The Role of Novel Bone Forming Agents in the Treatment of Osteoporosis

2020 ◽  
pp. 089719002096122
Author(s):  
Hansita B. Patel ◽  
Lynsie J. Lyerly ◽  
Cheryl K. Horlen
Keyword(s):  
Elderly Population ◽  
Cost Effective ◽  
The Elderly ◽  
Bisphosphonate Therapy ◽  
Evidence Based ◽  
First Line ◽  
Treatment Of Osteoporosis ◽  
Cost Effective Treatment

Osteoporosis is a growing epidemic that leads to significant morbidity and mortality among the elderly population due to associated fractures that lead to disabilities and reduced quality of life. Bisphosphonates are well-established as a first-line and cost-effective treatment for osteoporosis. Unfortunately, clinicians are often uncertain as to how to select treatments when bisphosphonates are ineffective as initial treatment or contraindicated. Romosozumab and abaloparatide are 2 alternative agents that have been recently FDA approved for the treatment of osteoporosis in postmenopausal women at high risk for fracture or patients who have failed or are intolerant to other osteoporosis therapies. Currently, the National Osteoporosis Foundation (NOF) has no formal recommendations in regard to these 2 novel agents. The purpose of this review is to help guide pharmacists on how to ensure appropriate utilization of these 2 novel bone-forming agents as potential alternatives to bisphosphonate therapy by providing evidence-based recommendations according to the current literature and key counseling points.

scholarly journals Omalizumab Reduces Unplanned Healthcare Interactions in Irish Patients With Chronic Spontaneous Urticaria

2021 ◽  
Vol 2 ◽  
Author(s):  
Katie Ridge ◽  
Vyanka Redenbaugh ◽  
Niall Conlon
Keyword(s):  
Cost Effective ◽  
Healthcare Resource Utilization ◽  
Decision Makers ◽  
Chronic Spontaneous Urticaria ◽  
First Line ◽  
Cost Effective Treatment ◽  
Before And After ◽  
Irish Data ◽  
Impaired Quality

Chronic spontaneous urticaria (CSU) is a common, debilitating skin disorder associated with impaired quality of life and psychological comorbidity. Symptoms can be difficult to control and many individuals will not respond to first line treatment. Due to the chronic and unpredictable nature of the disorder, patients frequently have repeated healthcare attendances. Despite this, little is known about healthcare resource utilization internationally. Furthermore, there is no Irish data to inform fundholding decision makers. Omalizumab is an anti IgE monoclonal antibody used in refractory urticaria. It is a comparatively high cost medicine and access to this treatment can be challenging. Recent assessments of omalizumab compared with usual care suggest that omalizumab is a cost-effective treatment for refractory urticaria. We carried out a retrospective review of 47 patients commenced on omalizumab. We evaluated unplanned primary and secondary care attendances and urticaria symptomatology before and after treatment. As expected, patients with refractory disease that were commenced on omalizumab had objective improvements in urticaria symptoms. Importantly, we show that this is reflected in a dramatic reduction in unplanned healthcare interactions at primary care and emergency departments. These data suggest that omalizumab may benefit these patients by reducing disease activity and thereby reducing the need for unplanned healthcare interactions.

scholarly journals Deskripsi Organizational Citizenship Behavior Perawat Untuk Lansia Di Wisma Harapan Asri Yayasan Mardiwijana Semarang”

PRAXIS ◽  
2021 ◽  
Vol 3 (2) ◽  
pp. 120
Author(s):  
Yulius Susilo ◽  
Rudy Elyadi
Keyword(s):  
Qualitative Research ◽  
Organizational Citizenship ◽  
Organizational Citizenship Behavior ◽  
Research Method ◽  
Elderly Population ◽  
The Elderly ◽  
Citizenship Behavior ◽  
Five Dimensions

The number of elderly population in Indonesia from year to year is increasing, so it is needed a place and assistance services for elderly citizens. Wisma Harapan Asri Semarang provides services so that the elderly residents feel comfortable and at ease. The nurses for the elderly have the role of assisting and serving elderly citizens. The performance of the nurses has an important role for the quality of the services of the elderly homestead. Improved services will be better if the nurses have the attitude and actions of the Organizational Citizenship Behavior (OCB) at work.This study aimed to determine the OCB of nurses based on five dimensions of OCB. The five dimensions of OCB according to Organ are: altruism, courtesy, conscientiousness, sportmanship, and civic virtue. Descriptive qualitative research method to describe the OCB actions of nurses. The results showed OCB of nurses in the high category. An effort to improve the performance of nurses in accordance with the five dimensions of OCB. Also efforts to improve the services of nurses to meet the needs of the elderly. This research is useful for Wisma Harapan Asri in an effort to shape the behavior of nurses to provide the best service for the elderly.

Cardiovascular Disease

2018 ◽  
Author(s):  
Mara Caroline ◽  
Ryan Bradley ◽  
Mimi Guarneri
Keyword(s):  
Cardiovascular Disease ◽  
Elderly Population ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Nutrient Deficiencies ◽  
Comorbid Conditions ◽  
Increased Risk ◽  
Increased Susceptibility

The older population is challenging to treat for numerous reasons, including comorbid conditions and increased susceptibility to adverse drug reactions, limiting medical therapy. They are at increased risk for loneliness and depression, which strongly impacts their cardiovascular outcomes, and they also have different values, usually prioritizing quality of life over mortality objectives. Finally, the elderly are underrepresented in cardiovascular clinical trials, thus limiting the applicability of guideline recommendations. This chapter emphasizes the importance of a comprehensive assessment of individual circumstances when assessing cardiovascular health in the elderly population. The chapter focuses on the role of nutrition, resiliency, and exercise for the prevention and treatment of cardiovascular disease. Nutrient deficiencies commonly seen with cardiovascular drugs are also discussed, as well as specific integrative strategies for optimizing dyslipidemia, atrial fibrillation, and heart failure in this population.

scholarly journals Effectiveness of Family Function in Quality of Life in Elderly Patients: An Evidence Based Case Report

2021 ◽  
Vol 1 (2) ◽  
pp. 52
Author(s):  
Muhammad Sobri Maulana
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Chronically Ill ◽  
The Elderly ◽  
Evidence Based ◽  
Literature Searching ◽  
Family Function ◽  
Based Medicine

Background: Geriatric care is an important part in healthcare and are sometimes neglected.  Family caregivers figures assume a key role in postponing and potentially forestalling standardization of chronically ill elderly patients. The role of family function in depression has been demonstrated from earlier studies, however, the part of family function in quality of life the elderly has not concentrated widely. Objective: To evaluate the connection between family function and quality of life. Methods: Literature searching was conducted through PubMed, Science Direct and Embase. Critical appraisal using appraisal sheet for prognosis from Oxford Center for Evidence Based Medicine in 2011. Results: One article was found with good validity showed that direct relationship between family function and quality of life is not associated. However, if depression is present it plays as a strong mediator between family function and quality of life. Conclusion: Family function mediated with depression plays an important role in quality of life in elderly patients.

scholarly journals Low bone mass in children and adolescents

2006 ◽  
Vol 50 (4) ◽  
pp. 775-782 ◽  
Author(s):  
João Lindolfo C. Borges ◽  
Cynthia M.A. Brandão
Keyword(s):  
Bone Mass ◽  
Elderly Population ◽  
The Elderly ◽  
Bone Fragility ◽  
Childhood And Adolescence ◽  
Low Bone Mass ◽  
Mass Measurements ◽  
Treatment Of Osteoporosis ◽  
Bone Mass Measurements

Osteoporosis is a disease characterized by low bone mass and micro architectural alterations of bone tissue leading to enhanced bone fragility and increased fracture risk. Although research in osteoporosis has focused mainly on the role of bone loss in the elderly population, it is becoming increasingly clear that the amount of bone that is gained during growth is also an important determinant of future resistance to fractures. Thus, considerable interest is being placed on defining preventive strategies that optimize the gain of bone mass during childhood and adolescence. Knowledge of the determinants accounting for the physiologic and genetic variations in bone accumulation in children will provide the best means toward the early diagnosis and treatment of osteoporosis. This article reviews the techniques available for bone mass measurements in children and the major determinants and diseases influencing bone accretion during childhood and adolescence.

Role of Calcium, Vitamin D and Bisphosphonates in the Treatment of Osteoporosis in patients with Cirrhosis

2021 ◽  
Vol 15 (9) ◽  
pp. 2147-2149
Author(s):  
Intikhab Alam ◽  
Muhammad Rafique Khan ◽  
Zahoor Ur Rehman ◽  
Younas Ahmed ◽  
Faizan Ayub ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Transplantation ◽  
Female Gender ◽  
The Elderly ◽  
Cholestatic Liver Disease ◽  
Biliary Cirrhosis ◽  
Treatment Of Osteoporosis ◽  
Women Alcoholics

Osteoporosis is a significant and prevalent consequence of cirrhosis due to its detrimental influence on quality of life through persistent pain and immobility. Additionally, its significant morbidity necessitates early detection and treatment. BD is most frequently encountered in the elderly, smokers, postmenopausal women, alcoholics, malnourished individuals, and those with cholestatic liver disease. The prevalence of osteoporosis has been observed to range between 12--55% in patients with cirrhosis. Patients with primary biliary cirrhosis (PBC) have a higher prevalence due to persistent cholestasis and female gender. Prior to orthotopic liver transplantation, about 60% of cases with PBC and primary sclerosing cholangitis (PSC) have osteoporosis. It is critical to diagnose and treat osteoporosis prior to liver transplantation because of deterioration in early months i.e. 6—12 after transplantation. This resulted in much fractures due to trauma i.e. 25—35%. This osteoporosis may be due to toxic effect of immune compromised therapy after transplantation. Keywords: Role of calcium, cirrhosis, vitamin D

scholarly journals Does Qigong Practice Have Benefits on the Management of Parkinson’s Disease?

J ◽  
2019 ◽  
Vol 2 (3) ◽  
pp. 352-363
Author(s):  
António Moreira ◽  
Luís Carlos Matos ◽  
Ana Maria Conceição
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cost Effective ◽  
Chronically Ill ◽  
The Elderly ◽  
Functional Mobility ◽  
Cost Effective Treatment ◽  
Hand Eye Coordination

Parkinson’s disease (PD) is a progressive neurological disorder leading to loss of autonomy and a decline in quality of life. Qigong, a practice rooted in traditional Chinese medicine, has been positively reported on a variety of complaints of chronically ill patients and on gait imbalance in the elderly. PubMed and B-On databases were accessed during March 2018 to carry out an inventory of relevant scientific papers relating PD to Qigong. Fifteen articles were found and analyzed allowing us to highlight that: (1) in addition to medication, Qigong shows potential gains in PD management; (2) there is a stabilizing effect of motor symptoms and positive results in several frequent autonomy symptoms; (3) Qigong is highly accepted by patients, and is a cost-effective treatment that can be self-practiced, improving sleep quality, gait speed, functional mobility and quality of life, thus reducing the risk of falling; (4) Qigong improves muscle hardness, functional ability to walk, hand–eye coordination and balance. Despite the promising results, the limitations and the disparity of experimental designs of the included studies do not allow us to have a conclusive answer to the question whether Qigong benefits the management of PD or not.

HUBUNGAN PERAN FAMILY CAREGIVER TERHADAP QUALITAS HIDUP LANSIA

2019 ◽  
Vol 11 (1) ◽  
pp. 51-56
Author(s):  
RIANI PRADARA JATI ◽  
Sekar Farah Nabila
Keyword(s):  
Quality Of Life ◽  
Family Caregiver ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
The Elderly ◽  
Chi Square ◽  
The Poor ◽  
The Family

  Penempatan peran yang baik bagi Family Caregiver sangatlah membantu lansia dalam meningkatkah qualitas hidupnya, meningkatkan motivasi dalam menjalankan hidup Penelitian ini bertujuan Mengetahui hubungan peran Family Caregiver dalam pemenuhan qualitas hidup bagi lansia di Kelurahan Langenharjo Kabupaten Kendal. DesainPenelitianDeskriptifKorelasional menggunakan pendekatan Krosectional,tehnikSamplingStratified Simple Random Sampling dengan karakteristik heterogen, dari populasi mempunyai hak yang sama untuk diseleksi sebagai sampel teknik undianPengambilan data dengan menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya. Uji statistik Chi-square, dengan taraf signifikasi 5%jumlah sampel pada penelitian ini 70 sampel pada Family Caregiver dari 213 populasi yang ada. Hasil penelitian dari 70 responden didapatkan Peran Family Caregiver tidak baik dengan qualitas hidup tidak baik 33 (47,1%), sedangkan Peran Family Caregiver kurang baik dengan qualitas hidup lansia baik 3 (4,3%). Untuk distribusi Peran Family Caregiver kurang baik dengan qualitas hidup lansia tidak baik sebanyak 6 responden (8,6%) sedangkan untuk distribusi Peran Family Caregiver kurang baik dengan qualitas hidup lansia baik sebanyak 23 responden (32,9%). Terakhir, untuk distribusi Peran Family Caregiver baik dengan qualitas hidup lansia tidak baik didapatkan hasil 2 responden (2, 9%) sedangkan untuk distribusi Peran Family Caregiver baik dengan qualitas hidup lansia baik didapatkan hasil 3 responden (4,3%)Menunjukkan nilai ρ value 0,001 (ρ < 0,05) berarti ada hubungan antara dukungan keluarga dengan kepatuhan lansia dalam keikutsertaan posyandu lansia. Disarankan kepada semua Family Cregiver lansia untuk mampu memahami pentingnya perhatian, dukungan bagi lansia dalammeningkatkan qualitas hidup yang lebih baik bagi lansia.   Kata kunci : Peran family caregiver, qualitas hidup, lansia.   ABSTRACT Placement of a good role for Family Caregiver is very helpful for the elderly to improve their quality of life, increase motivation in living life Research Objective: To know the relationship between the role of Family Caregiver in fulfilling quality of life for the elderly in Langenharjo Village, Kendal Regency. Descriptive Correlational Research Design uses a cross sectional approach, Sampling Stratified Simple Random Sampling technique with heterogeneous characteristics, from the population has the same right to be selected as a sample lottery technique Retrieving data using a questionnaire that has been tested for validity and reliability. Test Chi-square statistics, with a significance level of 5% the number of samples in this study 70 samples on the Family Caregiver from 213 populations. Results of the Study Of 70 respondents found the role of Family Caregiver was not good with poor quality of life 33 (47.1%) , while the role of the Family Caregiver is not good with the quality of life of a good elderly 3 (4.3%). For the distribution of the role of Family Caregiver is not good with the quality of life of the poor family as many as 6 respondents (8.6%) while for the distribution of the Role of Family Caregiver is not good with the quality of life of good elderly as many as 23 respondents (32.9%). Finally, the distribution of the Role of Family Caregiver with good quality of life for the poor is obtained by 2 respondents (2, 9%), while the distribution of the Role of Family Caregiver with good quality of life for the elderly is obtained by 3 respondents (4.3%). 0.001 (ρ <0.05) means that there is a relationship between family support and the compliance of the elderly in the participation of the elderly posyandu. It is recommended to all elderly Cregiver families to be able to understand the importance of attention, support for the elderly in improving the quality of life better for the elderly   Keywords: Role of Family Caregiver, Quality of Life, Elderly

scholarly journals A comparative study of the voice-related quality of life among Egyptian elderly with and without voice complaints

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Nesreen Fathi Mahmoud ◽  
Huda Zahran ◽  
Sherif Abdelmonam
Keyword(s):  
Quality Of Life ◽  
Elderly Population ◽  
Life Quality ◽  
Voice Disorders ◽  
The Elderly ◽  
Different Types ◽  
Related Quality ◽  
The Impact ◽  
The Voice

Abstract Background This study focuses on the self-perception of the voice in the elderly as assessed by the Voice-Related Quality of Life (V-RQOL) questionnaire. This work aimed to compare differences in the voice-related quality of life outcomes between (1) elderly with and without voice disorders, (2) female and male elderly with voice disorders, and (3) different types of voice disorders, and to explore the correlation between the V-RQOL and perceptual analysis done by the clinician. Forty-three dysphonic and 44 non-dysphonic elderly filled out the Voice-Related Quality of Life (V-RQOL) protocol that analyzes the impact of dysphonia on life quality. Vocal perceptual assessment of each subject with dysphonia was made by three voice therapists, followed by a flexible nasofibrolaryngoscope. Results A significant statistical difference was found between the means of total V-RQOL scores and its subdomains for each group (dysphonic and non-dysphonic). No significant differences were found between male and female elderly with dysphonia. The statistical analysis showed a significant correlation with the vocal assessment made by the clinicians and the V-RQOL self-assessment made by the subjects. Conclusions This study provides valuable information regarding the risk factors that contribute to vocal quality in the elderly population. Our results revealed that different types of voice disorders are common among the elderly population with significant negative effects on quality of life. It was observed that the poorest score on the V-RQOL was for functional voice disorders, followed by neoplastic lesions, whereas MAPLs had the best score on the V-RQOL.

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