Effect of Cardiac and Kidney Function on Walking and Hospitalization Days of Elderly Patients with Heart Failure: A Multicenter Cooperative Retrospective Cohort Study

ObjectivesLiver dysfunction is prevalent in patients with heart failure (HF) and can lead to poor prognosis. The albumin-bilirubin (ALBI) score is considered as an effective and convenient scoring system for assessing liver function. We analysed the correlation between ALBI and in-hospital mortality in patients with HF.DesignA retrospective cohort study.Setting and participantsA total of 9749 patients with HF (from January 2013 to December 2018) was enrolled and retrospectively analysed.Main outcome measuresThe main outcome is in-hospital mortality.ResultsALBI score was calculated using the formula (log10 bilirubin [umol/L] * 0.66) + (albumin [g/L] * −0.085), and analysed as a continuous variable as well as according to three categories. Following adjustment for multivariate analysis, patients which occurred in-hospital death was remarkably elevated in tertile 3 group (ALBI ≥2.27) (OR 1.671, 95% CI 1.228 to 2.274, p=0.001), relative to the other two groups (tertile 1: ≤2.59; tertile 2: −2.59 to −2.27). Considering ALBI score as a continuous variable, the in-hospital mortality among patients with HF increased by 8.2% for every 0.1-point increase in ALBI score (OR 1.082; 95% CI 1.052 to 1.114; p<0.001). The ALBI score for predicting in-hospital mortality under C-statistic was 0.650 (95% CI 0.641 to 0.660, p<0.001) and the cut-off value of ALBI score was −2.32 with a specificity of 0.630 and a sensitivity of 0.632. Moreover, ALBI score can enhance the predictive potential of NT-pro-BNP (NT-pro-BNP +ALBI vs NT-pro-BNP: C-statistic: z=1.990, p=0.0467; net reclassification improvement=0.4012, p<0.001; integrated discrimination improvement=0.0082, p<0.001).ConclusionsIn patients with HF, the ALBI score was an independent prognosticator of in-hospital mortality. The predictive significance of NT-proBNP +ALBI score was superior to NT-proBNP, and ALBI score can enhance the predictive potential of NT-proBNP.

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Mineralocorticoid receptor antagonist use after hospitalization of patients with heart failure and post-discharge outcomes: a single-center retrospective cohort study

BMC Cardiovascular Disorders ◽

10.1186/s12872-019-1175-3 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Matthew S. Durstenfeld ◽

Stuart D. Katz ◽

Hannah Park ◽

Saul Blecker

Keyword(s):

Heart Failure ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Mineralocorticoid Receptor ◽

Retrospective Cohort ◽

Single Center ◽

Post Discharge ◽

Mineralocorticoid Receptor Antagonist ◽

Patients With Heart Failure ◽

Discharge Outcomes

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Clinical Outcome of Septic Patients With Heart Failure With Preserved Ejection Fraction Presenting to the Emergency Department of a Tertiary Hospital: A Retrospective Cohort Study

Frontiers in Medicine ◽

10.3389/fmed.2020.517999 ◽

2020 ◽

Vol 7 ◽

Author(s):

Ralphe Bou Chebl ◽

Iskandar Berbari ◽

Rawan Safa ◽

Ali Shami ◽

Mohammad Sabra ◽

...

Keyword(s):

Heart Failure ◽

Emergency Department ◽

Cohort Study ◽

Clinical Outcome ◽

Ejection Fraction ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Tertiary Hospital ◽

Preserved Ejection Fraction ◽

Patients With Heart Failure

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Blood Pressure and Cardiovascular Disease in Older Patients With Diabetes: Retrospective Cohort Study

Journal of the American Heart Association ◽

10.1161/jaha.121.020999 ◽

2021 ◽

Author(s):

Sangmo Hong ◽

Jung Hwan Park ◽

Kyungdo Han ◽

Chang Beom Lee ◽

Dong Sun Kim ◽

...

Keyword(s):

Heart Failure ◽

Blood Pressure ◽

Cardiovascular Disease ◽

Cohort Study ◽

Elderly Patients ◽

Diastolic Blood Pressure ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Patients With Diabetes ◽

Composite Outcomes

Background Blood pressure (BP) targets in elderly patients with diabetes remain unclear. We evaluated the association between BP and cardiovascular disease in elderly patients with diabetes without cardiovascular disease or heart failure. Methods and Results We performed a retrospective cohort study of 225 563 elderly (aged ≥65 years) patients with diabetes without cardiovascular disease or heart failure from 2009 to 2017 using the National Health Information Database. We divided the participants by systolic BP (SBP) and diastolic BP. Primary composite outcomes were stroke, myocardial infarction, heart failure, and all‐cause death analyzed by Cox proportional hazards regression analysis adjusted for baseline covariates. During a median follow‐up of 7.76 years, the incidence rate of primary composite outcomes was 26.62 per 1000 person‐years. In multivariable Cox proportional hazard modeling, the risk of the primary outcome had a U‐curved association with SBP/diastolic blood pressure with a nadir between 120 and 129 mm Hg/65 and 69 mm Hg, respectively. Hypertension medication was associated with lower risk of primary composite outcomes in SBP ≥140 mm Hg ( P for interaction for SBP <0.001) and diastolic blood pressure ≥90 mm Hg ( P for interaction for diastolic blood pressure=0.018). In participants aged ≥80 years, SBP ≥160 mm Hg was only a marginally higher risk for primary composite outcomes (hazard ratio=1.11; 95% CI, 0.98–1.24). Conclusions In this large sample of older Korean patients with diabetes, cardiovascular events were more common in people with resting SBP or diastolic BP ≥140 or 95 mm Hg, respectively, and also more common in people with resting SBP or diastolic BP <120 or 65 mm Hg, respectively.

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Cardiac rehabilitation and all-cause mortality in patients with heart failure: A retrospective cohort study

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.328 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

B Buckley ◽

S Harrison ◽

E Fazio-Eynullayeva ◽

P Underhill ◽

R Sankaranarayanan ◽

...

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Cohort Study ◽

Propensity Score ◽

Cardiac Rehabilitation ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Lower Odds ◽

Patients With Heart Failure ◽

All Cause Mortality

Abstract Funding Acknowledgements Type of funding sources: None. Background Despite the benefits of exercise training in the secondary prevention of cardiovascular disease, there are conflicting findings for the impact of exercise-based cardiac rehabilitation (CR) on mortality for patients with heart failure (HF). Methods A retrospective cohort study was conducted which utilised a global federated health research network. Patients with a diagnosis of HF were compared between those with and without an electronic medical record of exercise-based CR within 6-months of a HF diagnosis. Patients with HF undergoing exercise-based CR were propensity score matched to HF patients without exercise-based CR by age, sex, race, co-morbidities, medications, and procedures. We ascertained 2-year incidence of all-cause mortality, hospitalisation, stroke, and atrial fibrillation. Results Following propensity score matching, a total of 40,364 patients with HF were identified. Exercise-based CR was associated with 42% lower odds of all-cause mortality (odds ratio 0.58, 95% confidence interval (CI): 0.54-0.62), 26% lower odds of hospitalisation (0.74, 95% CI 0.71-0.77), 37% lower odds of incident stroke (0.63, 95% CI 0.51-0.79), and 53% lower odds of incident atrial fibrillation (0.47, 95% CI 0.4-0.55) compared to matched controls. The beneficial association of exercise-based CR on all-cause mortality was consistent across stratification for sex, older age, included comorbidities, and HF subtype (all P < 0.0001), including patients with HFpEF (0.65, 95% CI 0.60-0.71). Conclusions Exercise-based CR was associated with lower odds of all-cause mortality, hospitalisations, incident stroke and incident atrial fibrillation at 2-years follow-up for patients with HF. The beneficial association of CR and lower mortality was consistent for patients with HFrEF and HFpEF.

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Clinical Practice Patterns in Constrictive Pericarditis Patients With Heart Failure: A Retrospective Cohort Study Using a National Inpatient Database in Japan

Clinical Cardiology ◽

10.1002/clc.22483 ◽

2015 ◽

Vol 38 (12) ◽

pp. 740-746 ◽

Cited By ~ 6

Author(s):

Toshiaki Isogai ◽

Hideo Yasunaga ◽

Hiroki Matsui ◽

Hiroyuki Tanaka ◽

Motoyuki Hisagi ◽

...

Keyword(s):

Heart Failure ◽

Cohort Study ◽

Clinical Practice ◽

Constrictive Pericarditis ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Practice Patterns ◽

Clinical Practice Patterns ◽

Patients With Heart Failure ◽

Inpatient Database

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Effect of albumin-globulin score and albumin to globulin ratio on survival in patients with heart failure: a retrospective cohort study in China

BMJ Open ◽

10.1136/bmjopen-2018-022960 ◽

2018 ◽

Vol 8 (7) ◽

pp. e022960 ◽

Cited By ~ 4

Author(s):

Kuan Li ◽

Wanrong Fu ◽

Yacong Bo ◽

Yongjian Zhu

Keyword(s):

Heart Failure ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Cox Regression ◽

Characteristic Curve ◽

Serum Levels ◽

Cox Regression Analysis ◽

Patients With Heart Failure ◽

Albumin To Globulin Ratio

ObjectiveTo investigate the combined effect of albumin (ALB) and globulin (GLB) on the overall survival (OS) of patients with heart failure (HF).DesignRetrospective cohort study.SettingA hospital.Participants404 patients first diagnosed with HF.MeasurementsSerum ALB and GLB were measured within 3 days after admission. The albumin to globulin ratio (AGR) was calculated as the ALB divided by the GLB. The receiver operating characteristic curve was used to calculate the cut-off points for ALB, GLB and AGR. Patients with low ALB levels (≤35.3 g/L) and high GLB levels (>27.0 g/L) were assigned an albumin-globulin score (AGS) of 2, those with only one of the two abnormalities were assigned an AGS of 1 and those with neither of the two abnormalities were assigned an AGS of 0.ResultsThe mean age of the 404 patients was 62.69±15.62, and 54.5% were male. 14 patients were lost to follow-up. 120 patients died from HF and 211 patients were readmitted to the hospital for worsening HF. Multivariate Cox regression analysis showed that higher AGR was significantly associated with favourable OS (HR, 0.61, 95% CI 0.38 to 0.98, p=0.040) but not AGS.ConclusionSerum levels of ALB and GLB are objective and easily measurable biomarkers which can be used in combination to predict the survival of patients with HF.

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