scholarly journals Papillary mucinous cystadenocarcinoma: rare malignant tumor in minor salivary gland

2016 ◽  
Vol 64 (2) ◽  
pp. 207-211
Author(s):  
Ronaldo Célio MARIANO ◽  
Marina Reis OLIVEIRA ◽  
Amanda de Carvalho SILVA ◽  
Lúcia de Carvalho Freire MARIANO ◽  
Pablo Agustin VARGAS ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Malignant Tumor ◽  
Minor Salivary Gland ◽  
Malignant Lesion ◽  
Distant Metastases ◽  
Mucinous Cystadenocarcinoma ◽  
Surgical Removal ◽  
Ki 67 ◽  
Lower Lip

ABSTRACT Clinical case description of a papillary mucinous cystadenocarcinoma, extremely rare malignant tumor in the salivary gland and difficult to diagnose, in geriatric patient. Patient with 86 years old was referred for treatment with nodular lesion on the inner side of left lower lip extending to the bucal mucosa, without any clinical appearances of malignancy. The lesion was asymptomatic, had flabby consistency and slow growth. Despite the favorable clinical features, after surgical removal, was diagnosed as papillary mucinous papillary mucinous cystadenocarcinoma. Nonetheless, the cellular atypia found was considered to be mild and immunohistochemical evaluation the reaction to Ki-67 was low, indicating a low rate of proliferation of the tumor. Medical evaluation confirmed the absence of systemic disorders or distant metastases. Although it is a malignant lesion, due to low degree of proliferation of lesion and the careful follow-up carried out, there was a favorable evolution after conservative treatment in a follow-up period of 11 years and six months.

scholarly journals Excision of Lower Lip Mucocele Using Injection of Hydrocolloid Dental Impression Material in a Pediatric Patient: A Case Report

2021 ◽  
Vol 11 (13) ◽  
pp. 5819
Author(s):  
Gianluca Botticelli ◽  
Marco Severino ◽  
Gianmaria Fabrizio Ferrazzano ◽  
Pedro Vittorini Velasquez ◽  
Carlo Franceschini ◽  
...  
Keyword(s):  
Minor Salivary Gland ◽  
Surgical Techniques ◽  
Surgical Excision ◽  
Complete Healing ◽  
Surgical Removal ◽  
Clinical Approach ◽  
Lower Lip ◽  
Impression Material ◽  
Dental Impression

Oral mucocele is a benign cystic exophytic lesion affecting the minor salivary gland and is especially present in pediatric patients (3% under 14 years). It is characterized by an extravasation or retention of fluid or mucus in the submucosal tissue of the minor salivary glands. Several surgical techniques have been proposed over the years, including the excision of the mucocele by using the injection of a hydrocolloid impression material in the light of the cyst to prevent the collapse of the cystic wall and solidify the lesion, resulting in a better cleavage plan. The combined clinical approach between the combination of Shira’s technique and the surgical excision of the cystic lesion results in a conservative surgical removal of the lesion. Here, we reported the removal of a labial mucocele in a 14-year-old male patient, using the injection of a hydrocolloid impression material. At a 12 months follow up, the patient showed complete healing of the surgical site, showing a pinkish lip lining mucosa without scarring or recurrence of the primary lesion. The combined therapeutic approach between Shira’s technique and surgical excision allows a safe and predictable excision of the labial mucocele, minimizing the risk of recurrence.

scholarly journals Median cleft of mandible and lower lip with ankyloglossia and ectopic minor salivary gland on tongue

2004 ◽  
Vol 37 (01) ◽  
pp. 67-70 ◽  
Author(s):  
Roshani E. Rana ◽  
Vinita A. Puri ◽  
Rahul K. Thakkur ◽  
A. S. Baliarsing
Keyword(s):  
Salivary Gland ◽  
Thyroid Cartilage ◽  
Minor Salivary Gland ◽  
Permanent Teeth ◽  
Central Incisor ◽  
Lower Lip ◽  
Median Cleft ◽  
Manubrium Sterni ◽  
Mandibular Teeth

ABSTRACTMedian cleft of lower lip and mandible is a rare anomaly. This Cleft has also been described as Cleft No. 30 of Tessier′s classification. In minor forms only lower lip is cleft. Frequently, the cleft extends into the mandibular symphysis and the tongue is attached to the cleft alveolar margin. At times the tongue may be bifid or absent, hyoid absent, thyroid cartilage underdeveloped, strap muscles atrophic, manubrium sterni absent, clavicles widely spaced etc. The earliest report of this anomaly was by Couronne′ in 1819. Since then very few cases have been reported in literature with variations. We describe a male child who presented at the age of 6 months with an ectopic salivary gland on the dorsum of the tongue in addition to median cleft of lower lip, ankyloglossia and notching of the mandible. Excision of mass on dorsum of tongue, release of ankyloglossia and lip from the alveolus followed by repair was done. No bony work was done since the mandible was only notched. On post-operative follow-up at 18 months, dentition was delayed in both maxillary as well as mandibular teeth and there was a gap between the lower central incisors. At the age of 2 years 4 months, the dentition is still not complete and the gap between the lower central incisors is very apparent. There is a supernumerary upper central incisor on right side. There is no mobility between the two segments of mandible. Speech is normal. A regular follow-up will be done to study the eruption of permanent central incisors at the age of 7 years and till eruption of all permanent teeth to assess the occlusion and to decide whether any bony work is needed or not.

scholarly journals Bilateral Symmetrical Mucocele of the Lower Lip: Report of a Rare Clinical Presentation

2014 ◽  
Vol 3 (2) ◽  
pp. 92-94 ◽  
Author(s):  
Hamed Mortazavi ◽  
Hamid Reza Khalighi ◽  
Maryam Baharvand ◽  
Majid Eshghpour
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Clinical Presentation ◽  
Benign Lesion ◽  
Minor Salivary Gland ◽  
Clinical Feature ◽  
Surgical Removal ◽  
Lower Lip ◽  
Histopathologic Evaluation ◽  
History Of

ABSTRACT Aim Oral mucocele (OM) is a common benign lesion in the oral cavity. We aimed to present an unusual clinical feature of OM. Materials and methods We report an 8-year-old girl presented with symmetrical bilateral masses on her lower lip with a known history of lip biting during school hours. After surgical removal of the lesions, histopathologic evaluation showed dilatation of minor salivary gland ducts because of mucus retention, and diagnosis of mucocele was established. Results According to our data, presence of bilateral mucocele was reported once before, which was an asymmetrical occurrence of lower lip mucocele causing malocclusion in a 3-year-old child. Conclusion Although rare, oral mucocele may present as bilateral symmetrical lesions. How to cite this article Mortazavi H, Khalighi HR, Baharvand M, Eshghpour M. Bilateral Symmetrical Mucocele of the Lower Lip: Report of a Rare Clinical Presentation. Int J Experiment Dent Sci 2014;3(2):92-94.

scholarly journals POS0782 FOLLICULAR DENDRITIC CELL NETWORKS IN MINOR SALIVARY GLAND BIOPSIES: A MARKER OF DISEASE ACTIVITY AT BASELINE AND DURING THE FOLLOW-UP IN SJÖGREN’S SYNDROME

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 644.2-644
Author(s):  
C. Baldini ◽  
F. Ferro ◽  
G. Fulvio ◽  
G. La Rocca ◽  
S. Fonzetti ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Dendritic Cell ◽  
Disease Activity ◽  
Inflammatory Infiltrate ◽  
Minor Salivary Gland ◽  
Sjogren’S Syndrome ◽  
Follicular Dendritic Cell ◽  
Sjogren's Syndrome ◽  
Follicular Dendritic

Background:Minor salivary gland biopsy (MSGB) has been increasingly recognized as an important tool for the stratification of patients with primary Sjögren’s syndrome (pSS). Recently, the presence of follicular dendritic cell (FDC) networks in the inflammatory infiltrate has been associated with more severe biological and serological abnormalities compared with less organized infiltrates.Objectives:To investigate the associations between the presence and number of FDC networks in foci and pSS glandular and extra-glandular disease activity at baseline and during the follow-up.Methods:Consecutive MSGBs performed in daily practice for clinically suspected pSS from January 2017 to October 2020 were reviewed. Patients’ demographic, clinical, biological and serological data were obtained from medical records. The ESSDAI was used to measure disease activity at baseline and at the end of the follow-up in pSS patients. For histopathology, 3 µm sections were cut from each formalin-fixed paraffin-embedded block of MSGBs and stained with haematoxylin and eosin (H&E). Immunohistochemical stainings were performed on additional 3 μm sections in order to detect T lymphocytes (CD3), B lymphocytes (CD20) and follicular dendritic cells (CD21). Glandular tissue areas, number of foci, focus score (FS) and the presence and number of FDC networks were assessed.Results:We reviewed 330 consecutive MSGBs from patients with suspected pSS: out of them 146/330 (44%) were classified as nonspecific chronic sialadenitis (NSCS) whereas 184/330 (56%) as focal lymphocytic sialadenitis (FLS). According to the ACR/EULAR criteria the diagnosis of pSS was confirmed in 130 patients (117 F:13 M, age 56±13 yrs). The mean (S.D) surface area of the MSGBs was 7.8 (3.9) mm2. The number of foci in the FLS samples ranged from 1 to 12 (mean (S.D)=3.1 (2.6)), whereas the FS ranged from 0.3 to 9.0 (mean (S.D) = 1.4 (1.2)).The presence of FDC networks was documented in 106/330 (32%) of the samples; in 54/106 (51%) of these MSGBs the number of FDC networks ranged from 2 to 8 (mean (S.D)=3.1 (1.4)). The number of FDC networks significantly correlated with the number of foci (r=0.721**) and FS (r=0.707**). Patients with FDC networks in the inflammatory infiltrate presented more serological abnormalities (i.e anti-Ro/SSA, anti-LA/SSB, Rheumatoid factor) and elevated IgG levels (p<0.001). In pSS patients, the number of FDC networks slightly correlated also with C4 levels (r=-0.216*), peripheral lymphocyte count (r=-0.274**) and with glandular (r=0.213*), and biological (r=0.230**) domains of the ESSDAI at baseline. After a mean (S.D) follow-up of 21(13) months, the number of FDC networks still correlated with the final total ESSDAI (r=0.312**).Conclusion:The presence and number of FDC networks in foci represent a useful histopathological parameter able to reflect disease activity at baseline and during the follow-up, thus allowing more personalized interventions.Disclosure of Interests:None declared

Hyalinizing clear cell carcinoma of the nasopharynx operated by trans-oral and trans-palatal approach

2015 ◽  
Vol 129 (S2) ◽  
pp. S95-S97 ◽  
Author(s):  
T Nakashima ◽  
R Yasumatsu ◽  
M Yamauchi ◽  
S Toh ◽  
T Nakano ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Gland ◽  
Good Prognosis ◽  
Salivary Gland Neoplasm ◽  
Hyalinizing Clear Cell Carcinoma

AbstractBackground:Hyalinizing clear cell carcinoma is a rare minor salivary gland neoplasm. The treatment of choice is surgical resection with or without post-operative radiotherapy. This tumour often demonstrates a good prognosis.Case report:We report a case of hyalinizing clear cell carcinoma arising in the nasopharynx. A 27-year-old female presented with progressive hearing disturbance and tinnitus. On examination, an expansile mass was observed in her nasopharynx. Biopsy was performed and the pathology results returned as clear cell carcinoma.Results and conclusion:Surgical resection was performed trans-orally accompanied by trans-palatal approach. She has no recurrence during more than two years of follow up.

scholarly journals Dysgenetic Polycystic Disease of Minor Salivary Gland: A Rare Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
N. Srikant ◽  
Shweta Yellapurkar ◽  
Karen Boaz ◽  
Mohan Baliga ◽  
Nidhi Manaktala ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Case Report ◽  
Rare Case ◽  
Minor Salivary Gland ◽  
Rare Entity ◽  
Review Of The Literature ◽  
Lower Lip ◽  
Polycystic Disease ◽  
Rare Case Report

Polycystic (dysgenetic) disease of the salivary glands is a rare entity that has only recently been described in the literature. The disease is more commonly seen in females and majority of the cases have presented as bilateral parotid gland swellings. This case presenting in a 21-year-old male is the first of this unusual entity involving solely the minor salivary gland on the lower lip. This case report highlights the importance for the clinician to be aware of this differential diagnosis, when treating an innocuous lesion like a mucocele.

Minor salivary gland biopsy: its importance in rheumatoid arthritis and secondary Sjögren's síndrome

2019 ◽  
pp. 15-18
Author(s):  
María Florencia Rodriguez ◽  
Cristian Troitiño ◽  
Felix Enrique Romanini ◽  
Anastasia Secco
Keyword(s):  
Rheumatoid Arthritis ◽  
Multivariate Analysis ◽  
Salivary Gland ◽  
Interstitial Lung Disease ◽  
Univariate Analysis ◽  
Minor Salivary Gland ◽  
Minor Salivary Gland Biopsy ◽  
Extraglandular Manifestations ◽  
Salivary Gland Biopsy

Secondary Sjögren’s Syndrome (SSs) is common in patients with Rheumatoid Arthritis (RA). Objectives: to determine if lymphocytic sialoadenifitis (FLS) is associated with clinical and serological differences in a group of patients with RA and SSs. Methods: patients with a diagnosis of RA and SSs were included, which of them presented FLS in the salivary gland biopsy, clinical and serological characteristics were compared. Results: 88 patients were included, 92% women, mean age of 53 years (SD ± 11.3) and 12.5 years of evolution of RA (RIC 6-7). 63.6% had SLF versus 36.4% who did not. In the univariate analysis, a statistically significant association was found between FLS + and the variables: parotidomegaly, interstitial lung disease, hypergammaglobulinemia, hypocomplementemia, rheumatoid factor, positive ANF, and extra-articular and/ or extraglandular manifestations. In the multivariate analysis, the variables independently associated with the presence of FLS were: extra-articular and/or extraglandular manifestations (OR 5.67, 95% CI 1.6-20), positive ANF (OR 11.7, 95% CI 1.6-83) and hypergammaglobulinemia (OR 21, 95% CI 2.46-179). Conclusion: patients with RA and SSs with FLS have a higher frequency of extra-articular and extraglandular manifestations and serological differences, which would imply a different clinical follow-up.

scholarly journals Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome

2003 ◽  
Vol 11 (3) ◽  
pp. 192-202 ◽  
Author(s):  
Mirian Aparecida Onofre ◽  
Heli Benedito Brosco ◽  
Rumio Taga
Keyword(s):  
Salivary Gland ◽  
Electron Microscope ◽  
Transmission Electron Microscope ◽  
Minor Salivary Gland ◽  
Myoepithelial Cells ◽  
Minor Salivary Glands ◽  
Van Der Woude Syndrome ◽  
Lower Lip ◽  
Transmission Electron ◽  
Congenital Fistula

The objective of the present study was to evaluate the glands of wall of congenital fistulae of the lower lip with the transmission electron microscope in order to characterize their microstructural pattern. Thin section of Araldite resin embedded congenital fistulae of the lower lip of four patients with Van der Woude syndrome from the Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo, Bauru, SP, were analyzed with a transmission electron microscope. The results showed that the glands were mostly made by typical mucous acini exhibiting, with certain frequency, myoepithelial cells surrounding them. In some of lobules, a few acini smaller than the typical mucous, showed granules of moderate electron density or containing a dense core or exhibiting small dense spherule and predominance granular material. These granules resemble to described recently by others in various human minor salivary glands. We concluded that glands associated with congenital fistula of lower lip of patients with Van der Woude syndrome, in spite of being located in vermilion border of the lip, showed at the transmission electron microscope characteristics of labial minor salivary gland, i.e, are mostly mucous with a few seromucous units, while typical seromucous demilunes are not present.

scholarly journals Prevalence of oral mucocele among outpatients at Saveetha Dental Hospital, India

2020 ◽  
Vol 16 (12) ◽  
pp. 1013-1018
Author(s):  
Ravindra Kumar Jain ◽  
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Minor Salivary Gland ◽  
Analysis Data ◽  
Patient Data ◽  
Lower Lip ◽  
History Data ◽  
Dental Hospital

Oral mucoceles are the most common benign minor salivary gland lesions. It is of interest to document the prevalence of oral mucocele among outpatients at the Saveetha Dental Hospital, India. We used patient data (12 case records) with mucocele occurrence for this analysis. Data included age, gender, diagnosis, lesion duration and relevant dental history. Data shows that oral mucocele were seen predominantly in males (66%) when compared to females (34%). The most affected site in the oral cavity was the lower lip (58%). Thus, data shows that oral mucocele was predominantly seen in males compared to females. Data also shows that the lower lip is often affected.

scholarly journals An unusual pleomorphic adenoma

2014 ◽  
Vol 62 (3) ◽  
pp. 319-324
Author(s):  
Christiano Sampaio QUEIROZ ◽  
Roberto Almeida de AZEVEDO ◽  
Antonio Irineu TRINDADE NETO ◽  
Caetano Guilherme Carvalho PONTES ◽  
Rafael de Queiroz MOURA
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Histopathological Examination ◽  
Minor Salivary Gland ◽  
Surgical Excision ◽  
Biological Behavior ◽  
Surgical Removal ◽  
Minor Salivary Glands ◽  
Recommended Treatment

Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. It constitutes approximately 90% of all benign salivary gland lesions and the parotid is the most affected location. When the minor salivary glands are affected, it mostly occurs at the junction of the hard and soft palates. The diagnosis is complex because of the great histological variety and biological behavior of this tumor, a histopathological examination being essential. The recommended treatment is surgical excision. For lesions located superficially in the parotid gland, superficial parotidectomy - identifying and preserving the facial nerve - is necessary. Lesions in the palate or gums sometimes demand a margin of safety, being excised below the periosteum, including the overlying mucosa. With correct surgical removal, the prognosis is excellent. The aim of this study is to report a case of an unusual minor salivary gland pleomorphic adenoma in the hard palate, describing the most important aspects of this pathology.

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