scholarly journals Clinical and epidemiological profile of blood donors with positive serology for viral hepatitis in southern Brazil

2011 ◽  
Vol 44 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Luciana da Silveira ◽  
Leonardo de Lucca Schiavon ◽  
Kerley Pereira da Silva ◽  
Thiago Barbieri Lopes ◽  
Marcos da Rocha Zaccaron ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Blood Donors ◽  
Blood Donation ◽  
Previous History ◽  
Southern Brazil ◽  
Positive Serology ◽  
Serological Tests ◽  
History Of ◽  
Epidemiological Profile ◽  
Epidemiological Characteristics

INTRODUCTION: Positive serological tests for hepatitis viruses B and C at blood banks are an important reason for blood deferral. Additionally, high residual risk for transfusing hepatitis-contaminated blood has been estimated in southern Brazil. This study aimed to identify risk factors for positive serological tests for viral hepatitis (VH) in blood donors (BD). METHODS: A case-control study included consecutive BD with positive serology for VH, between 2008 and 2009. Cases and controls (BD with negative serology for VH) were paired 1:1 by sex and donation date. Assessment of clinical and epidemiological characteristics related to viral hepatitis was conducted. RESULTS: Among 1,282 blood donors (641 cases and 641 controls), those with positive serology for viral hepatitis had higher mean age (p<0.001); higher proportion of replacement donation (p<0.001); first donation (p<0.001); and interviewer deferment (p=0.037), compared to controls. Furthermore, donors with positive tests were less regular donors (p<0.001), had less previous history of rejection (p=0.003) and showed lower hematocrit median before donation (p=0.019). Multivariate analysis demonstrated that age (OR=1.056, 95%CI 1.042-1.069, p<0.001), replacement donation (OR=1.545, 95%CI 1.171-2.038, p=0.002) and first donation (OR=9.931, 95%CI 7.486-13.173, p<0.001) were independently associated with positivity of serological tests for viral hepatitis. CONCLUSIONS: Specific characteristics of blood donors were associated with positive serology for viral hepatitis. These peculiarities should be taken into account when assessing candidates for blood donation.

scholarly journals Estimation of Serum Ferritin Levels in Blood Donors and its Association with Frequency of Blood Donation and Blood Indices

2021 ◽  
Author(s):  
Amrita S Kumar ◽  
A Geetha ◽  
Jim Joe ◽  
Arun Mathew Chacko
Keyword(s):  
Serum Ferritin ◽  
Blood Donors ◽  
Blood Donation ◽  
Iron Status ◽  
Previous History ◽  
P Value ◽  
Blood Indices ◽  
Iron Stores ◽  
Group I ◽  
History Of

Introduction: Blood donation is one of the most significant contributions that a person can make towards the society. A donor generally donates maximum 450 mL of blood at the time of donation. If 450 mL of blood is taken in a donation, men lose 242±17 mg and women lose 217±11 mg of iron. Hence, adequate iron stores are very important in maintenance of the donor’s health. Aim: To assess the influence of frequency of blood donation on iron levels of blood donors by estimating Haemoglobin (Hb) and other blood indices which reflect iron status of blood and serum ferritin which reflects body iron stores. Materials and Methods: The present study was a cross-sectional analytical study, conducted on 150 blood donors, 18-40 years of age presenting to the Blood Bank in Government Medical College, Kottayam, Kerala, India, between December 2016 to December 2017. Total of 150 donors were divided into four groups according to the number of donations per year. Group I were the first time donors with no previous history of blood donation, Group II- included those with history of donation once in the previous year, Group III- those donors with history of donation twice in the previous year and Group IV- those having history of donation thrice in the previous year. Six ml of whole blood collected from each donor, two ml was used for estimating Haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hb (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC) in haematology analyser. Serum separated from remaining four mL of blood underwent ferritin analysis by Chemiluminescence Immunoassay (CLIA) method. Iron stores were considered normal at serum ferritin value from 23.9-336ng/mL in males and 11-307ng/mL in females. Statistical analysis was performed in Statistical Package for the Social Sciences (SPSS) version 16.0. Analysis of Variance (ANOVA) test and Pearson correlation test were used to find association between various parameters and collected data. The p-value <0.05 was considered as statistically significant. Results: There was no significant correlation between serum ferritin level and frequency of blood donation. MCH, MCHC showed significant association (p-value 0.039 and 0.007, respectively) with frequency of blood donation. Low positive correlation was seen between Hb and PCV with serum ferritin levels (r=0.381, p-value <0.001 and r=0.354, p-value <0.001, respectively). Conclusion: There is no significant association between frequency of blood donation and serum ferritin levels.

scholarly journals Clinical and epidemiological profile of female blood donors with positive serology for viral hepatitis B

2015 ◽  
Vol 48 (5) ◽  
pp. 524-531
Author(s):  
Janaína Luz Narciso-Schiavon ◽  
Leonardo de Lucca Schiavon ◽  
Roberto José de Carvalho-Filho ◽  
Christine Takemi Emori ◽  
Fernando Akio Maryia ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Blood Donors ◽  
Positive Serology ◽  
Viral Hepatitis B ◽  
Epidemiological Profile

scholarly journals Epidemiological profile of hepatitis C in blood donors at the Uberaba Regional Blood Center

2009 ◽  
Vol 42 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Fernanda Bernadelli Garcia ◽  
Gilberto de Araújo Pereira ◽  
Paulo Roberto Juliano Martins ◽  
Helio Moraes-Souza
Keyword(s):  
Hepatitis C ◽  
Marital Status ◽  
Skin Color ◽  
Blood Donors ◽  
Fourth Generation ◽  
Positive Serology ◽  
Blood Center ◽  
Epidemiological Profile ◽  
Epidemiological Characteristics ◽  
First Time

The aim of the present study was to outline the serological profile of hepatitis C among blood donors seen at the Uberaba Regional Blood Center, Hemominas Foundation, over the last 14 years. The frequency of hepatitis C was compared between first-time and repeat donors and the epidemiological characteristics of those with positive and indeterminate ELISA anti-HCV (third and fourth generation) were analyzed based on the donor histories kept in the archives of the Uberaba Regional Blood Center. The serological ineligibility rate was 0.3%, with higher prevalence in the group of first-time donors. We did not find any significant differences regarding age, skin color, marital status or place of residence between eligible and ineligible donors; however, the frequency of positive serology was higher among men. The lower (0.3%) rate of ineligibility due to hepatitis C that was observed at the Uberaba Regional Blood Center, in relation to most Brazilian blood centers, is probably due to the large number of repeat donors (83.3%). This reinforces the importance of achieving donor commitment for increasing transfusion safety.

Human Serum Bilirubin

1957 ◽  
Vol 3 (5) ◽  
pp. 609-623 ◽  
Author(s):  
J E O'Hagan ◽  
Teresa Hamilton ◽  
E G Le Breton ◽  
A E Shaw
Keyword(s):  
Blood Donors ◽  
Serum Bilirubin ◽  
Previous History ◽  
Mean Value ◽  
Destructive Effect ◽  
History Of ◽  
Free Serum ◽  
High Bilirubin ◽  
Definite Correlation ◽  
Apparently Healthy

Abstract The technic of Powell (3) for the estimation of serum bilirubin has been modified by reading the optical density of the solutions shortly after mixing the reagents and using a standard based on a more appropriate solution of crystalline bilirubin in pigment-free serum. Seven specimens of bilirubin were examined spectrophotometric-ally; the disproportionality of the millimolar extinction coefficients at 453 mµ for the free-bilirubin and at 532 mµ for, the azobilirubin complex indicated the presence of an unreactive yellow pigment. The destructive effect of sunlight on solutions of biirubin, noted in the literature, was confirmed, hence all estimations were done without delay or exposure to light for any length of time. The results obtained on apparently healthy blood donors, to detect possible carriers of homologous serum hepatitis, revealed no definite correlation between previous history of jaundice and increased serum bilirubin values, but as a precautionary measure individuals with values above 1.5 mg. per 100 ml. were not accepted as donors. When 200 random values were plotted, the distribution curves gave a mean value higher for males than females. Furthermore, 108 donors (among the 25,000 screened) had biirubin values greater than 1.5 mg. per 100 ml. The eleven females of the group did not maintain high values, while 30 males recorded high values on more than one occasion, some consistently. No significant correlation was found between high bilirubin values and a previous history of jaundice, nor were any cases of posttrans-fusion hepatitis traced to these donors. Somewhat arbitrarily, 1.5 mg. per 100 ml. was chosen as the upper limit of normal.

Self-poisonings with Psychopharmacological Agents in Zagreb

1991 ◽  
Vol 10 (5) ◽  
pp. 305-309 ◽  
Author(s):  
G. Miličević ◽  
H. Prpić
Keyword(s):  
Retrospective Study ◽  
General Population ◽  
Previous History ◽  
Toxic Agent ◽  
Highly Educated ◽  
Male Ratio ◽  
History Of ◽  
The Unemployed ◽  
Epidemiological Characteristics ◽  
Psychopharmacological Agents

1 A 5-year retrospective study of 1743 episodes of self-poisoning in 1608 adult patients, was undertaken to determine the frequency of self-poisoning with psychopharmacological agents, the frequency of each toxic agent usage and the epidemiological characteristics of the poisoned population. 2 The annual incidence of self-poisoning in Zagreb was 38.7 per 100 000 adult inhabitants. The anxiolytic-antipsychotic-antidepressant usage ratio was 8.8:1.5:1.0 in total self-poisoning, whereas it was 4.9:1.5:1.0 in patients with a previous history of self-poisoning. The use of anxiolytics decreased and the use of antidepressants increased during the 5 years. 3 The female—male ratio was 3.8:1 and 77% of self-poisoned persons were aged 15-44 years. The incidence of self-poisoning was 74% higher in the urban than in the rural population. The proportion of self-poisoned persons was 204% higher among the unemployed than in the population as a whole. There were 76% more repetitors among highly educated and 43% fewer repetitors among students than in the general population. The use of antipsychotics was 120% higher in males than in females. The use of antidepressants was 107% higher in the highly educated. 4 The increased use of antidepressants in self-poisoning is an alarming signal and caution in their prescription seems to be indicated.

scholarly journals Frequency of Hepatitis B Virus carrier by Detecting AntiHBc Antibody among HBsAg Negative Blood Donors

2016 ◽  
Vol 15 (1) ◽  
pp. 66-69
Author(s):  
Kashfia Islam ◽  
Mazharul Hoque ◽  
Samsun Nahar ◽  
Syed Dawood Md. Taimur ◽  
Zeenat Farzana Rahman ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Blood Donors ◽  
Blood Donation ◽  
Hepatitis B Surface Antigen ◽  
Medical Science ◽  
Chromatography Method ◽  
Cross Sectional ◽  
B Virus ◽  
History Of

Background & Objective: Transfusion associated hepatitis B virus (TAHBV) infection continues to be a major problem despite mandatory screening for hepatitis B surface antigen (HBsAg). This is because HBsAg is not detected during the window period of the infection. This study was designed to assess the frequency of anti HBc antibody among HBsAg negative donor and also to determine the demographic profile of healthy blood donors.Material & Method: This cross sectional observational study was carried out in the Department of Transfusion Medicine, BSMMU, Dhaka during the period of May 2014 to April 2015. A total number of 100 consecutive healthy blood donors who were clinically and physically healthy and serologically found to be free from HBsAg, HCV and HIV by rapid chromographic test were included in this study.Results: Within the 100 patients among them history of jaundice was found in 17(17.0%). There all (100.0%) subjects had negative HBsAg and 14(14.0%) subjects had positive anti HBc-Ab. Anti HBc-Ab was statistically significant (p<0.001) in Z-test.Conclusion: This study was undertaken to assess the prevalence of anti HBc antibody among healthy blood donors with HBsAg negative in rapid chromatography method. The prevalence of anti HBc antibody was about 14 (14.0%) among 100 HBsAg negative blood donors. History of blood donation was found in almost two third 65 (65.0%). So, anti HBc antibody screening is an useful tool for estimating the risk of transfusion transmitted HBV infection.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.66-69

scholarly journals Transfusion-Transmitted Babesiosis

2018 ◽  
Vol 143 (1) ◽  
pp. 130-134 ◽  
Author(s):  
Tatiana Villatoro ◽  
Julie Katz Karp
Keyword(s):  
Blood Donors ◽  
Blood Donation ◽  
Significant Risk ◽  
The United States ◽  
Babesia Microti ◽  
Draft Guidance ◽  
Infected Blood ◽  
First Case ◽  
History Of ◽  
Dna Pcr

Babesiosis is most commonly caused by Babesia microti and is transmitted via the bite of an infected Ixodes spp tick. However, Babesia is also transmitted via blood transfusion. In the United States, the first case of transfusion-transmitted babesiosis was recognized in 1979, and in recent years, the incidence has rapidly increased. Because most of the infected blood donors do not experience any symptoms, they pose a significant risk to the blood supply. Donor deferral for a history of babesiosis is currently performed but is ineffective. In March 2018, the FDA licensed a DNA PCR and antibody assay that were used in tandem in pivotal trials for screening blood donors for B microti; with other assays still being evaluated under investigational new drug protocols. Blood donation screening is essential to reducing the risk of transfusion-transmitted babesiosis, which is why blood centers collecting in geographic regions of highest risk have been testing since approximately 2010. Investigational NAT assays of higher sensitivity are pending FDA review. Further, in July 2018, the FDA issued a draft guidance for reducing the risk of transfusion-transmitted babesiosis. Release of the final guidance may be postponed until sensitivities and specificities of all current and potential strategies have been properly evaluated.

scholarly journals Prevalence of Malaria Parasites Among Blood Donors in Selected Hospitals of Dhaka City

1970 ◽  
Vol 17 (2) ◽  
pp. 94-97 ◽  
Author(s):  
MM Hoque ◽  
MA Islam ◽  
HA Begum ◽  
M Rahman ◽  
SM Rahman ◽  
...  
Keyword(s):  
Thick Film ◽  
Blood Donors ◽  
Previous History ◽  
Demographic Characteristics ◽  
Malaria Parasites ◽  
Medicine Department ◽  
Blood Samples ◽  
History Of ◽  
Medical University ◽  
Key Words Malaria

Blood serves as a vehicle for transmission of blood-borne pathogens and transfusion-associated malaria is a potentially serious complication. The present study was conducted to determine the prevalence of Malaria parasites in blood donors. Total of 400 blood donors were selected from Transfusion Medicine Department of two teaching institutes, Bangabandhu Sheikh Mujib Medical University (BSMMU) and National Institute of Diseases of Chest and Hospital (NIDCH), Dhaka between the period of 1st January and 30th April 2003. The blood samples were examined under microscope by thick film in the laboratory of Institute of Epidemiology, Disease Control & Research (IEDCR), Dhaka. The socio-demographic characteristics of the study subjects show that 304 (76%) blood donors were males and 96 (24%) of them were females. The malaria parasites were found in 3 (0.76%) donors out of 400 donors. From 400 donors, 52 (13%) donors had the history of residence/ travel in malaria zone and 348 (87%) had no such history. The 8 (15%) out of 52 who had the history of residence/ travel in malaria zone had previous history of malaria and had taken anti-malarial drug. It can be concluded from the present study that there is some risk of transmission of malaria parasites in blood transfusion among the voluntary and professional blood donors in Bangladesh. Key words: Malaria parasites; Blood donors; Thick film. DOI: 10.3329/jdmc.v17i2.6590J Dhaka Med Coll. 2008; 17(2) : 94-97

scholarly journals Seroprevalence of human toxocariasis in Andean communities from the Northeast of Lima, Peru

2010 ◽  
Vol 52 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Yrma A. Espinoza ◽  
Pedro E. Huapaya ◽  
William H. Roldán ◽  
Susana Jiménez ◽  
Enma P. Abanto ◽  
...  
Keyword(s):  
Total Population ◽  
Intestinal Parasite ◽  
Previous History ◽  
Neurological Involvement ◽  
Positive Serology ◽  
Public Places ◽  
Blood Samples ◽  
History Of ◽  
Stool Samples ◽  
Ocular Signs

The aim of this study was to assess the seroprevalence of human toxocariasis in three Andean communities from the Northeast of Lima, Peru. A total of 303 subjects including children and adults were studied and blood samples were collected to detect anti-Toxocara antibodies by ELISA-IgG test and by hematological examination; stool samples were collected also for parasitological examination. The overall seroprevalence of toxocariasis observed in the total population was 20.46%, with a significant high proportion in children from one to 10 years old (p = 0.034). Among the subjects with positive serology, 32.26% of them had respiratory disturbances, 22.58% hepatomegaly, 17.74% ocular signs or symptoms, 14.51% abdominal pain, 9.68% neurological involvement, and 4.84% cutaneous signs, but none of these clinical features were associated to a positive serology by multivariate analysis. Furthermore, 79.03% of seropositive subjects also harbored at least one intestinal parasite, which was associated to a positive serology (p < 0.05). The presence of pets within the houses, a previous history of pica or geophagia and the use of public places were also present in this population, but only the latter was associated to the serology (p < 0.05). In conclusion, clinical, serological, and epidemiological evidences for larval Toxocara infection were found in the studied population.

VIRAL HEPATITIS MARKERS IN BLOOD DONORS WITH HISTORY OF JAUNDICE

The Lancet ◽  
1980 ◽  
Vol 315 (8168) ◽  
pp. 595-596 ◽  
Author(s):  
R.S. Tedder ◽  
C.H. Cameron ◽  
J.A.J. Barbara ◽  
D. Howell
Keyword(s):  
Viral Hepatitis ◽  
Blood Donors ◽  
History Of
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