Endocranial Vascular Patterns in a Familial Rabbit Model of Coronal Suture Synostosis

2001 ◽  
Vol 38 (6) ◽  
pp. 615-621 ◽  
Author(s):  
Annie M. Burrows ◽  
Valerie D. O'Loughlin ◽  
Mark P. Mooney ◽  
Timothy D. Smith ◽  
H. Wolfgang Losken ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Venous Sinus ◽  
Secondary Response ◽  
Intracranial Volume ◽  
Coronal Suture ◽  
Venous Sinuses ◽  
New Zealand White Rabbits ◽  
Dural Venous Sinus ◽  
Altered Form ◽  
Dural Venous Sinuses

Objective: The present study investigates the potential relationship between craniosynostosis and any changes in endocranial vasculature. The hypothesis that crania from rabbits with familial, nonsyndromic coronal suture synostosis and crania from rabbits with experimental immobilization of the coronal suture are associated with altered form of the middle meningeal vessels and dural venous sinuses is tested. Design: Silicone rubber endocasts from 14 adult New Zealand white rabbits (Oryctolagus cuniculus) with familial nonsyndromic coronal suture synostosis (five with bilateral coronal suture synostosis and nine with unilateral coronal suture synostosis) were made to assess middle meningeal vessel and dural venous sinus form. For comparative purposes, endocasts were made from 25 rabbits with normal, patent coronal sutures and 10 rabbits with experimental immobilization of the coronal suture. Impressions of the dural venous sinuses were assessed for depth and width. The area of the confluens of sinuses was also assessed. Impressions of the middle meningeal vessels were assessed for depth, width, and degree of convolution. For width of the dural venous sinuses and area of the confluens of sinuses, comparisons among groups were made with a one-way analysis of variance (ANOVA). For depth of the dural venous sinuses and impressions of the middle meningeal vessels, comparisons among groups were made using a Kruskal-Wallis one-way ANOVA. Results: Crania with familial coronal suture synostosis had significantly (p < .05) reduced posterior dural venous sinus dimensions when compared with both crania from rabbits with experimental immobilization of the coronal suture and rabbits with normal coronal sutures. Crania with both coronal suture synostosis and experimental immobilization had significant increases in dimensions of the middle meningeal vessels relative to normal crania. In addition, casts from rabbits with unicoronal suture synostosis showed marked asymmetry in the dural venous sinuses. Conclusions: These results support the hypothesis that craniosynostosis is associated with alterations in endocranial vasculature. These changes are most likely a secondary response to synostosis rather than a causal factor and may reflect increased intracranial pressure, decreased intracranial volume, and local accumulations and reductions of cerebrospinal fluid in the posterior region of the skull and immediately deep to the coronal suture.

scholarly journals Mechanical and structural characterisation of the dural venous sinuses

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Darragh R. Walsh ◽  
James J. Lynch ◽  
David T. O’ Connor ◽  
David T. Newport ◽  
John J. E. Mulvihill
Keyword(s):  
Structural Analysis ◽  
Venous Blood ◽  
Venous Sinus ◽  
Anatomical Location ◽  
Mechanical Stiffness ◽  
Structural Characterisation ◽  
Venous Sinuses ◽  
Integral Role ◽  
Dural Venous Sinus ◽  
Dural Venous Sinuses

AbstractThe dural venous sinuses play an integral role in draining venous blood from the cranial cavity. As a result of the sinuses anatomical location, they are of significant importance when evaluating the mechanopathology of traumatic brain injury (TBI). Despite the importance of the dural venous sinuses in normal neurophysiology, no mechanical analyses have been conducted on the tissues. In this study, we conduct mechanical and structural analysis on porcine dural venous sinus tissue to help elucidate the tissues’ function in healthy and diseased conditions. With longitudinal elastic moduli values ranging from 33 to 58 MPa, we demonstrate that the sinuses exhibit higher mechanical stiffness than that of native dural tissue, which may be of interest to the field of TBI modelling. Furthermore, by employing histological staining and a colour deconvolution protocol, we show that the sinuses have a collagen-dominant extracellular matrix, with collagen area fractions ranging from 84 to 94%, which likely explains the tissue’s large mechanical stiffness. In summary, we provide the first investigation of the dural venous sinus mechanical behaviour with accompanying structural analysis, which may aid in understanding TBI mechanopathology.

The repair of dural venous sinus wounds by autogenous venorrhaphy

1971 ◽  
Vol 35 (4) ◽  
pp. 392-395 ◽  
Author(s):  
Berkley L. Rish
Keyword(s):  
Venous Sinus ◽  
New Technique ◽  
Surgical Experience ◽  
Content Type ◽  
Venous Sinuses ◽  
Dural Venous Sinus ◽  
A New Technique ◽  
Combat Casualties ◽  
Fine Print ◽  
Dural Venous Sinuses

✓ Military surgical experience with acute wounds of the dural venous sinuses is reviewed. A new technique, autogenous venorrhaphy, is described and reported as the method used in 10 Vietnam combat casualties.

Anatomic Variations of the Dural Venous Sinuses: A Primer for the Practicing Neuroradiologist

Neurographics ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 223-227
Author(s):  
E. Pauls ◽  
E. Gulko ◽  
D. Sadowsky ◽  
A. Rizvi ◽  
W. Gomes ◽  
...  
Keyword(s):  
Anatomic Variation ◽  
Venous Sinus ◽  
Anatomic Variations ◽  
Common Variants ◽  
Normal Variants ◽  
Venous Sinuses ◽  
Firm Knowledge ◽  
Anatomic Variants ◽  
Dural Venous Sinus ◽  
Dural Venous Sinuses

The dural venous sinuses exhibit considerable anatomic variation. Firm knowledge of dural venous sinus anatomy and common anatomic variants is of importance for the practicing neuroradiologist to recognize normal variants from pathologic conditions. In this article, we review dural venous sinus anatomy and present common variants through an image-based approach.Learning Objective: Review normal intracranial dural venous system anatomy and common variants.

Retrograde 3D rotational venography (3DRV) for venous sinus stent placement in idiopathic intracranial hypertension

2017 ◽  
Vol 10 (8) ◽  
pp. 777-779 ◽  
Author(s):  
Christopher C Young ◽  
Ryan P Morton ◽  
Basavaraj V Ghodke ◽  
Michael R Levitt
Keyword(s):  
Intracranial Hypertension ◽  
Stent Placement ◽  
Idiopathic Intracranial Hypertension ◽  
Three Dimensional ◽  
Venous Sinus ◽  
Flat Panel ◽  
Venous Sinuses ◽  
Contrast Enhanced ◽  
Sinus Stenosis ◽  
Dural Venous Sinus

BackgroundDural venous sinus stenting has emerged as an effective and durable treatment for idiopathic intracranial hypertension (IIH). Improved visualization of the venous sinuses can improve stent placement.MethodsWe present two cases of IIH treated with venous sinus stenting in which retrograde three-dimensional rotational venography (3DRV) provided superior anatomical details of the venous sinuses for optimal sizing and positioning of stent.ResultsComparison of pre-stent 3DRV with post-stent contrast-enhanced flat panel detector CT allowed confirmation of stent placement and the result of stenosis dilation.ConclusionThis 3DRV technique provides precise visualization of venous sinus stenosis prior to stenting without the need for arterial cerebral angiography during the treatment course.

scholarly journals Dural venous sinus thrombosis: The combination of noncontrast CT, MRI and PC-MR venography to enhance accuracy

2018 ◽  
Vol 31 (5) ◽  
pp. 473-481 ◽  
Author(s):  
Kerem Ozturk ◽  
Esra Soylu ◽  
Mufit Parlak
Keyword(s):  
Sinus Thrombosis ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis ◽  
Venous Sinuses ◽  
Noncontrast Ct ◽  
Mri Sequences ◽  
Dural Venous Sinus ◽  
Signal Changes ◽  
T1 And T2 ◽  
Dural Venous Sinus Thrombosis

Aim The aim of this article is to determine whether a combination of noncontrast CT (NCCT), three-dimensional-phase contrast magnetic resonance venography (3D PC-MRV), T1- and T2-weighted MRI sequences can help to identify acute and subacute dural venous sinus thrombosis (DVST) with greater accuracy. Methods A total of 147 patients with DVST ( n = 30) and a control group ( n = 117) underwent NCCT, T1- and T2-weighted MRI sequences, and 3D PC-MRV from 2012 to 2016. Two experienced observers interpreted the images retrospectively for the presence of DVST. Nonvisualization of the dural venous sinuses on 3D PC-MRV and signal changes supporting acute or subacute thrombus on T2- and T1-weighted images were considered a direct sign of DVST. Also, using circle region of interest (ROI) techniques, attenuation measurement from each sinus was obtained on NCCT. Sensitivity and specificity were computed for these modalities separately and in combination for diagnosis of DVST using digital subtraction angiography as the reference standard. Results Nonvisualization of venous sinuses on 3D PC-MRV (sensitivity 100%, specificity 71%) in combination with both applying Hounsfield unit (HU) threshold values of greater than 60 on NCCT (sensitivity 70%, specificity 94%) and acquiring signal changes supporting DVST on T2- and T1-weighted images (sensitivity 83%, specificity 96%), were found to have 100% sensitivity and 100% specificity in the identification of acute or subacute DVST. Conclusion The combination of NCCT, T1- and T2-weighted MRI and 3D PC-MRV may allow the diagnosis of acute or subacute DVST and may obviate the need for contrast usage in patients with renal impairment or contrast allergies.

scholarly journals Postoperative cerebral venous sinus thrombosis in the setting of surgery adjacent to the major dural venous sinuses

2019 ◽  
Vol 131 (4) ◽  
pp. 1317-1323 ◽  
Author(s):  
Carolina Gesteira Benjamin ◽  
Rajeev D. Sen ◽  
John G. Golfinos ◽  
Chandra Sen ◽  
J. Thomas Roland ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Csf Leak ◽  
Tumor Type ◽  
Venous Sinus Thrombosis ◽  
Venous Sinuses ◽  
Dural Venous Sinuses

OBJECTIVECerebral venous sinus thrombosis (CVST) is a known complication of surgeries near the major dural venous sinuses. While the majority of CVSTs are asymptomatic, severe sinus thromboses can have devastating consequences. The objective of this study was to prospectively evaluate the true incidence and risk factors associated with postoperative CVST and comment on management strategies.METHODSA prospective study of 74 patients who underwent a retrosigmoid, translabyrinthine, or suboccipital approach for posterior fossa tumors, or a supratentorial craniotomy for parasagittal/falcine tumors, was performed. All patients underwent pre- and postoperative imaging to evaluate sinus patency. Demographic, clinical, and operative data were collected. Statistical analysis was performed to identify incidence and risk factors.RESULTSTwenty-four (32.4%) of 74 patients had postoperative MR venograms confirming CVST, and all were asymptomatic. No risk factors, including age (p = 0.352), BMI (p = 0.454), sex (p = 0.955), surgical approach (p = 0.909), length of surgery (p = 0.785), fluid balance (p = 0.943), mannitol use (p = 0.136), tumor type (p = 0.46, p = 0.321), or extent of resection (p = 0.253), were statistically correlated with thrombosis. All patients were treated conservatively, with only 1 patient receiving intravenous fluids. There were no instances of venous infarctions, hemorrhages, or neurological deficits. The rate of CSF leakage was significantly higher in the thrombosis group than in the nonthrombosis group (p = 0.01).CONCLUSIONSThis prospective study shows that the radiographic incidence of postoperative CVST is higher than that previously reported in retrospective studies. In the absence of symptoms, these thromboses can be treated conservatively. While no risk factors were identified, there may be an association between postoperative CVST and CSF leak.

scholarly journals Study of the Soil—Plant (Carrot)—Animal Cycle of Nutritive and Hazardous Minerals in a Rabbit Model

1999 ◽  
Vol 47 (2) ◽  
pp. 181-190 ◽  
Author(s):  
A. Bersényi ◽  
S. Fekete ◽  
I. Hullár ◽  
I. Kádár ◽  
M. Szilágyi ◽  
...  
Keyword(s):  
Crude Protein ◽  
Dry Matter ◽  
Rabbit Model ◽  
Basal Diet ◽  
The Body ◽  
High Concentration ◽  
New Zealand White Rabbits ◽  
Heavy Metal Salts ◽  
Experimental Treatments ◽  
Rate Of Accumulation

Carrots were grown on soils polluted by heavy metal salts. Each particular microelement reached a high concentration [molybdenum (Mo) 39.00, cadmium (Cd) 2.30, lead (Pb) 4.01, mercury (Hg) 30.00, and selenium (Se) 36.20 mg/kg dry matter] in the carrot. In a metabolic balance trial conducted with 15 male and 15 female New Zealand White rabbits, the control animals (n = 5) were fed ad libitum with concentrate as basal diet, while the other rabbits received the basal diet and carrots containing the particular microelement. Blood samples were taken to determine the activity of serum enzymes. To investigate the metabolism of Mo, Cd, Pb, Hg and Se, samples were taken from the heart, liver, lungs, kidneys, spleen, ovaries/testicles, entire digestive tract, adipose tissue, femur, hair, faeces and urine. Carrot had significantly higher digestibility for all nutrients than the rabbit concentrate. Carrot samples of high Pb content had the lowest digestibility of crude protein. The microelements differed in their rate of accumulation in the organs examined: Mo and Cd accumulated in the kidneys, Pb in the kidneys, liver, bones and lungs, Hg in the kidneys and liver, while Se in the liver, kidneys and heart. The proportions of microelements eliminated from the body either via the faeces and urine (Mo 80.18% and Se 47.41%) or via the faeces (Cd 37.86%, Pb 66.39%, Hg 64.65%) were determined. Pathohistological examination revealed that the rate of spermatogenesis was reduced in the Mo, Cd, Pb and Hg groups compared to the control. Lead, Cd and Hg intake resulted in a considerable decrease in gamma-glutamyltransferase (GGT) and in an increase of alkaline phosphatase (ALP) activity because of damages to the kidneys and bones. All experimental treatments decreased the activity of cholinesterase (CHE) because of lesions in the liver.

Early Neuromotor Behavior in Craniosynostotic Rabbits

2003 ◽  
Vol 40 (5) ◽  
pp. 486-492 ◽  
Author(s):  
Ronal L. Mitchell ◽  
Timothy E. Barbano ◽  
H. Wolfgang Losken ◽  
Michael I. Siegel ◽  
Mark P. Mooney
Keyword(s):  
Early Onset ◽  
Rabbit Model ◽  
Zealand White Rabbit ◽  
Psychomotor Development ◽  
Activity Levels ◽  
Coronal Suture ◽  
Wild Type ◽  
Significant Group ◽  
Delayed Onset ◽  
Neuromotor Development

Objective Clinical studies have shown both abnormal and normal mental and psychomotor development in patients with craniosynostosis. However, a number of confounding variables make study comparisons difficult. For these reasons, the present study describes early neuromotor development in an homogeneous rabbit model of craniosynostosis. Design Fifty-three newborn New Zealand white rabbit kits were used: 13 were wild-type, normal control rabbits; 23 had delayed-onset coronal suture synostosis (onset is approximately 57 to 74 days post conception); and 17 had early-onset coronal suture synostosis (onset is approximately 21 to 25 days post conception). All rabbits were observed individually and blindly in an open field, daily for 2 minutes, from birth through the first 14 days of life. The first day of emergence of 10 different mature behaviors and developmental events (in developmental order of appearance: falling, righting, cliff avoidance, first sign of fur, body elevation, head elevation, circling, dragging, eye opening, and hopping) was recorded for each kit. Daily activity levels (grid crossing), and body weights were also recorded. Results Significant group (p < .05) differences were observed in 9 of 11 measures. Both synostosed groups had significantly (p < .05) accelerated onset of behavior in 8 of 9 measures, compared with wild-type controls. The early-onset synostosis group had significantly (p < .05) accelerated onset in five of eight measures, compared with wild-type controls, and three of eight measures, compared with the delayed-onset synostosis group. Conclusions Synostotic rabbits showed precocious neuromotor development possibly through frontal lobe constrictions and altered brain activity from increased intracranial pressure, although primary genetic effects cannot be ruled out.

Normal and variant anatomy of the dural venous sinuses

1994 ◽  
Vol 15 (6) ◽  
pp. 499-519 ◽  
Author(s):  
Joel K. Curé ◽  
Pamela Van Tassel ◽  
M. Timothy Smith
Keyword(s):  
Venous Sinuses ◽  
Variant Anatomy ◽  
Dural Venous Sinuses

Pseudotumor cerebri syndrome: venous sinus obstruction and its treatment with stent placement

2003 ◽  
Vol 98 (5) ◽  
pp. 1045-1055 ◽  
Author(s):  
Brian K. Owler ◽  
Geoffrey Parker ◽  
G. Michael Halmagyi ◽  
Victoria G. Dunne ◽  
Verity Grinnell ◽  
...  
Keyword(s):  
Stent Placement ◽  
Pseudotumor Cerebri ◽  
Venous Sinus ◽  
Stent Insertion ◽  
Benign Intracranial Hypertension ◽  
Content Type ◽  
Venous Sinuses ◽  
Pseudotumor Cerebri Syndrome ◽  
New Treatment ◽  
Fine Print

Object. Pseudotumor cerebri, or benign intracranial hypertension, is a condition of raised intracranial pressure in the absence of a mass lesion or cerebral edema. It is characterized by headache and visual deterioration that may culminate in blindness. Pseudotumor cerebri is caused by venous sinus obstruction in an unknown percentage of cases. The purpose of this study was to investigate the role of cerebral venous sinus disease in pseudotumor cerebri and the potential of endoluminal venous sinus stent placement as a new treatment. Methods. Nine consecutive patients in whom diagnoses of pseudotumor cerebri had been made underwent examination with direct retrograde cerebral venography (DRCV) and manometry to characterize the morphological features and venous pressures in their cerebral venous sinuses. The cerebrospinal fluid (CSF) pressure was measured simultaneously in two patients. If patients had an amenable lesion they were treated using an endoluminal venous sinus stent. Five patients demonstrated morphological obstruction of the venous transverse sinuses (TSs). All lesions were associated with a distinct pressure gradient and raised proximal venous sinus pressures. Four patients underwent stent insertion in the venous sinuses and reported that their headaches improved immediately after the procedure and remained so at 6 months. Vision was improved in three patients, whereas it remained poor in one despite normalized CSF pressures. Conclusions. Patients with pseudotumor cerebri should be evaluated with DRCV and manometry because venous TS obstruction is probably more common than is currently appreciated. In patients with a lesion of the venous sinuses, treatment with an endoluminal venous sinus stent is a viable alternative for amenable lesions.

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