scholarly journals Use of light-cured resin to manufacture occlusal splints: report of two cases

2012 ◽  
Vol 23 (4) ◽  
pp. 457-460 ◽  
Author(s):  
Mieszko Więckiewicz ◽  
Marta Miernik ◽  
Włodzimierz Więckiewicz
Keyword(s):  
Clinical Practice ◽  
Rapid Development ◽  
Dental Materials ◽  
Daily Clinical Practice ◽  
Functional Disorders ◽  
Practical Application ◽  
The Past ◽  
Occlusal Splints ◽  
Stomatognathic System ◽  
Different Types

This article presents selected cases of patients with functional disorders of the stomatognathic system. This group of patients had a need to made different types of removable occlusal splints. In the past, occlusal appliances were made mostly using self-cured acrylate materials, which for many years had no replacements. The rapid development of dental materials technology led to creation of thermo-formable materials and resins, which can successfully replace traditional acrylic materials in daily clinical practice. A practical application of light-cured resin in the fabrication of the occlusal splints in two clinical cases is reported and discussed herein.

The CSF p-tau181/Aβ42 Ratio Offers a Good Accuracy “In Vivo” in the Differential Diagnosis of Alzheimer’s Dementia

2019 ◽  
Vol 16 (7) ◽  
pp. 587-595 ◽  
Author(s):  
Roberto Santangelo ◽  
Alessandro Dell'Edera ◽  
Arianna Sala ◽  
Giordano Cecchetti ◽  
Federico Masserini ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Diagnosis ◽  
Fdg Pet ◽  
Amyloid Β ◽  
Cost Effective ◽  
Daily Clinical Practice ◽  
Different Types ◽  
Experimental Trials ◽  
Csf Findings

Background: The incoming disease-modifying therapies against Alzheimer’s disease (AD) require reliable diagnostic markers to correctly enroll patients all over the world. CSF AD biomarkers, namely amyloid-β 42 (Aβ42), total tau (t-tau), and tau phosphorylated at threonine 181 (p-tau181), showed good diagnostic accuracy in detecting AD pathology, but their real usefulness in daily clinical practice is still a matter of debate. Therefore, further validation in complex clinical settings, that is patients with different types of dementia, is needed to uphold their future worldwide adoption. Methods: We measured CSF AD biomarkers’ concentrations in a sample of 526 patients with a clinical diagnosis of dementia (277 with AD and 249 with Other Type of Dementia, OTD). Brain FDG-PET was also considered in a subsample of 54 patients with a mismatch between the clinical diagnosis and the CSF findings. Results: A p-tau181/Aβ42 ratio higher than 0.13 showed the best diagnostic performance in differentiating AD from OTD (86% accuracy index, 74% sensitivity, 81% specificity). In cases with a mismatch between clinical diagnosis and CSF findings, brain FDG-PET partially agreed with the p-tau181/Aβ42 ratio, thus determining an increase in CSF accuracy. Conclusions: The p-tau181/Aβ42 ratio alone might reliably detect AD pathology in heterogeneous samples of patients suffering from different types of dementia. It might constitute a simple, cost-effective and reproducible in vivo proxy of AD suitable to be adopted worldwide not only in daily clinical practice but also in future experimental trials, to avoid the enrolment of misdiagnosed AD patients.

scholarly journals A fogászati implantátumok csontbeépülését befolyásoló „klasszikus” tényezők változásai az elmúlt évtizedekben

2019 ◽  
Vol 160 (37) ◽  
pp. 1455-1463
Author(s):  
Ferenc Koppány ◽  
Kinga Bérczy ◽  
Kinga Körmöczi ◽  
Zsolt Németh
Keyword(s):  
Clinical Practice ◽  
Surgical Technique ◽  
Inorganic Material ◽  
Clinical Success ◽  
Basic Research ◽  
Daily Clinical Practice ◽  
Functional Connection ◽  
The Past ◽  
Bone Integration ◽  
Material Form

Abstract: Nowadays, it is almost naturally taken among dentists that seemed unimaginable a few decades ago, namely that an inorganic material (titanium) inserted in an organic environment (bone) can be integrated and become a permanent pillar of prosthetics. Bone integration – meaning a structural and functional connection between the implant and the bone – itself was discovered and described in the late 1960s. This provides the basis of dental implantology. In those days, the conditions affecting the positive or negative course of bone integration have been formulated. This process is investigated at the level of basic research and rarely mentioned in the daily clinical practice. The material, form, and surface of the implant all contribute to success if we design well and apply the correct surgical technique. Our goal is to present the changes that have taken place over the past decades, which have resulted in an increasingly perfect integration and clinical success of implants. Orv Hetil. 2019; 160(37): 1455–1463.

Thermal Transport Across Carbon Nanotube Connected by Molecular Linkers

2011 ◽  
Author(s):  
Jun Liu ◽  
Mohamed Alhashme ◽  
Ronggui Yang
Keyword(s):  
Thermal Transport ◽  
Large Scale ◽  
Normal Modes ◽  
Thermal Conductance ◽  
Nonequilibrium Molecular Dynamics ◽  
Practical Application ◽  
The Past ◽  
Interfacial Thermal Conductance ◽  
Macro Scale ◽  
Different Types

Carbon nanotubes (CNTs) have been reported to have excellent thermal and mechanical properties over the past two decades. However, the practical application of CNT-based technologies has been limited, due to the inability to transform the excellent properties of single CNTs into macroscopic applications. CNT network structure connects CNTs and can be possibly scaled up to macro-scale CNT-based application. In this paper, nonequilibrium molecular dynamics is applied to investigate thermal transport across two CNTs connected longitudinally by molecular linkers. We show the effect of different types and lengths of molecular linkers on interfacial thermal conductance. We also analyze the density of vibrational normal modes to further understand the interfacial thermal conductance between different molecular linkers and CNTs. These results provide guidance for choosing molecular linkers to build up large-scale CNT-based network structures.

scholarly journals THE IMPACT OF NEW TARGETING METHODS IN THE CANCER THERAPY

2019 ◽  
pp. 1-6
Author(s):  
ZAKARIYA AL-MASHHADANI ◽  
RUA A. NASER ◽  
MUNAF H. ZALZALA
Keyword(s):  
Cancer Therapy ◽  
Literature Review ◽  
Information Sources ◽  
Rapid Development ◽  
Malignant Cell ◽  
Cancer Targeting ◽  
The Past ◽  
Toxic Drug ◽  
Different Types ◽  
The Impact

Rapid development has achieved in treating tumor to stop malignant cell growth and metastasis in the past decade. Numerous researches have emerged to increase potency and efficacy with novel methods for drug delivery. The main objective of this literature review was to illustrate the impact of current new targeting methods to other previous delivering systems to select the most appropriate method in cancer therapy. This review first gave a brief summary of cancer structure and highlighted the main roles of targeting systems. Different types of delivering systems have been addressed in this literature review with focusing on the latest carrier derived from malarial protein. The remarkable advantages and main limitations of the later have been also discussed. PubMed and Science Direct were the main search engines that have been used as information sources to prepare this review. Articles related to cancer targeting system, active and passive processes, current nanoparticles, antibody carriers, and current novel cancer carriers were used as sources in this review. Important points from many references published in the last decade (2008-2018) were selected and included. Several targeting methods were introduced to enhance the efficacy and tolerability of the toxic drug by active and passive processes, but there is still no conclusive carrier without certain drawbacks. A combination of targeting methods probably shows the most appropriate choice for increasing selectivity and safety of anticancer drugs via reducing the concentration of carriers used.

Disease activity–based management of rheumatoid arthritis in Dutch daily clinical practice has improved over the past decade

2020 ◽  
Vol 39 (4) ◽  
pp. 1131-1139
Author(s):  
Marieke J. Spijk-de Jonge ◽  
Julia M. Weijers ◽  
Laura W. M. Boerboom ◽  
Anita M. P. Huis ◽  
Femke Atsma ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Disease Activity ◽  
Daily Clinical Practice ◽  
The Past

Treatment of epilepsy in daily clinical practice: have outcomes improved over the past 10 years?

2013 ◽  
Vol 260 (11) ◽  
pp. 2736-2743 ◽  
Author(s):  
Merel Wassenaar ◽  
Inger Heijl ◽  
Frans S. S. Leijten ◽  
Paul Linden ◽  
Sabine G. Uijl ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Daily Clinical Practice ◽  
The Past ◽  
Treatment Of Epilepsy

Study of the Molecular Architecture of Keratin Filaments by Electron Microscopy

1982 ◽  
Vol 40 ◽  
pp. 118-119
Author(s):  
U. Aebi ◽  
P. Rew ◽  
T.-T. Sun
Keyword(s):  
Electron Microscopy ◽  
Structural Organization ◽  
Cell Types ◽  
Structural Features ◽  
Molecular Architecture ◽  
The Past ◽  
Keratin Filaments ◽  
Different Types ◽  
10 Nm Filaments ◽  
Different Cell Types

Various types of intermediate-sized (10-nm) filaments have been found and described in many different cell types during the past few years. Despite the differences in the chemical composition among the different types of filaments, they all yield common structural features: they are usually up to several microns long and have a diameter of 7 to 10 nm; there is evidence that they are made of several 2 to 3.5 nm wide protofilaments which are helically wound around each other; the secondary structure of the polypeptides constituting the filaments is rich in ∞-helix. However a detailed description of their structural organization is lacking to date.

“Bridging Gaps – Improving Outcomes”: Problem domains in schizophrenia research, treatment and policy

2016 ◽  
Vol 13 (03) ◽  
pp. 118-120
Author(s):  
W. Wölwer ◽  
W. Gaebel ◽  
V. Toeller
Keyword(s):  
Clinical Practice ◽  
Mental Healthcare ◽  
Knowledge Gaps ◽  
Everyday Clinical Practice ◽  
Treatment Gaps ◽  
Different Types

Summary Background: The provision of mental healthcare for patients with schizophrenia is still characterized both by knowledge gaps and by treatment gaps in everyday clinical practice. Aim: This article discusses the different types of treatment gaps in schizophrenia and describes actions taken to overcome these gaps especially in Europe.

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