18 (8) ◽  
pp. 1515-1522 ◽  
Author(s):  
Thomas Fréour ◽  
Charline Miossec ◽  
Kalyane Bach-Ngohou ◽  
Thomas Dejoie ◽  
Mathurin Flamant ◽  
...  
Keyword(s):  
Young Women ◽  
Ovarian Reserve ◽  
Reproductive Age ◽  
Women Of Reproductive Age

scholarly journals Laparoscopy in the diagnosis and treatment of chronic recurrent salpingo-oophoritis

2005 ◽  
Vol 54 (5S) ◽  
pp. 34-34
Author(s):  
G. Zh. Bodykov ◽  
А. Т. Raisova ◽  
N. Р. Dolinskaya
Keyword(s):  
Young Women ◽  
Reproductive Age ◽  
Diagnosis And Treatment ◽  
Women Of Reproductive Age ◽  
Significant Impairment ◽  
Persistent Disability ◽  
Chronic Course

The relevance of the problem under study is due to an increase in gynecological morbidity rates, especially an increase in salpingo-oophoritis, characterized by a chronic course, frequent recurrence, severity of consequences and significant impairment of specific functions with persistent disability in young women of reproductive age.

scholarly journals Risk Factors Associated with Impaired Ovarian Reserve in Young Women of Reproductive Age with Crohn’s Disease

2020 ◽  
Vol 18 (2) ◽  
pp. 200-209 ◽  
Author(s):  
Yue Zhao ◽  
Baili Chen ◽  
Yao He ◽  
Shenghong Zhang ◽  
Yun Qiu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Crohn’S Disease ◽  
Young Women ◽  
Ovarian Reserve ◽  
Disease State ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Factors Associated ◽  
Active Disease

Background/Aims: Crohn’s disease (CD) primarily affects young female adults of reproductive age. Few studies have been conducted on this population’s ovarian reserve status. The aim of study was to investigate potential risk factors associated with low ovarian reserve, as reflected by serum anti-Müllerian hormone (AMH) in women of reproductive age with CD.Methods: This was a case-control study. Cases included 87 patients with established CD, and healthy controls were matched by age, height and weight in a 1:1 ratio. Serum AMH levels were measured by enzyme-linked immunosorbent assay.Results: The average serum AMH level was significantly lower in CD patients than in control group (2.47±2.08 ng/mL vs. 3.87±1.96 ng/mL, respectively, <i>P</i><0.001). Serum AMH levels were comparable between CD patients and control group under 25 years of age (4.41±1.52 ng/mL vs. 3.49±2.10 ng/mL, <i>P</i>=0.06), however, serum AMH levels were significantly lower in CD patients over 25 years of age compared to control group (<i>P</i><0.05). Multivariable analysis showed that an age greater than 25 (odds ratio [OR], 10.03; 95% confidence interval [CI], 1.90–52.93, <i>P</i>=0.007), active disease state (OR, 27.99; 95% CI, 6.13–127.95, <i>P</i><0.001) and thalidomide use (OR, 15.66; 95% CI, 2.22–110.65, <i>P</i>=0.006) were independent risk factors associated with low ovarian reserve (serum AMH levels <2 ng/mL) in CD patients. Conclusions: Ovarian reserve is impaired in young women of reproductive age with CD. Age over 25 and an active disease state were both independently associated with low ovarian reserve. Thalidomide use could result in impaired ovarian reserve.

scholarly journals Recomendações Sobre a Abordagem da Esclerose Múltipla na Gravidez, Parto e Pós-Parto: Posição de Consenso do Grupo de Estudos de Esclerose Múltipla e da Sociedade Portuguesa de Obstetrícia e Medicina Materno-Fetal

2018 ◽  
Vol 31 (12) ◽  
pp. 785
Author(s):  
Sónia Batista ◽  
Ana Martins da Silva ◽  
Maria José Sá ◽  
Lívia Sousa ◽  
João De Sá ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Young Women ◽  
Postpartum Period ◽  
State Of The Art ◽  
Healthcare Providers ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Disease Modifying Therapies ◽  
Multiple Sclerosis Patients

Multiple sclerosis typically affects young women of reproductive age. Therefore, all healthcare providers involved in the follow-up of multiple sclerosis patients must be prepared to discuss pregnancy and breastfeeding issues, and provide the best possible counselling. However, there are still many doubts and heterogeneous clinical approaches partly due to the lack of consensus and guidelines. Concerning the handling of disease modifying therapies during pregnancy and the postpartum period, uncertainties have been complicated by the increase in recent years of the number of available treatments. This article aims to present the state-of-the-art and provide guidance based on the best level of available evidence and expert opinion regarding the management of multiple sclerosis patients at different stages: pregnancy planning, pregnancy, partum, and the postpartum period.

Features of clinical course of vulva cancer in reproductive patients.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15519-e15519
Author(s):  
Ekaterina Nerodo ◽  
Galina A. Nerodo
Keyword(s):  
Elderly Patients ◽  
Cancer Patients ◽  
Clinical Course ◽  
Young Patients ◽  
The Elderly ◽  
Reproductive Age ◽  
Free Survival ◽  
Early Stages ◽  
The One ◽  
Vulva Cancer

e15519 Background: The significant increase of vulva cancer patients in young and middle age is observed during the last ten years. Methods: To compare the clinical course of vulva cancer in reproductive patients (under 50 years of age) with the one in elderly agewe performed the comparative analysis of clinical characteristics of 839 vulva cancer patients, aged 20-90, with stages I-IV carcinoma who underwent standard complex antitumour treatment. Results: The reproductive group included 64 patients (7.6%), 775 patients (92.4%) were over 50 years. These included prevailed groups of 61-70 years of age – 38% and 71-80 years of age – 34%. Early stages of the disease were observed in 48% of all cases, st. III-IV – in 52%. In the reproductive group st. I was observed in 18.75%, st. II – 51.56%, st. III – 23.43%, st. IV – 6.25%. 70.03% patients of reproductive age had early stages of the disease, that is significantly higher than in the group of elderly patients: 51-70 years of age – 55%, 71-80 years of age – 40%, more than 80 years of age – only 25%(p<0.05). Age characteristics of vulva cancer patients in reproductive group were the following: 20-30 years of age – 10.9%, 31-40 years of age – 32.8%, 41-50 years of age – 56.25%. Organ-preserving operations carried out according to strict individual indications were performed to 35 sexually active patients in early stages. Relapses of the disease were revealed in 11 patients out of 64 (17%) in the reproductive group, and in 180 out of 775 (23.2%) patients in the elderly group(p<0,05) Relapses occurred in 8% of reproductive patients with st. I of the disease, st. II – 9%, st. III – 46%. Med locoregional free-survival was in st.I-72,3 mon. ,in st. II-61,3 mon., in st III-17,3 mon. All patients with inoperable tumour relapse underwent chemotherapy with subsequent tumour removal. Conclusions: Vulva cancer in patients of reproductive age is revealed in early stages more often that in elderly patients. There is a possibility to perform organ-preserving operations in young patients, which doesn't lead to relapse increase.

Nuptiality, education, infant mortality and fertility in Sri Lanka

1979 ◽  
Vol 11 (2) ◽  
pp. 133-140 ◽  
Author(s):  
Dallas F. S. Fernando
Keyword(s):  
Regression Analysis ◽  
Sri Lanka ◽  
Infant Mortality ◽  
Young Women ◽  
Reproductive Age ◽  
Sri Lankan ◽  
Women Of Reproductive Age ◽  
Fertility Variation ◽  
Education Of Women ◽  
Practical Measure

SummaryThe determinants of fertility variation among districts of Sri Lanka are explored by multiple regression analysis. The proportion of young women who are married (age 20–24), and the proportion of women of reproductive age who have received at least 5 years of education, account respectively for 46% and 24% of district variation in total fertility. Infant mortality variation accounts for only 8%. From the results it is argued that encouragement of education of women and postponement of marriage is one practical measure which will help to reduce Sri Lankan fertility.

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