Determination of Facial Symmetry in Unilateral Cleft Lip and Palate Patients from Three-Dimensional Data: Technical Report and Assessment of Measurement Errors

2006 ◽  
Vol 43 (2) ◽  
pp. 129-137 ◽  
Author(s):  
Emeka Nkenke ◽  
Bernhard Lehner ◽  
Manuel Kramer ◽  
Gerd Haeusler ◽  
Stefanie Benz ◽  
...  
Keyword(s):  
Measurement Errors ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Intraclass Correlation ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Intraclass Correlation Coefficients ◽  
Surface Areas ◽  
Technical Report

Objective To assess measurement errors of a novel technique for the three-dimensional determination of the degree of facial symmetry in patients suffering from unilateral cleft lip and palate malformations. Design Technical report, reliability study. Setting Cleft Lip and Palate Center of the University of Erlangen-Nuremberg, Erlangen, Germany. Patients The three-dimensional facial surface data of five 10-year-old unilateral cleft lip and palate patients were subjected to the analysis. Distances, angles, surface areas, and volumes were assessed twice. Main Outcome Measures Calculations were made for method error, intraclass correlation coefficient, and repeatability of the measurements of distances, angles, surface areas, and volumes. Results The method errors were less than 1 mm for distances and less than 1.5° for angles. The intraclass correlation coefficients showed values greater than .90 for all parameters. The repeatability values were comparable for cleft and noncleft sides. Conclusion The small method errors, high intraclass correlation coefficients, and comparable repeatability values for cleft and noncleft sides reveal that the new technique is appropriate for clinical use.

scholarly journals The Slavcleft: a three-center study of the outcome of treatment of cleft lip and palate. Nasolabial appearance

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10631
Author(s):  
Adam Stebel ◽  
Wanda Urbanová ◽  
Irena Klimova ◽  
Andrzej Brudnicki ◽  
Ivana Dubovska ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Intraclass Correlation ◽  
Surgical Techniques ◽  
Correlation Coefficients ◽  
Group Differences ◽  
Treatment Protocols ◽  
Intraclass Correlation Coefficients ◽  
Numeric Scale

Background There is a multitude of protocols of treatment of cleft lip and palate (CLP) worldwide differing in number of operations, surgical techniques, and timings of surgeries. Despite, facial appearance in subjects with CLP is rarely ideal and residual stigmata are easy to notice in many patients irrespective of the protocol. The prospective controlled investigations are optimal for comparing effectiveness of treatment protocols. Because prospective studies are very challenging to perform in CLP field, it is reasonable to retrospectively assess different surgical protocols to identify the promising ones and then to test them in a prospective way. Methods Our objective was to assess the nasolabial appearance in a preadolescent Slavic population with unilateral cleft lip and palate (UCLP) by using the 0–200 numeric scale with reference photographs. Patients treated in Warsaw, Poland (n = 32), Prague, Czech Republic (n = 26) and Bratislava, Slovakia (n = 17) were included in this retrospective study. Each cleft center used a unique surgical protocol. Two panels of professional raters (n = 7) and laypeople (n = 10) scored blindly the nasolabial esthetics on cropped frontal and profile images with cropped reference photograph present on the same slide. Intra- and inter-rater agreement was assessed with Cronbach’s alpha, intraclass correlation coefficients, t-tests, and Bland–Altman plots. Inter-group differences were evaluated with one-way ANOVA and regression analysis. Results The agreement within and between raters was acceptable. We found that patients treated in Warsaw, Prague, and Bratislava showed comparable nasolabial appearance on frontal and profile photographs when judged by both professional raters (p > 0.05) and laypeople (p > 0.05). Regression analysis did not identify influence of gender, group (i.e., Warsaw, Prague, and Bratislava), age at lip repair, surgeon, and age at photographic assessment on esthetic outcome (p > 0.05). Conclusion This study showed that none of the surgical protocols showed superiority to produce good nasolabial appearance.

scholarly journals Is There a Correlation Between Nasolabial Appearance and Dentoalveolar Relationships in Patients With Repaired Unilateral Cleft Lip and Palate?

2019 ◽  
Vol 57 (1) ◽  
pp. 21-28
Author(s):  
Tara V. N. Lee ◽  
Anthony J. Ireland ◽  
Nikki E. Atack ◽  
Scott A. Deacon ◽  
Timothy E. M. Jones ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Outcome Measure ◽  
Cleft Lip And Palate ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Poor Agreement ◽  
Intraclass Correlation Coefficients ◽  
Dental Hospital ◽  
The Aesthetic ◽  
University Of Bristol

Objective: To determine whether a relationship exists between the aesthetic scores given to photographic records of the nasolabial region of patients with repaired unilateral cleft lip and palate (UCLP) and the 5-Year Olds’ Index scores of study models for the same participants. Design: Retrospective study. Setting: University of Bristol Dental Hospital, United Kingdom. Participants: Patients with nonsyndromic UCLP previously enrolled in the Cleft Care UK (CCUK) Study. Methods: The CCUK participants, who had both study models and photographs (frontal and worm’s eye view), were identified and their records retrieved. These were rated by 2 consultants and 2 senior registrars in orthodontics. The 5-Year Olds’ Index was used to score the study models, and at a separate sitting, a 5-point Likert scale was used to score the cropped frontal and worm’s eye view photographs of the same children. The results were analyzed using intraclass correlation coefficients and Cohen κ. Main Outcome Measures: Correlation between the aesthetic scores of the photographic views and the concordant 5-Year Olds’ Index scores of the study models. Results: The intraclass correlation coefficient scores showed very poor agreement between the photographic views and their concordant study models. The level of inter- and intra-rater reliability was strongest when scoring the study models. Conclusions: There was no agreement between the scores given to various photographic views and their corresponding study models. Scoring the study models using the 5-Year Olds’ Index was the most reliable outcome measure for this age-group.

Comparison of Three Methods of Rating Nasolabial Appearance in Cleft Lip and Palate

2017 ◽  
Vol 54 (4) ◽  
pp. 400-407 ◽  
Author(s):  
Sylwia A. Fudalej ◽  
Dries Desmedt ◽  
Ewald Bronkhorst ◽  
Piotr S. Fudalej
Keyword(s):  
Analogue Scale ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Intraclass Correlation Coefficients ◽  
Numerical Scale ◽  
Profile View ◽  
Continuous Scale ◽  
University Of Bern

Objective To investigate which of three methods of rating nasolabial appearance—esthetic index, visual analogue scale (VAS), or numerical scale with reference photographs—is optimal. Design Experimental study. Setting Radboud University Medical Centre, The Netherlands and University of Bern, Switzerland. Subjects and Methods Cropped photographs of 60 patients with complete unilateral cleft lip and palate (mean age = 10.8 years) were used for rating. A panel of eight raters rated four components of nasolabial morphology (nasal shape, nose deviation, vermillion border, and profile view) using three methods: 5-point esthetic index, 100 mm VAS, and 0 to 200 numerical scale with reference photographs (reference scores method). Method reliability was assessed by re-evaluation of 20 images after >1 month. Intraclass correlation coefficients were calculated to evaluate consistency of each method. Results Overall reference scores method always produced more reproducible results (i.e., higher ICCs) than did VAS or the esthetic index. However, statistically significant differences were found between reference scores and esthetic index in rating nasal shape, nose deviation, and vermillion border only ( P < 0.001, <0.001, and 0.012, respectively) and between reference scores and VAS in rating nose deviation and vermillion border ( P < 0.001 and 0.017, respectively). Conclusion We recommend the use of reference photographs along with the VAS or numerical (from 0 to 200) semi-continuous scale. The esthetic index, based on a Likert-type scale, seems to produce the most variable results and, therefore, is not preferred.

scholarly journals Automatic 3D dense phenotyping provides reliable and accurate shape quantification of the human mandible

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pieter-Jan Verhelst ◽  
H. Matthews ◽  
L. Verstraete ◽  
F. Van der Cruyssen ◽  
D. Mulier ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Intraclass Correlation ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Surface Registration ◽  
Anatomical Landmarks ◽  
Centroid Size ◽  
Intraclass Correlation Coefficients ◽  
Total Variability ◽  
Automatic Phenotyping

AbstractAutomatic craniomaxillofacial (CMF) three dimensional (3D) dense phenotyping promises quantification of the complete CMF shape compared to the limiting use of sparse landmarks in classical phenotyping. This study assesses the accuracy and reliability of this new approach on the human mandible. Classic and automatic phenotyping techniques were applied on 30 unaltered and 20 operated human mandibles. Seven observers indicated 26 anatomical landmarks on each mandible three times. All mandibles were subjected to three rounds of automatic phenotyping using Meshmonk. The toolbox performed non-rigid surface registration of a template mandibular mesh consisting of 17,415 quasi landmarks on each target mandible and the quasi landmarks corresponding to the 26 anatomical locations of interest were identified. Repeated-measures reliability was assessed using root mean square (RMS) distances of repeated landmark indications to their centroid. Automatic phenotyping showed very low RMS distances confirming excellent repeated-measures reliability. The average Euclidean distance between manual and corresponding automatic landmarks was 1.40 mm for the unaltered and 1.76 mm for the operated sample. Centroid sizes from the automatic and manual shape configurations were highly similar with intraclass correlation coefficients (ICC) of > 0.99. Reproducibility coefficients for centroid size were < 2 mm, accounting for < 1% of the total variability of the centroid size of the mandibles in this sample. ICC’s for the multivariate set of 325 interlandmark distances were all > 0.90 indicating again high similarity between shapes quantified by classic or automatic phenotyping. Combined, these findings established high accuracy and repeated-measures reliability of the automatic approach. 3D dense CMF phenotyping of the human mandible using the Meshmonk toolbox introduces a novel improvement in quantifying CMF shape.

scholarly journals Interday Reliability and Usefulness of a Reactive Strength Index Derived From 2 Maximal Rebound Jump Tests

2019 ◽  
Vol 14 (9) ◽  
pp. 1200-1204
Author(s):  
Thomas M. Comyns ◽  
Eamonn P. Flanagan ◽  
Sean Fleming ◽  
Evan Fitzgerald ◽  
Damian J. Harper
Keyword(s):  
Female Athletes ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Strength Index ◽  
Warm Up ◽  
Intraclass Correlation Coefficients ◽  
Jump Test ◽  
Moderate Change ◽  
Familiarization Session

Purpose: To examine the interday reliability and usefulness of a reactive strength index (RSI) derived from a maximal 5-rebound jump test (5max RJT) and a maximal 10-rebound jump test (10/5 RJT). Methods: Twenty male field-sport athletes (24.5 [3.0] y, 1.78 [0.1] m, 84.9 [5.2] kg) and 15 female participants (21.1 [0.9] y, 1.65 [0.73] m, 62.0 [5.1] kg) performed 2 maximal repetitions of the 5max RJT and the 10/5 RJT on 2 testing days after a specific warm-up. A 1-wk period separated testing days, and these sessions were preceded by a familiarization session. RSI was calculated by dividing jump height (in meters) by contact time (in seconds). The 5max RJT and the 10/5 RJT trial with the highest RSI on each testing day were used for reliability and usefulness analysis. Results: Both tests were deemed reliable for determining RSI for male, female, and pooled male and female cohorts, as the intraclass correlation coefficients were ≥.80 and the coefficient of variation was ≤10%. Only the 5max RJT was rated as “good” at detecting the smallest worthwhile change in performance for female athletes (smallest worthwhile change: 0.10 > typical error: 0.07). The 5max RJT for men and the 10/5 RJT for men and women were rated “good” in detecting a moderate change in performance only. Conclusions: Both tests are reliable for the determination of RSI, but the usefulness of the tests in detecting the smallest worthwhile change is questionable.

scholarly journals Integration of digital maxillary dental casts with 3D facial images in orthodontic patients:

2019 ◽  
Vol 90 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Zhuoxing Xiao ◽  
Zijin Liu ◽  
Yan Gu
Keyword(s):  
Intraclass Correlation ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Reference Standards ◽  
Clinical Diagnostics ◽  
Step Method ◽  
Intraclass Correlation Coefficients ◽  
Orthodontic Patients ◽  
Facial Images ◽  
Dental Casts

ABSTRACT Objective To evaluate three-dimensional (3D) accuracy and reliability of nonradiographic dentofacial images integrated with a two-step method. Methods 3D facial images, cone-beam computed tomography (CBCT) images and digital maxillary dental casts were obtained from 20 pre-orthodontic subjects. Digital dental casts were integrated into 3D facial images using a two-step method based on the anterior tooth area. 3D coordinate values of five dental landmarks were identified in both dentofacial images and CBCT images. The accuracy of the integration method was assessed with paired t-tests between dentofacial images and CBCT-based reference standards. Intraclass correlation coefficients (ICCs) were assessed for the reliability of dentofacial images and CBCT-based images. Analysis of variance and Kruskal-Wallis tests evaluated the accuracy of the method in different dimensions. Results There was no statistical difference between dentofacial images and CBCT reference standards in both translational and rotational dimensions (P &gt; .05). Translational mean absolute errors for full dentitions were within 0.42 mm and ICCs were over 0.998 in x, y, and z directions. Rotational mean absolute errors for full dentitions were within 0.92° and ICCs over 0.734 in pitch, yaw, and roll orientations. Integration errors were significantly greater in the first molar, z-translation, and pitch rotation (P &lt; .05). Conclusions Integrating 3D dentofacial images with the two-step method is precise and acceptable for clinical diagnostics and scientific purposes. Errors were greater in the molar region, z-translation, and pitch rotation.

scholarly journals Measurement of Cortical Dopamine D1 Receptor Binding with [11C]SCH 23390: A Test–Retest Analysis

2001 ◽  
Vol 21 (10) ◽  
pp. 1146-1150 ◽  
Author(s):  
Jussi Hirvonen ◽  
Kjell Någren ◽  
Jaana Kajander ◽  
Jarmo Hietala
Keyword(s):  
Sch 23390 ◽  
Intraclass Correlation ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
D1 Receptor ◽  
Binding Potential ◽  
Intraclass Correlation Coefficients ◽  
Cortical Areas ◽  
Scan Time ◽  
Positron Emission

[11C]SCH 23390 is a standard ligand for positron emission tomography (PET) studies on striatal dopamine D1 receptors. Its usefulness for cortical D1 receptor quantification in human PET studies has been questioned but has not been addressed previously. The authors tested the reproducibility of [11C]SCH 23390 binding potential (BP) in cortical areas in five healthy volunteers using three-dimensional PET. Measurement of D1 receptor BP was reproducible in basal ganglia, as well as in all cortical areas studied (intraclass correlation coefficients between 0.81 and 0.92). The absolute variability in cortical areas was 9.21% ± 0.07%. The reproducibility of cortical D1 receptor BP measurement with [11C]SCH 23390 is equal to that observed with a more recent D1 -ligand, [11C]NNC 112. [11C]NNC 112 produces slightly higher specific-to-nonspecific binding ratios but has markedly slower kinetics resulting in a need for a longer scan time. These aspects should be considered when designing studies on the cortical D1 -like receptors.

Genetic variation in the quantitative levels of an NADP (H)-binding protein (FX) in human erythrocytes

Blood ◽  
1981 ◽  
Vol 57 (2) ◽  
pp. 209-217 ◽  
Author(s):  
L Lenzerini ◽  
U Benatti ◽  
A Morelli ◽  
S Pontremoli ◽  
A De Flora ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Preliminary Data ◽  
Binding Protein ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Red Cell ◽  
Genetic Origin ◽  
Intraclass Correlation Coefficients ◽  
The Individual

Abstract FX is a red cell NADP(H)-binding protein that has been well defined biochemically and immunologically but whose function is still unknown. Preliminary data indicated that the levels of this protein are significantly increased in hemizygotes, heterozygotes, and homozygotes for the G6PD Mediterranean mutant, thus raising the question of whether or not the individual variation in FX levels is more or less directly influenced by X-linked genes. The present study, based on a large series of population and family data collected in Sardinia, confirms unequivocally the above mentioned interaction, but shows at the same time that the variances in FX levels “between sibships” are 2–3 times larger than those “within sibships,” when the analysis is done separately for the G6PD-normal or the G6PD-deficient sibs. From the comparison of the interclass and intraclass correlation coefficients, it appears that about 60% of the total variation of FX is of genetic origin. Moreover, the FX levels of children, analyzed in a pairwise manner, were found to be more positively correlated with those of their fathers (r = 0.39) than with those of their maternal grandfathers (0.20). This latter finding obviously favors the conclusion that “autosomal”; rather than “X-linked” genes are involved in the determination of the FX levels.

scholarly journals Reproducibility and reliability of three-dimensional soft tissue landmark identification using three-dimensional stereophotogrammetry

2016 ◽  
Vol 86 (6) ◽  
pp. 1004-1009 ◽  
Author(s):  
Asli Baysal ◽  
Ahmet Oguz Sahan ◽  
Mehmet Ali Ozturk ◽  
Tancan Uysal
Keyword(s):  
Soft Tissue ◽  
Statistical Significance ◽  
Intraclass Correlation ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Intraclass Correlation Coefficients ◽  
Paired Samples ◽  
Landmark Identification ◽  
The Difference ◽  
Intraexaminer Reliability

ABSTRACT Objective: To evaluate the intraexaminer repeatability and interexaminer reproducibility of soft tissue landmarks on three-dimensional (3-D) stereophogrammetric images. Materials and Methods: Thirty-four stereophotogrammetric images were taken and 19 soft tissue points were identified. The images were obtained using the 3-DMD Face (3-DMD TM Ltd, Atlanta, Ga) system. Two examiners marked 34 images manually with a mouse-driven cursor 4 weeks apart. Intraexaminer marking differences were calculated and classified as &lt;0.5 mm, 0.5–1 mm, and &gt;1 mm. Intraclass correlation coefficients were calculated for intraexaminer reliability. A paired-samples t-test was used to evaluate the difference between the examiners. Interexaminer reproducibility was evaluated by kappa analysis. Statistical significance was set at P &lt; .05. Results: Only one landmark (labiale superior) had an intraexaminer marking difference less than 0.5 mm. Existing landmarks had an intraexaminer difference less than 1 mm, but higher than 0.5 mm. The intraclass correlation coefficients (ICCs) indicated good intraexaminer repeatability for both observers. The ICC range for examiners 1 and 2 was 0.986–1.000 and 0.990–1.000, respectively. Kappa scores showed good interexaminer agreement, especially on the z-axis. Conclusions: Except labiale superior, the soft tissue landmarks used in this study were shown to have moderate reproducibility, but the difference between the landmarks was less than 1 mm, and they had clinically acceptable reproducibility.

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