scholarly journals Hormonal treatment of vulvar vaginal atrophy (VVA): Are there options to reduce or avoid systemic adverse effects and risks?

2018 ◽  
Vol 4 (6) ◽  
Author(s):  
Xiangyan RUAN ◽  
Alfred O MUECK
Keyword(s):  
Adverse Effects ◽  
Hormonal Treatment ◽  
Vaginal Atrophy

Non-hormonal treatment of vulvo-vaginal atrophy-related symptoms in post-menopausal women

2015 ◽  
Vol 35 (8) ◽  
pp. 835-838 ◽  
Author(s):  
C. Tersigni ◽  
N. Di Simone ◽  
E. Tempestilli ◽  
F. Cianfrini ◽  
R. Russo ◽  
...  
Keyword(s):  
Hormonal Treatment ◽  
Vaginal Atrophy ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals Quality-of-Life Impact of Primary Treatments for Localized Prostate Cancer in Patients Without Hormonal Treatment

2010 ◽  
Vol 28 (31) ◽  
pp. 4687-4696 ◽  
Author(s):  
Yolanda Pardo ◽  
Ferran Guedea ◽  
Ferrán Aguiló ◽  
Pablo Fernández ◽  
Víctor Macías ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Urinary Incontinence ◽  
Sexual Dysfunction ◽  
Radical Prostatectomy ◽  
Adverse Effects ◽  
Hormonal Treatment ◽  
External Radiotherapy

Purpose Earlier studies evaluating the effect on quality of life (QoL) of localized prostate cancer interventions included patients receiving adjuvant hormone therapy, which could have affected their outcomes. Our objective was to compare the QoL impact of the three most common primary treatments on patients who were not receiving adjuvant hormonal treatment. Patients and Methods This was a prospective study of 435 patients treated with radical prostatectomy, external-beam radiotherapy, or brachytherapy. QoL was assessed before and after treatment with the Short Form-36 and the Expanded Prostate Cancer Index Composite. Differences between groups were tested by analysis of variance. Distribution of outcome at 3 years was examined by stratifying according to baseline status. Generalized estimating equation models were constructed to assess the effect of treatment over time. Results Compared with the brachytherapy group, the prostatectomy group showed greater deterioration on urinary incontinence and sexual scores but better urinary irritative-obstructive results (−18.22, −13.19, and +6.38, respectively, at 3 years; P < .001). In patients with urinary irritative-obstructive symptoms at baseline, improvement was observed in 64% of those treated with nerve-sparing radical prostatectomy. Higher bowel worsening (−2.87, P = .04) was observed in the external radiotherapy group, with 20% of patients reporting bowel symptoms. Conclusion Radical prostatectomy caused urinary incontinence and sexual dysfunction but improved pre-existing urinary irritative-obstructive symptoms. External radiotherapy and brachytherapy caused urinary irritative-obstructive adverse effects and some sexual dysfunction. External radiotherapy also caused bowel adverse effects. Relevant differences between treatment groups persisted for up to 3 years of follow-up, although the difference in sexual adverse effects between brachytherapy and prostatectomy tended to decline over long-term follow-up. These results provide valuable information for clinical decision making.

Adherence to tamoxifen in Mexican young women with breast cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12003-e12003
Author(s):  
Cynthia Mayte Villarreal-Garza ◽  
Bertha Alejandra Martinez-Cannon ◽  
Andrea Castro-Sanchez ◽  
Alejandra Platas ◽  
Alan Fonseca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adverse Effects ◽  
Significant Proportion ◽  
Medication Possession Ratio ◽  
Hormonal Treatment ◽  
Recurrence Risk ◽  
Young Group ◽  
Long Term Effects ◽  
Increased Risk ◽  
Adherence Data

e12003 Background: Young age has been associated with significantly increased risk of breast cancer (BC) death among women with luminal BC. One contributing factor might be the low rate of tamoxifen (TMX) adherence previously reported in this young group. Given that in Mexico a disproportionate rate of BC is diagnosed among YW, information regarding TMX adherence is particularly relevant. Our study's aim was to report TMX adherence in Mexican YW and its associated determinants. Methods: Consecutive patients ≤40y at diagnosis at the National Cancer Institute in Mexico City, under TMX treatment, completed a multiple-choice survey regarding the use and attitudes about hormonal therapy and adherence. Data of TMX disposal was collected from the pharmacy’s records, and the medication possession ratio (MPR) was calculated; an MPR ≥80% was considered adherent. Results: 135 YW with a median age at diagnosis of 35.7y (24-40) were included. 77% were undergraduate, 28% unpaired and 33% childless. Median follow-up was 26 months. 95% of patients reported a regular TMX intake: 70% did not miss any doses, while 25% missed 1-6 doses a month. Only 45% considered that the information received regarding TMX therapy was sufficient and for 37% was incomprehensive. 43% thought TMX significantly reduced their recurrence-risk and 60% strongly believed that they needed to be on TMX treatment. 73% of women reported adverse effects, being menopausal symptoms the most frequent, but only 27% were worried about the treatment long-term effects. From the 99 patients with a pharmacy record, 73% had an MPR > 80%. No significant factor was statistically associated with TMX adherence. Conclusions: Although Mexican YW and pharmacy data surprisingly sustained higher rates of TMX adherence compared to previous data, still a significant proportion of patients were non-adherent. Two-thirds of our patients reported having adverse effects, which might contribute to late TMX discontinuation. Since the newer recommendations of double hormonal blockade could lead to higher withdrawal rates of endocrine therapy in YW, adherence should be emphasized and closely monitored. Accordingly, hormonal treatment adherence should be a key component in the medical assessment of young luminal BC patients.

Therapeutic Ultrasound as a Novel, Non-hormonal Treatment of Vulvo-vaginal Atrophy: A Pilot Phase II Study

2017 ◽  
Vol 147 (1) ◽  
pp. 235
Author(s):  
S. MacLaughlan ◽  
H. Rockweiler ◽  
R. Krone ◽  
S. Middleton ◽  
D. Blayney
Keyword(s):  
Phase Ii ◽  
Phase Ii Study ◽  
Therapeutic Ultrasound ◽  
Hormonal Treatment ◽  
Vaginal Atrophy ◽  
Pilot Phase

Non-Hormonal Replacement Therapy Regimens: Do they have an Effect on Cardiovascular Risk?

2019 ◽  
Vol 17 (6) ◽  
pp. 573-578 ◽  
Author(s):  
Evangelia Mareti ◽  
Christina Ampatzi ◽  
Stavroula A. Paschou ◽  
Evangelia Voziki ◽  
Dimitrios G. Goulis
Keyword(s):  
Blood Pressure ◽  
Adverse Effects ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Hormonal Treatment ◽  
Menopausal Symptoms ◽  
Cochrane Library ◽  
Cvd Risk ◽  
Mortality And Morbidity ◽  
Post Menopausal ◽  
Hormonal Treatments

Introduction: Menopause is associated with adverse effects on quality of life of perimenopausal and post-menopausal women. It also has an impact on the development of cardiovascular disease (CVD). Hormonal treatments are the most effective medications for menopausal symptoms relief. Given the fact that hormonal treatments are contraindicated for many women, non-hormonal treatment, such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs), gabapentin, pregabalin, clonidine and phytoestrogens, constitute alternative treatments. Nevertheless, little is known about their effects on CVD risk. Methods: PubMed, EMBASE and Cochrane Library were searched for the effects of non-hormonal treatment on CVD risk, blood pressure, heart rate, lipids and glucose concentrations, weight gain, cardiovascular events, stroke, mortality and morbidity. Results: Phytoestrogens, pregabalin and gabapentin seem to have no adverse effects on the cardiovascular system. Phytoestrogens, in particular, seem to reduce CVD risk through many pathways. On the other hand, SSRIs and SNRIs, although effective in reducing menopausal vasomotor symptoms, should be cautiously administered to women with known CVD (e.g. with cardiac arrhythmias, atherosclerotic disease or stroke). As clonidine has been associated with cardiovascular adverse effects, it should be administered only in cases where blood pressure regulation is mandatory. Conclusion: Further research is needed to produce definite conclusions regarding the cardiovascular safety of non-hormonal medications for menopausal symptoms relief.

The effect on the health of lactating cows of treatment with galactopoietic doses of thyroxine or iodinated casein

1953 ◽  
Vol 43 (2) ◽  
pp. 236-251 ◽  
Author(s):  
F. B. Leech ◽  
G. L. Bailey
Keyword(s):  
Adverse Effects ◽  
Hormonal Treatment ◽  
Large Field ◽  
Control Group ◽  
Lactation Period ◽  
Experimental Procedure ◽  
Lactating Cows ◽  
Reproductive Life ◽  
Cow Health ◽  
And Control

1. The effect on cow health of galactopoietic stimulation with thyroactive materials was determined from a statistical study of the results of a large field experiment involving 2000 cows over a 3-year period.2. The same experimental procedure was followed on thirty-seven farms scattered over England, Scotland and Wales. This procedure was planned to ensure that half the cows in each herd would receive a course of treatment with iodinated casein or thyroxine, and that the other half would constitute a suitable set of controls. Cows that remained in the herds received second and third treatments in successive lactations.3. The galactopoietic stimulation was started at a fixed interval after calving, irrespective of the season of the year.4. The use of the thyroactive materials in successive lactations did not have any serious adverse effects on the health of cows. The effect on productivity was less than had been expected, since the increase in milk yield resulting during the period of hormonal treatment was often largely or completely negatived by a shortening of the lactation period.5. The incidence of disease was somewhat greater in the treated than the control group, the principal contribution to this difference being from the diseases described as digestive disorders. There were some other differences of lesser significance.6. The rate of disposal of treated and control groups was almost identical.7. There were no adverse effects on the reproductive life of treated cows; factors studied were the efficiency of coitus, interval between parturitions, length of gestation and incidence of abnormalities at parturition.

"Aphrodisiac Activity of Roots of Mimosa pudica Linn. Ethanolic Extract in Mice"

2009 ◽  
Vol 2 (1) ◽  
pp. 477-486
Author(s):  
Milind Pande ◽  
Anupam Pathak
Keyword(s):  
Adverse Effects ◽  
Hormonal Treatment ◽  
Ethanolic Extract ◽  
Normal Male ◽  
Appreciable Effect ◽  
Mimosa Pudica ◽  
Male Mice ◽  
Reference Drug ◽  
Hormonal Levels ◽  
Sustained Increase

The present study was aimed to investigate the effect ethanolic extract of roots of Mimusa pudica Linn. (Mimosae) on libido of sexually normal Swiss Albino male mice. The suspension of the extract was administered orally at the dose of 100, 250, and 500 mg / kg, to different groups of male mice (n = 6) once a day for seven days. The female albino mice involved in mating were made receptive by hormonal treatment. The general libido and potency were determined and compared with the standard reference drug sildenafil citrate. A change in hormonal parameter like testosterone was evaluated. Oral administration of the extract significantly increased the libido and hormonal levels of testosterone. The most appreciable effect of the extract was observed at the dose of 500 mg/kg. The results indicated that the ethanolic extract of roots of Mimusa pudica Linn. (Mimosae) produced a significant and sustained increase in the aphrodisiac activity of normal male mice, without any adverse effects.

The Influence of Specimen Thickness in Quantitative Electron Energy Loss Spectroscopy

1980 ◽  
Vol 38 ◽  
pp. 112-113
Author(s):  
Nestor J. Zaluzec
Keyword(s):  
Quantitative Analysis ◽  
Adverse Effects ◽  
Energy Loss ◽  
Electron Energy ◽  
Electron Energy Loss Spectroscopy ◽  
Materials Science ◽  
Light Element ◽  
Specimen Thickness ◽  
Element Analysis ◽  
Electron Energy Loss

The application of electron energy loss spectroscopy (EELS) to light element analysis is rapidly becoming an important aspect of the microcharacterization of solids in materials science, however relatively stringent requirements exist on the specimen thickness under which one can obtain EELS data due to the adverse effects of multiple inelastic scattering.1,2 This study was initiated to determine the limitations on quantitative analysis of EELS data due to specimen thickness.

Sign in / Sign up

Export Citation Format

Share Document