scholarly journals Haptoglobin study in myasthenia gravis

2008 ◽  
Vol 66 (2a) ◽  
pp. 229-233 ◽  
Author(s):  
Leonardo H. Mendonça Oliveira ◽  
Marcondes C. França Jr ◽  
Anamarli Nucci ◽  
Denise Madureira de Oliveira ◽  
Elza Myiuki Kimura ◽  
...  
Keyword(s):  
Linear Regression ◽  
Myasthenia Gravis ◽  
Disease Severity ◽  
Disease Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Functional Scale ◽  
Cross Sectional ◽  
Student’S T ◽  
Student’S T Test

OBJECTIVE: A cross-sectional study of haptoglobin (Hp) in myasthenia gravis (MG) was designed, with the objective to identify its values and correlate them with different disease status. METHOD: 46 patients were enrolled in the study, all having disease severity established according to the quantitative myasthenia gravis strength scores (QMGSS). Based on the functional scale determined by Myasthenia Gravis Foundation of America (MGFA) recommendations, patients were classified as having: complete stable remission (CSR; n=10); minimal manifestations-0 (MM0; n=6), minimal manifestations-1 (MM1; n=4); pharmacological remission (PR; n=6). Two other groups participated: thymomatous patients (T; n=10) and patients without imunosuppression or thymectomy, until the assessment for Hp (WIT; n=10). Hp dosage was done by immunonephelometry, blindly to clinical data. Student's t-test, Anova test and linear regression were employed for statistical analyses. RESULTS: Statistically significant differences occurred between CSR+MM0xWIT groups (86.62x157.57, p<0.001) and PR+MM1xWIT groups (73.93x157.57, p<0.001). Linear regression showed correlation between Hp levels and QMGSS (r=0.759, p<0.001). CONCLUSION: Our results suggest that Hp may be useful in clinical practice as a disease severity marker in MG.

scholarly journals Phonological performance measured by speech severity indices compared with correlated factors

2007 ◽  
Vol 125 (6) ◽  
pp. 309-314 ◽  
Author(s):  
Haydée Fiszbein Wertzner ◽  
Luciana Amaro ◽  
Daniela Evaristo dos Santos Galea
Keyword(s):  
Cross Sectional Study ◽  
Speech Impairment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Density Index ◽  
Upper Respiratory ◽  
Student’S T ◽  
Correlated Factors ◽  
Spearman’S Correlation ◽  
Student’S T Test

CONTEXT AND OBJECTIVE: Some factors seem to influence speech impairment among phonologically disordered children. The aim was to compare severity indices with some correlated factors. DESIGN AND SETTING: Observational, analytical and cross-sectional study conducted within the Language-Speech-Hearing Sciences Course, Universidade de São Paulo. METHOD: Fifty phonologically disordered children with ages ranging from 4 to 11 years took part. The indices were calculated from phonology tests and were correlated with anamnesis and audiological data. Student’s t test and Spearman’s correlation were used to compare percentages of consonants correct (PCC) and process density index (PDI) for children with and without otitis, upper respiratory histories and audiological abnormalities, with regard to whether or not they were comprehended during assessment, their ages when they started to speak and their ages at the assessment. RESULTS: The higher the age at the assessment was, the higher the PCC (imitation: 0.468; naming: 0.431; Spearman’s correlation) and the lower the PDI (imitation: 0.459; naming: 0.431); the later the child started to speak, the lower the PCC (imitation p = 0.064; naming p = 0.050) and the higher the PDI (imitation p = 0.067; naming p = 0.042). There were differences between groups with and without upper respiratory history (PCC: imitation p = 0.016, naming p = 0.005; PDI: imitation p = 0.014, naming p = 0.008). There was no difference between the groups regarding otitis, comprehension during the assessment and audiological data. CONCLUSIONS: Children with upper respiratory histories who began to speak later presented more severe speech impairment indices.

scholarly journals Evaluation of efficacy and utility of spirometry data in elderly (>65years) individuals with or without lung diseases

2019 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Vindhya Ponnathota ◽  
Sujatha Gogineni ◽  
Silpa Kasireddy
Keyword(s):  
Lung Diseases ◽  
Elderly Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Monitoring Tool ◽  
Cross Sectional ◽  
Proper Understanding ◽  
Significant Difference ◽  
Student’S T ◽  
Student’S T Test

Background: Spirometry is an important diagnostic monitoring tool for various lung disorders. Ventilatory function can be assessed by spirometry. Also, we can find whether it is obstructive or restrictive disease. An appropriate technique is essential to ensure accurate results. Spirometry requires proper understanding and cooperation of the patient while doing the test. The objective was to evaluate the efficacy and utility of spirometry data in elderly (>65years) individuals with or without lung diseases.Methods: A hospital based cross sectional study was carried out among 199 subjects who were then divided into 100 controls and 99 cases. Spirometry was carried out among all subjects. The values of spirometry were compared among cases and controls as well as across age and sex groups. Student’s t-test was applied.Results: After studying the spirometric data in elderly population with or without lung disease, there was significant difference between cases and controls as far as pack years of smoking was concerned. There was significant difference in FEV1, FVC and FEV1/FVC between the cases and controls. As the age increased the spirometric values decreased. The spirometry was normal in controls in majority compared to none in cases.Conclusions: Spirometry should be used by all primary care and specialist physicians even in elderly population.

scholarly journals FACTORS ASSOCIATED WITH SYMPTOMS OF DEPRESSION AMONG OLDER ADULTS DURING THE COVID-19 PANDEMIC

2021 ◽  
Vol 30 ◽  
Author(s):  
Fernanda Maria Vieira Pereira-Ávila ◽  
Simon Ching Lam ◽  
Maithê de Carvalho e Lemos Goulart ◽  
Fernanda Garcia Bezerra Góes ◽  
Natália Maria Vieira Pereira-Caldeira ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Associated ◽  
Symptoms Of Depression ◽  
Student’S T ◽  
Student’S T Test

ABSTRACT Objective: to identify factors associated with depressive symptoms among older adults during the COVID-19 pandemic. Method: a cross-sectional study developed in all regions of Brazil, using an electronic form among older adults aged 60 or over. Data were collected from April 17 to May 15, 2020. Measures of central tendency and dispersion were used. For comparison of means, Student’s t-test and analysis of variance were applied, considering p≤0.05. For association of factors, chi-square was adopted with bivariate analyzes and logistic regression. Results: nine hundred (100.0%) older adults participated in the study. The general score for symptoms of depression was 3.8 (SD=4.4), 818 (91.9%) had no or mild depressive symptoms. Women (p <0.01) have more symptoms than men. The income variable is a predictor of depressive symptoms (OR=0.56; CI: 0.34-0.91; p=0.020). Conclusion: the main factors associated with symptoms of depression were sex, income, education and occupations that expose them to COVID-19 had the highest depression scores.

scholarly journals Comparação dos níveis de agilidade em crianças em idade escolar praticantes e não praticantes de judô: um estudo seccional

2019 ◽  
Vol 88 (3) ◽  
Author(s):  
Wescley Rufino De Queiroz ◽  
Rodrigo Gomes de Souza Vale ◽  
Leandro Lima Silva ◽  
Carlos Soares Pernambuco ◽  
Rodolfo Alkmim Moreira Nunes ◽  
...  
Keyword(s):  
Intervention Studies ◽  
Cross Sectional Study ◽  
School Age Children ◽  
School Age ◽  
Sectional Study ◽  
Cross Sectional ◽  
Physical Quality ◽  
The Difference ◽  
Student’S T ◽  
Student’S T Test

Introdução: A agilidade é fundamental para o judô, uma luta que demanda força e potência e utiliza mudanças bruscas de direção. Pouco se investigou, no Brasil, a respeito da qualidade física agilidade em crianças escolares pré-puberes.Objetivo: Comparar o nível de agilidade entre crianças praticantes e não-praticantes de judô de uma escola pública.Métodos: Pesquisa descritiva de corte transversal comparativa, da qual participaram 77 crianças de ambos os sexos: 47 praticantes de judô e 30 não praticantes. Teste t de Student para amostras independentes foi aplicado para a comparação entre os grupos.Resultados: Os praticantes regulares de judô exibiram maiores níveis de agilidade (10,98±0,79 segundos) do que os não praticantes de judô (13,48±0,74 segundos) e a diferença foi significativa (p=0,0001).Conclusão: Crianças que praticam judô apresentaram níveis maiores de agilidade do que as participantes de iniciação esportiva em outras modalidades, sugerindo que o treinamento de judô pode favorecer o desenvolvimento dessa capacidade física mais do que as demais modalidades. Outros estudos de intervenção devem ser conduzidos para esclarecer essa associação. Comparison of Agility Levels in Judo-Practicing and Non-Practicing School-Age Children: A Cross-Sectional StudyIntroduction: Introduction: Agility is fundamental to judo, a fight that demands strength and power and uses sudden changes of direction. Little has been investigated in Brazil regarding physical quality agility in prepubescent school children.Objective: To compare the level of agility between practicing and non-practicing children of judo in a public school.Methods: A descriptive comparative cross-sectional study was conducted in which 77 children of both sexes participated: 47 judo practitioners and 30 non-practitioners. Student's t-test for independent samples was applied for comparison between groups.Results: Regular judo practitioners exhibited higher levels of agility (10.98 ± 0.79 seconds) than non-judo practitioners (13.48 ± 0.74 seconds) and the difference was significant (p = 0.0001).Conclusion: Children who practice judo showed more agility than participants of sports initiation in other modalities suggesting that judo training may favor the development of this physical capacity more than the other modalities. Further intervention studies should be conducted to clarify this association.

scholarly journals Prevalence of dyslipidemia in children from 2 to 9 years old

2020 ◽  
Vol 73 (suppl 4) ◽  
Author(s):  
Josianne Alves de Freitas Maia ◽  
Francisco José Maia Pinto ◽  
Francisco Regis da Silva ◽  
Débora Sâmara Guimarães Dantas ◽  
Rafaella Maria Monteiro Sampaio ◽  
...  
Keyword(s):  
Prevalence Ratio ◽  
Cross Sectional Study ◽  
Preschool Age ◽  
School Age ◽  
Test Results ◽  
Sectional Study ◽  
Cross Sectional ◽  
Coronary Diseases ◽  
Student’S T ◽  
Student’S T Test

ABSTRACT Objective: Analyze the occurrence of dyslipidaemia and associated factors in children aged 2 to 9 years. Method: Cross-sectional study, carried out with 700 children, in a region of Northeast Brazil. For comparison of means, Student’s t test was used; and, for the comparison of medians, the Mann-Whitney test. Results: A prevalence of dyslipidaemia of 68.4% was found. In isolation, the majority had a level of: total desirable cholesterol (386; 55.1%), undesirable lipoprotein cholesterol (376; 53.7%), low density lipoproteins - desirable cholesterol (514; 73.4%) and desirable triglyceride (509; 72.7%). In the final multivariate model, only the variable “preschool age” was significant (prevalence ratio = 1.14), indicating that these children are more likely to have dyslipidaemia than those of school age. Conclusion: An association was found between dyslipidaemia and preschool age. The need for programs and strategies to better understand this problem is indicated, in addition to preventing early coronary diseases.

scholarly journals Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Jorge Ivan Gamez-Nava ◽  
Valeria Diaz-Rizo ◽  
Edsaul Emilio Perez-Guerrero ◽  
Jose Francisco Muñoz-Valle ◽  
Ana Miriam Saldaña-Cruz ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Linear Regression ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Macrophage Migration Inhibitory Factor ◽  
Cross Sectional Study ◽  
Macrophage Migration ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional

Abstract Background To date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial. Objective To assess the utility of serum MIF, leptin, adiponectin and resistin levels as markers of proteinuria and renal dysfunction in lupus nephritis. Methods Cross-sectional study including 196 systemic lupus erythematosus (SLE) patients and 52 healthy controls (HCs). Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Renal SLE involvement was investigated by renal-SLEDAI. MIF, adiponectin, leptin and resistin levels were quantified by ELISA. We assessed the correlations of quantitative variables by Spearman correlation (rs). Multivariable linear regression adjusted the variables associated with the severity of proteinuria. Results SLE patients had higher MIF (p = 0.02) and adiponectin (p < 0.001) than HCs. Patients with renal SLE involvement (n = 43) had higher adiponectin (19.0 vs 13.3 μg/mL, p = 0.002) and resistin (10.7 vs 8.9 ng/mL, p = 0.01) than patients with non-renal SLE (n = 153). Proteinuria correlated with high adiponectin (rs = 0.19, p < 0.009) and resistin (rs = 0.26, p < 0.001). MIF (rs = 0.27, p = 0.04). Resistin correlated with increased creatinine (rs = 0.18, p = 0.02). High renal-SLEDAI correlated with adiponectin (rs = 0.21, p = 0.004). Multiple linear regression showed that elevated adiponectin (p = 0.02), younger age (p = 0.04) and low MIF (p = 0.02) were associated with the severity of proteinuria. Low MIF and high adiponectin levels interacted to explain the association with the severity of proteinuria (R2 = 0.41). Conclusions High adiponectin combined with low MIF concentrations int+eract to explain the severity of proteinuria in renal SLE. These findings highlight the relevance of adiponectin, resistin and MIF as markers of LN.

scholarly journals Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis. A cross-sectional study.

2020 ◽  
Author(s):  
Jorge Ivan Gamez-Nava ◽  
Valeria Diaz-Rizo ◽  
Edsaul Emilio Perez-Guerrero ◽  
Jose Francisco Muñoz-Valle ◽  
Ana Miriam Saldaña-Cruz ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Linear Regression ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Macrophage Migration Inhibitory Factor ◽  
Cross Sectional Study ◽  
Macrophage Migration ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional

Abstract Background To date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial.Objective To assess the utility of serum MIF, leptin, adiponectin and resistin levels as markers of proteinuria and renal dysfunction in lupus nephritis.Methods Cross-sectional study including 196 systemic lupus erythematosus (SLE) patients and 52 healthy controls (HCs). Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Renal SLE involvement was investigated by renal-SLEDAI. MIF, adiponectin, leptin and resistin levels were quantified by ELISA. We assessed the correlations of quantitative variables by Spearman correlation (rs). Multivariable linear regression adjusted the variables associated with the severity of proteinuria. Results SLE patients had higher MIF (p=0.02) and adiponectin (p<0.001) than HCs. Patients with renal SLE involvement (n=43) had higher adiponectin (19.0 vs 13.3 µg/mL, p=0.002) and resistin (10.7 vs 8.9 ng/mL, p=0.01) than patients with non-renal SLE (n=153). Proteinuria correlated with high adiponectin (rs=0.19, p<0.009) and resistin (rs=26, p<0.001). MIF (rs=0.27, p=0.04). Resistin correlated with increased creatinine (rs= 0.18, p=0.02). High renal-SLEDAI correlated with adiponectin (rs=0.21, p=0.004). Multiple linear regression showed that elevated adiponectin (p=0.02), younger age (p=0.04) and low MIF (p=0.02) were associated with the severity of proteinuria. Low MIF and high adiponectin levels interacted to explain the association with the severity of proteinuria (R2=0.41).Conclusions High adiponectin combined with low MIF concentrations interact to explain the severity of proteinuria in renal SLE. These findings highlight the relevance of adiponectin, resistin and MIF as markers of LN.

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