Clinical characteristics of skin manifestations with the novel coronavirus infection COVID-19 caused by SARS-CoV-2

In late 2019, a new viral infection appeared in China, which spread around the world, causing a pandemic. The causative agent of the new coronavirus infection COVID-19 is the SARS-CoV-2 coronavirus. The review presents modern data on the epidemiology, pathogenesis and course of the novel coronavirus infection COVID-19 in children. Chinese, American and European scientists have described a variety of cutaneous manifestations in children with COVID-19. The article provides a literature review of the cutaneous manifestations of COVID-19 coronavirus infection in children. During our own observation of 301 patients with coronavirus infection COVID-19 caused by SARS-CoV-2 at the Bashlyaevs Children Hospital in Moscow from May 17 to November 16, 2020, it was revealed that 39 (13 %) patients had skin manifestations. The article presents a classification of skin manifestations characteristic of COVID-19. A brief description of each group is given.

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Dermatological manifestations in novel coronavirus infection COVID-19

Тромбоз, гемостаз и реология ◽

10.25555/thr.2021.2.0971 ◽

2021 ◽

Author(s):

А.А. Хрянин ◽

В.Г. Стуров ◽

А.П. Надеев ◽

В.К. Бочарова

Keyword(s):

Primary Infection ◽

Skin Lesions ◽

The Novel ◽

Skin Manifestations ◽

Skin Symptoms ◽

Coronavirus Infection ◽

Novel Coronavirus ◽

The Complement System ◽

Secondary Consequence

Обзор посвящен анализу дерматологических проявлений при новой коронавирусной инфекции COVID-19, информация о которых непрерывно обновляется и дополняется. Однако до сих пор имеющиеся данные не были систематизированы. Цель обзора: проанализировать дерматологические проявления новой коронавирусной инфекции COVID-19. В среднем, у 12,5–20,4% пациентов с подтвержденным COVID-19 развились кожные проявления. Вопрос о том, являются ли кожные симптомы вторичным следствием респираторной инфекции или первичной инфекцией самой кожи, на данный момент остается открытым. Обсуждаются вероятные механизмы развития поражений кожи и роли системы комплемента и гиперкоагуляции крови в патогенезе развития дерматологических проявлений. В обзоре также приводятся клинические примеры вовлечения кожных покровов в инфекционный процесс при COVID-19. Поскольку COVID-19 имеет тенденцию к бессимптомному течению в течение 14 дней после заражения, кожные проявления могут служить индикатором инфекции, способствуя своевременной диагностике. Кроме того, осведомленность врачей о кожных симптомах, связанных с инфекцией COVID-19, имеет решающее значение для предотвращения неправильного диагноза заболевания. Review focuses on the analysis of dermatological manifestations of the novel coronovirus infection COVID-19; this information is continuously updated and supplemented. However, the available data have not been systematized until now. The purpose of this review is to analyze the dermatological manifestations of the novel coronavirus infection COVID-19. On average, 12.5–20.4% of patients with confirmed COVID-19 have developed skin manifestations. Whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself presently remains still open. Possible mechanisms of skin lesions development are discussed as well as the role of the complement system and blood hypercoagulation in the pathogenesis of the dermatological manifestations. The review also provides clinical examples of skin involvement in the infectious process in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days of infection, so skin manifestations can serve as an indicator of infection, facilitating timely diagnosis. Moreover, physicians’ awareness of skin symptoms associated with COVID-19 is crucial for preventing misdiagnosis of the disease.

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The Dermatological Manifestations in the Coronavirus Infection COVID-19

The Russian Archives of Internal Medicine ◽

10.20514/2226-6704-2020-10-6-422-429 ◽

2020 ◽

Vol 10 (6) ◽

pp. 422-429

Author(s):

A. S. Dvornikov ◽

A. A. Silin ◽

T. A. Gaydina ◽

V. N. Larina ◽

P. A. Skripkina ◽

...

Keyword(s):

Drug Treatment ◽

Clinical Picture ◽

Viral Infections ◽

Skin Lesions ◽

The Novel ◽

Skin Manifestations ◽

Depth Analysis ◽

Vesicular Rash ◽

Coronavirus Infection ◽

Novel Coronavirus

The variety of dermatological manifestations in patients with the novel coronavirus infection COVID-19, the incidence of which depends on concomitant pathology and the characteristics of drug treatment, and their characteristics are similar to those that occur with conventional viral infections is discussed. At the present time it is proposed to distinguish several groups depending on the cause and mechanism of development: angiitis of the skin; papulo-squamous rash and pink lichen; measles rash and infectious erythema; papulo-vesicular rash; toxidermia; urticarial eruptions and artifical lesions. The variety of the clinical picture of the skin manifestations of coronavirus infection requires in-depth analysis in order to interpret correctly the skin lesions and other infectious exanthema and dermatoses in patients with COVID-19.

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Association and treatment of diabetes in patients affected by Covid-19

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3591 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 1198-1201

Author(s):

Syed Yasir Afaque

Keyword(s):

Diabetes Mellitus ◽

Prognostic Value ◽

Heart Diseases ◽

The Novel ◽

The World ◽

Treatment Of Diabetes ◽

Coronavirus Infection ◽

Composite Outcomes ◽

Novel Coronavirus ◽

The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

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Clinical characteristics and epidemiology survey of lung transplantation recipients accepting surgeries during COVID-19 pandemic：from area near Hubei Province (Preprint)

10.2196/preprints.22781 ◽

2020 ◽

Author(s):

Lingxiao Qiu ◽

Shanshan Chen ◽

Cong Wang ◽

Caihong Liu ◽

Huaqi Wang ◽

...

Keyword(s):

Lung Transplantation ◽

Clinical Characteristics ◽

Lung Transplant ◽

The Novel ◽

Web Based ◽

Transplant Program ◽

Medical Institutions ◽

Survey Results ◽

Wbc Count ◽

Novel Coronavirus

BACKGROUND Lung transplantation recipients (LTx) are more susceptible to severe acute respiratory syndrome-corona virus-2 (SARS-Cov-2) and suffer severer outcomes than healthy subjects. OBJECTIVE Here we aim to analyze whether it was appropriate to maintain lung transplant programs in medical institutions accepting coronavirus disease 2019 (COVID-19) patients. METHODS Methods: the clinical characteristics, laboratory testing, and epidemiology survey results of 10 LTx recipients undergoing allograft lung transplantation surgeries in the First Affiliated Hospital of Zhengzhou University during the COVID-19 pandemic were collected. A web-based epidemiology questionnaire was used to collect the information of LTx recipients after discharge. RESULTS A total of 10 LTx recipients were identified. The main cause of lung transplantation was idiopathic interstitial pneumonia (60%), with another rare case of cystic fibrosis. Comorbidities involved hyperlipidemia, subclinical hyperthyroidism, diabetes, viral hepatitis of type B. The average white blood cell (WBC) count and average lymphocyte count were 9.5±3.9×109 cells/liter and 1.7±1.1×109 cells/liter, respectively. 40% of the LTx recipients had lymphopenia. Impaired alanine aminotransferase (ALT) and aspartate transaminase (AST) were observed in LTx recipients. Good habitats of hand hygiene (100%), wearing protective masks behaviors (100%), indoor ventilation behaviors (100%), indoor disinfection measures (83%), personal tableware (67%), separate room (100%), personal bedsheets/ quilts (100%) and drinking glasses (100%) were observed during the follow-up. None of the LTx recipients or their family members get infected with SARS-CoV-2 during the novel coronavirus pandemic. CONCLUSIONS Under the premise of taking appropriate preventive measures during hospitalization and after discharge, the lung transplant program can be maintained in the medical institution that accepts patients with COVID-19. INTERNATIONAL REGISTERED REPORT RR2-doi: https://doi.org/10.1101/2020.07.06.20147264

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High cytokine levels and cytokine storm in the novel coronavirus infection

Vrač skoroj pomoŝi (Emergency Doctor) ◽

10.33920/med-02-2102-04 ◽

2021 ◽

pp. 38-47

Author(s):

Maksim Leonidovich Maksimov ◽

Albina Ayratovna Zvegintseva ◽

Lyudmila Yurievna Kulagina ◽

Albina Zainutdinovna Nigmedzyanova ◽

Elvina Ramisovna Kadyseva

Keyword(s):

Peripheral Blood ◽

High Frequency ◽

The Novel ◽

Cytokine Storm ◽

The Public ◽

Systemic Inflammatory Reaction ◽

Scientific World ◽

Cytokine Levels ◽

Coronavirus Infection ◽

Novel Coronavirus

A review article is based on current foreign sources. The level of cytokines in the peripheral blood can be increased in many diseases, but in some cases there may be an excess of their normal concentration in tens, hundreds or more times with the development of a peculiar clinical picture, which is based on a systemic inflammatory reaction. In the literature this condition has received the figurative name «cytokine storm», which highlights an extremely violent reaction of the immune system with an unknown (often unfavorable) outcome. Close attention of the scientific world and the public to the problem of extremely high levels of cytokines in the peripheral blood (hypercytokinemia) was drawn due to the high frequency of the cytokine storm in the novel coronavirus infection.

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FEATURES OF THE COURSE AND TACTICS OF MANAGING CHILDREN WITH KIDNEYS AND URINARY TRACT DISEASES DURING THE PANDEMIC OF NEW CORONAVIRUS INFECTION COVID-19

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2021-100-4-74-79 ◽

2021 ◽

Vol 100 (4) ◽

pp. 74-79

Author(s):

I.M. Kagantsov ◽

◽

V.V. Sizonov ◽

V.G. Svarich ◽

K.P. Piskunov ◽

...

Keyword(s):

Age Groups ◽

Clinical Manifestations ◽

Routine Care ◽

The Novel ◽

Urinary System ◽

Death Rates ◽

Global Pandemic ◽

Coronavirus Infection ◽

Novel Coronavirus ◽

Significant Health

The novel coronavirus infection (SARS-CoV-2), which first appeared in Wuhan, China in December 2019, has been declared a global pandemic by WHO. COVID-19 affects people of all age groups. The disease in children is usually asymptomatic or mild compared to adults, and with a significantly lower death rates. Data on kidney damage in children with COVID-19, as well as the effect of coronavirus infection on the course of diseases of the genitourinary system, are limited, the risks of contracting a new coronavirus infection in children with significant health problems, including those with chronic kidney disease, remain uncertain. The pandemic has affected the activities of surgeons treating diseases of the urinary system in children. Since the prospects for the end of the pandemic are vague, it is necessary to formulate criteria for selecting patients who can and should be provided with routine care in the pandemic. The purpose of this review is to highlight the features of the clinical manifestations and treatment of children with COVID-19, occurring against the background of previous renal pathology or complicating its course.

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