scholarly journals Hierarchical Macro Strategy Model for MOBA Game AI

2019 ◽  
Vol 33 ◽  
pp. 1206-1213 ◽  
Author(s):  
Bin Wu
Keyword(s):  
Strategy Model ◽  
Game Ai ◽  
Great Progress ◽  
Micro Level ◽  
Comprehensive Evaluations ◽  
Player Ranking ◽  
Partially Observable ◽  
Complete Solutions ◽  
Made In ◽  
Human Player

The next challenge of game AI lies in Real Time Strategy (RTS) games. RTS games provide partially observable gaming environments, where agents interact with one another in an action space much larger than that of GO. Mastering RTS games requires both strong macro strategies and delicate micro level execution. Recently, great progress has been made in micro level execution, while complete solutions for macro strategies are still lacking. In this paper, we propose a novel learning-based Hierarchical Macro Strategy model for mastering MOBA games, a sub-genre of RTS games. Trained by the Hierarchical Macro Strategy model, agents explicitly make macro strategy decisions and further guide their micro level execution. Moreover, each of the agents makes independent strategy decisions, while simultaneously communicating with the allies through leveraging a novel imitated crossagent communication mechanism. We perform comprehensive evaluations on a popular 5v5 Multiplayer Online Battle Arena (MOBA) game. Our 5-AI team achieves a 48% winning rate against human player teams which are ranked top 1% in the player ranking system.

scholarly journals Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2978
Author(s):  
Chia-Jung Li ◽  
Yen-Dun Tony Tzeng ◽  
Yi-Han Chiu ◽  
Hung-Yu Lin ◽  
Ming-Feng Hou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
High Efficiency ◽  
Early Recurrence ◽  
New Developments ◽  
Great Progress ◽  
Low Toxicity ◽  
Made In

Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.

Rhodium-Catalyzed, Phosphorus(III)-Directed Hydroarylation of Internal Alkynes: Facile and Efficient Access to New Phosphine Ligands

Synlett ◽  
2020 ◽  
Author(s):  
Minyan Wang ◽  
Zhuangzhi Shi ◽  
Huanhuan Luo ◽  
Dawei Wang
Keyword(s):  
High Selectivity ◽  
Enantiomeric Excess ◽  
Phosphine Ligands ◽  
Rapid Construction ◽  
Efficient Access ◽  
Internal Alkynes ◽  
Great Progress ◽  
Chiral Phosphine Ligands ◽  
Optimized Conditions ◽  
Made In

AbstractOrganophosphines are an important class of ligands widely used in organic chemistry. Although great progress has recently been made in the rapid construction of new phosphines through Rh- or Ru-catalyzed C–H bond functionalizations, synthetic access to more diverse phosphines remains a challenge. We describe an efficient process for the rhodium-catalyzed phosphorus(III)-directed hydroarylation of internal alkynes to generate various alkenylated and 2′,6′-dialkenylated biarylphosphines with high selectivity. A range of diverse alkynes and phosphines were effectively prepared with broad functional-group compatibility under the optimized conditions. In addition, the developed protocol can be extended to modify chiral phosphine ligands, providing enantioenriched alkenylated phosphines without erosion of the enantiomeric excess.

Accountability in an Era of Celebrity

2019 ◽  
pp. 150-174
Author(s):  
Martha C. Nussbaum
Keyword(s):  
Social Norms ◽  
Sexual Violence ◽  
Working Women ◽  
Historical Evolution ◽  
The Public ◽  
Great Progress ◽  
The Law ◽  
Made In

While great progress has been made in regards to sexual violence and accountability, Martha C. Nussbaum argues that the culture of celebrity remains a significant hurdle. In this chapter, Nussbaum traces the historical evolution and progress of the law and social norms concerning sexual violence. Identifying the obstacles and complexities that have faced those fighting for justice, she shows how working women, feminist lawyers, and recently the #MeToo movement have pushed forward the frontier of accountability. While history provides reason for hope, a recalcitrant problem remains: lack of accountability for celebrities and sports stars. Given the big money and structures of power behind the culture of celebrity, Nussbaum argues that the public must rise up and express outrage in order to bring about change.

scholarly journals Atomic Physics of the 12-μm and Related Lines

1994 ◽  
Vol 154 ◽  
pp. 297-307
Author(s):  
Edward S. Chang
Keyword(s):  
Atomic Physics ◽  
Stark Effect ◽  
Disk Center ◽  
Emission Peak ◽  
Emission Lines ◽  
Line Profiles ◽  
Great Progress ◽  
Quadratic Stark Effect ◽  
Rydberg Transitions ◽  
Made In

The 12 μm emission lines were unexpectedly detected about a decade ago. Great progress has been made in understanding the atomic physics underlying these high-l Rydberg transitions in Mg I and other atoms. In a magnetic field, their Landé g factor is shown to be unity. At disk center, the shift of the absorption trough relative to the emission peak is demonstrated to be due to the quadratic Stark Effect, permitting measurement of the photospheric electric field strengths. Other related lines of Mg I require accurate atomic fine structure data to interpret properly their complex line profiles. Related lines are found in the ATMOS spectra for C I, Na I, Al I, Si I, Ca I, and Fe I, in addition to H I.

An Integrative Approach to the Assessment and Treatment of Inflammatory Conditions

2017 ◽  
Author(s):  
Mark Liponis ◽  
Bettina Martin
Keyword(s):  
Integrative Approach ◽  
The Past ◽  
Inflammatory Conditions ◽  
Improved Outcomes ◽  
Targeted Treatments ◽  
Great Progress ◽  
Assessment And Treatment ◽  
The Many ◽  
Made In

The past two decades have seen great progress in recognizing the importance of inflammation in medicine. Increased focus on inflammation in both prevention and treatment has improved outcomes and quality of life in chronic diseases. Science has improved our understanding of inflammation’s many causes and effects on health, and many advances have been made in the availability of targeted therapeutic options for treating inflammation. This chapter gives an overview of recognizing the many causes of inflammation, its many targeted treatments strategies, and the questions that still surround it. It discusses several integrative approaches to reducing inflammation, including exercise, diet, and different strategies for managing sleep, mood, and stress, such as meditation and massage.

The application of artificial intelligence and radiomics in lung cancer

2020 ◽  
Vol 3 (3) ◽  
pp. 214-227
Author(s):  
Yaojie Zhou ◽  
Xiuyuan Xu ◽  
Lujia Song ◽  
Chengdi Wang ◽  
Jixiang Guo ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Lung Cancer ◽  
Early Diagnosis ◽  
Medical Management ◽  
Causes Of Death ◽  
Current Application ◽  
The World ◽  
Great Progress ◽  
Made In

Abstract Lung cancer is one of the most leading causes of death throughout the world, and there is an urgent requirement for the precision medical management of it. Artificial intelligence (AI) consisting of numerous advanced techniques has been widely applied in the field of medical care. Meanwhile, radiomics based on traditional machine learning also does a great job in mining information through medical images. With the integration of AI and radiomics, great progress has been made in the early diagnosis, specific characterization, and prognosis of lung cancer, which has aroused attention all over the world. In this study, we give a brief review of the current application of AI and radiomics for precision medical management in lung cancer.

scholarly journals Advances in research on the effects of natural drugs with immune-promoting effects on immune function

2020 ◽  
Vol 18 ◽  
pp. 205873922092687
Author(s):  
Lu Wang ◽  
Sha Li ◽  
Haibo Liu ◽  
Lidao Bao
Keyword(s):  
Pharmacological Effects ◽  
Specific Immunity ◽  
Natural Medicine ◽  
Wide Range ◽  
Great Progress ◽  
New Ideas ◽  
Natural Drugs ◽  
Natural Medicines ◽  
Made In

Immune-enhanced natural medicines have gradually formed unique functions and usages through long-term medical practice, which contained rich immunological ideas and contents. The immune-enhancing natural medicine has a wide range of pharmacological effects in anti-inflammatory, anti-tumor, anti-viral, and immunity enhancement. In recent years, great progress has been made in the study of immune-enhanced natural drugs. In this article, the main active ingredients of some natural drugs with immune-enhancing function are reviewed, which can enhance immunity by regulating the level of some cytokines and affecting the function of non-specific immunity and specific immunity. The experimental research provides the basis and prospects for the research and development of immune-enhanced natural drugs in the future, providing new ideas for immunotherapy.

Des Harmonies poétiques et religieuses de Lamartine à celles de Franz Liszt

2013 ◽  
Vol 54 (1) ◽  
pp. 21-34
Author(s):  
Serge Gut
Keyword(s):  
Franz Liszt ◽  
Great Progress ◽  
Piano Cycle ◽  
Made In

The connections between Lamartine’s collection of poetry Harmonies poétiques et religieuses and the piano cycle with the same title by Liszt are very complex — sometimes even enigmatic. However, because of the great progress made in recent years regarding the genesis of Liszt’s cycle spanning over twenty years it is now possible to provide some clarification on the influences exerted by Lamartine’s poems on the corresponding pieces by Liszt. Each piece of Liszt’s three successive piano cycles is examined in terms of the influence due to Lamartine’s collection.

PRESENT STATUS AND FUTURE PROSPECTS OF HYPERNUCLEAR PHYSICS

2009 ◽  
Vol 24 (11) ◽  
pp. 2101-2109 ◽  
Author(s):  
H. TAMURA
Keyword(s):  
Fine Structure ◽  
Present Status ◽  
Experimental Studies ◽  
Theoretical Development ◽  
Future Prospects ◽  
Great Progress ◽  
Nuclear Systems ◽  
Γ Ray ◽  
Hypernuclear Physics ◽  
Made In

In recent years, great progress has been made in hypernuclear physics through new experimental techniques as well as theoretical development. Precision γ-ray spectroscopy of hypernuclei has revealed fine structure of various light Λ hypernuclei. Introduction of the (π-, K+) reaction has opened a possibility of studying neutron-rich Λ hypernuclei. The J-PARC facility will allow us to accelerate these experimental studies of Λ hypernuclei and extend hypernuclear physics to double strangess nuclear systems.

scholarly journals The MUP Zagros Project: tracking the Middle–Upper Palaeolithic transition in the Kermanshah region, west-central Zagros, Iran

Antiquity ◽  
2017 ◽  
Vol 91 (355) ◽  
Author(s):  
Saman Heydari-Guran ◽  
Elham Ghasidian
Keyword(s):  
Middle East ◽  
Upper Palaeolithic ◽  
Iranian Plateau ◽  
Intensive Research ◽  
West Central ◽  
Major Interest ◽  
Great Progress ◽  
Made In

In recent decades, the Eurasian Middle–Upper Palaeolithic (M–UP) transition has been a topic of major interest among palaeoanthropologists. Great progress has been made in several domains, particularly palaeogenetics, which have revealed the complex ancestry of early Eurasians. This progress—including the identification of a ghost lineage of Eurasians in the Middle East—is providing important new biogeographical hypotheses. A key region for such topics is the Iranian Plateau—an area that has so far not been subject to intensive research.

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