scholarly journals Physical exercise and metformin in the prevention of pre-eclampsia: systematic review

2020 ◽  
Vol 33 ◽  
Author(s):  
Iramar Baptistella do Nascimento ◽  
Mayco Morais Nunes ◽  
Raquel Fleig
Keyword(s):  
Systematic Review ◽  
Physical Exercise ◽  
Web Of Science ◽  
Circulatory System ◽  
Case Control ◽  
Review Of The Literature ◽  
Metabolic Factors ◽  
Case Control Studies ◽  
Bias Assessment ◽  
Black Scale

Abstract Introduction: Pre-eclampsia is a disorder that may occur during pregnancy but is still unknown and / or multifactorial causes. Objective: To verify whether physical exercise and metformin may be helpful in preventing preeclampsia. Method: This is a systematic review of the literature in PubMed / MEDLINE, Web of Science, Scopus, LILACS and Cochrane. This review followed the critiques of the PRISMA checklist. Bias assessment was used for the Cochrane Handbook for Systematical Reviews of Interventions (Version 5.1.0) for clinical trials and the Downs and Black scale for cohort and case-control studies. Results: 17 studies were within the established criteria. The subjects evaluated were: pre-eclampsia, cardiovascular metabolic factors, physiotherapeutic therapies and the effects of physical exercise and metformin on the circulatory system. Conclusion: There is a need for adapted techniques and new protocols according to the contingencies and complications of pregnancy. During pregnancy, it is suggested a greater interdisciplinarity of knowledge among professionals and that the therapy receives adjustments against the metabolic alterations of the reproductive system. In order to prevent preeclampsia, the study suggests a program of individual exercises that include greater assistance, verification and / or comprehension of possible changes and their limits during pregnancy. As well as, the adjuvant use of metformin of 1000 mg/d in the initial phase, with the purpose of maintaining the effects of the drug due to renal clearance during pregnancy, until reaching a maximum of 1500 mg/d, to avoid side effects of the drug.

scholarly journals Association of ABO Polymorphisms and Pancreatic Cancer/ Cardiocerebrovascular Disease: a Meta-analysis.

2020 ◽  
Author(s):  
Yanxia Li ◽  
Luyang Liu ◽  
Yubei Huang ◽  
Hong Zheng ◽  
Lian Li
Keyword(s):  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Bias Assessment ◽  
Heterogeneity Test ◽  
Pancreatic Cancers ◽  
The Relationship ◽  
Eligible Case

Abstract Background: ABO gene polymorphisms have been reported to be associated with the risk of multiple cancers and cardiocerebrovascular disease s. However, the results remained controversial. In this study, we conducted a systematic review and meta-analysis to clarify the association between two SNPs (rs505922 and rs657152) in ABO gene and cancers/ cardiocerebrovascular disease s. Method: All eligible case-control studies come from PubMed, Embase and Web of Science up to Jan. 1, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 12.0. Results : A total of nineteen articles involving twenty-two case-control populations were included according to inclusion and exclusion criteria. Twelve populations (20,820 cases and 27,837 controls) were used to evaluate the relationship between rs505922 and overall cancers and nine populations (22,275 cases and 71,549 controls) were included to assess the association between rs505922 and cardiocerebrovascular diseases. The results showed a significant association between the rs505922 polymorphism and cancers (CvsT: OR=1.13, 95%CI=1.05-1.22, P =0.001), and cardiocerebrovascular diseases (OR=1.36, 95%CI=1.19-1.57, P <0.001). Five populations (8,660 cases and 10,618 controls) were included to evaluate association between rs657152 and cancers and five populations (8,105 cases and 6,712 controls) were included to estimate the relationship between rs657152 and cardiocerebrovascular diseases. The result of meta-analysis reveals that rs657152 was significantly associated with cancers (OR=1.18, 95%CI=1.13-1.23, P <0.001) and cardiocerebrovascular diseases (OR=1.54, 95%CI=1.24-1.92, P <0.001). Conclusion: Our study suggested that ABO polymorphisms might serve as a risk factor of pancreatic cancers and cardiocerebrovascular diseases.

Dhat Syndrome: A Systematic Review

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Udina ◽  
H. Foulon ◽  
D. Corcoles ◽  
L. Rodriguez ◽  
S. Battacharyya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Indian Subcontinent ◽  
Economic Status ◽  
Case Control ◽  
Review Of The Literature ◽  
Inclusion Criteria ◽  
Case Control Studies ◽  
Young Males ◽  
Language Restriction ◽  
High Degree

Background:Dhat syndrome is a widely recognized clinical condition from the Indian subcontinent characterized by a preoccupation with semen loss in urine and other symptoms such as fatigue or depressed mood. This condition has been considered to be a culture-bound syndrome, and may be considered to be a culturally manifestation of depression or anxiety.Aims:The purpose of this paper was to perform a systematic review of published literature on Dhat syndrome.Methods:A review of the literature on Dhat syndrome until July 2008, without any language restriction was conducted by a search of the MEDLINE and PsycLIT indexing services using the following key words:Dhat syndrome, semen loss anxiety and loss of semen syndrome. Inclusion criteria were any case-control or cross-over study.Results:Twenty-three studies were identified, of which 10 met the inclusion criteria. There were 8 cross-over and 2 case-control studies. The reviewed studies included a total number of 680 cases and 93 controls. Patients included in these studies were mostly unmarried, young males (25.4 years old;18-45 years) from a poor socio-economic status. Majority of the studies involved patients from the Indian subcontinent. Some studies reported concomitant depressive symptoms (50%), anxiety (40%), fatigue (30%) and sexual problems (40%). Only 4 studies reported information about treatment (psychotherapy and pharmacotherapy).Conclusions:There was a high degree of heterogeneity among the studies reviewed. In conclusion, Dhat syndrome appears to be commonly associated with depression, anxiety and somatic symptoms. More studies are warranted related to the various treatment approaches for this condition.

scholarly journals Association of ABO Polymorphisms and Cancer/Cardiocerebrovascular Disease: a Meta-analysis

2019 ◽  
Author(s):  
Yanxia Li ◽  
Luyang Liu ◽  
Yubei Huang ◽  
Hong Zheng ◽  
Lian Li
Keyword(s):  
Gene Polymorphisms ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Bias Assessment ◽  
Heterogeneity Test ◽  
The Relationship ◽  
Eligible Case

Abstract Background: ABO gene polymorphisms have been reported to be associated with the risk of multiple cancers and cardiocerebrovascular diseases. However, the results remained controversial. In this study, we conducted a systematic review and meta-analysis to clarify the association between two SNPs (rs505922 and rs657152) in ABO gene and cancers/cardiocerebrovascular diseases. Method: All eligible case-control studies come from PubMed, Embase and Web of Science up to Jan. 1, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 12.0. Results: A total of eighteen articles involving twenty-nine case-control populations were included according to inclusion and exclusion criteria. Eleven populations (16,929 cases and 23,941 controls) were used to evaluate the relationship between rs505922 and overall cancers and nine populations (22,275 cases and 71,549 controls) were included to assess the association between rs505922 and cardiocerebrovascular diseases. The results showed a significant association between the rs505922 polymorphism and cancers (CvsT: OR=1.13, 95% CI=1.04-1.22, P=0.003), and cardiocerebrovascular diseases (OR=1.36, 95%CI=1.19-1.57, P<0.001). Four populations (5,158 cases and 7,021 controls) were included to evaluate association between rs657152 and cancers and five populations (8,105 cases and 6,712 controls) were included to estimate the relationship between rs657152 and cardiocerebrovascular diseases. The result of meta-analysis reveals that rs657152 was significantly associated with cancers (OR=1.16, 95%CI=1.09-1.24, P<0.001) and cardiocerebrovascular diseases (OR=1.54, 95%CI=1.24-1.92, P<0.001). Conclusion: Our study suggested that ABO polymorphisms may serve as a risk factor of cancers and cardiocerebrovascular diseases.

scholarly journals Polimorfismos de nucleotídeos único no gene IGFBP3 e o processo de carcinogênese: uma revisão sistemática

2021 ◽  
Vol 10 (1) ◽  
pp. e48810111978
Author(s):  
Paulo Pedro de Freitas ◽  
Israel Faustino dos Santos ◽  
Denise Macedo da Silva ◽  
Cristiane Araújo Nascimento ◽  
Ana Caroline Melo dos Santos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Growth Factor ◽  
Cell Growth ◽  
Genetic Variants ◽  
Web Of Science ◽  
Case Control ◽  
Case Control Studies ◽  
Suppression Method ◽  
Cell Growth Suppression

Introduction: Insulin-like growth factor binding protein -3 (IGFBP3) is the main mediator of IGF-1/IGF-1R binding, and may inhibit the binding between IGF-1 and IGF-1R and trigger cell growth suppression. Method: This study is a systematic review in which searches were conducted in Pubmed, Web of science, Science direct and Scopus databases for studies published in the period 2010-2020, including case-control studies that evaluated the association of polymorphisms in the IGFBP3 gene with cancer. Results: Of the 6 studies included, 5 were conducted in China and 1 in Iran, published in 2015 (n=2), 2014 (n=2), 2013 (n=1) and 2011 (n=1). In all, there were 5 types of cancer studied: esophagus (n=2), prostate (n=1), colorectal (n=1), breast (n=1) and gastric (n=1). In the studies chosen, 8 SNPs located in the IGFBP3 gene were evaluated: rs2854744, rs2854746, rs2132572, rs9282734, rs3110697, rs2960436, rs2270628 and rs10282088. Only the Zhao et al studies. (2015) and Liu et al. (2015) found a relationship between SNPs in the IGFBP3 gene with cancer. Two studies (Qian et al., 2014 and Qian et al., 2011) did not describe allelic frequencies in their results. Conclusion: Based on the studies we can demonstrate that the findings on the association of polymorphisms in the IGFBP3 gene with cancers are confusing, divergent and the role of the IGF pathway in carcinogenesis has not been clearly defined. However, the studies bring strong evidence that suggests possible relationships of this pathway and genetic variants with the carcinogenesis process in several types of cancer.

scholarly journals Association of ABO Polymorphisms and Pancreatic Cancer/ Cardiocerebrovascular Disease: a Meta-analysis.

2020 ◽  
Author(s):  
Yanxia Li ◽  
Luyang Liu ◽  
Yubei Huang ◽  
Hong Zheng ◽  
Lian Li
Keyword(s):  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Bias Assessment ◽  
Heterogeneity Test ◽  
Pancreatic Cancers ◽  
The Relationship ◽  
Eligible Case

Abstract Background: ABO gene polymorphisms have been reported to be associated with the risk of multiple cancers and cardiocerebrovascular disease s. However, the results remained controversial. In this study, we conducted a systematic review and meta-analysis to clarify the association between two SNPs (rs505922 and rs657152) in ABO gene and cancers/ cardiocerebrovascular disease s. Method: All eligible case-control studies come from PubMed, Embase and Web of Science up to Jan. 1, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 12.0. Results : A total of nineteen articles involving twenty-two case-control populations were included according to inclusion and exclusion criteria. Twelve populations (20,820 cases and 27,837 controls) were used to evaluate the relationship between rs505922 and overall cancers and nine populations (22,275 cases and 71,549 controls) were included to assess the association between rs505922 and cardiocerebrovascular diseases. The results showed a significant association between the rs505922 polymorphism and cancers (CvsT: OR=1.13, 95%CI=1.05-1.22, P =0.001), and cardiocerebrovascular diseases (OR=1.36, 95%CI=1.19-1.57, P <0.001). Five populations (8,660 cases and 10,618 controls) were included to evaluate association between rs657152 and cancers and five populations (8,105 cases and 6,712 controls) were included to estimate the relationship between rs657152 and cardiocerebrovascular diseases. The result of meta-analysis reveals that rs657152 was significantly associated with cancers (OR=1.18, 95%CI=1.13-1.23, P <0.001) and cardiocerebrovascular diseases (OR=1.54, 95%CI=1.24-1.92, P <0.001). Conclusion: Our study suggested that ABO polymorphisms might serve as a risk factor of pancreatic cancers and cardiocerebrovascular diseases.

scholarly journals Association of ABO Polymorphisms and Pancreatic Cancer/Cardiocerebrovascular Disease: a Meta-analysis

2020 ◽  
Author(s):  
Yanxia Li ◽  
Luyang Liu ◽  
Yubei Huang ◽  
Hong Zheng ◽  
Lian Li
Keyword(s):  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Bias Assessment ◽  
Heterogeneity Test ◽  
Pancreatic Cancers ◽  
The Relationship ◽  
Eligible Case

Abstract Background: ABO gene polymorphisms have been reported to be associated with the risk of multiple cancers and cardiocerebrovascular disease s. However, the results remained controversial. In this study, we conducted a systematic review and meta-analysis to clarify the association between two SNPs (rs505922 and rs657152) in ABO gene and cancers/ cardiocerebrovascular disease s. Method: All eligible case-control studies come from PubMed, Embase and Web of Science up to Jan. 1, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 12.0. Results : A total of nineteen articles involving twenty-two case-control populations were included according to inclusion and exclusion criteria. Twelve populations (20,820 cases and 27,837 controls) were used to evaluate the relationship between rs505922 and overall cancers and nine populations (22,275 cases and 71,549 controls) were included to assess the association between rs505922 and cardiocerebrovascular diseases. The results showed a significant association between the rs505922 polymorphism and cancers (CvsT: OR=1.13, 95%CI=1.05-1.22, P =0.001), and cardiocerebrovascular diseases (OR=1.36, 95%CI=1.19-1.57, P <0.001). Five populations (8,660 cases and 10,618 controls) were included to evaluate association between rs657152 and cancers and five populations (8,105 cases and 6,712 controls) were included to estimate the relationship between rs657152 and cardiocerebrovascular diseases. The result of meta-analysis reveals that rs657152 was significantly associated with cancers (OR=1.18, 95%CI=1.13-1.23, P <0.001) and cardiocerebrovascular diseases (OR=1.54, 95%CI=1.24-1.92, P <0.001). Conclusion: Our study suggested that ABO polymorphisms might serve as a risk factor of pancreatic cancers and cardiocerebrovascular diseases.

scholarly journals Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094794
Author(s):  
Jie Liu ◽  
Chunrong Li ◽  
Xiaoyang Zhou ◽  
Jian Sun ◽  
Meng Zhu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Web Of Science ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Gene Variants ◽  
Case Control Studies ◽  
The Relationship

Objective In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed. Methods Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case–control studies with 2890 cases and 3043 controls. Results This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population. Conclusions Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population.

Association of MMP-2 -753C>T and MMP-9 -1562C>T Polymorphisms with Chronic/Aggressive Periodontitis Risk: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Fatemeh MASHHADIABBAS ◽  
Hossein NEAMATZADEH ◽  
Elnaz FOROUGHI ◽  
Seyed Alireza DASTGHEIB ◽  
Soudabeh FARAHNAK ◽  
...  
Keyword(s):  
Systematic Review ◽  
Literature Search ◽  
Web Of Science ◽  
Meta Analysis ◽  
Aggressive Periodontitis ◽  
Case Control ◽  
Matrix Metalloproteinase 2 ◽  
Case Control Studies ◽  
Functional Polymorphisms ◽  
The Matrix

Background: Two functional polymorphisms in the matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) genes may contribute to periodontitis pathogenesis. However, the results were inconsistent and inconclusive. Therefore, to clarify precise associations of MMP-2 -753 C>T and MMP-9 -1562C>T polymorphisms with chronic (CP) and aggressive (AgP) periodontitis, we performed a systematic review and meta-analysis. Methods: A literature search was conducted using PubMed, Google Scholar, Embase, and Web of Science databases until 5 July 2017. The data were analyzed with CMA software, and risk estimates are expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: Nineteen case-control studies in ten publications with 2089 periodontitis cases and 2345 controls met the criteria. The pooled ORs indicated that MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms were not significantly associated with risk of periodontitis in overall analysis. Stratified analyses by ethnicity and periodontitis type indicated that the MMP-9 -1562C>T polymorphism showed a significant association with the risk of periodontitis among Caucasians and CP/AgP subgroup, whereas MMP-2 -753C>T polymorphism was significantly associated with periodontitis risk only among Asians. Conclusion: MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms may not be associated with risk of periodontitis in overall population. However, MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms might have influence on the susceptibility of periodontitis by ethnicity.  

scholarly journals Are mental disorders related to disbelief in free will? A systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria E. Moreira-de-Oliveira ◽  
Gabriela B. de Menezes ◽  
Samara dos Santos-Ribeiro ◽  
Luana D. Laurito ◽  
Ana P. Ribeiro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mental Disorders ◽  
Mental Disorder ◽  
Free Will ◽  
Search Strategy ◽  
Web Of Science ◽  
Case Control ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Study Selection

Abstract Background The nature and existence of free will have been debated for centuries. Since some psychiatric disorders are known to interfere with one’s ability to control their actions and thoughts (e.g., schizophrenia), the investigation of the psychiatric facet of free will beliefs seems to be relevant. In this systematic review, we were interested in clarifying if and how having a mental disorder affects individuals’ beliefs in free will by comparing psychiatric vs. non-psychiatric samples. Methods A systematic search of MEDLINE, Web of Science, EMBASE, and PsycINFO databases was performed between 04 and 09 November 2020. The search strategy included “free will” and related constructs and terms related to DSM-5 mental disorders characterized by psychotic, compulsive, avoidant, or impulsive symptoms. Eligible designs of studies included case-control and cohort studies. Study selection took place in committee meetings consisting of six researchers. Quality assessment of the selected studies was performed through the Joanna Briggs Institute Appraisal Checklist for Case Control Studies. Results After removing duplicates, a total of 12,218 titles/abstracts were screened. Inclusion and exclusion criteria were followed, and three articles were eventually selected. Conclusions It is not possible to provide unequivocal confirmation that having a mental disorder can or cannot affect someone’s belief in free will. Studies with different mental disorders should be conducted in this field. Systematic review registration PROSPERO CRD42018109468.

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