Dermatological manifestations in novel coronavirus infection COVID-19

2021 ◽  
Author(s):  
А.А. Хрянин ◽  
В.Г. Стуров ◽  
А.П. Надеев ◽  
В.К. Бочарова
Keyword(s):  
Primary Infection ◽  
Skin Lesions ◽  
The Novel ◽  
Skin Manifestations ◽  
Skin Symptoms ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
The Complement System ◽  
Secondary Consequence

Обзор посвящен анализу дерматологических проявлений при новой коронавирусной инфекции COVID-19, информация о которых непрерывно обновляется и дополняется. Однако до сих пор имеющиеся данные не были систематизированы. Цель обзора: проанализировать дерматологические проявления новой коронавирусной инфекции COVID-19. В среднем, у 12,5–20,4% пациентов с подтвержденным COVID-19 развились кожные проявления. Вопрос о том, являются ли кожные симптомы вторичным следствием респираторной инфекции или первичной инфекцией самой кожи, на данный момент остается открытым. Обсуждаются вероятные механизмы развития поражений кожи и роли системы комплемента и гиперкоагуляции крови в патогенезе развития дерматологических проявлений. В обзоре также приводятся клинические примеры вовлечения кожных покровов в инфекционный процесс при COVID-19. Поскольку COVID-19 имеет тенденцию к бессимптомному течению в течение 14 дней после заражения, кожные проявления могут служить индикатором инфекции, способствуя своевременной диагностике. Кроме того, осведомленность врачей о кожных симптомах, связанных с инфекцией COVID-19, имеет решающее значение для предотвращения неправильного диагноза заболевания. Review focuses on the analysis of dermatological manifestations of the novel coronovirus infection COVID-19; this information is continuously updated and supplemented. However, the available data have not been systematized until now. The purpose of this review is to analyze the dermatological manifestations of the novel coronavirus infection COVID-19. On average, 12.5–20.4% of patients with confirmed COVID-19 have developed skin manifestations. Whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself presently remains still open. Possible mechanisms of skin lesions development are discussed as well as the role of the complement system and blood hypercoagulation in the pathogenesis of the dermatological manifestations. The review also provides clinical examples of skin involvement in the infectious process in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days of infection, so skin manifestations can serve as an indicator of infection, facilitating timely diagnosis. Moreover, physicians’ awareness of skin symptoms associated with COVID-19 is crucial for preventing misdiagnosis of the disease.

scholarly journals Skin manifestations of a new coronovirus infection COVID-19 caused by SARS-CoV-2

2020 ◽  
Vol 96 (3) ◽  
pp. 53-62
Author(s):  
Aleksey A. Khryanin ◽  
Viktor G. Sturov ◽  
Alexander P. Nadeev ◽  
Valentina К. Bocharova
Keyword(s):  
Complement System ◽  
Primary Infection ◽  
Skin Lesions ◽  
Skin Manifestations ◽  
Skin Symptoms ◽  
Coronavirus Infection ◽  
Mechanisms Of Development ◽  
The Moment ◽  
Secondary Consequence

The review is devoted to the skin manifestations of new coronovirus infection (SARS-CoV-2), information about which is constantly updated. However, this information has not been systematized yet. The purpose of this review is to analyze the dermatological manifestations of a new coronavirus infection. On average, 12.520.4% of patients with confirmed COVID-19 have developed skin manifestations. The question of whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself remains open at the moment. The possible mechanisms of development of skin lesions and the role of diseases of complement system and blood hypercoagulation in the pathogenesis of the disease are discussed in the article. The review also provides descriptive and clinical examples of skin manifestations in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days, skin manifestations can be an indicator of infection, which leads to the timely diagnosis. In addition, doctors' awareness about skin symptoms associated with COVID-19 infection plays a big role in preventing misdiagnosis of the disease. The authors cite their own clinical сase of a patient with COVID-19 and associated skin angiitis.

scholarly journals The Dermatological Manifestations in the Coronavirus Infection COVID-19

2020 ◽  
Vol 10 (6) ◽  
pp. 422-429
Author(s):  
A. S. Dvornikov ◽  
A. A. Silin ◽  
T. A. Gaydina ◽  
V. N. Larina ◽  
P. A. Skripkina ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Clinical Picture ◽  
Viral Infections ◽  
Skin Lesions ◽  
The Novel ◽  
Skin Manifestations ◽  
Depth Analysis ◽  
Vesicular Rash ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The variety of dermatological manifestations in patients with the novel coronavirus infection COVID-19, the incidence of which depends on concomitant pathology and the characteristics of drug treatment, and their characteristics are similar to those that occur with conventional viral infections is discussed. At the present time it is proposed to distinguish several groups depending on the cause and mechanism of development: angiitis of the skin; papulo-squamous rash and pink lichen; measles rash and infectious erythema; papulo-vesicular rash; toxidermia; urticarial eruptions and artifical lesions. The variety of the clinical picture of the skin manifestations of coronavirus infection requires in-depth analysis in order to interpret correctly the skin lesions and other infectious exanthema and dermatoses in patients with COVID-19.

scholarly journals Cutaneous manifestations in children with the new coronavirus infection COVID-19

2021 ◽  
Vol 25 (1) ◽  
pp. 16-24
Author(s):  
O. B. Tamrazova ◽  
A. S. Stadnikova ◽  
E. V. Rudikova
Keyword(s):  
Literature Review ◽  
Viral Infection ◽  
Causative Agent ◽  
The Novel ◽  
Cutaneous Manifestations ◽  
Skin Manifestations ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus

In late 2019, a new viral infection appeared in China, which spread around the world, causing a pandemic. The causative agent of the new coronavirus infection COVID-19 is the SARS-CoV-2 coronavirus. The review presents modern data on the epidemiology, pathogenesis and course of the novel coronavirus infection COVID-19 in children. Chinese, American and European scientists have described a variety of cutaneous manifestations in children with COVID-19. The article provides a literature review of the cutaneous manifestations of COVID-19 coronavirus infection in children. During our own observation of 301 patients with coronavirus infection COVID-19 caused by SARS-CoV-2 at the Bashlyaevs Children Hospital in Moscow from May 17 to November 16, 2020, it was revealed that 39 (13 %) patients had skin manifestations. The article presents a classification of skin manifestations characteristic of COVID-19. A brief description of each group is given.

scholarly journals Cytokine Storm in the Novel Coronavirus Infection and Methods of its Correction

2021 ◽  
Vol 65 (11-12) ◽  
pp. 27-37
Author(s):  
A. V. Ershov ◽  
V. D. Surova ◽  
V. T. Dolgikh ◽  
T. I. Dolgikh
Keyword(s):  
Fatal Outcome ◽  
Lung Damage ◽  
The Novel ◽  
Cytokine Storm ◽  
Leading Role ◽  
Average Impact ◽  
Average Impact Factor ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The aim of the study was to identify the role of cytokine storm in COVID-19, that emerged at the end of 2019, based on the analysis of 80 publications, including 17.4% Russian and 82.6% foreign publications for 2014–2020 with an average impact factor of 11.94 and a maximum of 74.699. This review includes an in-depth discussion of the possible causes and pathogenetic factors of cytokine storm syndrome development caused by COVID-19. The results of research on the use of various principles of cytokine storm correction are provided. It has been established that lung damage and the development of a fatal outcome are caused not by the virus itself, but by the hyperreaction of the body's immune system. The leading role in this process belongs to the cytokine storm, including the action of IL-6.

scholarly journals Role of nutrients regulation in the immune system in preventing COVID-19 infection: A brief review

2021 ◽  
Vol 13 (2) ◽  
pp. 760-765
Author(s):  
Anamika Chauhan
Keyword(s):  
Immune System ◽  
Age Groups ◽  
World Health ◽  
The Novel ◽  
Beneficial Effects ◽  
Coronavirus Infection ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

This review aimed to focus on using foods to boost immunity against COVID-19 in all age groups. In human, coronavirus causes the common cold, severe acute respiratory syndrome (SARS), and a major threat to public health. The novel coronavirus was declared a pandemic by the World Health Organization due to its rapid infectivity. COVID-19 infection is most probably reported in people with low immunity response. The nutrients, which show beneficial effects on the immune system, are called immune nutrients and diet is called immune diet. A healthy diet can reduce the risk of infection of COVID-19 and can prevent disease. Nutritional food intake is also necessary for people with chronic illness, obese persons, diabetes, cardiovascular disease, cognitive dysfunction like anxiety and depression. All nutrients are essential for maintaining immunity and providing appropriate amounts of protein, fat, carbohydrate, vitamins, and minerals for the surveillance mode of keeping us from getting sick. The use of plenty of water, minerals such as micronutrients, zinc, copper, selenium, iron, magnesium, food rich in vitamins, and a good lifestyle can promote health and overwhelm this coronavirus infection.

Clinical characteristics of skin manifestations with the novel coronavirus infection COVID-19 caused by SARS-CoV-2

2020 ◽  
Vol 19 (3) ◽  
pp. 271
Author(s):  
N.N. Potekaev ◽  
O.V. Zhukova ◽  
D.N. Protsenko ◽  
G.M. Kozhevnikova ◽  
O.M. Demina ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
The Novel ◽  
Skin Manifestations ◽  
Coronavirus Infection ◽  
Novel Coronavirus

scholarly journals A case of SARS-CoV-2 reinfection in a patient with obstructive sleep apnea managed with telemedicine

2021 ◽  
Vol 14 (2) ◽  
pp. e240496
Author(s):  
Isabelo Sicsic Jr ◽  
Andres R Chacon ◽  
Moe Zaw ◽  
Kori Ascher ◽  
Alexandre Abreu ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Acute Infection ◽  
Adaptive Immune Response ◽  
The Novel ◽  
Adaptive Immune ◽  
Obstructive Sleep ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The novel coronavirus (SARS-CoV-2) has produced millions of infections and deaths worldwide. It is believed that adaptive immunity to the virus occurs although with variation in its pattern and duration. While uncommon, confirmed reinfection with the novel coronavirus has been reported. Telemedicine has emerged as a viable tool for the delivery of healthcare in lieu of in-person patient contact. The variable and occasionally rapid course of clinical disease raises safety concerns of using telemedicine in the clinical management of acute infection with the novel coronavirus. We present a case of novel coronavirus infection in an immunocompetent individual with obstructive sleep apnea (OSA) who failed to manifest an adaptive immune response to acute infection and was subsequently reinfected. The case highlights the use of telemedicine in managing novel coronavirus respiratory disease and the potential role of OSA as a disease facilitator.

scholarly journals Electrolyte deficiency after the novel coronavirus infection and post-COVID asthenia

2021 ◽  
Vol 5 (5) ◽  
pp. 245-251
Author(s):  
E.Yu. Ebzeeva ◽  
◽  
O.D. Ostroumova ◽  
I.F. Krotkova ◽  
E.V. Mironova ◽  
...  
Keyword(s):  
Pathological Condition ◽  
Acute Infection ◽  
High Rate ◽  
The Novel ◽  
Specific Syndrome ◽  
Study Results ◽  
Somatic Disorders ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Asthenia is a non-specific syndrome common in general practice and occurs in patients with acute and chronic somatic disorders, including infectious ones. The novel coronavirus infection (COVID-19) is one of the leading causes of severe and persistent asthenia. The hypothalamicpituitary- adrenal axis is essential for the development of asthenia since its dysfunction provoked by various factors (including infections) results in electrolyte metabolism impairment with hypokalemia and hypomagnesemia. This paper describes a hypothetical pathogenic mechanism of asthenia after the COVID-19, which implies over-activation of the renin-angiotensin-aldosterone system that, in particular, leads to hypokalemia. The role of pharmacotherapy prescribed for the COVID-19 is highlighted. Study results demonstrate a high rate of hypokalemia in patients with the COVID-19 and suggest a direct correlation between the severity of hypokalemia and the activity of viral infection. Furthermore, the detection of electrolyte abnormalities is essential in both acute infection and convalescence. Finally, the authors consider ways of relieving this pathological condition. KEYWORDS: novel coronavirus infection, COVID-19, post-infectious asthenia, angiotensin-converting enzyme, hypokalemia, hypomagnesemia. FOR CITATION: Ebzeeva E.Yu., Ostroumova O.D., Krotkova I.F. et al. Electrolyte deficiency after the novel coronavirus infection and post- COVID asthenia. Russian Medical Inquiry. 2021;5(5):245–251 (in Russ.). DOI: 10.32364/2587-6821-2021-5-5-245-251.

scholarly journals COVID-19 Therapy: the Role of Antirheumatic Drugs

2021 ◽  
Vol 66 (7-8) ◽  
pp. 83-89
Author(s):  
M. A. Litvinova ◽  
N. V. Muravyeva ◽  
B. S. Belov
Keyword(s):  
The Novel ◽  
Huge Amount ◽  
Close Attention ◽  
Antirheumatic Drugs ◽  
Coronavirus Infection ◽  
Underlying Mechanisms ◽  
Novel Coronavirus ◽  
Contradictory Data ◽  
Selection Of

Currently, the close attention of the medical and international community is still riveted on the novel coronavirus infection, which caused the pandemic in 2020. Understanding the underlying mechanisms of coronavirus disease-2019 (COVID-19) made it possible to move from the empirical selection of therapy, which was observed at the beginning of the pandemic, to the pathogenetically justified prescription of drugs, including glucocorticoids, anticoagulants, as well as some antirheumatic drugs. However, despite the huge amount of scientific and clinical material accumulated over 1.5 years, the interest in this problem does not wane both due to the existence of a number of unresolved issues, and due to the constant emergence of new (often contradictory) data.

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