Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae)
2002 ◽
Vol 44
(2)
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pp. 109-112
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Keyword(s):
Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds.
1984 ◽
Vol 47
(1)
◽
pp. 61-64
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2018 ◽
Vol 15
(1)
◽
pp. 31-36
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Keyword(s):
1996 ◽
Vol 63
(2)
◽
pp. 257-267
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Keyword(s):
2014 ◽
Vol 83
(4)
◽
pp. 281-294
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1996 ◽
Vol 24
(4)
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pp. 358-362
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