MARINE MICROBES: SOURCES OF NATURAL BIOACTIVE COMPOUNDS FOR APPLICATION IN PHARMACEUTICAL RESEARCH

The ocean is the major essential source of structurally unique natural products that are mainly present in living organisms. The essential products extracted from marine microbes and marine algae are highly analyzed areas in instinctive product research. Marine algae are the novel food with potential nutritional values used for multiple purposes in industry and medicine. They show pharmacological activities which are helpful for the invention of bioactive compounds. Furthermore, marine algae have shown to provide an abundant source of natural bioactive compounds with antidiabetic, anti-inflammatory, antiviral, antifungal, hypolipidemic, antioxidant, anti-hypercholesterolemia, antibacterial, and antineoplastic properties. They produce new secondary metabolites that possess biological activities and have the potential to be developed as therapeutic agents. Macroalgal lectins, fucoidans, kainoids, and other substances have been routinely used in the research of biomedical and also have biological activities. The potential pharmaceutical, medicinal, and research applications of these compounds are discussed.

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Significance and potential of marine microbial natural bioactive compounds against biofilms/biofouling: necessity for green chemistry

PeerJ ◽

10.7717/peerj.5049 ◽

2018 ◽

Vol 6 ◽

pp. e5049 ◽

Cited By ~ 17

Author(s):

Mohd Adnan ◽

Eyad Alshammari ◽

Mitesh Patel ◽

Syed Amir Ashraf ◽

Saif Khan ◽

...

Keyword(s):

Bioactive Compounds ◽

Sea Water ◽

Cell Communication ◽

Life Forms ◽

Bioactive Metabolites ◽

Chemical Components ◽

Toxic Substances ◽

Marine Microbes ◽

Terrestrial Environments ◽

Promising Source

Natural products from the unique environments of sea water and oceans represent a largely unfamiliar source for isolation of new microbes, which are potent producers of secondary bioactive metabolites. These unique life-forms from the marine ecosphere have served as an important source of drugs since ancient times and still offer a valuable resource for novel findings by providing remedial treatments. Therefore, it can be expected that many naturally bioactive marine microbial compounds with novel structures and bioactivities against those from terrestrial environments may be found among marine metabolites. Biofilms in aquatic environment possess serious problems to naval forces and oceanic industries around the globe. Current anti-biofilm or anti-biofouling technology is based on the use of toxic substances that can be harmful to their surrounding natural locales. Comprehensive research has been done to examine the bioactive potential of marine microbes. Results are remarkably varied and dynamic, but there is an urgent need for bioactive compounds with environmentally friendly or “green” chemical activities. Marine microbes have the potential as upcoming and promising source of non-toxic compounds with sustainable anti-biofouling/anti-biofilm properties as they can produce substances that can inhibit not only the chemical components required for biofilm production but also the attachment, microorganism growth, and/or cell–cell communication.

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Natural bioactive compounds and antimicrobial potential of Pavetta indica L.

Journal of Analytical & Pharmaceutical Research ◽

10.15406/japlr.2021.10.00381 ◽

2021 ◽

Vol 10 (4) ◽

pp. 161-164

Author(s):

Gobalakrishnan R ◽

Bhuvaneswari R

Keyword(s):

Antimicrobial Activity ◽

Bioactive Compounds ◽

Antimicrobial Agents ◽

Soluble Sugars ◽

Pharmaceutical Research ◽

Ethanolic Extract ◽

Soluble Starch ◽

Terrestrial Plants ◽

Antimicrobial Potential ◽

Wide Range

Terrestrial plants have opened up a new perspective for pharmaceutical research and development of novel antimicrobial agents for the treatment of microbial diseases. Therefore, it is necessary to start an urgent need to screen the plants for novel bioactive compounds. In this context, present study was carried out to screen phytochemical constituents from leaves of Pavetta indica L., and its antimicrobial potential. P. indica leaves possess Chlorophyll a (1.21 ±0.05 mg g-1), Chlorophyll b (1.61 ±0.09 mg g-1), total chlorophyll (2.82 ±0.13 mg g-1), carotenoids (0.57 ±0.06 mg g-1), total soluble sugars (30.08 ±0.79 mg g-1), total soluble starch (13.54 ± 0.72), total soluble proteins (47.81 ± 2.82 mg g-1), total free amino acids (5.77 ± 0.69 mg g-1), total phenol (7.67 ± 0.72 mg g-1), hydroxyl phenols (5.74 ± 0.29 mg g-1) and lipids (53.53 ± 2.50 mg g-1) while alkaloids, tannins, steroids, phenolic compounds, saponins, triterpenoids and cardiac glycosides were also present in the leaves of P. indica. Absolute ethanolic extract of P. indica showed significant antimicrobial activity against all the tested pathogens, followed by aqueous extract. In concluded that, P. indica leaves crude extracts have wide range of bioactive compounds and which might be led to potential antimicrobial activity. They may lend to developing novel therapeutic agent to different infectious diseases.

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