scholarly journals Recurrence of cardiac myxoma. Clinical and morphological aspects

2018 ◽  
Vol 19 (4) ◽  
pp. 48-53
Author(s):  
I. M. Iljinsky ◽  
A. S. Ivanov ◽  
M. K. Lugovsky ◽  
N. P. Mozhejko
Keyword(s):  
Left Atrium ◽  
Cardiac Myxoma ◽  
Interatrial Septum ◽  
Surgical Removal ◽  
Small Tumor ◽  
Morphological Aspects ◽  
Tumor Fragment ◽  
Radical Removal ◽  
Prevention Of Recurrence ◽  
Research Show

Aim: to conduct a one-center retrospective research of heart myxoma relapses in a large group of patients. Materials and methods. Since 1992 to 2016 115 surgical removal of sporadic cardiac myxoma was performed (44 male, 71 female).Results. Two (1.7%) patients had recurrence of sporadic myxoma of the left atrium. One patient had the tumor returned due to inadequate removal of the tumor. Myxoma was removed without excising the place of fi xation to the interatrial septum. The second patient possibly had recurrence of myxoma due to the conservation of a small tumor fragment in another part of the interatrial septum that was not diagnosed during the removal of the primary tumor. Conclusion. Recurrence of sporadic myxoma of the left atrium is rare. The reasons for the recurrence may be different but usually it is due to non-radical removal of the tumor. The results of our research show that even removal of the myxoma together with the interatrial septum does not fully guarantee the prevention of recurrence. The recurrence of sporadic cardiac myxoma is possibly associated with minor formations that are not diagnosed during surgery. We cannot exclude the possibility of forming myxoma denovo also. 

scholarly journals P841 Case report of cardiac myxoma presenting with palpitations in young female

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
A Nalmpantis
Keyword(s):  
Case Report ◽  
Mitral Valve ◽  
Cardiac Function ◽  
Left Atrium ◽  
Cardiac Myxoma ◽  
Young Female ◽  
Normal Function ◽  
Atrial Myxoma ◽  
Surgical Removal ◽  
Common Symptom

Abstract Funding Acknowledgements none Introduction Atrial myxoma is a benign tumor of the heart , most commonly found in left atrium. The tumor must be surgically removed, because if remain untreated can lead to embolism, to arrhythmia and/or obstruction of mitral valve. Case report A 29 years old female presented due to palpitations and fatigue In the last two-three months. From recent blood tests she had a normal hematocrit and normal function of the thyroid gland. From the physical examination she had a blood pressure of 95/55 mmHg, S1S2 without any murmur, ECG with sinus rhythm and rsr" pattern. A bedside transthoracic echocardiography has performed and the findings were normal left systolic cardiac function, normal right systolic cardiac function, a large mass in left atrium without obstruction of mitral valve and a mild mitral regurgitation. The young female has been submitted for surgical removal of the cardiac mass and the anatomopathological examination has confirmed the benign nature of the atrial myxoma. Conlusion A common symptom such as palpitations are , has lead the young female to us in order to evaluate her and finally to reveal a benign cardiac tumor . Abstract P841 Figure. myxoma

scholarly journals P174 Left atrial myxoma presenting in a cystic form

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
B Yagmur ◽  
E Simsek ◽  
M Ozbaran ◽  
C Soydas Cinar
Keyword(s):  
Left Atrium ◽  
Cardiac Myxoma ◽  
Three Dimensional ◽  
Interatrial Septum ◽  
Two Dimensional ◽  
Left Atrial Myxoma ◽  
Cystic Form ◽  
Dimensional Echocardiography ◽  
Grade 3 ◽  
Diastolic Murmur

Abstract Background Early diagnosis of atrial myxomas may be a challenge because of their synptoms are often nonspecific. Two-dimensional echocardiography is the diagnostic procedure of choice. Case presentation A 42-year-old woman presented with complaints of palpitation and fatigue. Physical examination revealed a diastolic murmur at the apex. Two-dimensional transthoracic echocardiography revealed an extremely mobile mass in the left atrium that consisted of multiple cystic and solid parts. Three-dimensional transesophageal echocardiography showed that the 4.3x3.3 cm mass was connected to the interatrial septum through a 0.7 cm pedincle, and it moved between the atrium and the ventricle through the mitral valve with each carciac cycle. Grade 1 mitral and aortic regurgitation and grade 3 tricuspid regurgitation was accompanied by a SPAP of 90 mmHG. The mass was surgically excised. Histopathologic diagnosis was myxoma. Discussion Types of cystic masses that can appear in the left atrium are myxomas, hydatid cysts and interatrial septal aneurysms. In our case report, echocardiographic findings of a mass that was connected to the IAS with a pedicle were supportive of cardiac myxoma. If not removed, myxomas may cause major complications like stroke, rupture, and hemodynamic problems. Surgery was indicated because the mass was cystic and highly mobile. Abstract P174 Figure. mass

scholarly journals The Question of Relapse of a Cardiac Myxoma: an Unusual Case from Practice

2021 ◽  
pp. 35-41
Author(s):  
R. M. Vitovskiy ◽  
V. V. Isaіenko ◽  
O. A. Pishchurin ◽  
I. G. Jakovenko ◽  
V. F. Onishchenko
Keyword(s):  
Left Atrium ◽  
Unusual Case ◽  
Thoracoscopic Surgery ◽  
Cardiac Myxoma ◽  
Carney Complex ◽  
Left Ventricular ◽  
Surgical Removal ◽  
Cardiac Tumors ◽  
Careful Study ◽  
Heart Tumors

Various studies demonstrate that recurrence of cardiac myxoma (CM) occurs in 2.1–5.3% of cases. In cases of treatment of familial myxoma, the need for reoperations can reach 20–25%. It should be taken into account that among all benign cardiac tumors, CM is detected in up to 80% of cases, and the need for its surgical removal is beyond doubt. The aim. To present a case that is of particular interest due to an unusual multiple myxomas lesion of the heart of multi-chamber localization. Material and methods. This article presents an unusual case of detecting multiple myxomas of multi-cameral heart lesions 6 years after removal of myxoma of the left atrium of typical localization. The distinguishing feature of the course of the disease lies in the fact that in this case, a careful study of the life history did not reveal the characteristic signs of familial myxomas and Carney complex which is most often characteristic of multi-chamber lesions of the heart by a tumor process. At the same time, during the surgical removal of the myxoma of the left ventricle, the myxomas of the left and right atrium were revealed, which began to grow. A technical feature of the removal of the left ventricular myxoma of the apical localization was the use of video cameras and instruments for thoracoscopic surgery, which greatly facilitated revi-sion and removal of the hard-to-reach neoplasm. Our experience in surgical treatment of CM equals to 868 operations. Wherein, repeated operations performed in 12 patients were due to recurrence or appearance of a tumor in place other than the primary localization. Conclusions. CM recurrence is one of infrequent complications in the postoperative period, which, however, requires some vigilance and annual Echo monitoring. In the vast majority of cases, CM was represented by the so-called sporadic myxomas, which are more often localized in the left atrium, and rarely recur. If CM is suspected, it is necessary to exclude the possibility of “myxoma syndrome”, which has the frequency of 0.8%, according to our data. The use of the instruments for thoracoscopic surgery can greatly facilitate the removal of hard-to-reach heart tumors localization.

Histologically verified cerebral aneurysm formation secondary to embolism from cardiac myxoma

1995 ◽  
Vol 83 (1) ◽  
pp. 170-173 ◽  
Author(s):  
Kazuhide Furuya ◽  
Tomio Sasaki ◽  
Yuhei Yoshimoto ◽  
Yoshifumi Okada ◽  
Takamitsu Fujimaki ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cardiac Tumor ◽  
Arterial Wall ◽  
Cardiac Myxoma ◽  
Cerebral Aneurysms ◽  
Surgical Removal ◽  
Arterial Aneurysm ◽  
Content Type ◽  
Aneurysm Formation ◽  
Aneurysm Wall

✓ Multiple aneurysm formation secondary to an embolism from the cardiac myxoma is a well-known phenomenon. The cerebral arterial aneurysm formation process involved remains to be elucidated, although occupation of the arterial wall by tumor cells has been proven histologically. The authors present the case of a patient in whom tumor cells in the aneurysm wall were demonstrated and penetration of viable myxoma cells into the wall was also observed 19 months after surgical removal of the cardiac tumor. Such findings have never before been verified histologically. In light of the histological findings, the authors discuss the therapeutic problems associated with cerebral aneurysms resulting from cardiac myxoma.

Atypical Left Ventricular Myxoma: Unusual Echocardiographic and Histopathological Features

2018 ◽  
Vol 11 (4) ◽  
pp. NP129-NP131
Author(s):  
Sushil Azad ◽  
Nilanjan Dutta ◽  
Kuntal Roy Chowdhuri ◽  
Tarun Raina Ramman ◽  
Nishit Chandra ◽  
...  
Keyword(s):  
Hydatid Cyst ◽  
Histopathological Examination ◽  
Cardiac Myxoma ◽  
Surgical Excision ◽  
Interatrial Septum ◽  
Left Ventricular ◽  
Cardiac Tumors ◽  
Complete Surgical Excision ◽  
Vascular Proliferation ◽  
Cardiac Myxomas

Cardiac myxomas are the most common primary cardiac tumors and are typically attached to the interatrial septum. Left ventricular myxomas are exceedingly rare and presentation in children is all the more uncommon. We report a case of left ventricular myxoma with very atypical cystic appearance raising an initial suspicion of a hydatid cyst. Subsequently, cardiac magnetic resonance imaging was done, which ruled out the diagnosis of hydatid cyst. Complete surgical excision was done through transaortic and transmitral route. Histopathological examination revealed it to be a cardiac myxoma with vascular proliferation, which on echocardiography had appeared as a polycystic lesion. This is a very unusual histopathological presentation of cardiac myxoma.

Clarifying the anatomy of the superior sinus venosus defect

Heart ◽  
2021 ◽  
pp. heartjnl-2021-319334
Author(s):  
Jay Relan ◽  
Saurabh Kumar Gupta ◽  
Rengarajan Rajagopal ◽  
Sivasubramanian Ramakrishnan ◽  
Gurpreet Singh Gulati ◽  
...  
Keyword(s):  
Left Atrium ◽  
Pulmonary Vein ◽  
Pulmonary Veins ◽  
Interatrial Septum ◽  
Sinus Venosus ◽  
Caval Vein ◽  
Therapeutic Implications ◽  
Superior Caval Vein ◽  
Inferior Pulmonary Vein ◽  
The Right

ObjectivesWe sought to clarify the variations in the anatomy of the superior cavoatrial junction and anomalously connected pulmonary veins in patients with superior sinus venosus defects using computed tomographic (CT) angiography.MethodsCT angiograms of 96 consecutive patients known to have superior sinus venosus defects were analysed.ResultsThe median age of the patients was 34.5 years. In seven (7%) patients, the defect showed significant caudal extension, having a supero-inferior dimension greater than 25 mm. All patients had anomalous connection of the right superior pulmonary vein. The right middle and right inferior pulmonary vein were also connected anomalously in 88 (92%) and 17 (18%) patients, respectively. Anomalous connection of the right inferior pulmonary vein was more common in those with significant caudal extension of the defect (57% vs 15%, p=0.005). Among anomalously connected pulmonary veins, the right superior, middle, and inferior pulmonary veins were committed to the left atrium in 6, 17, and 11 patients, respectively. The superior caval vein over-rode the interatrial septum in 67 (70%) patients, with greater than 50% over-ride in 3 patients.ConclusionAnomalous connection of the right-sided pulmonary veins is universal, but is not limited to the right upper lobe. Not all individuals have over-riding of superior caval vein. In a minority of patients, the defect has significant caudal extension, and anomalously connected pulmonary veins are committed to the left atrium. These findings have significant clinical and therapeutic implications.

Abstract 18782: Regional Action Potential Heterogeneity in the Murine Pitx2c Deficient Left Atrium

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Andrew P Holmes ◽  
Ting Yu ◽  
Fahima Syeda ◽  
Nigel A Brown ◽  
Larissa Fabritz ◽  
...  
Keyword(s):  
Action Potential ◽  
Left Atrium ◽  
Lateral Wall ◽  
Interatrial Septum ◽  
The Other ◽  
Wild Type ◽  
Genetic Abnormalities ◽  
Mapping System ◽  
Pitx2 Gene ◽  
Partial Depletion

Introduction and hypothesis: Genetic abnormalities close to the Pitx2 gene correlate more strongly with atrial fibrillation (AF) than any other genetic modification. It is known that Pitx2c mRNA is expressed in the adult left atrium (LA), but its relevance for the electrical integrity of cardiomyocytes throughout the atria remains unresolved. We therefore compared regional action potential (AP) morphology in PITX2c +/- and wild type (WT) littermate mice. Methods: Transmembrane (T) and optical (O) APs were recorded from superfused intact, isolated LA paced at 100ms. TAPs were recorded from three distinct regions on the LA epicardium: 1) the junction with the interatrial septum (S), 2) the medial muscular dome (M) and 3) the lateral wall (L). OAPs were recorded using a custom murine atrial optical mapping system using the Hamamatsu ORCA flash 4 and Di-4-Anepps. Results: OAPs were shorter in Pitx2c deficient LA (AP duration (APD70); WT 13±2ms, n=4 LA vs Pitx2c +/- 9±1ms, n=4 LA, all data as mean±SEM, p<0.05). Simultaneous recordings of OAPs from multiple LA regions showed an AP gradient with longer OAPs at the septum than at the lateral wall, in both genotypes. In WT LA, TAPs were longer and of greater amplitude at the septum than in the other two regions (APD90; S 26±1ms, M 19±1mV and L 19±1ms, APA; S 81±1mV, M 76±2mV and L 76±2mV, n=6 LA, p<0.05). In Pitx2c +/- , TAPs were shorter than WT in all three regions tested and exhibited the same regional patterning (S 20±1ms, M 15±1ms and L 16±1, n=7 LA, p<0.05). The regional AP amplitude gradient was not apparent, or at least shifted more towards the lateral wall, in PITX2c +/- atria (APA; S 77±2mV, M 76±3mV and L 74±2mV, n=7 LA, ns). Conclusion: Partial depletion in Pitx2c mRNA expression causes a uniform APD shortening throughout the LA and loss of regional changes in AP amplitude. Identification of the targets downstream of Pitx2 accounting for these changes will help to better understand the mechanisms conveying AF due to reduced Pitx2 function.

Left atrial high-grade rhabdomyosarcoma; an unusual location

2020 ◽  
pp. 021849232098348
Author(s):  
Hemant Chaturvedi ◽  
Ravindra Singh Rao ◽  
Navneet Mehta ◽  
Ajeet Bana
Keyword(s):  
New York ◽  
Heart Association ◽  
Surgical Excision ◽  
Interatrial Septum ◽  
Large Mass ◽  
Surgical Removal ◽  
High Grade ◽  
Class Iii ◽  
Term Survival ◽  
New York Heart Association

A 63-year-old diabetic and hypertensive lady presented in New York Heart Association class III–IV dyspnea on exertion. Echocardiography showed a large mass attached to the anterior mitral leaflet and the base of the interatrial septum. After removal of the mass and excision of the anterior and posterior mitral leaflets, a bioprosthetic valve was deployed. The postoperative course was uneventful. Histopathology showed that the tumor was a high-grade rhabdomyosarcoma. Although it is a highly lethal tumor, surgical removal was indicated to relieve dyspnea, clarify the diagnosis, and improve short-term survival. Our patient survived for 8 months after surgical excision.

scholarly journals Concomitant tumourous lesions in the left atrium and aortic valve suspected to be myxoma

2019 ◽  
Vol 57 (5) ◽  
pp. 1011-1012 ◽  
Author(s):  
Yuriy Mandryk ◽  
Markus Czesla ◽  
Christian Flora ◽  
Parwis Massoudy
Keyword(s):  
Aortic Valve ◽  
Left Atrium ◽  
Cardiac Myxoma ◽  
Transoesophageal Echocardiography ◽  
Papillary Fibroelastoma ◽  
Single Patient ◽  
Non Invasive ◽  
Cardiac Tumours ◽  
Multiple Primary ◽  
Diagnostic Modalities

Abstract The occurrence of multiple primary cardiac tumours in a single patient is extremely rare. Despite growing expertise in non-invasive diagnostic modalities, especially in transoesophageal echocardiography, only a few cases report the coincidence of papillary fibroelastoma of the aortic valve and myxoma of the left atrium. Moreover, echocardiographic as well as a macroscopic distinction between cardiac myxoma and cardiac fibroelastoma may be difficult. Only post-excisional histopathology provides diagnostic safety. Cryoablation of the remnant tissue prevents recurrence in both the aortic valve and the left atrium.

scholarly journals P853 Bilateral lower limb ischemia in a healthy young man what if the heart was hiding the etiology

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Mouadili ◽  
A Tamdy ◽  
B El Fatmi ◽  
S Elkarimi
Keyword(s):  
Popliteal Artery ◽  
Lower Limb ◽  
Cardiac Myxoma ◽  
Clinical Manifestations ◽  
Limb Ischemia ◽  
Atrial Myxoma ◽  
Surgical Removal ◽  
Left Atrial Myxoma ◽  
Tibial Arteries ◽  
The Right

Abstract Cardiac myxoma is the most common benign cardiac tumor with diverse nonspecific clinical manifestations; moreover, atrial myxoma embolization to the peripheral vessels is rare. A 24-year-old man presented tothe emergency departement complaining ofpain and coldness of his two lower extremities. The right femoral pulse was normally felt while the pulses of the left lower limb from the femoral down to the posterior and anterior tibial arteries were not felt. Bilateral thrombectomy was performed on emergency basisand a fatty-like mass from the left femoral artery was removed. The histological examination of this mass was suggestive of myxoma.So, transthoracic echocardiography was done and confirmed the diagnosis of myxoma that was seen in the left atrium and measuring about 10X6 cm in its maximal dimensions. Surgical removal of the myxoma was done later and the patient recovered uneventfully. Conclusion Although myxomas are rare, they should be considered in the differential diagnosis of peripheral embolic disease, especially when an embolic event occurs in a young adult without evidence of endocarditis or arrhythmia. Echocardiography is the modality of choice for diagnosis and follow-up of this type of tumors. FIGURE 1: CTA (computed tomography angiography) showing Occlusion of the left popliteal artery and occlusion of the distal part of the right popliteal artery FIGURE 2: macroscopic view of gelatinous left atrial myxoma

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