scholarly journals Comprehensive Oral Cancer Examination of the Extra-oral and Intra-oral Regions of the Head and Neck

MedEdPORTAL ◽  
2012 ◽  
Vol 8 (1) ◽  
Author(s):  
Nereyda Polo Clark ◽  
Pamela R. Sandow
Keyword(s):  
Oral Cancer ◽  
Head And Neck ◽  
Oral Cancer Examination

scholarly journals Antimetastatic Effects of Sesamin on Human Head and Neck Squamous Cell Carcinoma through Regulation of Matrix Metalloproteinase-2

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2248 ◽  
Author(s):  
Jian-Ming Chen ◽  
Pei-Yin Chen ◽  
Chia-Chieh Lin ◽  
Ming-Chang Hsieh ◽  
Jen-Tsun Lin
Keyword(s):  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Head And Neck ◽  
Mapk Pathway ◽  
Human Head ◽  
Mapk Signaling ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Dependent Manner

Background: Sesamin is a lignin present in sesame oil from the bark of Zanthoxylum spp. Sesamin reportedly has anticarcinogenic potential and exerts anti-inflammatory effects on several tumors. Hypothesis/Purpose: However, the effect of sesamin on metastatic progression in human head and neck squamous carcinoma (HNSCC) remains unknown in vitro and in vivo; hence, we investigated the effect of sesamin on HNSCC cells in vitro. Methods and Results: Sesamin-treated human oral cancer cell lines FaDu, HSC-3, and Ca9-22 were subjected to a wound-healing assay. Furthermore, Western blotting was performed to assess the effect of sesamin on the expression levels of matrix metalloproteinase (MMP)-2 and proteins of the MAPK signaling pathway, including p-ERK1/2, P-p38, and p-JNK1/2. In addition, we investigated the association between MMP-2 expression and the MAPK pathway in sesamin-treated oral cancer cells. Sesamin inhibited cell migration and invasion in FaDu, Ca9-22, and HSC-3 cells and suppressed MMP-2 at noncytotoxic concentrations (0 to 40 μM). Furthermore, sesamin significantly reduced p38 MAPK and JNK phosphorylation in a dose-dependent manner in FaDu and HSC-3 cells. Conclusions: These results indicate that sesamin suppresses the migration and invasion of HNSCC cells by regulating MMP-2 and is thus a potential antimetastatic agent for treating HNSCC.

scholarly journals General rules for clinical and pathological studies on oral cancer (2nd edition): a synopsis

2021 ◽  
Vol 26 (4) ◽  
pp. 623-635
Author(s):  
Yoshihide Ota ◽  
◽  
Tadahide Noguchi ◽  
Eiichiro Ariji ◽  
Chihiro Fushimi ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Oral Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Medical Information ◽  
English Edition ◽  
General Rules ◽  
Treatment Research ◽  
Basic Concepts ◽  
8Th Edition

AbstractFor doctors and other medical staff treating oral cancer, it is necessary to standardize the basic concepts and rules for oral cancer to achieve progress in its treatment, research, and diagnosis. Oral cancer is an integral part of head and neck cancer and is treated in accordance with the general rules for head and neck cancer. However, detailed rules based on the specific characteristics of oral cancer are essential. The objective of this article was to contribute to the development of the diagnosis, treatment, and research of oral cancer, based on the correct and useful medical information of clinical, surgical, pathological, and imaging findings accumulated from individual patients at various institutions. Our general rules were revised as the UICC was revised for the 8th edition and were published as the Japanese second edition in 2019. In this paper, the English edition of the “Rules” section is primarily presented.

scholarly journals Guidelines for the Surgical Management of Oral Cancer: Korean Society of Thyroid-Head and Neck Surgery

2019 ◽  
Vol 12 (2) ◽  
pp. 107-144 ◽  
Author(s):  
◽  
Young-Hoon Joo ◽  
Jae-Keun Cho ◽  
Bon Seok Koo ◽  
Minsu Kwon ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Head And Neck ◽  
Surgical Management ◽  
Neck Surgery ◽  
Head And Neck Surgery ◽  
Korean Society

scholarly journals OC-020 Sentinel lymph node biopsy for early stage oral cancer; experience of 3 Dutch Head and Neck centers

2019 ◽  
Vol 132 ◽  
pp. 12-13
Author(s):  
I. Den Toom ◽  
K. Boeve ◽  
R. Van Es ◽  
B. De Keizer ◽  
S. Van Weert ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cancer ◽  
Head And Neck ◽  
Early Stage ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Cancer Experience

scholarly journals Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision

2019 ◽  
Vol 30 (2) ◽  
pp. 45-49 ◽  
Author(s):  
N.J. D’Silva ◽  
J.S. Gutkind
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Head And Neck ◽  
Treatment Strategies ◽  
Head And Neck Cancers ◽  
Mechanistic Studies ◽  
Nerve Tumor ◽  
Personalized Approach ◽  
Key Pathways

Head and neck cancers are among the 10 most common cancers in the world and include cancers of the oral cavity, hypopharynx, larynx, nasopharynx, and oropharynx. At least 90% of head and neck cancers are squamous cell carcinomas (SCCs). This summary discusses the integration of clinical and mechanistic studies in achieving diagnostic and therapeutic precision in the context of oral cancer. Specifically, based on recent mechanistic studies, a subsequent study reevaluated current diagnostic criteria of perineural invasion in patients with oral cavity SCC showing that overall survival could be associated with nerve-tumor distance; validation of the findings of this study from a small group of patients could lead to a personalized approach to treatment selection in patients with oral cavity SCC. Moreover, delineation of key pathways in SCC revealed novel treatment targets that can be exploited to develop personalized treatment strategies to achieve long-term remission.

Role of Salivary Biomarkers for Early Detection of Oral Squamous Cell Carcinoma

2017 ◽  
Vol 2 (3) ◽  
pp. 155-160 ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Early Detection ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Biological Fluid ◽  
Salivary Biomarkers

ABSTRACT Introduction Oral cancer is a potentially fatal disease, which constitutes an important portion of tumors of the head and neck region. Among head and neck cancers, oral squamous cell carcinomas (OSCCs) constitute 90% of total cancers. Regardless of the fact that the oral cavity is easily accessible to the accumulation of carcinogens, most oral cancers are typically detected at an advanced stage leading to lower survival rate among subjects. Abnormal cellular products elucidated from malignant cells can be detected and measured in various body fluids including saliva, which constitute tumor markers. Saliva, an aqueous biological fluid, is in direct contact with the oral cancer lesion. Hence, the saliva in any stage of oral cancer constitutes abnormal deoxyribonucleic acid (DNA), acid (RNA), and protein molecules. Saliva, being a noninvasive diagnostic aid, can be an alternative to serum for early detection, status of chemotherapy regime, and also patient prognosis. This article aims at providing a brief overview of various salivary biomarkers and their implications in oral cancer. How to cite this article Gupta P. Role of Salivary Biomarkers for Early Detection of Oral Squamous Cell Carcinoma. Int J Adv Integ Med Sci 2017;2(3):155-160.

Sign in / Sign up

Export Citation Format

Share Document