scholarly journals Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome

2019 ◽  
Vol 45 (3) ◽  
Author(s):  
Adriane Dal Bosco ◽  
Filipe Boeira Schedler ◽  
Josieli Raskopf Colares ◽  
Elisângela Gonçalves Schemitt ◽  
Renata Minuzzo Hartmann ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Weight Ratio ◽  
Hepatopulmonary Syndrome ◽  
Antioxidant Effect ◽  
Biliary Duct ◽  
Body Weight Ratio ◽  
Pulmonary Tissue ◽  
Male Wistar Rats ◽  
Hepatic Histology ◽  
And Oxidative Stress

ABSTRACT Objective: To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL). Methods: Sixteen male Wistar rats, divided into four Sham groups: BDL group, Sham + MEL group and BDL + MEL. The pulmonary and hepatic histology, lipoperoxidation and antioxidant activity of lung tissue, alveolar-arterial O2 difference and lung / body weight ratio (%) were evaluated. Results: When comparing the groups, could be observed an increase of vasodilation and pulmonary fibrosis in the BDL group and the reduction of this in relation to the BDL + MEL group. It was also observed significant changes in the activity of catalase, ApCO2, ApO2 in the LBD group when compared to the other groups. Conclusion: The use of MEL has been shown to be effective in reducing vasodilation, fibrosis levels and oxidative stress as well as gas exchange in an experimental HPS model.

scholarly journals Moringa oleiferaSupplemented Diets Prevented Nickel-Induced Nephrotoxicity in Wistar Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
O. S. Adeyemi ◽  
T. C. Elebiyo
Keyword(s):  
Wistar Rats ◽  
Moringa Oleifera ◽  
Weight Ratio ◽  
Normal Diet ◽  
Oral Exposure ◽  
Renal Tubules ◽  
Nickel Sulphate ◽  
Significant Elevation ◽  
Body Weight Ratio ◽  
Male Wistar Rats

Background. TheMoringa oleiferaplant has been implicated for several therapeutic potentials.Objective. To evaluate whether addition ofM. oleiferato diet has protective effect against nickel-induced nephrotoxicity in rats.Methodology. Male Wistar rats were assigned into six groups of five. The rats were given oral exposure to 20 mg/kg nickel sulphate (NiSO4) in normal saline and sustained on either normal diet or diets supplemented withMoringa oleiferaat different concentrations for 21 days. 24 hours after cessation of treatments, all animals were sacrificed under slight anesthesia. The blood and kidney samples were collected for biochemical and histopathology analyses, respectively.Results. NiSO4exposure reduced the kidney-to-body weight ratio in rats and caused significant elevation in the levels of plasma creatinine, urea, and potassium. Also, the plasma level of sodium was decreased by NiSO4exposure. However, addition ofM. oleiferato diets averted the nickel-induced alteration to the level of creatinine and urea. The histopathology revealed damaged renal tubules and glomerular walls caused by NiSO4exposure. In contrast, the damages were ameliorated by theM. oleiferasupplemented diets.Conclusion. The addition ofM. oleiferato diet afforded significant protection against nickel-induced nephrotoxicity.

scholarly journals Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1999
Author(s):  
Lidia V. Kravchenko ◽  
Ilya V. Aksenov ◽  
Nikolay S. Nikitin ◽  
Galina V. Guseva ◽  
Ludmila I. Avrenyeva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Liver Disease ◽  
Lipoic Acid ◽  
Lipid Accumulation ◽  
Wistar Rats ◽  
Weight Ratio ◽  
Body Weight Ratio ◽  
Deficient Diet ◽  
Male Wistar Rats

Non-alcoholic fatty liver disease (NAFLD) is currently estimated as the most prevalent chronic liver disease in all age groups. An increasing body of evidence obtained in experimental and clinical data indicates that oxidative stress is the most important pathogenic factor in the development of NAFLD. The study aimed to investigate the impact of α-lipoic acid (LA), widely used as an antioxidant, on the effects of a hypercaloric choline-deficient diet. Male Wistar rats were divided into three groups: control diet (C); hypercaloric choline-deficient diet (HCCD), and hypercaloric choline-deficient diet with α-lipoic acid (HCCD+LA). Supplementation of HCCD with LA for eight weeks led to a decrease in visceral adipose tissue/body weight ratio, the activity of liver glutathione peroxidase and paraoxonase-1, plasma, and liver total antioxidant activity, as well as an increase in liver/body weight ratio, liver total lipid and triglyceride content, and liver transaminase activities compared to the HCCD group without LA. In conclusion, our study shows that α-lipoic acid detains obesity development but exacerbates the severity of diet-induced oxidative stress and lipid accumulation in the liver of male Wistar rats fed a hypercaloric choline-deficient diet.

scholarly journals Effects of melatonin on liver and lung tissues of animals with bile duct ligation-induced hepatopulmonary syndrome

2021 ◽  
Vol 5 (1) ◽  
pp. 097-105
Author(s):  
Dal Bosco Adriane ◽  
Colares Josieli Raskopf ◽  
Bona Sílvia ◽  
De Andrade Lívia Barboza ◽  
Forgiarini Jr. Luiz Alberto ◽  
...  
Keyword(s):  
Bile Duct ◽  
Wistar Rats ◽  
Histological Analysis ◽  
Bile Duct Ligation ◽  
Hepatopulmonary Syndrome ◽  
Lung Parenchyma ◽  
Antioxidant Effect ◽  
Biliary Cirrhosis ◽  
Duct Ligation ◽  
Male Wistar Rats

The objective was to assess the antioxidant effect of melatonin (MLT) on liver and lung tissues of animals with bile duct ligation (BDL)-induced hepato-pulmonary syndrome (HPS). A model of BDL-induced biliary cirrhosis was used in male Wistar rats. Results suggest that MLT has an antioxidant effect on liver and lung tissues in animals with BDL-induced HPS by higher activity of antioxidant enzymes in the group HPS treated with MLT and the histological analysis of lung parenchyma showing decreased damage in this same group, including other analysis described below.

Geraniol improved memory impairment and neurotoxicity induced by zinc oxide nanoparticles in male wistar rats through its antioxidant effect

Life Sciences ◽  
2021 ◽  
pp. 119823
Author(s):  
Maryam Farokhcheh ◽  
Leilabeigom Hejazian ◽  
Zeinab Akbarnejad ◽  
Fereshteh Pourabdolhossein ◽  
Seyed Mohammad Hosseini ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Memory Impairment ◽  
Wistar Rats ◽  
Antioxidant Effect ◽  
Oxide Nanoparticles ◽  
Male Wistar Rats

Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male wistar rats- a preliminary study

2015 ◽  
Vol 31 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Wahab Imam Abdulmajeed ◽  
Habeeb Bolakale Sulieman ◽  
Maymunah Oloruntosin Zubayr ◽  
Aminu Imam ◽  
Abdulbasit Amin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Preliminary Study ◽  
And Oxidative Stress

Studies on the toxicological effect of the aqueous extract of the fresh, dried and boiled berries of Solanum aculeastrum Dunal in male Wistar rats

2009 ◽  
Vol 28 (12) ◽  
pp. 765-775 ◽  
Author(s):  
OM Aboyade ◽  
MT Yakubu ◽  
DS Grierson ◽  
AJ Afolayan
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Haemoglobin Concentration ◽  
Weight Ratio ◽  
The Body ◽  
Corpuscular Haemoglobin ◽  
Toxicological Effect ◽  
Male Wistar Rats ◽  
Mean Corpuscular Haemoglobin

The toxicological effect of the aqueous extract of fresh, dried and boiled berries of Solanum aculeastrum Dunal at 1, 10 and 25 mg/kg body weight was investigated in male Wistar rats for 28 days. The parameters used were the body weight of the animals and absolute weights of the organs, haematological parameters, renal and liver functional endpoints. The animals gained appreciable weight and showed no signs of clinical toxicity. The dried (DB), boiled dried (BDB), fresh (FB) and boiled fresh berry (BFB) extracts reduced (p < .05) the heart-, liver-and spleen-body weight ratio of the animals whereas that of the lung was not altered. The kidney and testes-body weight ratios were specifically altered by the different extract. All these were not accompanied by any histomorphological changes. The extracts did not alter (p > .05) the levels of RBC, Hb, PCV and albumin of the animals. The platelets were decreased by the DB and FB whereas BFB increased this parameter. The FB and BFB at all the doses also reduced the mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) of the animals. With the exception of the FB where the creatinine and chloride levels decreased, other extracts did not alter the level of these kidney parameters. Only FB increased the levels of uric acid and urea. All the extract decreased the serum alanine aminotransferase (ALT) of the animal. The levels of total protein, globulin, total and conjugated bilirubin were not altered by DB and BDB whereas these indices were increased by FB and BFB. The DB and BDB increased the serum alkaline phosphatase (ALP) activity whereas FB decreased the activity of the enzyme. In contrast, DB and BDB decreased the serum aspartate aminotransferase (AST) activity of the animals whereas FB and BFB increased the activity of the enzyme. The FB and BFB also increased the levels of potassium, magnesium and phosphorus of the animals. Overall, the alterations in the biochemical parameters by the various extracts of S. aculeastrum berries at these doses indicated that the normal functioning of these organs may be adversely affected. However, drying and boiling might reduce the toxic effect of the berries.

scholarly journals The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
António Nogueira ◽  
Francisco Peixoto ◽  
Maria Manuel Oliveira ◽  
Carlos André Pires ◽  
Bruno Colaço ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Renal Mass ◽  
Wistar Rats ◽  
Reduced Glutathione ◽  
Mass Reduction ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
And Oxidative Stress

Purpose.This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction.Methods. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment(n=14); RMR + CAA: RMR rats treated with CAA(n=13); SO: SO rats without treatment(n=13); and SO + CAA: SO rats treated with CAA(n=13). CAA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months.Results.RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity(p<0.05)and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity(p<0.05)and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function.Conclusions.These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.

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