scholarly journals Does iron-fortified chewing gum influence the biochemical profile of school-going children (6–10 yrs.)?

2021 ◽  
Vol 33 (1) ◽  
pp. 29-38
Author(s):  
Muhammad Azeem ◽  
Mian Kamran Sharif ◽  
Fais-Ul-Hassan Shah ◽  
Maratab Ali ◽  
Muhammad Amer Nazir ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Blood Cells ◽  
Iron Status ◽  
White Blood Cells ◽  
Maximum Increase ◽  
Blood Profile ◽  
Mean Cell Volume ◽  
Chewing Gums ◽  
The Impact ◽  
Mean Cell Hemoglobin

Iron deficiency has become a common nutritional problem of developing countries, especially in children. This study approached to tackle the issue of iron deficiency by inexpensive fortified food such as chewing gums, which is commonly consumed by children. In this study, iron-fortified chewing gums were prepared by adding ferrous sulfate (FeSO4) and sodium iron EDTA (NaFeEDTA) 30 mg/100 g. An efficacy trial was conducted to determine the impact of iron-fortified chewing gums on the blood profile and iron status of school-going children (n = 300). Results showed maximum increase in blood profile and iron status that is, serum ferritin (10.43%), hemoglobin (3.22%), hematocrit (3.42%), red blood cells (3.05%), mean cell volume (1.55%), mean cell hemoglobin (5.43%), total white blood cells count (9.09%), and platelets count (4.40%) as compared with control whereas decrease in mean cell hemoglobin concentration (1.90%) and neutrophils (3.33%) was also observed. The study concluded that FeSO4 and NaFeEDTA (1:1) fortification of chewing gums is an appropriate approach for mitigating iron deficiency among the target population.

scholarly journals Evaluation and additional recommendations for preparing a whole blood control material

1998 ◽  
Vol 32 (2) ◽  
pp. 107-111
Author(s):  
Nilda E. Fink ◽  
Alejandra Fernández Alberti ◽  
Isabel Crispini ◽  
Norberto V. Cabutti ◽  
Daniel Mazziotta
Keyword(s):  
Coefficient Of Variation ◽  
Whole Blood ◽  
Blood Cells ◽  
Low Cost ◽  
White Blood Cells ◽  
Hemoglobin Concentration ◽  
Control Material ◽  
Mean Cell Volume ◽  
Automated Methods ◽  
Mean Cell Hemoglobin

OBJECTIVE: The assessment of an easy to prepare and low cost control material for Hematology, available for manual and automated methods. MATERIAL AND METHOD: Aliquots of stabilized whole blood were prepared by partial fixation with aldehydes; the stability at different temperatures (4. 20 and 37 °C) during periods of up to 8-9 weeks and aliquot variability with both methods were controlled. RESULTS: Aliquot variability with automated methods at day 1, expressed as CV% (coefficient of variation) was: white blood cells (WBC) 2.7, red blood cells (RBC) 0.7, hemoglobin (Hb) 0.6, hematocrit (Hct) 0.7, mean cell volume (MCV) 0.3, mean cell hemoglobin (MCH) 0.6, mean cell hemoglobin concentration (MCHC) 0.7, and platelets (PLT) 4.6. The CV (coefficient of variation) percentages obtained with manual methods in one of the batches were: WBC 23, Hct 2.8, Hb 4.5, MCHC 5.9, PLT 41. Samples stored at 4ºC and 20ºC showed good stability, only a very low initial hemolysis being observed, whereas those stored at 37ºC deteriobed a rapidly (metahemoglobin formation, aggregation of WBC and platelets, as well as alteration of erythrocyte indexes). CONCLUSIONS: It was confirmed that, as long as there is no exposure to high temperatures during distribution, this material is stable, allowing assessment, both esternal and internal, for control purposes, with acceptable reproductivity, both for manual and auttomatic methods.

scholarly journals The Effect of Breadfruit Leaf Flour (Artocarpus altilis) on Number of Blood Cells And Correlation Between Cholesterol Blood and Meat of Tegal Ducks 10 Weeks Age

2018 ◽  
Vol 19 (3) ◽  
pp. 179
Author(s):  
Elly Tugiyanti ◽  
Emmy Susanti
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Regression Coefficient ◽  
White Blood Cells ◽  
Blood Cholesterol ◽  
Blood Profile ◽  
Artocarpus Altilis ◽  
Randomized Design ◽  
Leaf Powder ◽  
Completely Randomized Design

The purpose of this research was to know the effect of breadfruit leaves flour in feed to blood profile and correlation between cholesterol, HDL and LDL of blood with meat cholesterol of maleTegal duck of 10 weeks old. The material used was Day Old Duck of male Tegal duck  as much as 120 heads with experimental research methods and Completely Randomized Design (CRD). There were 6 treatments: feed without breadfruit leaf powder, feed + breadfruit flour 3% / kg feed, feed + breadfruit flour 6% / kg feed, feed + breadfruit flour 9% / kg feed, feed + flour breadfruit 12% / kg feed, and feed + breadfruit flour 15% / kg feed. Each treatment was repeated 5 times and each replication consisted of 4 ducks. The variables observed were the number of red blood cells, white blood cells, HDL, LDL, blood triglycerides, correlation between cholesterol, HDL and LDL blood with meat cholesterol of male Tegal duck of 10 weeks old.  The result of the analysis showed that the supplementation of breadfruit leaves has significant effect (P <0,05) on the number of red blood cells, white blood cells, HDL, and blood triglyceride. There is a positive correlation between blood cholesterol with duck meat cholesterol which given breadfruit leaf powder. This research can be concluded that the supplementation of breadfruit leaf powder (Artocarpus altilis) can increase the number of red blood cells, white blood cells, blood HDL level but lowers blood cholesterol and triglyceride blood of male Tegal duck of 10 weeks old. Cholesterol meat is affected by blood cholesterol with regression coefficient of 0.780941, influenced by LDL (r = 0.407849), but negatively affected by HDL (r = -0.47022).

scholarly journals The prevalence of leukocyte abnormalities among Sudanese patients with sickle cell disease

2021 ◽  
Vol 9 (1) ◽  
pp. 262-267
Author(s):  
Tarig Osman Khalafallah Ahmed ◽  
Ekhlas Alrasheid Abu Elfadul ◽  
Ahmed A. Agab Eldour ◽  
Omer Ibrahim Abdallah Mohammed
Keyword(s):  
Sickle Cell Disease ◽  
Cell Volume ◽  
Sickle Cell ◽  
Blood Cells ◽  
White Blood Cells ◽  
Blood Film ◽  
Cell Disease ◽  
Mean Cell Volume ◽  
Blood Disorder ◽  
Age Range

Sickle cell disease (SCD) is an inherited blood disorder that affects red blood cells. The study was conducted in Elobied town during the period May 2011 to September 2011. The aim of this study is to detect the abnormalities of leucocytes among sickle cell anemic patients. 40 sickle cell anemic patients; age range between 8 months to 23 years. Blood sample was taken for all patients and the laboratory investigation were performed using automated estimation for: hemoglobin (Hb), Packed cell volume (PCV), red cell count (RBCs), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell concentration (MCHC), and total white blood cells, comment on blood film using manual methods. The conclusion of this study there is increase in total white blood cells with shift to left in neutrophil precursor in sickle cell patients with complications ,the most immature cells are band form, myelocytes and metamyelocytes, and there also lymphocytosis and neutrophilia which has been increases in response to infections.

Inherited and Acquired Modifiers of Iron Status May Dramatically Affect the Phenotypic Expression of Dehydrated Hereditary Stomatocytosis

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 1281-1281
Author(s):  
Corentin Orvain ◽  
Lydie Da Costa ◽  
Richard van Wijk ◽  
Serge Pissard ◽  
Veronique Picard ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Hemolytic Anemia ◽  
Iron Status ◽  
Phenotypic Expression ◽  
Wild Type ◽  
Clinical Prognosis ◽  
Normal Value ◽  
Iron Stores ◽  
The Impact

Abstract Background: Hereditary stomatocytosis is an inherited disorder of the erythrocyte membrane responsible of chronic hemolytic anemia. Recent advances in the understanding of this group of diseases came from the identification of the molecular basis of this disorder. Mutations in the SLC4A1, FAM38A, RHAG, and SLC2A1 genes have been shown to cause different subtypes of hereditary stomatocytosis. Dehydrated hereditary stomatocytosis (DHSt) is due to mutations in the FAM38A gene coding for the mechanotransduction protein PIEZO1 and to the newly discovered mutations in the KCNN4 gene encoding the Gardos channel. It is important to recognize this entity and differentiate it from hereditary spherocytosis as patients with HSt develop severe and sometimes lethal thromboembolic complications following splenectomy. Also, some patients develop progressive and severe iron overload (IO) despite well compensated hemolysis and no or little transfusion requirement. It is unclear why patients have such different clinical features regarding hemolytic anemia and IO. We describe herein the impact of inherited and acquired modifiers of iron status on the phenotypic expression of DHSt. Patients & Methods: We describe four patients (3 related and 1 unrelated) with proven DHSt due to FAM38A mutations, who displayed varying degrees of iron load. Results: The four reported patients were referred to our specialized outpatient consultation (center of expertise on rare iron overload) for investigation. Their clinical, laboratory and radiological features are summarized in the Table. It is noteworthy that both index cases were initially referred for investigation of hyperferritinemia. Iron levels closely correlated with the degree of hemolysis and with the severity of the clinical complications. One female patient with severe iron overload suffered from chronic anemia, acute hemolytic episodes, and symptomatic gallstones requiring cholecystectomy while one male patient with severe iron overload suffered from a thrombotic event. The two other female patients with no or moderate iron overload had no or mild hemolysis. Genetic modifiers increasing iron stores, such as the presence of the HFE C282Y mutation, and possibly the gender (male), were accompanied with higher liver iron concentration, increased hemolysis and clinical manifestations. On the opposite, females with normal or low iron stores (iron deficiency anaemia (ID) due to gynecologic bleedings) displayed no or mild hemolytic manifestations. It is noteworthy that in the female with ID no clinical or biological manifestations of hemolysis and of stomatocytosis were found initially (normal specialized phenotypic tests). The diagnosis was made by genetic analyses. Restoration of the iron stores resulted in the appearance of biological signs of hemolysis. Conclusion: Iron overload or iron deficiency dramatically alter the clinical presentation of DHST due to PIEZO1 defects. The search for genetic or acquired causes of iron overload (or deficiency) is an important step in the evaluation of the clinical prognosis and the modulation of iron store may help in the management of the patients. Table Clinical, biological, and radiological characteristics of the 4 patients N: normal value; NA: not available; wt: wild-type; ID: iron deficiency Table. Clinical, biological, and radiological characteristics of the 4 patients. / N: normal value; NA: not available; wt: wild-type; ID: iron deficiency Disclosures Cartron: Roche: Consultancy, Honoraria; Celgene: Honoraria; Gilead: Honoraria; Jansen: Honoraria.

scholarly journals Impact of iron fortification on anaemia and iron deficiency among pre-school children living in Rural Ghana

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246362
Author(s):  
Samuel Kofi Tchum ◽  
Fareed Kow Arthur ◽  
Bright Adu ◽  
Samuel Asamoah Sakyi ◽  
Latifatu Alhassan Abubakar ◽  
...  
Keyword(s):  
Placebo Group ◽  
Iron Deficiency ◽  
School Children ◽  
Iron Status ◽  
Intervention Group ◽  
Iron Group ◽  
Double Burden ◽  
Micronutrient Powder ◽  
The Impact

Anaemia in young sub-Saharan African children may be due to the double burden of malaria and iron deficiency. Primary analysis of a double-blind, cluster randomized trial of iron containing micronutrient powder supplementation in Ghanaian children aged 6 to 35 months found no difference in malaria risk between intervention and placebo groups. Here, we performed a secondary analysis of the trial data to assess the impact of long-term prophylactic iron fortificant on the risk of iron deficiency and anaemia in trial subjects. This population-based randomized-cluster trial involved 1958 children aged between 6 to 35 months, identified at home and able to eat semi-solid foods. The intervention group (n = 967) received a daily dose containing 12.5 mg elemental iron (as ferrous fumarate), vitamin A (400 μg), ascorbic acid (30 mg) and zinc (5 mg). The placebo group (n = 991) received a similar micronutrient powder but without iron. Micronutrient powder was provided daily to both groups for 5 months. At baseline and endline, health assessment questionnaires were administered and blood samples collected for analysis. The two groups had similar baseline anthropometry, anaemia, iron status, demographic characteristics, and dietary intakes (p > 0.05). Of the 1904 (97.2%) children who remained at the end of the intervention, the intervention group had significantly higher haemoglobin (p = 0.0001) and serum ferritin (p = 0.0002) levels than the placebo group. Soluble transferrin receptor levels were more saturated among children from the iron group compared to non-iron group (p = 0.012). Anaemia status in the iron group improved compared to the placebo group (p = 0.03). Continued long-term routine use of micronutrient powder containing prophylactic iron reduced anaemia, iron deficiency and iron deficiency anaemia among pre-school children living in rural Ghana’s malaria endemic area.

scholarly journals The Impact of the Differential White Blood Cells in the Diagnosis of the Acute Right Iliac Fossa Pathology

2020 ◽  
Vol 10 (5) ◽  
pp. 6082-6087
Keyword(s):  
Statistical Analysis ◽  
Observational Study ◽  
Blood Cells ◽  
Iliac Fossa ◽  
White Blood Cells ◽  
Common Symptom ◽  
Pain Diagnosis ◽  
Diagnostic Difficulties ◽  
Right Iliac Fossa Pain ◽  
The Impact

Acute Right Iliac Fossa Pain is a common symptom which has shown diagnostic difficulties for the surgical emergency clinic. A White Blood Cells test is required for Acute Right Iliac Fossa Pain diagnosis. In this study, we aimed to clarify the importance of Differential White Blood Cells test for Acute Right Iliac Fossa Pain diagnosis. The present observational study was conducted in in Heet General Hospital over a period of five months included 62 patients from both genders of different ages (5-45 years) who were suffering from Acute Right Iliac Fossa Pain. All patients were subjected to Differential White Blood Cells test which was carried out in the hospital laboratory using (Hematology Pentra 60 Series HORIBA ABX SAS). A statistical analysis were then run using ANOVA and LSD tests. The analysis have shown the means of each type as follow; NEU (8.3516), LYM (31.2984), MON, (6.1952), GRA (62.6790) 10^3/mm3. Also, a comparison among all the WBCs types and also between and within groups was performed using one and two ways Analysis of Variance ANOVA tests which have shown that there are significant differences of all differentials WBCs types. p<0.05 was considered statistically significant. Based on our findings, it can be clearly stated that Differential White Blood Cells tests (not only WBC) are very important for the clear diagnosis of Acute Right Iliac Fossa Pathology.

scholarly journals Reticulocyte and Erythrocyte Hemoglobin Parameters for Iron Deficiency and Anemia Diagnostics in Patient Blood Management. A Narrative Review

2021 ◽  
Vol 10 (18) ◽  
pp. 4250
Author(s):  
Christian Hoenemann ◽  
Norbert Ostendorf ◽  
Alexander Zarbock ◽  
Dietrich Doll ◽  
Olaf Hagemann ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Blood Loss ◽  
Blood Cells ◽  
Blood Count ◽  
Iron Status ◽  
Full Blood Count ◽  
Patient Blood Management ◽  
Acute Blood Loss ◽  
Blood Management ◽  
Main Factors

Anemia, iron deficiency and other hematinic deficiencies are a major cause of perioperative transfusion needs and are associated with increased morbidity and mortality. Anemia can be caused either by decreased production of hemoglobin or red blood cells or by increased consumption and blood loss. Decreased production can involve anything from erythropoietin or vitamin B12 insufficiency to absolute or functional lack of iron. Thus, to achieve the goal of patient blood management, anemia must be addressed by addressing its causes. The traditional parameters to diagnose anemia, despite offering elaborate options, are not ideally suited to giving a simple overview of the causes of anemia, e.g., iron status for erythropoiesis, especially during the acute phase of inflammation, acute blood loss or iron deficiency. Reticulocyte hemoglobin can thus help to uncover the cause of the anemia and to identify the main factors inhibiting erythropoiesis. Regardless of the cause of anemia, reticulocyte hemoglobin can also quickly track the success of therapy and, together with the regular full blood count it is measured alongside, help in clearing the patient for surgery.

scholarly journals Serum transferrin receptor: a quantitative measure of tissue iron deficiency

Blood ◽  
1990 ◽  
Vol 75 (9) ◽  
pp. 1870-1876 ◽  
Author(s):  
BS Skikne ◽  
CH Flowers ◽  
JD Cook
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Transferrin Receptor ◽  
Iron Status ◽  
Serum Transferrin ◽  
Mean Cell Volume ◽  
Functional Iron Deficiency ◽  
Iron Stores ◽  
Serum Transferrin Receptor ◽  
Tissue Iron

Abstract This study was undertaken to evaluate the role of serum transferrin receptor measurements in the assessment of iron status. Repeated phlebotomies were performed in 14 normal volunteer subjects to obtain varying degrees of iron deficiency. Serial measurements of serum iron, total iron-binding capacity, mean cell volume (MCV), free erythrocyte protoporphyrin (FEP), red cell mean index, serum ferritin, and serum transferrin receptor were performed throughout the phlebotomy program. There was no change in receptor levels during the phase of storage iron depletion. When the serum ferritin level reached subnormal values there was an increase in serum receptor levels, which continued throughout the phlebotomy program. Functional iron deficiency was defined as a reduction in body iron beyond the point of depleted iron stores. The serum receptor level was a more sensitive and reliable guide to the degree of functional iron deficiency than either the FEP or MCV. Our studies indicate that the serum receptor measurement is of particular value in identifying mild iron deficiency of recent onset. The iron status of a population can be fully assessed by using serum ferritin as a measure of iron stores, serum receptor as a measure of mild tissue iron deficiency, and hemoglobin concentration as a measure of advanced iron deficiency.

Growth performance and blood profile of West African dwarf goats fed urea treatedwild cocoyam (Colocasia esculentum) mea

2020 ◽  
Vol 45 (1) ◽  
pp. 360-366
Author(s):  
O. Y. Adedeji ◽  
S. O. Odukoya ◽  
O. M. Odetola ◽  
O. A. Awodele ◽  
A. A. Saka
Keyword(s):  
Growth Performance ◽  
Blood Cells ◽  
White Blood Cells ◽  
West African ◽  
Daily Weight Gain ◽  
Average Weight ◽  
Edible Plant ◽  
Blood Profile ◽  
West African Dwarf ◽  
Dietary Treatments

Wild cocoyam is a non edible plant found growing around riversides and can serve as source of energy to ruminants. Hence, a twelve weeks study was conducted to investigate the effect of wild cocoyam – urea meal on the growth performance and blood profile of West African dwarf (WAD) goats. Twelve WAD goats with an average weight of 7.25 ± 0.04kg were randomly allotted into four dietary treatments: T1 (raw wild cocoyam), T2 (urea treated wild cocoyam), T3 (urea treated cooked wild cocoyam) and T4 (urea treated fermented wild cocoyam), replicated thrice in a completely randomized design. Results obtained showed that the experimental diets significantly (p < 0.05) influenced the growth performance. Goats fed urea treated cooked wild cocoyam had the best feed conversion ratio (10.35), the highest values of dry matter intake (405.35 g/day) and daily weight gain (39.17 g/day) when compared to other dietary treatments. The dietary treatments did not significantly (p < 0.05) influence the haematological parameters except the red blood cells (9.62 - 11.67×106 mm3),white blood cells (4.07-9.05×106 mm3) and monocytes (1.00-2.50%). No significant (p>0.05) differences among the dietary treatments were observed in all the serum biochemical indices evaluated except for urea which ranged from 15.50 – 28.70mg/dl. It can therefore be concluded that addition of urea with processing, further improved the utilization of the experimental diets thus improving performance of the animals.

A Prospective, Observational Study of the Effectiveness and Safety of a Weekly Fixed Dose of Darbepoetin alfa with Current Practice Iron Management for the Treatment of Chemotherapy-Induced Anemia (CIA): A Subanalysis in Patients (pts) with Lymphoproliferative Malignancies (LPM).

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3715-3715
Author(s):  
A. Alegre ◽  
A. Salar ◽  
I. Roig ◽  
J.C. Bermejo ◽  
A. Palacios ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Iron Deficiency ◽  
Darbepoetin Alfa ◽  
Iron Status ◽  
Oral Iron ◽  
Fixed Dose ◽  
Fatigue Score ◽  
Absolute Iron Deficiency ◽  
The Impact ◽  
Hematopoietic Response

Abstract Background: Darbepoetin alfa (Aranesp®) is a unique erythropoiesis-stimulating protein effective for the treatment of CIA when administered weekly (QW), every 2 weeks (wks) or every 3 wks. Fixed dosing of darbepoetin alfa is routinely used in clinical practice, but little data are available on its patterns of use and the impact of iron status on its effectiveness. Methods: This was a subanalysis of LPM pts included in a prospective, single-arm, multicenter study conducted in Spain. Pts were ≥ 18 yrs old, anemic (hemoglobin [Hb] ≤11 g/dL), scheduled to receive ≥ 12 wks of chemotherapy, and without iron, vitamin B12, or folate deficiencies. Pts were treated with darbepoetin alfa 150 mcg QW; the dose was to be doubled to 300 mcg QW if Hb increased <1 g/dL after 4 wks. Oral iron (200 mg QD) was recommended if transferrin saturation was ≤ 30%, transferrin was ≥ 400 mcg/dL, and/or ferritin was ≤ 300 mcg/L at any time during the study. The primary endpoint was hematopoietic response (Hb increase ≥ 2 g/dL or Hb ≥ 12g/dL in the absence of transfusions in the previous 28 days). Secondary endpoints included the percentage of pts with functional or absolute iron deficiency and its correlation with response rates, change in FACT-Fatigue score from baseline to end of treatment (EOT), and safety. Results: Of a total of 293 patients enrolled, 129 had LPM and were included in this analysis. Of the LPM patients, 55% were women, median age was 67.3 yrs (range: 20.6–88.4), median weight was 67 kg (range: 40.5–115.0). Eleven percent had Hodgkin’s disease, 33.9% had non-Hodgkin’s lymphoma. 5.5% had chronic lymphocytic leukemia, and 49.6% had multiple myeloma. Most pts (80.5%) had baseline Hb between 9–11 g/dL; 19.5 % had Hb < 9 g/dL. Darbepoetin alfa was administered for a median of 16 wks (range:1–16). At wk 5, 25.6 % of pts had their dose doubled to 300 mcg QW. The observed hematopoietic response was 70.73% (95%CI: 62.69, 78.77). The proportion of pts transfused from wk 5 to EOT was 12.7%. During the study, 31.5% pts received oral iron, 10.3% developed absolute iron deficiency, and 8% had iron blockade. Mean (95% CI) FACT-Fatigue score increased from 34.1 (32.2, 35.9) to 40.0 (38.2, 41.8) (p<0.0001). Darbepoetin alfa was well tolerated with 2.4% of pts experiencing adverse events considered related to the study drug. Conclusions: darbepoetin alfa, given as a fixed dose, is an effective and well-tolerated treatment for CIA in pts with LPM. Darbepoetin alfa significantly improved health-related quality of life in this routine clinical practice setting.

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