scholarly journals Low bone mass in children and adolescents

2006 ◽  
Vol 50 (4) ◽  
pp. 775-782 ◽  
Author(s):  
João Lindolfo C. Borges ◽  
Cynthia M.A. Brandão
Keyword(s):  
Bone Mass ◽  
Elderly Population ◽  
The Elderly ◽  
Bone Fragility ◽  
Childhood And Adolescence ◽  
Low Bone Mass ◽  
Mass Measurements ◽  
Treatment Of Osteoporosis ◽  
Bone Mass Measurements

Osteoporosis is a disease characterized by low bone mass and micro architectural alterations of bone tissue leading to enhanced bone fragility and increased fracture risk. Although research in osteoporosis has focused mainly on the role of bone loss in the elderly population, it is becoming increasingly clear that the amount of bone that is gained during growth is also an important determinant of future resistance to fractures. Thus, considerable interest is being placed on defining preventive strategies that optimize the gain of bone mass during childhood and adolescence. Knowledge of the determinants accounting for the physiologic and genetic variations in bone accumulation in children will provide the best means toward the early diagnosis and treatment of osteoporosis. This article reviews the techniques available for bone mass measurements in children and the major determinants and diseases influencing bone accretion during childhood and adolescence.

The Role of Novel Bone Forming Agents in the Treatment of Osteoporosis

2020 ◽  
pp. 089719002096122
Author(s):  
Hansita B. Patel ◽  
Lynsie J. Lyerly ◽  
Cheryl K. Horlen
Keyword(s):  
Elderly Population ◽  
Cost Effective ◽  
The Elderly ◽  
Bisphosphonate Therapy ◽  
Evidence Based ◽  
First Line ◽  
Treatment Of Osteoporosis ◽  
Cost Effective Treatment

Osteoporosis is a growing epidemic that leads to significant morbidity and mortality among the elderly population due to associated fractures that lead to disabilities and reduced quality of life. Bisphosphonates are well-established as a first-line and cost-effective treatment for osteoporosis. Unfortunately, clinicians are often uncertain as to how to select treatments when bisphosphonates are ineffective as initial treatment or contraindicated. Romosozumab and abaloparatide are 2 alternative agents that have been recently FDA approved for the treatment of osteoporosis in postmenopausal women at high risk for fracture or patients who have failed or are intolerant to other osteoporosis therapies. Currently, the National Osteoporosis Foundation (NOF) has no formal recommendations in regard to these 2 novel agents. The purpose of this review is to help guide pharmacists on how to ensure appropriate utilization of these 2 novel bone-forming agents as potential alternatives to bisphosphonate therapy by providing evidence-based recommendations according to the current literature and key counseling points.

scholarly journals Mechanisms of bone anabolism regulated by statins

2012 ◽  
Vol 32 (6) ◽  
pp. 511-519 ◽  
Author(s):  
Feng Ruan ◽  
Qiang Zheng ◽  
Jinfu Wang
Keyword(s):  
Cardiovascular Disease ◽  
Bone Mass ◽  
Elderly Population ◽  
The Elderly ◽  
Common Disease ◽  
Anabolic Effect ◽  
Treatment Of Osteoporosis ◽  
Reductase Inhibitors ◽  
Osteoblast Apoptosis ◽  
Coa Reductase

Osteoporosis is a common disease in the elderly population. The progress of this disease results in the reduction of bone mass and can increase the incidence of fractures. Drugs presently used clinically can block the aggravation of this disease. However, these drugs cannot increase the bone mass and may result in certain side effects. Statins, also known as HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, have been widely prescribed for CVD (cardiovascular disease) for decades. Nonetheless, several studies have demonstrated that statins exert bone anabolic effect and may be helpful for the treatment of osteoporosis. Several experiments have analysed the mechanisms of bone anabolism regulated by statins. In the present paper, we review the mechanisms of promoting osteogenesis, suppressing osteoblast apoptosis and inhibiting osteoclastogenesis.

Gambaran Kejadian Tindakan Kekerasan pada Lansia : Literature Review

2021 ◽  
Vol 1 ◽  
pp. 1425-1436
Author(s):  
Dyah Pratiwi ◽  
Dyah Putri Aryati
Keyword(s):  
Literature Review ◽  
Elderly Population ◽  
Elder Abuse ◽  
The Elderly ◽  
Social Changes ◽  
Psychological Violence

AbstractThe increasing elderly population in Indonesia continues to grow. The elderly are individuals who experience physiological, psychological, and social changes. Therefore, the elderly is vulnerable to violence. Elder abuse persists in various areas in Indonesia. However, cases of elder abuse are often hidden because they are considered unimportant and the victims do not know where to report it. The purpose of this study was to describe the incidence of acts of violence in the elderly. The methodused in this study was a literature review by searching for articles in the PubMed and Google scolar database with the keyword: Elderly or Aged or Geriatric or Elder and Abuse or Violence with article limits from 2011-2020. There were five articles found. They had been critically reviewed using Strobe instruments. The results based on the five articles analysed showed some characteristics. Most of the respondents were 60-69 years old (50%), female (60%), education literate or primary (63%), married (67%), lived with other (59%), the elderly do not experience violence2.286, elderly experience violence 807, the type of violence that wa soften experienced by the elderly namely psychological violence is found to be (40%). Based on the five articles analysed, it can be concluded that the most violence experienced by the elderly is psychological violence. Therefore, the role of nurses is needed to provide services for families to prevent acts of violence in the elderly.Keywords: Elderly; persecution, violence AbstrakPeningkatan penduduk lansia di Indonesia terus bertambah. Lansia merupakan salah satu individu yang mengalami perubahan secara fisiologis, psikologis dan sosial sehingga lansia rentan mengalami tindakan kekerasan. Kekerasan terhadap lansia masih terjadi diberbagai wilayah di Indonesia. Namun, kasus kekerasan lansia kerap disembunyikan karena dianggap tidak penting dan korban tidak mengetahui lembaga yang dapat menerima laporan. Tujuan penelitian ini untuk mengetahui gambaran kejadian tindakan kekerasan pada lansia. Metode yang digunakan penelitian ini menggunakan literature review dengan mencari artikel pada database Pubmed dan Googlescholar dengan kata kunci :Elderly OR Aged OR Geriatric OR Elder AND Abuse ORViolencedengan batasan artikel dari 2011-2020 didapatkan 5 artikel yang telah dilakukan telaah kritis dengan menggunakan instrument Strobe. Hasil berdasarkan lima artikel yang dianalisa menunjukkan bahwa data karakteristik usia responden mayoritas 60-69 tahun yaitu (50%), berjenis kelamin perempuan sebanyak (60%), pendidikan literate or primarysebanyak (63%), berstatus menikah yaitu (67%), lived with other sebanyak (59%), lansia yang tidak mengalami kekerasan sebanyak 2.286, lansia yang mengalami kekerasan sebanyak 807 dan jenis kekerasan yang sering dialami lansia yaitu kekerasan psikologis didapatkan (40%). Berdasarkan dari kelima artikel yang dianalisa dapat disimpulkan bahwa kekerasan yang paling banyak dialami lansia yaitu kekerasan psikologis. Oleh sebab itu diperlukan peran perawat untuk memberikan pelayanan bagi keluarga untuk mencegah terjadinya tindakan kekerasan pada lansia.Kata kunci: Kekerasan; penganiayaan; usia lanjut

COMPARISON OF BONE MASS MEASUREMENTS IN OSTEOPOROSIS

1985 ◽  
Vol 9 (3) ◽  
pp. 636
Author(s):  
S. M. Ott ◽  
J. A. Hanson ◽  
R. F. Kileoyne ◽  
R. Murano ◽  
T. K. Lewellen ◽  
...  
Keyword(s):  
Bone Mass ◽  
Mass Measurements ◽  
Bone Mass Measurements

scholarly journals Decline in rates of clearance of IgG-sensitized erythrocytes with increasing age

Blood ◽  
1988 ◽  
Vol 71 (6) ◽  
pp. 1726-1730
Author(s):  
KA Melez ◽  
LF Fries ◽  
BS Bender ◽  
T Quinn ◽  
MM Frank
Keyword(s):  
Aging Process ◽  
Elderly Population ◽  
The Elderly ◽  
Older Individuals ◽  
Immune Functions ◽  
Macrophage Function ◽  
Normal Volunteers ◽  
Age Related ◽  
Male Subjects

Decreased immune functions have been suggested as a cause for the increased incidence of autoimmunity, malignancy, and infection in the elderly population. To assess the possible role of changes in macrophage function in the aging process we studied the Fc receptor- mediated clearance of IgG-coated erythrocytes in 56 healthy normal volunteers by following the removal of radiolabeled autologous erythrocytes. An age-related decrease in Fc-mediated clearance rates in both female and male subjects was found, which suggests a physiological decline of this macrophage function in older individuals.

scholarly journals ROLE OF TRIVIDHA ROGAYATANA IN THE MANIFESTATION OF ESSENTIAL HYPERTENSION W.S.R. TO PRAGYAPARADA - A CONCEPTUAL STUDY

2021 ◽  
Vol 9 (8) ◽  
pp. 1733-1736
Author(s):  
Ajay Kumar Nigwal ◽  
Lajwanti Keswani ◽  
Rajesh Kumar Malviya ◽  
Arvind Kumar Yadav
Keyword(s):  
Elderly Population ◽  
Antihypertensive Drugs ◽  
Adult Population ◽  
The Elderly ◽  
Elevated Blood ◽  
The World ◽  
Causes Of Disease ◽  
Conceptual Study ◽  
Day By Day

Cardiovascular disease such as hypertension will be the largest cause of death and disability in India by 2020. The prevalence of hypertension is increasing globally and currently, more than 1 billion people have hypertension. About 26.4% of the world adult population in 2000 had hypertension and 29.2% were projected to have this con- dition by 2025. Elevated blood pressure affects 1 billion individuals and causes an estimated 10.4 million deaths per year. Thus, hypertension is needed to be studied. Though a lot of potent antihypertensive drugs are available today none of them is free from untoward adverse effects. Especially the elderly population poorly tolerates these drugs. The global incidence of hypertension is increasing day by day and is a very common problem nowadays. Ayurveda has classified the causes of disease into three main categories: - 1. Asatmendriyartha Samyoga 2. Pragyaparada and 3. Parinama (Kaala), these three main causes of disease enable different kinds of diseases to manifest. Firstly, they lead to the imbalance of body /or mind by vitiation the Tridosha. The consequence of the imbalance is a disturbance of the basic biological principles. Hypertension is a lifestyle disorder. Ayurveda causes of lifestyle disorders are mainly Pragyaparada. Pragyaparadha is the main cause of all noncommunicable dis- eases (NCDs) such as diabetes, cancer, hypertension etc. Keywords: Asatmendriyartha, Pragyaparada, Parinama, Trividha Rogaayatanas, Hypertension.

scholarly journals Nutritional aspects of the prevention and treatment of osteoporosis

2010 ◽  
Vol 54 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Bárbara Santarosa Emo Peters ◽  
Lígia Araújo Martini
Keyword(s):  
Bone Mass ◽  
Bone Health ◽  
Critical Role ◽  
Bone Fragility ◽  
Vitamin Supplementation ◽  
Treatment Of Osteoporosis ◽  
Age Related ◽  
Consequent Increase ◽  
Global Health Problem ◽  
Optimal Protection

Osteoporosis is a global health problem characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture. Nutrition plays a critical role in reducing the risk of osteoporosis through its effect on all of these fragility factors, especially on the development and maintenance of bone mass. An adequate calcium, vitamin D and protein intake resulted in reduced bone remodeling, better calcium retention, reduced age-related bone loss, and reduced fracture risk. Recent evidence indicates that a healthy dietary pattern including dairy products (mainly fat free), fruit and vegetables and adequate amounts of meat, fish and poultry is positively related to bone health. Furthermore, mineral and vitamin supplementation should be closely monitored by health professionals since it could have adverse effects and be insufficient to ensure optimal protection of bone health.

Limitations in Bone-Mass Measurements with 241Am

1975 ◽  
pp. 43-46
Author(s):  
G. E. Rösingh ◽  
G. Hart ◽  
J. B. v. d. Schoot ◽  
K. L. M. Bon-Nijssen
Keyword(s):  
Bone Mass ◽  
Mass Measurements ◽  
Bone Mass Measurements
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