scholarly journals Lucio's Phenomenon. Case study of an exceptional response to treatment exclusively with multibacillary multidrug therapy

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 93-96 ◽  
Author(s):  
Amanda Braga Peixoto ◽  
Poliana Santin Portela ◽  
Fabiano Roberto Pereira de Carvalho Leal ◽  
Arles Martins Brotas ◽  
Nilton Carlos dos Santos Rodrigues
Keyword(s):  
Weight Loss ◽  
Male Patient ◽  
Lepromatous Leprosy ◽  
Response To Treatment ◽  
Multidrug Therapy ◽  
Cutaneous Lesions ◽  
Histopathological Findings ◽  
Lucio’S Phenomenon

Lucio's phenomenon represents a serious cutaneous necrotizing reaction, which can occur with Lucio's leprosy and also in other forms of lepromatous leprosy. The authors discuss the case of a 63-year-old male patient presenting with ulcers and necrotic cutaneous lesions on the limbs, torso and face, associated with recurring sinusitis, hoarseness and a weight loss of 25 kilos over the last year. Bacilloscopy of intradermal scrapings showed a bacilloscopic index of 5 and the histopathological findings were compatible with the diagnosis of Lucio's phenomenon. The chosen treatment was exclusively multibacillary multidrug therapy, resulting in important dermatological improvement after one month of therapy. The authors present an impressive case of Lucio's phenomenon with an exceptional response to treatment exclusively with multibacillary multidrug therapy.

scholarly journals Lucio's phenomenon: another case reported in Brazil

2012 ◽  
Vol 87 (2) ◽  
pp. 296-300 ◽  
Author(s):  
Rodrigo Monteiro ◽  
Marcelo Guimarães Tiezzi ◽  
Marilda Aparecida Milanez Morgado de Abreu ◽  
Claudia Cardoso Macedo de Oliveira ◽  
Eduardo Vinícios Mendes Roncada ◽  
...  
Keyword(s):  
Rare Event ◽  
Lepromatous Leprosy ◽  
Coagulation System ◽  
Multidrug Therapy ◽  
Tissue Necrosis ◽  
Inflammatory Reactions ◽  
Vascular Lumen ◽  
Endothelial Proliferation ◽  
Lucio’S Phenomenon

Lucio's phenomenon is defined as a variant of type 2 leprosy reaction. It is a rare event, occurring in the evolution of leprosy of Lucio and other forms of lepromatous leprosy. It has an exacerbated proliferation of Hansen bacilli in its pathophysiology, which invade blood vessel walls and injure endothelial cells, causing endothelial proliferation and decreasing the vascular lumen. This fact, associated with inflammatory reactions and changes in the coagulation system causes vascular thrombosis, ischemia, infarction and tissue necrosis, leading to the histopathological characteristic of the phenomenon. We report a case of lepromatous leprosy with irregular treatment that developed Lucio's phenomenon. Treatment with multidrug therapy, antibiotics, steroids and thalidomide achieved a favorable outcome.

Cutaneous ulceration as a presenting feature of type 1 lepra reaction: A case report

2022 ◽  
pp. 004947552110686
Author(s):  
Pallavi Hegde ◽  
Deepti Jaiswal ◽  
Varsha M Shetty ◽  
Kanthilatha Pai ◽  
Raghavendra Rao
Keyword(s):  
Case Report ◽  
Erythema Nodosum ◽  
Immunological Response ◽  
Lepromatous Leprosy ◽  
Multidrug Therapy ◽  
Cutaneous Lesions ◽  
Erythema Nodosum Leprosum

Reactions in leprosy represent sudden shift in the immunological response and are seen in 11–25% of affected patients. It can be seen before, during or after the completion of multidrug therapy (MDT). 1 Two types of reactions are recognized; Type 1 reaction (T1R), seen in borderline leprosy, affecting mainly skin and nerves; type 2 reaction (T2R) or erythema nodosum leprosum (ENL), seen in lepromatous leprosy, characterized by systemic features in addition to cutaneous lesions. Trophic ulcers and ulcerating ENL are well known entities while cutaneous ulceration in T1R is extremely rare; we describe an immune-competent woman with cutaneous ulceration as a presenting feature to highlight the need to recognize this entity at the earliest opportunity.

Pituitary insufficiency following traumatic thoracic injury in adolescent male patient-case study

2017 ◽  
Author(s):  
Aleksandra Gilis-Januszewska ◽  
Malgorzata Wilusz ◽  
Renata Turek-Jabrocka ◽  
Jacek Pantoflinski ◽  
Malgorzata Trofimiuk-Muldner ◽  
...  
Keyword(s):  
Male Patient ◽  
Adolescent Male ◽  
Thoracic Injury ◽  
Pituitary Insufficiency ◽  
Patient Case

Ayurvedic management of Leukoplakia - A Case Study

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Makadia Krishna ◽  
Ronakgiri V. Gosai ◽  
Virpariya Jignesh ◽  
Chabhadiya Nilesh ◽  
Katrodiya Jayesh ◽  
...  
Keyword(s):  
High Risk ◽  
Oral Mucosa ◽  
Male Patient ◽  
Soft Palate ◽  
Burning Sensation ◽  
Oral Leukoplakia ◽  
Premalignant Lesion ◽  
Allopathic Medicine ◽  
Floor Of The Mouth

Oral leukoplakia (OL) is a premalignant lesion described as “a predominant white lesion of the oral mucosa which cannot be defined as any other known lesion”. OL located on the floor of the mouth, soft palate and tongue are considered as high-risk lesions, while, in other areas, they may be considered as of low malignancy risk. A Forty five years old male patient had complaints of white lesion on left lat. Surface of tongue, along with burning sensation since 4-5 months. He was diagnosed with Leukoplakia and he had taken allopathic medicine for 4 to 5 times, but it was inversely relapsed, so he was treated with Pratisarana of Bibhitaka Churna and Rasayana Churna, Yastimadhu Ghanavati as lozenges along with Rasayana tablets orally for a period of 6 months. After 6 month therapy, white lesion became disappear and no burning sensation. Thus this patient was successfully treated with above therapy with no recurrence or any complications till date.

Case Study: Weight Loss Leads to Cost Savings and Improvement in Metabolic Syndrome

2005 ◽  
Vol 18 (2) ◽  
pp. 77-79 ◽  
Author(s):  
K. C. Trussell ◽  
D. Hinnen ◽  
P. Gray ◽  
S. A. Drake-Nisly ◽  
K. M. Bratcher ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Cost Savings

Composite lymphoma of follicular B-cell and peripheral T-cell types with distinct zone distribution in a 75-year-old male patient: a case study

2018 ◽  
Vol 76 ◽  
pp. 110-116 ◽  
Author(s):  
John Tanaka ◽  
Pu Su ◽  
Catherine Luedke ◽  
Rachel Jug ◽  
Lian-He Yang ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
Male Patient ◽  
Cell Types ◽  
Composite Lymphoma

scholarly journals Miltefosine Administration in Cats with Refractory Sporotrichosis

2018 ◽  
Vol 46 (1) ◽  
pp. 7
Author(s):  
Francina Dos Santos Silva ◽  
Simone Carvalho dos Santos Cunha ◽  
Andrea Regina de Souza Baptista ◽  
Vivian Dos Santos Baptista ◽  
Kássia Valéria Gomes Coelho da Silva ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sporothrix Schenckii ◽  
Clinical Signs ◽  
Public Health Problem ◽  
Parasite Load ◽  
Small Population ◽  
Fungal Culture ◽  
Cutaneous Lesions

Background: Sporotrichosis is a zoonosis caused by fungi of the Sporothrix schenckii complex. Cats have important zoonotic potential due to the high parasite load found in the cutaneous lesions. Refractory cases to antifungal therapy are increasing, becoming a public health problem. Miltefosine is a drug with high in vitro activity against Sporothrix brasiliensis. However, this efficacy has not been confirmed in vivo yet and administration has not been studied in the feline species. This study aimed to evaluate the effectiveness and safety of miltefosine administration in cats with resistant sporotrichosis.Materials, Methods & Results: Ten cats with refractory sporotrichosis were included in this study. Inclusion criteria were previous diagnosis for sporotrichosis associated with therapy with oral antifungals (itraconazole and/or potassium iodide) for more than one year, followed by one of these conditions: incomplete clinical remission, worsening of disease during treatment or recurrence after conventional treatment. Cats underwent clinical and dermatological examinations. Data on lifestyle and previous treatments were provided by the owners. Fungal culture and histochemical techniques were performed in all cats before miltefosine treatment. Blood samples were collected before and during the study for laboratory tests, such as blood count, blood urea nitrogen (BUN), serum creatinine, alanine aminotransferase (ALT) and alkaline phosphatase, as well as serology for Feline Immunodeficiency (FIV) and Feline Leukemia (FeLV). Miltefosine was prescribed at a dosage of 2 mg/kg orally every 24 h. The animals were monitored by phone during the whole process and reassessed on days 0, 15, 30 and 45 of the treatment. Out of 10 cats, lesions were present on the nose in nine, ears in four, periocular areas in one and limbs in four. One cat received treatment for 45 days, six for 30 days, one for 21 days, one for 15 days and one for 3 days. One cat showed no response to the treatment and nine showed disease progression. Hyporexia and weight loss were the most frequent clinical signs related to miltefosine treatment, followed by sialorrhea, vomiting and diarrhea. Few adverse effects on hematology and biochemistry (mainly renal and hepatic parameters) were observed during the study. Hematocrit decrease was observed in four animals. However, only one cat had hematocrit decrease below normal values (anemia), which was already present before miltefosine administration. Other cats had a decrease of five points. Three cats showed elevation in leucometria and four in plasma protein. In relation to renal and hepatic biochemistry, one animal showed a BUN increase and another one showed a transient increase in ALT. Two animals started the treatment with increased ALT but had no problems during the study and values decreased even during the miltefosine administration.Discussion: Although two cats showed sialorrhea, most owners did not report difficulty in administering the drug orally, representing an advantage of this medication. Weight loss, secondary to gastrointestinal changes, was the most clinically relevant alteration. The most frequent hematological alteration was hematocrit decrease and only the animal that started the study with 20% hematocrit ended the study with anemia. Renal and hepatic parameters were not significant in the cats of this study. Miltefosine did not lead to sporotrichosis remission in this small population of cats, which reveals that, despite its in vitro efficacy against Sporothrix spp., the drug is not effective in vivo in the feline species. Further studies are needed to investigate the efficacy of this drug in a larger number of cats, and possible reasons for its in vivo ineffectiveness.

scholarly journals Tufted angioma in ear auricle: importance of the differential diagnosis

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 113-115 ◽  
Author(s):  
Carla Andréa Avelar Pires ◽  
Brena Andrade de Sousa ◽  
Gabriela Athayde Amin ◽  
Maraya de Jesus Semblano Bittencourt ◽  
Mario Fernando Ribeiro de Miranda ◽  
...  
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Clinical Features ◽  
Male Patient ◽  
Lepromatous Leprosy ◽  
Vascular Proliferation ◽  
Tufted Angioma ◽  
Ear Auricle ◽  
Histological Characteristics ◽  
Children And Young Adults

Tufted angioma is an acquired vascular proliferation with specific histological characteristics. The most common clinical features are erythematous macules. It occurs predominantly in children and young adults, especially in the chest and neck. We report the case of a male patient, 12 years old, with an increased right ear auricle associated with erythematous macules and increased local temperature, referred with a diagnosis of lepromatous leprosy; however, this diagnosis was questioned. Histopathology was consistent with tufted angioma.

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