scholarly journals Canine papillomatosis: a retrospective study of 24 cases (2001-2011) and immunohistochemical characterization

2012 ◽  
Vol 32 (7) ◽  
pp. 653-657 ◽  
Author(s):  
Matheus V. Bianchi ◽  
Renata A. Casagrande ◽  
Tatiane T.N. Watanabe ◽  
Angelica T.B. Wouters ◽  
Flademir Wouters ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Stratum Corneum ◽  
Granular Layer ◽  
Histological Evaluation ◽  
Cell Nuclei ◽  
Viral Particles ◽  
Mixed Breed ◽  
Positive Immunostaining ◽  
Epithelial Lesions ◽  
Spinous Layer

A retrospective study of 24 cases of papillomas in dogs was performed from January 2001 to March 2011. Additionally, immunohistochemistry (IHC) was used to characterize and evaluate the samples. We found that disease was observed more in mixed breed dogs, ages ranging from 6 months to 10 years (mean 3.1 years), and there was no gender predilection. The main lesion sites were the skin (75%), lips (16.7%), and eyelids (8.3%). Upon histological evaluation, we observed papillary exophytic proliferation of squamous epithelium and papillary endophytic proliferation (inverted) in 87.5% and 12.5% of cases, respectively. The tumors were characterized by spinous layer hyperplasia (87.5%) with koilocytes (70.8%) and intranuclear pale basophilic inclusions bodies (8.3%), prominent granular layer with large amounts of keratohyalin granules (95.8%), and hyperkeratosis in the stratum corneum (100%). Positive immunostaining for Papillomavirus was found in 83.3% of cases, which were distributed between the granular layer and the stratum corneum. These findings indicate the following: that papillomas in dogs are caused by Papillomavirus, the viral cytopathic effect induces epithelial lesions, viral particles are found inside the cell nuclei, and inclusions bodies are rare.

A Retrospective Study of Dogs Infected with Ehrlichia canis from 2017-2019 in the Thonburi Area of Bangkok Province, Thailand

2020 ◽  
Keyword(s):  
Body Weight ◽  
Retrospective Study ◽  
Liver Enzymes ◽  
Serum Biochemistry ◽  
Ehrlichia Canis ◽  
Housing System ◽  
Housing Systems ◽  
Mixed Breed ◽  
Canine Monocytic Ehrlichiosis ◽  
Open Housing

Ehrlichia canis is a tick-borne rickettsia. It can cause canine monocytic ehrlichiosis (CME). Infected dogs are often reported to have changes in their blood values, such as anemia, thrombocytopenia, increased liver enzymes, and increased kidney function values. This study aimed to collect data that may be related to infected dogs, including age, gender, breed, weight, close-open housing system, the use of ectoparasiticides products. The sample comprised 57 infected dogs. Collecting hematology and serum biochemistry changes in comparison with the reference values of dogs detected with Ehrlichia canis from 2017-2019, Thonburi District, Bangkok, Thailand was also carried out. In summary, dogs infected with Ehrlichia canis mostly included mixed-breed dogs aged between 1 and 10 years. There were no differences in body weight or housing systems. Dogs that had never used ectoparasiticide products or used them intermittently were infected more often (by 7.14 times) than protected. Clinical hematology and serum biochemistry found anemia, thrombocytopenia, and increased liver enzymes.

Expression of corneodesmosin in the granular layer and stratum corneum of normal and diseased epidermis

1997 ◽  
Vol 137 (6) ◽  
pp. 864-873 ◽  
Author(s):  
M. HAFTEK ◽  
M. SIMON ◽  
J. KANITAKIS ◽  
S. MARECHAL ◽  
A. CLAUDY ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Granular Layer

scholarly journals Caveolae Are Involved in the Trafficking of Mouse Polyomavirus Virions and Artificial VP1 Pseudocapsids toward Cell Nuclei

2001 ◽  
Vol 75 (22) ◽  
pp. 10880-10891 ◽  
Author(s):  
Zuzana Richterová ◽  
David Liebl ◽  
Martin Horák ◽  
Zdena Palková ◽  
Jitka Štokrová ◽  
...  
Keyword(s):  
Viral Particle ◽  
Stress Fibers ◽  
Particle Movement ◽  
Cell Nuclei ◽  
Membrane Structures ◽  
Caveolin 1 ◽  
Strong Signal ◽  
Artificial Virus ◽  
Viral Particles ◽  
Perinuclear Area

ABSTRACT Electron and confocal microscopy were used to observe the entry and the movement of polyomavirus virions and artificial virus-like particles (VP1 pseudocapsids) in mouse fibroblasts and epithelial cells. No visible differences in adsorption and internalization of virions and VP1 pseudocapsids (“empty” or containing DNA) were observed. Viral particles entered cells internalized in smooth monopinocytic vesicles, often in the proximity of larger, caveola-like invaginations. Both “empty” vesicles derived from caveolae and vesicles containing viral particles were stained with the anti-caveolin-1 antibody, and the two types of vesicles often fused in the cytoplasm. Colocalization of VP1 with caveolin-1 was observed during viral particle movement from the plasma membrane throughout the cytoplasm to the perinuclear area. Empty vesicles and vesicles with viral particles moved predominantly along microfilaments. Particle movement was accompanied by transient disorganization of actin stress fibers. Microfilaments decorated by the VP1 immunofluorescent signal could be seen as concentric curves, apparently along membrane structures that probably represent endoplasmic reticulum. Colocalization of VP1 with tubulin was mostly observed in areas close to the cell nuclei and on mitotic tubulin structures. By 3 h postinfection, a strong signal of the VP1 (but no viral particles) had accumulated in the proximity of nuclei, around the outer nuclear membrane. However, the vast majority of VP1 pseudocapsids did not enter the nuclei.

scholarly journals A case of symmetric keratoderma with pronounced changes in the autonomic nervous system

1937 ◽  
Vol 33 (11) ◽  
pp. 1381-1383
Author(s):  
A. M. Leizerovsky
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Stratum Corneum ◽  
Granular Layer ◽  
Pathological Process ◽  
Basal Cells ◽  
Autonomic Nervous ◽  
Actual Impact ◽  
Chemical Factors ◽  
Physical And Chemical

The epidermis, as you know, throughout the life of the organism undergoes constant transformation: from the multiplication of basal cells, through the malpighian layer to the granular layer and, finally, to the stratum corneum, consisting of lamellar cells devoid of nucleus and protoplasm, physiologically always undergoing desquamation ... Moderate thickening of the stratum corneum of the palms and soles, as a result of the actual impact on these areas of various physical and chemical factors, is not always a pathological process.

A Case Series of 25 Dogs with Chondrosarcoma

1992 ◽  
Vol 05 (01) ◽  
pp. 13-17 ◽  
Author(s):  
Marina Brash ◽  
M. A. O. Atilola ◽  
Joanne Cockshutt ◽  
Anne Sylvestre
Keyword(s):  
Survival Rates ◽  
Case Series ◽  
Prognostic Indicator ◽  
Histological Evaluation ◽  
Histological Grading ◽  
Survival Times ◽  
Diagnostic Features ◽  
Mixed Breed ◽  
Radiographic Changes ◽  
Made In

SummaryThe purpose of this study was to examine clinical, radiographic and histological features as well as post-diagnosis survival times of 25 dogs with chrondrosarcoma (CS). The diagnoses were made on histological evaluation of surgical biopsies or post-mortem specimens. Mixed breed dogs were found to be at higher risk.Chondrosarcoma of the proximal humerus was the most difficult to diagnose, clinically resembling a nerve sheath tumour and offering few gross abnormalities or radiographic changes. Chrondrosarcoma was transarticular in one case.The histological grading used was not well correlated with survival times; location of the CS seemed to be a better indicator of prognosis. Dogs with CS on a limb had the best survival rates, whereas those with CS of the vertebrae had the worst outcome. Surgery was beneficial in the cases of CS located on facial bones and limbs.The purpose of this paper was to examine the clinical and diagnostic features and survival rates of dogs with chondrosarcoma (CS). Histological diagnoses were made in all cases, mixed breeds were over represented. The location of the tumour was a better prognostic indicator than the histological grading. Dogs with CS on a limb had the longest survival times.

Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis

1991 ◽  
Vol 96 (5) ◽  
pp. 666-672 ◽  
Author(s):  
Elizabeth H. Hamilton ◽  
Richard E. Payne ◽  
Edward J. O'keefe
Keyword(s):  
Stratum Corneum ◽  
Granular Layer ◽  
Human Epidermis ◽  
Normal Human

scholarly journals Proliferative activity of the epithelium in squamous epithelial lesions of the cervix

2021 ◽  
Vol 50 (1) ◽  
pp. 34-36
Author(s):  
I. B. Manukhin ◽  
G. .N. Minkina
Keyword(s):  
Proliferative Activity ◽  
Cell Nuclei ◽  
Squamous Intraepithelial Lesion ◽  
Low Degree ◽  
Stratified Squamous Epithelium ◽  
Intraepithelial Lesion ◽  
Epithelial Lesions ◽  
High Degree ◽  
Proliferating Cell

As a criterion for precancerous changes in the stratified squamous epithelium of the cervix, its proliferative activity, studied using monoclonal antibodies PC-10 to the antigen of proliferating cell nuclei (PCNA), is considered. The results of the studies showed that patients with a low degree of squamous intraepithelial lesion are characterized by weak proliferative activity, and for patients with a high degree of lesion it is moderate and pronounced. An increase in proliferative activity is a prognostic factor that determines long-term persistence and the likely progression of the lesion.

Outcomes of Dogs Presented for Cataract Evaluation: A Retrospective Study

2005 ◽  
Vol 41 (4) ◽  
pp. 235-240 ◽  
Author(s):  
Elizabeth A. Adkins ◽  
Diane V.H. Hendrix
Keyword(s):  
Retrospective Study ◽  
Cataract Surgery ◽  
Retinal Degeneration ◽  
Common Reason ◽  
Odds Ratios ◽  
Cocker Spaniel ◽  
University Of Tennessee ◽  
Mixed Breed ◽  
The University ◽  
Purebred Dogs

Two hundred and forty-four dogs were evaluated for cataracts at the University of Tennessee from January 2001 to December 2002. Fifty-four canine breeds were affected. Odds ratios for cataracts were significantly higher for six purebred dogs (including the cocker spaniel, miniature schnauzer, toy poodle, Boston terrier, miniature poodle, and bichon frise) compared with mixed-breed dogs. One hundred fifty-nine dogs did not have cataract surgery. The most common reason for dogs not having surgery was retinal degeneration (n=66).

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