scholarly journals INTIMA-MEDIA THICKNESS OF THE CAROTID ARTERIES IS AFFECTED BY PUBERTAL MATURATION IN HEALTHY ADOLESCENTS

2019 ◽  
Vol 37 (4) ◽  
pp. 428-434 ◽  
Author(s):  
Jovita Lane Soares Santos Zanini ◽  
Tânia Maria Barreto Rodrigues ◽  
Cristina Botelho Barra ◽  
Maria Francisca Tereza Freire Filgueiras ◽  
Ivani Novato Silva
Keyword(s):  
Clinical Laboratory ◽  
Task Force ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
World Health ◽  
Pubertal Stage ◽  
Pubertal Maturation ◽  
Media Thickness ◽  
Ultrasound Evaluation ◽  
The Right

ABSTRACT Objective: To contribute to the assessment of normal parameters of carotid intima-media thickness (CIMT) in healthy adolescents. Methods: A cross-sectional study was conducted through clinical, laboratory and ultrasound evaluation in 61 healthy adolescents. The inclusion criteria consisted of being in good health. The exclusion criteria were: presence or history of any chronic disease; being obese or overweight according to the World Health Organization (WHO) established criterion; continuous use of medication; or presenting a febrile condition or requiring medication within 48-hours prior to assessment. The pubertal stages were evaluated using the Tanner criteria. The high-resolution B-mode ultrasound examinations were performed according to the recommendations of the Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Results: Adolescents were 14±2.6 years old, 62.3% female, 19 (31%) at early puberty (Tanner II and III), and 38 (62%) at late puberty (Tanner IV and V). They presented normal clinical and laboratorial parameters. CIMT values were 0.46±0.04 to 0.55±0.04 mm on the right and 0.48±0.02 to 0.53±0.04 mm on the left, according to pubertal maturation. CIMT values increased significantly on the right and left sides, according to pubertal stage (p<0.001 and p=0.016), and maximum internal diameters of the common carotid artery (p<0.025 and p<0.003). It was higher in males compared to females. Conclusions: An increase in CIMT in the healthy adolescents group, according to both age, and the degree of pubertal maturation should be considered when evaluating adolescents in diagnostic procedures.

scholarly journals Assessment of carotid intima-media thickness in hypothyroidism and the effect of thyroid replacement therapy

2018 ◽  
Vol 5 (2) ◽  
pp. 281
Author(s):  
Varun Vijayan ◽  
Jayasingh K. ◽  
Jayaraman G. ◽  
Siva Ranganathan Green ◽  
Deyagarasan E.
Keyword(s):  
Body Mass Index ◽  
Total Cholesterol ◽  
Intima Media Thickness ◽  
Thyroid Function Test ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Function Test ◽  
The Mean ◽  
The Right ◽  
Progression Of Atherosclerosis

Background: Carotid artery intima-media thickness (CAIMT) measurement in hypothyroidism will help assess the progression of atherosclerosis and timely intervention may prevent vascular complications.Methods: This study included 30 clinical hypothyroid (CH), 30 subclinical hypothyroid (SCH) and 30 euthyroid. As per procedure, informed consent was taken from the patients in prescribed formats before their participation in the study. Patients were divided into 3 groups of CHs, SCH and Controls after obtaining the thyroid function test values. CAIMT on the right side was measured in the three groups for comparison. Other parameters included age, sex, height, weight, body mass index (BMI), total cholesterol and triglycerides. After 4 months of levothyroxine therapy, CAIMT, total cholesterol and triglycerides were reassessed.Results: The CAIMT was increased in CH and SCH group when compared to euthyroid individuals. The mean CAIMT in CH group was 0.60±0.009cm, in SCH group it was 0.055±0.010 cm and in controls it was 0.047±0.006 cm. After 4 months of levothyroxine therapy, there was no change observed in the mean CAIMT values.Conclusions: CAIMT levels were increased in CH and SCH group when compared to euthyroid group. There was no regression of CAIMT after 4 months of levothyroxine therapy.

scholarly journals Ultrasound semiautomatic versus manual estimation of carotid intima-media thickness: reproducibility and cardiovascular risk stratification

2020 ◽  
Vol 22 (4) ◽  
pp. 402
Author(s):  
Caterina Beatrice Monti ◽  
Marco Alì ◽  
Davide Capra ◽  
Federico Wiedenmann ◽  
Giulia Lastella ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Image Quality ◽  
Quality Index ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Imaging Biomarker ◽  
Improve Image Quality ◽  
Media Thickness ◽  
The Right ◽  
Image Quality Index

Aims: Carotid intima-media thickness (CIMT) is used increasingly as an imaging biomarker of cardiovascular risk (CVR). Our aim was to compare semiautomatic CIMT (sCIMT) versus manual CIMT (mCIMT) for reproducibility and prediction of CVR.Materials and methods: Two independent readers measured sCIMT and mCIMT on previously acquired images of the right common carotid artery of 200 consecutive patients. Measurements were performed twice, four weeks apart; sCIMT was reported along with an image quality index (IQI) provided by the software. CVR stratification was compared for thresholds established by mCIMT studies, adapted for sCIMT according to a regression model.Results: sCIMT (median 0.67 mm, interquartile range [IQR] 0.57‒0.76 mm) was significantly lower (p<0.001) than mCIMT (median 0.76 mm, IQR 0.63‒0.84 mm; ρ=0.832, p<0.001, slope 0.714, intercept 0.124). Overall, intra-reader reproducibility was 76% for sCIMT and 83% for mCIMT (p=0.002), inter-reader reproducibility 75% and 76%, respectively (p=0.316). In 129 cases with IQI≥0.65, reproducibility was significantly higher (p≤0.004) for sCIMT than for mCIMT (intra-reader 85% versus 83%, inter-reader 80% versus 77%,). The agreement between sCIMT and mCIMT for CVR stratification was fair both overall (κ=0.270) and for IQI≥0.65 (κ=0.345), crude concordance being 79% and 88%, respectively.Conclusions: Reproducibility of sCIMT was not higher than mCIMT overall but sCIMT was significantly more reproducible than mCIMT for high-IQI cases. sCIMT cannot be used for CVR stratification due to fair concordance with mCIMT, even for high IQI. More research is required to improve image quality and define sCIMT-based thresholds for stratification of CVR. 

Changes in carotid artery intima-media thickness during the cardiac cycle – a comparative study in early childhood, mid-childhood, and adulthood

VASA ◽  
2017 ◽  
Vol 46 (4) ◽  
pp. 275-281 ◽  
Author(s):  
Kuna Rueb ◽  
Jonathan Mynard ◽  
Richard Liu ◽  
Melissa Wake ◽  
Peter Vuillermin ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Cardiac Cycle ◽  
Age Groups ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cine Sequence ◽  
Carotid Imt ◽  
Media Thickness ◽  
Adults And Children ◽  
The Right

Abstract. Background: Carotid intima-media thickness (CIMT), an ultrasonographic marker of cardiovascular risk, is increasingly used in adults and children. The choice of specific images used to quantify CIMT from a cine sequence is often based on image quality rather than on a consistent point in the cardiac cycle. This methodological study quantified the imprecision that may be introduced by variation of CIMT during the cardiac cycle. Probands and methods: Data from four-year-olds, 11 to 12-year-olds, and adults (n=30 each age group) were selected retrospectively from two population-derived studies. Far wall CIMT of the right common carotid artery was measured at end-diastole and peak systole using standardized protocols. All images were analysed using semi-automated edge-detection software. Results: In all age groups CIMT varied significantly during the cardiac cycle and was largest at end-diastole. The mean difference in CIMT between end-diastole and peak systole was greater in four-year-olds (38 μm; 95 % confidence interval (CI) 33 to 43 μm) and 11 to 12-year-olds (31 μm; CI 26 to 36 μm) than in adults (18 μm; CI 16 to 22 μm). Carotid IMT increased by 8.8 % (CI 7.7 to 9.8 %), 6.9 % (CI 5.8 to 8.1 %), and 3.8 % (CI 3.1 to 4.5 %) between minimum and maximum arterial diameter in four-year-olds, 11 to 12-year-olds, and adults, respectively. The greatest variation in CIMT during the cardiac cycle was observed in children (up to 14 %). Conclusions: Inconsistent timing of CIMT measurement during the cardiac cycle is an avoidable source of imprecision, especially in children, in whom inter-individual differences are smallest. As CIMT is largest at end-diastole, this is the most appropriate time point for consistent and comparable measurements to be made.

scholarly journals Effect of sitagliptine and vildagliptine on carotid intima/media thickness in patients with type 2 diabetes mellitus

2021 ◽  
Vol 9 (5) ◽  
pp. 1388
Author(s):  
Ganeswar Sethy ◽  
Geetanjali Sethy ◽  
Ranjit Rout ◽  
Abinash Panda ◽  
Adya Anwesha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Control Group ◽  
P Value ◽  
Media Thickness ◽  
The Right

Background: Atherosclerosis is a known macro-vascular complication of diabetes mellitus. Gliptins, as a drug class have non-glycemic beneficial action on blood vessels and in addition to their anti-diabetic effects. This study was carried out to find out the effects of sitagliptin and vildagliptin on common carotid intima-media thickness in patients with type 2 diabetes mellitus.Methods: The observational longitudinal study was carried out on 100 patients with 80 patients with confirmed clinical diagnosis of type 2 diabetes mellitus. They were divided in 3 groups. Group A and Group B received drugs, either sitagliptine or vildagliptin and Group C control group did not receive any drug. High resolution B-mode ultrasonography was carried out for the measurement of intima-media thickness (IMT) of both the common carotid arteries (CCA). Data analysis was done using Microsoft excel spreadsheet and GraphPad Prism version 7.0 (free trial version) software package. A p value of ≤ 0.05 was considered as statistically significant.Results: The baseline value for the control group was 0.812±0.0748 mm for both the right and left CCA. At 52 weeks the CCA IMT for the right and left CCA were 1.0185± 0.272 mm and 0.936±0.149 mm respectively. At 104 weeks the CCA IMT for the right and left CCA were 0.923±0.243 mm and 0.859±0.123 mm respectively.Conclusions: There was a significant decrease in carotid intima-media thickness in patients of type-2 diabetes mellitus treated with sitagliptin and vildagliptin.

scholarly journals Comparison Analysis of Childhood Body Mass Index Cut-offs in Predicting Adulthood Carotid Intima Media Thickness: Tehran Lipid and Glucose Study

2021 ◽  
Author(s):  
Farhad Hosseinpanah ◽  
Amirhosein Seyedhoseinpour ◽  
Maryam Barzin ◽  
Maryam Mahdavi ◽  
Erfan Tasdighi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Diseases ◽  
Body Mass ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Overweight And Obesity ◽  
World Health ◽  
Media Thickness ◽  
Childhood Body Mass Index

Abstract Background: The prevalence of obesity among children and adolescences have been increased, which can consequently increase the prevalence of metabolic and cardiovascular diseases later in life. The objective of this study is to compare the ability of different childhood body mass index cut-offs in prediction of carotid intima media thickness (CIMT) as an indicator of subclinical atherosclerosis. Methods: Participants were categorized into normal weight, overweight and obesity group, based on world health organization (WHO), center for disease control and prevention (CDC), international obesity task force (IOTF) and local IOTF cut-offs. After 18 years of follow up CIMT was measured. Akaike’s information criterion and relative efficiency were measured in order to compare regression models on the role of obesity on CIMT.Results: In this prospective cohort study, 1295 subjects aged 3 to 18 years old were enrolled. The overall prevalence of overweight was 15.4, 11.5, 16.3 and 14.1 along with obesity prevalence of 6.6, 8.5, 7.7 and 5.0 percent based on WHO, CDC, local IOTF and international IOTF criteria, respectively. CIMT was higher in obese compare to normal groups across all classification criteria. After regression analysis, international IOTF was the best to predict adulthood CIMT, followed by local IOTF and WHO. CDC had the least discriminatory ability. Conclusion: Due to the results of this study, IOTF could be a better tool in national and international surveillances of children in order to define overweight and obesity, which can help us to intervene more effectively in reducing the burden of cardiovascular diseases.

scholarly journals Ultrasound Evaluation of Carotid Intima-Media Thickness in Children

2015 ◽  
Vol 22 (11) ◽  
pp. 1141-1147 ◽  
Author(s):  
Matias Epifanio ◽  
Matteo Baldisserotto ◽  
Edgar E. Sarria ◽  
Arthur Lazaretti ◽  
Rita Mattiello
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Ultrasound Evaluation

scholarly journals Ultrasound evaluation of carotid artery intima-media thickness in patients with risk factors for cardiovascular disease

2017 ◽  
Vol 4 (2) ◽  
pp. 16 ◽  
Author(s):  
Ibrahim A. Awad ◽  
Hanan Y. Abbas
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Cardiovascular Risk Factors ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Ultrasound Evaluation ◽  
And Gender

Objective: The study purpose was to assess the change of carotid artery intima-media thickness (CAIMT) in patients with cardiovascular risk factors (CVRF), and determine the main factor that causing the abnormal IMT.Methods: We collected the data of 89 patients who underwent a carotid artery ultrasound between February 2011 and November 2012 (43 men and 46 women aged between 20-80 years old). All patients included in the study had one of the following cardiovascular risk factors: smoking (n = 40), arterial hypertension (n = 25) or diabetes mellitus (n = 24). The IMT of the common carotid artery was measured and the results were correlated with the recorded risk factor. Correlation with the patient’s age and gender was also performed.Results: The study revealed abnormal IMT (> 1 mm) in a total of 71 (79.8%) patients. These included 22 (88%) patients with hypertension, 19 (79.2%) patients with diabetes mellitus and 30 (75%) patients who were smokers (p < .05 for all 3 risk factors). While aging was also associated with increased IMT (p < .05), no gender differences were noted (p > .05).Conclusions: The present study showed that ultrasound is an excellent, noninvasive method for evaluation of carotid intima-media thickness. The main risk factors associated with abnormal carotid IMT were hypertension, diabetes mellitus, smoking andpatient’s age.

scholarly journals Carotid intima-media thickness and hemodynamic parameters: reproducibility of manual measurements with Doppler ultrasound

2015 ◽  
Vol 17 (2) ◽  
pp. 167 ◽  
Author(s):  
Juana M Plasencia Martinez ◽  
Jose M Garcia Santos ◽  
Maria L Paredes Marti­nez ◽  
Ana Moreno Pastor
Keyword(s):  
Intraclass Correlation ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Ultra Sound ◽  
Hemodynamic Parameters ◽  
Carotid Ultrasound ◽  
Carotid Imt ◽  
Media Thickness ◽  
The Common ◽  
The Right

Aims: To evaluate the carotid ultrasound intra- and interobserver agreements in a common clinical scenario when making manual measurements of the intima-media thickness (IMT) and peak systolic (PSV) and end diastolic (EDV) velocities in the common (CCA) and the internal carotid (ICA) arteries. Material and methods: Three different experienced operators per- formed two time-point carotid ultrasounds in 21 patients with cardiovascular risk factors. Each operator measured freehand the CCA IMT three consecutive times in each examination. The CCA and ICA hemodynamic parameters were acquired just once. For our purpose we took the average (IMTmean) and maximum (IMTmax) IMT values. Quantitative variables were analyzed with the t-student, and ANOVA test. Agreements were evaluated with the Intraclass Correlation Coefficient (ICC). Results: IMTmean intraobserver agreement was better on the left (ICC: 0.930-0.851-0.916, operators 1-2-3) than on the right (ICC: 0.789-0.580-0.673, operators 1-2-3). IMTmax agreements (Left ICC: 0.821-0.723-0.853, operators 1-2-3; Right ICC: 0.669- 0.421-0.480, operators 1-2-3) were lower and more variable. Interobserver agreements for IMTmean (ICC: 0.852-0.860; first-second ultrasound) and IMTmax (ICC: 0.859-0.835; first-second ultrasound) were excellent on the left, but fair-good and more variable on the right (IMTmean; ICC: 0.680-0.809; first-second ultrasound; IMTmax; 0.694-0.799; first-second ultra- sound). Intraobserver agreements were fair-moderate for PSVs and good-excellent for EDVs. Interobserver agreements were good-excellent for both PSVs and EDVs. Overall, 95% confidence intervals were narrower for the left IMTmean and CCA velocities. Conclusions: Intra and interobserver agreements in carotid ultrasound are variable. In order to improve carotid IMT agreements, IMTmean is preferable over IMTmax.

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