scholarly journals Features of local therapy of acute inflammatory diseases of the oropharynx in children

2018 ◽  
pp. 98-101
Author(s):  
T.V. Marushko ◽  
◽  
A.O. Asonov ◽  
Keyword(s):  
Inflammatory Diseases ◽  
Local Therapy

Biologics in Microangiopathic Wounds

2018 ◽  
Vol 17 (4) ◽  
pp. 205-213
Author(s):  
Massimo Papi ◽  
Claudia Papi
Keyword(s):  
Inflammatory Diseases ◽  
Platelet Rich Plasma ◽  
Connective Tissue Diseases ◽  
Local Therapy ◽  
Biologic Agents ◽  
Biologic Drugs ◽  
New Class ◽  
Skin Ulcers ◽  
Inflammatory Processes ◽  
Inflammatory Molecules

In the last decades the possibility to diagnose a skin ulcer has greatly improved. We learnt that a consistent percentage of nonhealing ulcers may be caused by a microangiopathic disorder that has not been properly investigated and cured. Pathogenetically, we can distinguish 2 main groups: (1) ulcers due to inflammatory microangiopathy, mainly including cutaneous small and medium vessel vasculitis, pyoderma gangrenosum, and connective tissue diseases, and (2) ulcers due to occlusive microangiopathy. The group of microangiopathic occlusive ulcers is more heterogeneous and includes different disorders ranging from livedo vasculopathy to calciphylaxis, hydroxyurea-induced ulcers, antiphospholipid antibodies ulcers, and various other types. These conditions can induce thromboses or anatomo-functional occlusion of cutaneous microvessels. Despite different physiopathologic mechanisms, the ulcer resulting from a primitive microangiopathy may receive basic treatments that are in the complex similar to other pathogenetically different wounds, including MOIST-based local therapy and elastic compression when it is not contraindicated. Persistent inflammatory processes are increasingly demonstrated as responsible for the chronicity of many skin ulcers. New data concerning the biological phases of wound healing and the molecules that play crucial roles in this process suggested the use of new specific therapies. Some of them such as growth factors and platelet-rich plasma are prevalently used as topical biologic agents with variable benefits. In recent years, a new class of systemic anti-inflammatory molecules, better known as biologic drugs, have been introduced in the cure of chronic inflammatory diseases that can induce microangiopathic injuries and ulcerative complication. They enlarged the therapeutic options in case of nonresponder microangiopathic ulcers and could represent a future model of “pathogenetically based” therapy of skin ulcers.

scholarly journals Mechanisms of benzydamine action against local inflammatory process

2019 ◽  
pp. 78-86 ◽  
Author(s):  
G. V. Poryadin ◽  
J. M. Salmasi ◽  
A. N. Kazimirsky
Keyword(s):  
Immune System ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Local Therapy ◽  
Mechanisms Of Action ◽  
Pharmacological Effects ◽  
Inflammatory Processes ◽  
Antimicrobic Activity ◽  
Acute And Chronic Inflammation ◽  
Inflammatory Action

Local inflammatory diseases caused by various infections are one of the most common pathologies in medical practice. For example, tonsillopharyngitis. This disease is extremely frequent for a physician’s practice. There is a fair amount of drugs, which supposed to be helpful against tonsillopharyngitis, but different drugs are also not the same in their pharmacological effects. In gynecological practice, frequent diseases are specific and non-specific vulvovaginitis, which have inflammatory and infectious components. For administrating local pharmacotherapy in gynecology against inflammation, a large number of drugs with different mechanisms of action are proposed. In this study, we focused on key pathological mechanisms associated with acute and chronic inflammation, for which these drugs should be exposed by their pharmacokinetic and pharmacodynamic properties. The best combination of these properties is available for benzydamine hydrochloride. Benzydamine hydrochloride has a wide antimicrobic activity against bacteria and Candida spices both albicans and non-albicans strains and allows to influence on etiologic cause of the disease. Also benzydamine hydrochloride associated with «cytokine» mechanism of anti-inflammatory action, which means that he does not affect COX enzymes and it allows to avoid gastrotoxic adverse events. Also, in this work showed and discussed aspects of the interaction of benzydamine with local immune system and justification of useful usage the benzydamine for local therapy of acute and chronic inflammatory processes caused by various infections.

scholarly journals Diagnosis and treatment of diffuse otitis externa

2019 ◽  
pp. 20-24
Author(s):  
A. V. Gurov ◽  
M. A. Yushkina
Keyword(s):  
Staphylococcus Aureus ◽  
Otitis Externa ◽  
Inflammatory Diseases ◽  
Acute Otitis Media ◽  
Local Therapy ◽  
Chronic Inflammatory Diseases ◽  
Diffuse Inflammation ◽  
Patients With Diabetes ◽  
Topical Medications

The article deals with modern concepts of etiology, pathogenesis, diagnostics and treatment of inflammatory diseases of the outer ear. The problem of otitis externa flow in patients with diabetes is covered. The role of various microorganisms is discussed: Staphylococcus aureus, bacteria of Enterobacteriaceae family, fungi of Aspergillus, Candida, Penicillium, Mucor genera in the development of diffuse inflammation, variants of using local topical medications in the treatment of acute and chronic inflammatory diseases of the outer ear, as well as local therapy of otitis externa in combination with acute otitis media are considered. As the most effective and safe means the authors suggest using the local combined drug Candibiotic, which contains antibacterial, fungicidal, corticosteroid and analgesic components that affect the main pathogenesis factors of the disease.

scholarly journals The Antibacterial Eye Ointments in the Treatment of Eyelids and Conjunctiva Acute and Chronic Diseases

2019 ◽  
Vol 16 (1) ◽  
pp. 31-37 ◽  
Author(s):  
V. N. Trubilin ◽  
E. G. Poluninа ◽  
D. V. Andzhelova ◽  
V. V. Kurenkov ◽  
Yu. V. Evstigneeva ◽  
...  
Keyword(s):  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Local Therapy ◽  
Drug Efficacy ◽  
Structural Features ◽  
Acute Stage ◽  
Ointment Base ◽  
Medicinal Substances ◽  
High Level ◽  
The Impact

Currently, there are many studies on the effectiveness of ointment ophthalmological medicines. Ophthalmic ointments are unique because they have a multi-component action mechanism. On the one hand, the action of the medicinal substance itself is prolonged due to the ointment base, and on the other hand, due to the structural features of the conjunctival cavity mucosa, these medicinal substances are very rapidly absorbed. In the treatment of ocular surface pathology, including as meibomiitis, barley and chalazions, local therapy and ointment forms are preferred. The purpose of the study was the investigation the antibacterial eye ointment effectiveness of domestic production Oftocipro — a fluoroquinolone derivative for the treatment of acute and chronic eyelid and conjunctiva diseases. During the study patients were divided into 2 groups with acute and chronic inflammatory diseases of the eyelids and conjunctiva in the acute stage. It is known that chronic pathological processes are often stopped in longer periods. This fact was a prerequisite for assessing the effectiveness of Ontocipro with a comparative analysis of the dynamics of subjective (patient complaints) and objective (biomicroscopy, tear production tests) indicators characterizing the severity of the inflammatory process. The study has showed a high drug efficacy, when it is applied topically 3–4 times a day. The average time to relieve the inflammatory process was 3–7 days. The possibility of using the drug Oftocipro locally, when it is applied to the eyelid area, without affecting the conjunctival cavity, allows to minimize the impact area due to the ointment base and limit the risk of side effects in the form of a violation of the natural conjunctival microflora. Considering high level of tolerance and low allergenicity of the drug Oftotsipro, it can be recommended for widespread use for the treatment of acute and chronic blepharoconjunctivitis, barley and chalazion in the acute stage, as well as meibomiitis.

scholarly journals Combined drugs in local therapy of infectious vulvovaginitis are a priority area of ​​today

2021 ◽  
Vol 4 ◽  
pp. 83-92
Author(s):  
V.I. Mamchur ◽  
S.M. Dronov
Keyword(s):  
Inflammatory Diseases ◽  
Local Treatment ◽  
Local Therapy ◽  
Aerobic Vaginitis ◽  
Old Patients ◽  
Normative Documents ◽  
Treatment Regimens ◽  
Genital Area ◽  
Number Of Patients ◽  
Combined Drugs

One of the key and strategically important problems of modern gynecology both around the world and in Ukraine is infectious and inflammatory diseases (IVD) of the lower genital tract: according to various estimates, back in the 90s of the last century, this diagnosis was made in about 40 % of patients in gynecological hospitals. Over the first decade of the 21st century, the incidence rate of genital IVI increased 1.4 times in 18–24-year-old patients, and 1.8 times in 25–29-year-old patients. At the same time, the costs of diagnostics and treatment have increased, which reach 50-60% of all costs for the provision of gynecological care to the population.In the structure of gynecological morbidity, the indicator of the number of patients with infectious and inflammatory diseases of the genital area continues to occupy a leading position in terms of frequency in the population, amounting to 60.4-65.0%, however, information from different authors regarding their true prevalence is very contradictory. So, according to the materials of the 33rd European Congress of the International Union against for Sexually Transmitted Infections (IUSTI-Europe), bacterial vaginosis (BV) occurs in 12-80% of women, vulvovaginal candidiasis – VVC (at least one episode in life) - in 75%, aerobic vaginitis (AV) – in 15-25% [8]. According to other authors, the prevalence of BV is 24-30%, VVC – 9.7-11.7%, nonspecific (aerobic) vaginitis – 5.0-23.7%.Combined drugs Neo-Penotran® Forte and Gainomax have a high safety profile, which is due to the unique features of the pharmacokinetics and pharmacodynamics of their components. This determines the advantages in the speed of bactericidal action over other antibacterial and antimycotic agents. These drugs are highly effective in the local treatment of BV and vulvovaginal infections, reaching 98.5% in some nosologies.The effectiveness and safety of the use of Neo-Penotran® Forte and Gainomax in the treatment of infections of the female genital area served as the basis for their inclusion in standard treatment regimens according to indications, and their use is regulated by the normative documents of the Ministry of Health of Ukraine.

Etiotropic treatment of inflammatory diseases of the external and middle ear

2021 ◽  
Vol 20 (6) ◽  
pp. 115-124
Author(s):  
A. Yu. Ovchinnikov ◽  
◽  
S. S. Egiyan ◽  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Otitis Externa ◽  
Inflammatory Diseases ◽  
Local Therapy ◽  
Bacteriological Examination ◽  
High Efficacy ◽  
Suppurative Otitis Media ◽  
Good Tolerance ◽  
Ear Infections

The comparative analysis of the clinical efficacy of drugs for local therapy in patients with acute otitis externa, acute purulent otitis media and exacerbation of chronic suppurative otitis media is presented. The results of the clinical study, dynamic bacteriological examination confirm the high efficacy, safety and good tolerance of dioxidine in etiotropic treatment of external and middle ear infections.

Complications of Inflammatory Diseases of the Sinuses

1993 ◽  
Vol 26 (4) ◽  
pp. 639-655 ◽  
Author(s):  
James A. Stankiewicz ◽  
David J. Newell ◽  
Albert H. Park
Keyword(s):  
Inflammatory Diseases
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