scholarly journals Type of Oral Cleft and Mothers’ Perceptions of Care, Health Status, and Outcomes for Preadolescent Children

2006 ◽  
Vol 43 (6) ◽  
pp. 715-721 ◽  
Author(s):  
Peter C. Damiano ◽  
Margaret C. Tyler ◽  
Paul A. Romitti ◽  
Elizabeth T. Momany ◽  
John W. Canady ◽  
...  
Keyword(s):  
Health Status ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Quality Care ◽  
Population Based ◽  
Inherited Disorders ◽  
Health Care Need ◽  
Oral Clefts ◽  
Oral Cleft ◽  
Outcomes Of Care

Objective: To evaluate the outcomes of care for children by type of oral cleft. Design: Data were collected through structured telephone interviews during 2003 in Iowa with mothers of 2- to 12-year-old children with oral clefts. Interviews with mothers of children with clubfoot and statewide data on Iowa children were used for comparison. Participants: Participants included mothers of children in Iowa born between 1990 and 2000 with nonsyndromic oral clefts. Children were identified by the statewide Iowa Registry for Congenital and Inherited Disorders. Main Outcome Measures: Rating of cleft care, severity of condition, health status, esthetic outcome, speech, and school performance were evaluated by type of oral cleft. Results: Children with cleft lip and palate were most likely to have their clefts rated as very severe. Children with palatal involvement were reported to have a lower health status and were almost twice as likely to be identified as having a special health care need compared with either children with cleft lip or children statewide. Children with cleft lip had more esthetic concerns; children with palatal involvement had the most speech concerns. Conclusions: Although mothers generally believed their children had received high-quality care, ratings of the children's current health status and outcomes of care varied significantly by type of cleft (cleft lip, cleft palate, and cleft lip and palate). Differences observed in this population-based study support the proposition that cleft type should be considered when examining outcomes of care for children with oral clefts.

scholarly journals A Population-Based Study of Effects of Genetic Loci on Orofacial Clefts

2017 ◽  
Vol 96 (11) ◽  
pp. 1322-1329 ◽  
Author(s):  
L.M. Moreno Uribe ◽  
T. Fomina ◽  
R.G. Munger ◽  
P.A. Romitti ◽  
M.M. Jenkins ◽  
...  
Keyword(s):  
Multiple Testing ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Association Studies ◽  
Total Sample ◽  
Population Based ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
European Descent ◽  
Oral Clefts

Prior genome-wide association studies for oral clefts have focused on clinic-based samples with unclear generalizability. Prior samples were also small for investigating effects by cleft type and exclusively studied isolated clefts (those occurring without other birth defects). We estimated the effects of 17 top loci on cleft types in both isolated and nonisolated cases in the largest consortium to date of European-descent population-based studies. Our analytic approach focused on a mother-child dyad case-control design, but it also allowed analyzing mother-only or child-only genotypes to maximize power. Our total sample included 1,875 cases with isolated clefts, 459 cases with nonisolated clefts, and 3,749 controls. After correcting for multiple testing, we observed significant associations between fetal single-nucleotide polymorphisms (SNPs) at IRF6, PAX7, 8q21.3, 8q24, KIAA1598-VAX1, and MAFB and isolated cleft lip only (CLO) and cleft lip and palate (CLP). Significant associations were observed between isolated CLO and fetal SNPs near TPM1 and NOG1 and between CLP and fetal SNPs at ABCA4-ARHGAP29, THADA, FOXE1, and SPRY2. Overall, effects were similar for isolated CLO and CLP, except for ABCA4-ARHGAP29. A protective effect was observed for the fetal NOG1 SNP on cleft palate only, opposite in direction to the effect on CLO. For most fetal SNPs, a dose-response allelic effect was observed. No evidence of parent-of-origin or maternal genome effects was observed. Overall, effect direction and magnitude were similar between isolated and nonisolated clefts, suggesting that several loci are modifiers of cleft risk in both isolated and nonisolated forms. Our results provide reliable estimates of the effects of top loci on risks of oral clefts in a population of European descent.

scholarly journals Evaluation of Facial Esthetics in Rehabilitated Adults with Complete Unilateral Cleft Lip and Palate: A Comparison between Professionals with and without Experience in Oral Cleft Rehabilitation

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Araci Malagodi Almeida ◽  
Leopoldino Capelozza Filho ◽  
Flavio Mauro Ferrari Junior ◽  
Rita de Cassia Moura Carvalho Lauris ◽  
Daniela Gamba Garib
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Single Center ◽  
Oral Clefts ◽  
Rehabilitation Process ◽  
Oral Cleft ◽  
Facial Esthetics

Objectives. The aim of this study was to evaluate the facial esthetics of White-Brazilian adults with complete unilateral cleft lip and palate (UCLP) rehabilitated at a single center. Design. 30 patients (13 females; 17 males; mean age of 24.0 years), rehabilitated at a single center, were photographed and evaluated by 25 examiners, 5 orthodontists, and 5 plastic surgeons dealing with oral clefts, 5 orthodontists and 5 plastic surgeons with no experience in the cleft treatment, and 5 laymen. Their facial profiles were classified into esthetically unpleasant, esthetically acceptable, and esthetically pleasant. Results. Orthodontists dealing with oral clefts classified the majority of the sample as esthetically pleasant. Plastic surgeons dealing with oral cleft, orthodontists, and plastic surgeons without experience with oral clefts classified most of the sample as esthetically acceptable. Laymen evaluation also considered the majority of the sample as esthetically acceptable. Conclusions. The facial profiles of rehabilitated adults with UCLP were classified mostly as esthetically acceptable, with variations among the categories of examiners. The examiners dealing with oral clefts gave higher scores to the facial esthetics when compared to professionals without experience in oral clefts and laypersons, probably due to their knowledge of the limitations involved in the rehabilitation process.

scholarly journals Early academic achievement in children with isolated clefts: a population-based study in England

2017 ◽  
Vol 103 (4) ◽  
pp. 356-362 ◽  
Author(s):  
Kate Jane Fitzsimons ◽  
Lynn P Copley ◽  
Efrosini Setakis ◽  
Susan C Charman ◽  
Scott A Deacon ◽  
...  
Keyword(s):  
Academic Achievement ◽  
Personal Development ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Hospital Admissions ◽  
Surgical Techniques ◽  
Population Based ◽  
National Average ◽  
Oral Cleft ◽  
Z Scores

ObjectivesWe used national data to study differences in academic achievement between 5-year-old children with an isolated oral cleft and the general population. We also assessed differences by cleft type.MethodsChildren born in England with an oral cleft were identified in a national cleft registry. Their records were linked to databases of hospital admissions (to identify additional anomalies) and educational outcomes. Z-scores (signed number of SD actual score is above national average) were calculated to make outcome scores comparable across school years and across six assessed areas (personal development, communication and language, maths, knowledge of world, physical development andcreative development).Results2802 children without additional anomalies, 5 years old between 2006 and 2012, were included. Academic achievement was significantly below national average for all six assessed areas with z-scores ranging from −0.24 (95% CI −0.32 to −0.16) for knowledge of world to −0.31 (−0.38 to −0.23) for personal development. Differences were small with only a cleft lip but considerably larger with clefts involving the palate. 29.4% of children were documented as having special education needs (national rate 9.7%), which varied according to cleft type from 13.2% with cleft lip to 47.6% with bilateral cleft lip and palate.ConclusionsCompared with national average, 5-year-old children with an isolated oral cleft, especially those involving the palate, have significantly poorer academic achievement across all areas of learning. These outcomes reflect results of modern surgical techniques and multidisciplinary approach. Children with a cleft may benefit from extra academic support when starting school.

scholarly journals Case–Parent Trio Studies in Cleft Lip and Palate

2020 ◽  
Vol 07 (03) ◽  
pp. 075-079
Author(s):  
Mahamad Irfanulla Khan ◽  
Prashanth CS
Keyword(s):  
Genetic Variants ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Association Studies ◽  
Geographical Location ◽  
Genetic Association Studies ◽  
Population Based ◽  
Genome Wide Association Studies ◽  
Family Based ◽  
Study Designs

AbstractCleft lip with or without cleft palate (CL/P) is one of the most common congenital malformations in humans involving various genetic and environmental risk factors. The prevalence of CL/P varies according to geographical location, ethnicity, race, gender, and socioeconomic status, affecting approximately 1 in 800 live births worldwide. Genetic studies aim to understand the mechanisms contributory to a phenotype by measuring the association between genetic variants and also between genetic variants and phenotype population. Genome-wide association studies are standard tools used to discover genetic loci related to a trait of interest. Genetic association studies are generally divided into two main design types: population-based studies and family-based studies. The epidemiological population-based studies comprise unrelated individuals that directly compare the frequency of genetic variants between (usually independent) cases and controls. The alternative to population-based studies (case–control designs) includes various family-based study designs that comprise related individuals. An example of such a study is a case–parent trio design study, which is commonly employed in genetics to identify the variants underlying complex human disease where transmission of alleles from parents to offspring is studied. This article describes the fundamentals of case–parent trio study, trio design and its significances, statistical methods, and limitations of the trio studies.

scholarly journals Demographic Characteristics, Care, and Outcomes for Children with Oral Clefts in Three States Using Participants from the National Birth Defects Prevention Study

2009 ◽  
Vol 46 (6) ◽  
pp. 575-582 ◽  
Author(s):  
Peter Damiano ◽  
Margaret Tyler ◽  
Paul A. Romitti ◽  
Charlotte Druschel ◽  
April A. Austin ◽  
...  
Keyword(s):  
Health Care ◽  
New York ◽  
Health Status ◽  
Birth Defects ◽  
Population Based ◽  
Primary Objective ◽  
Demographic Characteristics ◽  
Prevention Study ◽  
Care Needs ◽  
Oral Clefts

Objective: The primary objective of this study was to evaluate whether there were differences in the characteristics and outcomes of care for children with oral clefts (OCs) among population-based samples in three states. Design: Data on the health status and on speech and esthetic outcomes were collected using structured telephone interviews conducted during 2005–2006 with mothers of children with OCs aged 2 to 7 in Arkansas, Iowa, and New York. Participants: Mothers of children born with nonsyndromic OCs on or after January 1, 1998, and on or before December 31, 2003, in Arkansas, Iowa, or New York. Subjects were identified through their participation in the ongoing National Birth Defects Prevention Study. Main Outcome Measures: Demographic characteristics, rating of cleft care, severity of condition, health status, esthetic outcomes, and speech problems were evaluated by state of residence. Results: Children with OCs from Arkansas were from lower income families, and their parents were less likely to be married. Children with OCs from Arkansas were more likely to have special health care needs and to require mental health care. Few differences were found across states in type of cleft, severity of cleft, or outcomes of cleft care. Conclusions: Combining results from population-based samples across multiple studies increases the variability of sample characteristics. Including multiple states can be an efficient way to learn more about the outcomes of medical care for less common conditions such as oral cleft.

scholarly journals School performance for children with cleft lip and palate: a population-based study

2016 ◽  
Vol 43 (2) ◽  
pp. 222-231 ◽  
Author(s):  
J. C. Bell ◽  
C. Raynes-Greenow ◽  
R. Turner ◽  
C. Bower ◽  
A. Dodson ◽  
...  
Keyword(s):  
School Performance ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Population Based Study

Academic Achievement in Individuals with Cleft: A Population-Based Register Study

2012 ◽  
Vol 49 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Martin Persson ◽  
Magnus Becker ◽  
Henry Svensson
Keyword(s):  
Academic Achievement ◽  
General Population ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Study Data ◽  
Control Group ◽  
High Grade ◽  
Compulsory School ◽  
Grade Point

Objective The focus of this study was to determine whether there were any significant differences in academic achievement between students with a cleft and the general population of Swedish students at the typical time of graduation from compulsory school (usually 16 years of age). Design A retrospective population-based study. Data were obtained from the Swedish Medical Birth Register for the years 1973 through 1986 and were linked to the Swedish School–Grade Register. Participants A total of 511 individuals with cleft palate (CP), 651 individuals with cleft lip (CL), and 830 individuals with cleft lip and palate (CLP) were compared with a control group consisting of 1,249,404 individuals. Main Outcome Measures (1) Not receiving school leaving certificate; (2) odds of receiving lowest grade and reduced odds of receiving a high grade in the following subjects: (a) Mathematics, (b) English, (c) Swedish, (d) Physical Education, and (e) grade point average (GPA). Results The group with cleft had higher odds of not receiving leaving certificates in comparison with the general population. They also had higher odds of receiving the lowest grade and/or reduced odds of receiving a high grade in the subjects analyzed together, with strong evidence of lower GPA in comparison with the general population. Individuals with CP were affected the most, followed by individuals with CLP; least affected were individuals with CL. Conclusion This study clearly indicates that adolescents with cleft lip and/or palate in Sweden experience significant deficits in their educational achievements in compulsory school.

Population-Based Study on the Practice of Breastfeeding in Children Born with Cleft Lip and Palate

2005 ◽  
Vol 42 (6) ◽  
pp. 687-693 ◽  
Author(s):  
Letícia W. Garcez ◽  
Elsa R. J. Giugliani
Keyword(s):  
Cleft Palate ◽  
Median Duration ◽  
Exclusive Breastfeeding ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Breastfeeding Duration ◽  
Porto Alegre ◽  
Initiation Rate ◽  
Population Based Study

Objective To investigate the practice of breastfeeding and related difficulties in children born in Porto Alegre, Brazil, with cleft lip, cleft palate, and cleft lip with cleft palate. Design Cohort, observational, and population-based study. Population and Sample Mothers of all children born in 2001 and 2002 with cleft lip and palate in the city of Porto Alegre, Brazil (n = 31), were interviewed in their homes. From the information collected, the frequencies of breastfeeding and exclusive breastfeeding in the first year of life were estimated and the median duration was computed according to the type of cleft. A descriptive analysis was used to study the difficulties. Main Indicators Initiation rate, pattern, duration, and difficulties of breastfeeding and exclusive breastfeeding. Results The initiation rate of breastfeeding was 100% and its median duration was 42.5 days. Exclusive breastfeeding was initiated by 67.7% of the sample and maintained for 15 days (median). The breastfeeding duration was significantly higher in the presence of cleft lip, being equal or even superior to (in the case of exclusive breastfeeding) the median of Porto Alegre's general population. The most frequently mentioned difficulties were weak suction, difficulty attaching to the breast, and breast milk escaping through the nostrils. Conclusions In spite of the diverse difficulties reported and the lack of professional support after discharge from the maternity wards, the initiation rate and the duration of breastfeeding of children with cleft lip and palate found in this study reinforce the theory that this malformation, especially cleft lip, is compatible with successful breastfeeding.

scholarly journals Effect of Cleft Lip With or Without Palate on Pediatric General and Dental Growth in Korea: a Nationwide Population-based Cohort Study

2021 ◽  
Author(s):  
Jeong Yeop Ryu ◽  
Tae Hyun Park ◽  
Joon Seok Lee ◽  
Jung Dug Yang ◽  
Ho Yun Chung ◽  
...  
Keyword(s):  
Head Circumference ◽  
Cleft Lip ◽  
Primary Teeth ◽  
Cleft Lip And Palate ◽  
Dental Treatment ◽  
Population Based ◽  
Population Based Study ◽  
The Status ◽  
Dental Screening ◽  
Lower Height

Abstract There are very few nationwide studies discussing the height, weight, head circumference, and dental screening of children with cleft lip with or without palate (CL/P), with most reports on this subject based on a 1900s cohort. This study aimed to characterize CL/P children in the 2000s in terms of height, weight, head circumference, and dental screening. This nationwide population-based study evaluated the National Health Insurance Service-Infants and Children’s Health Screening (NHIS-INCHS), specifically the height, weight, and head circumference of millions of children. Dental screening data, including the status of each tooth and comprehensive dental judgment, were also evaluated. Syndromic and nonsyndromic CL/P children had lower height, weight, and head circumference than no CL/P children until the age of 66–71 months. Children with cleft palate only or both cleft lip and palate showed similar results. Regarding dental screening, the primary teeth of CL/P children erupted later and fell out faster than no CL/P children. Dental caries was also more common in CL/P children. Children with CL/P had inferior general growth, regardless of palatoplasty surgery. More aggressive dental treatment was required for CL/P children due to the instability of primary teeth and tendency for caries.

Sign in / Sign up

Export Citation Format

Share Document