scholarly journals Research progress of icariin, an extract of traditional Chinese medicine, in the treatment of asthma

2022 ◽  
Vol 50 (1) ◽  
pp. 9-16
Author(s):  
Jia-ying Yuan ◽  
Zhi-ying Tong ◽  
Yu-chao Dong ◽  
Jia-yi Zhao ◽  
Yan Shang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Biological Activities ◽  
Airway Disease ◽  
Research Direction ◽  
Research Progress ◽  
Therapeutic Drug ◽  
First Choice ◽  
Wide Range ◽  
New Research

Bronchial asthma is a common chronic airway disease, and long-term management of asthma is the focus and difficulty of clinical treatment. Glucocorticoids are often used as the first choice for the treatment of asthma. However, the occurrence of hormone dependence, hormone resistance, local and systemic adverse reactions caused by hormone application also brings problems for the treatment of asthma. Finding safe and effective new therapeutic drugs is an important research direction at present. Icariin is the effective ingredient of traditional Chinese medicine Epimedium. It has various biological activities such as anti-inflammatory, anti-oxidative stress, and immune regulation. It has high safety and has a wide range of clinical applications. Icariin has the characteristics of multi-target intervention in the treatment of asthma. This article reviews recent studies in order to provide new research directions for further therapeutic drug development.

scholarly journals Research Progress on the Antitumor Effect of Polysaccharides from Fungus Used in Traditional Chinese Medicine

2021 ◽  
Vol 5 (5) ◽  
pp. 7-10
Author(s):  
Ru Xiang ◽  
Bing Xu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Antitumor Effect ◽  
Biological Activities ◽  
Research Progress ◽  
Cancer Breast ◽  
Wide Range ◽  
Low Toxicity ◽  
Fungal Polysaccharides ◽  
Cancer Côlon

Cancer is a serious threat to human health. Fungal polysaccharide is a polar biological macromolecule with low toxicity. It has a wide range of biological activities, including immune regulation, antitumor activity, and antiviral activity. In recent years, the research results have shown that polysaccharides from fungus in traditional Chinese medicine have excellent antitumor effect in liver cancer, gastric cancer, breast cancer, colon cancer, esophageal cancer, and lung cancer. Therefore, the research and development of fungal polysaccharides are of great significance for the development of antitumor drugs in the future.

scholarly journals Chemical Constituents of Yarsagumba (Ophiocordyceps sinensis (Berk.) Sung et al.), a Valued Traditional Himalayan Medicine

2013 ◽  
Vol 13 (1) ◽  
pp. 43-58 ◽  
Author(s):  
Sabina Shrestha ◽  
Bhushan Shrestha ◽  
Ji-Hae Park ◽  
Dae-Young Lee ◽  
Jin-Gyeong Cho ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Health Conditions ◽  
Nitrogenous Compounds ◽  
Entomogenous Fungus ◽  
Ophiocordyceps Sinensis ◽  
Wide Range

Ophiocordyceps sinensis (Berk.) Sung et al. is popularly known as Yarsagumba (winter worm summer grass) in Nepal. It is a well-known entomogenous fungus distributed in alpine nival zone of trans-Himalayas and Tibetan Plateau. Its occurrence in extreme biological niche and cohabitation with insect [Thitarodes (Hepialus)] larvae has led to unique assemblage of metabolites including proteins and nitrogenous compounds, polysaccharides, sterols, nucleosides, fatty acids and their derivatives, vitamins and inorganics. In traditional Chinese medicine, it is one of the most trusted main ingredients for several preparations of remedy from wide range of human health conditions. Several biological activities from O. sinensis have been reported that include anti-inflammatory, antioxidant, antitumor, anti-metastatic, immunomodulatory, antimicrobial, insecticidal, hypolipidaemic, hypoglycemic, anti-ageing, lipolytic, neuroprotective, renoprotective effects, etc. The chemical constituents and their pharmacological uses are reviewed here highlighting the potentiality of this highly esteemed traditional Himalayan medicine. Nepal Journal of Science and Technology Vol. 13, No. 1 (2012) 43-58 DOI: http://dx.doi.org/10.3126/njst.v13i1.7398

scholarly journals Research Progress of Treating Diabetic Nephropathy with Traditional Chinese Medicine

2021 ◽  
Vol 5 (4) ◽  
pp. 97-99
Author(s):  
Ningjing Wu ◽  
Rong Li ◽  
Zongliang Song
Keyword(s):  
Diabetic Nephropathy ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Research Direction ◽  
Research Progress ◽  
Syndrome Differentiation ◽  
Clinical Effects ◽  
Clinical Use ◽  
Unique Role ◽  
Syndrome Differentiation And Treatment

By collecting and sorting out the literature and journals on the clinical use of Chinese medicine in the treatment of diabetic nephropathy in recent years, it is concluded that Chinese medicine is effective in the treatment of DKD. Chinese medicine therapy has a unique role in the treatment of diabetic nephropathy. How to correct syndrome differentiation and treatment? Improving clinical effects is the research direction that all medical staff will work together in the future.

scholarly journals Research Progress on Refractory Hypertension in Traditional Chinese Medicine

2021 ◽  
Vol 5 (4) ◽  
pp. 121-124
Author(s):  
Nana Zhou ◽  
Jinyu Chen ◽  
Ru Han ◽  
Yuanlin Lei
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Research Direction ◽  
Cerebrovascular Diseases ◽  
Research Progress ◽  
Refractory Hypertension ◽  
The Public ◽  
Disability Rate ◽  
The Government ◽  
Very High

At present, the mortality rate and disability rate caused by cardiovascular and cerebrovascular diseases are very high in China. Individuals with refractory hypertension are at a greater risk of developing chronic kidney disease, heart failure, stroke and myocardial infarction. Therefore, how to effectively control blood pressure and identify the cause of refractory hypertension is a problem that medical workers need to solve, and it is also the key to prevent cardiovascular disease. In recent years, the government actively supports the development of traditional Chinese medicine. Since the curative effect of traditional Chinese medicine is recognized by the public, the prospect of traditional Chinese medicine in the prevention and treatment of refractory hypertension is considerable, and it is expected to become the main key research direction in the future.

scholarly journals Advances in the role of miRNAs in the occurrence and development of osteosarcoma

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 1003-1011
Author(s):  
Guanyu Zhang ◽  
Yiran Li ◽  
Jiasheng Xu ◽  
Zhenfang Xiong
Keyword(s):  
Target Gene ◽  
Early Stage ◽  
Research Direction ◽  
Research Progress ◽  
Skeletal System ◽  
Translation Process ◽  
Non Coding Rnas ◽  
New Research ◽  
Post Transcriptional Regulation

AbstractOsteosarcoma (OS) is the most common primary malignant tumor of the skeletal system in the clinic. It mainly occurs in adolescent patients and the pathogenesis of the disease is very complicated. The distant metastasis may occur in the early stage, and the prognosis is poor. MicroRNAs (miRNAs) are non-coding RNAs of about 18–25 nt in length that are involved in post-transcriptional regulation of genes. miRNAs can regulate target gene expression by promoting the degradation of target mRNAs or inhibiting the translation process, thereby the proliferation of OS cells can be inhibited and the apoptosis can be promoted; in this way, miRNAs can affect the metabolism of OS cells and can also participate in the occurrence, invasion, metastasis, and recurrence of OS. Some miRNAs have already been found to be closely related to the prognosis of patients with OS. Unlike other reviews, this review summarizes the miRNA molecules closely related to the development, diagnosis, prognosis, and treatment of OS in recent years. The expression and influence of miRNA molecule on OS were discussed in detail, and the related research progress was summarized to provide a new research direction for early diagnosis and treatment of OS.

scholarly journals Research progress in use of traditional Chinese medicine for treatment of spinal cord injury

2020 ◽  
Vol 127 ◽  
pp. 110136 ◽  
Author(s):  
Yubao Lu ◽  
Jingjing Yang ◽  
Xuexi Wang ◽  
Zhanjun Ma ◽  
Sheng Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Research Progress ◽  
Cord Injury

Phytochemistry and Pharmacology of the Genus Pedicularis Used in Traditional Chinese Medicine

2014 ◽  
Vol 42 (05) ◽  
pp. 1071-1098 ◽  
Author(s):  
Mao-Xing Li ◽  
Xi-Rui He ◽  
Rui Tao ◽  
Xinyuan Cao
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
In Vivo Studies ◽  
Chemical Components ◽  
Wide Range ◽  
Phenylpropanoid Glycosides

In the present review, the literature data on the chemical constituents and biological investigations of the genus Pedicularis are summarized. Some species of Pedicularis have been widely applied in traditional Chinese medicine. A wide range of chemical components including iridoid glycosides, phenylpropanoid glycosides (PhGs), lignans glycosides, flavonoids, alkaloids and other compounds have been isolated and identified from the genus Pedicularis. In vitro and in vivo studies indicated some monomer compounds and extracts from the genus Pedicularis have been found to possess antitumor, hepatoprotective, anti-oxidative, antihaemolysis, antibacterial activity, fatigue relief of skeletal muscle, nootropic effect and other activities.

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