Mechanisms of action and clinical effectiveness of ultratonotherapy in the complex treatment of foot onychomycosis

Author(s):  
M.M. Tlish ◽  
M.E. Shavilova ◽  
A.A. Matishev
2020 ◽  
pp. 82-94 ◽  
Author(s):  
V. O. Belash ◽  
L. R. Urazgalieva ◽  
R. I. Fayzullina ◽  
L. G. Agasarov

Introduction. Degenerative-dystrophic changes in the spine are the most common chronic human diseases. Pronounced clinical manifestations of vertebrogenic diseases are observed during active labor activity and represent one of the most frequent causes of temporary disability. It is also known that any pain syndromes are accompanied by the development of psychovegetative disorders, which reduces the effectiveness of treatment. In recent years, there has been a reasonable increase in the interest of the medical community to the non-drug treatment methods. It is caused by the polypharmacotherapy side effects, an increased numbers of allergic reactions, problems with polypragmasia, and a low level of compliance. At the same time, the question of the possibility of various non-drug treatment methods combining is quite acute.The goal of research is to substantiate the clinical effectiveness of the combined application of osteopathic correction and reflexotherapy in the complex treatment of patients with dorsopathy at the cervical-thoracic level.Materials and methods. A prospective controlled randomized study was conducted on the basis of the medical clinics of LLC «Family Health» (Kazan) and ANO «Center for SEB assistance» (Kazan) from April 2018 to May 2019. The study involved 52 people with dorsopathy at the cervical-thoracic level, aged from 25 to 45 years. In accordance with the exclusion criteria, 7 people dropped out of the study. The remaining patients (45 people), depending on the used treatment method, were divided by a simple randomization method using a random number generator into three groups of 15 people. The first group (main group) received osteopathic correction and reflexotherapyon the background of standard drug therapy; the second and the third groups (control groups) received only osteopathic correction orreflexotherapy, respectively, on the background of standard drug therapy. The osteopathic examination was performed for all patients regardless of the group, before and after the course of therapy, with the formation of an osteopathic conclusion.Also there was the estimation of the degree of pain syndrome severity,the asthenia, and the degree of accumulated emotional and energy charge that does not get out in a person.Results. It was found in the course of the study that the inclusion of osteopathic correction and reflexotherapy in the complex therapy of patients with dorsopathy at the cervical-thoracic level is clinically more effective than the isolated use of these methods. Such complex therapy allows to achieve a more significant reduction in the severity of the pain syndrome by VAS (p<0,05), relief of internal emotional tension (p<0,05), and increase the effectiveness of correction of dominant somatic dysfunction. Based on the obtained data, it could be assumed that reflexotherapy potentiates the effects of osteopathic correction.Conclusion. Based on the study, it can be concluded that the combination of osteopathic correction and reflexotherapy in the treatment of patients with dorsopathy at the cervical-thoracic level increases the clinical effectiveness of the standard drug therapy. At the same time, it is worth noting the potentiating effect of the combined use of two non-medicinal methods. The question of combining of various non-drug treatment methods is quite acute today, so this study will be continued. 


2021 ◽  
Vol 50 (2) ◽  
pp. 76-79
Author(s):  
K. A. Gabelova

The clinical effectiveness o f complex enzymotherapy with preparation Vobenzim in treatment o f gestosis was studied in comparison with traditional therapy. The author analyzes the course оf gestation and delivery, and the state оf neonates in women with nephropathy o f I degree, who got common treatment (28 patients) and complex treatment including Vobenzim (17patients). Positive clinical effect o f complex enzymotherapy in case o f nephropathy is displayed in decreasing of edematic syndrome, eliminating or decreasing o f proteinuria, lowering o f blood pressure and impairment o f fetalhypoxia in labors. It goes along with the reduction o f immune complexes fixed in placenta.


2021 ◽  
pp. 117-121
Author(s):  
B. V. Petryuk ◽  
T. A. Petryuk ◽  
L. P. Khomko ◽  
O. Yо. Khomko ◽  
I. E. Semenyuk

Summary. The purpose of the research was to explore the appropriateness of combined usage of enterosorption amplification and intratissular electrophoresis (ITE) of antibiotics in injured with the substantial thermal burns. Clinical effect of the enterosorbtion and ITE antibacterial drugs in burn disease cases was studied in 26 patients with superficial and deep dermal burns (IIb-III deg.) from 27 to 60 % of their body surface. Enterosgel was prescribed from 3rd day after injury for 15–20 g 3–4 times a day for 7–14 days. ITE of antibiotics conducted from the 3–4 day by the «Поток-1» device, applying the direct current with density 0,03-0,05 mAh/cm2 for 60 min. Materials and methods. The authors studied the leukocyte reaction by a general blood test. The degree of intoxication was determined by the level of molecules of average mass and blood plasma electrical conductivity. They evaluated the dynamics of the wound process, conducted bacteriological and cytological researches of the burn wounds in dynamics on 1–3, 6–7, 13–14, and 19-21 days after traumatization. Results and discussion. This treatment tactic allows to reduce the level of endogenous intoxication, to optimize the course of the wound process in the area of thermal damage, to intensify demarcation-cleansing processes and reparative regeneration, which increases the clinical effectiveness of treatment. Conclusions. As a result of the research, it was found that the combined usage of enterosorption detoxification by enterosgel and ITE of antibacterial drugs in the complex treatment of victims with widespread burns is appropriate and justified.


Author(s):  
Paolo Governa ◽  
Giulia Baini ◽  
Vittoria Borgonetti ◽  
Giulia Cettolin ◽  
Daniela Giachetti ◽  
...  

Phytotherapy has long been a source of medicinal products and many attempts to use herbal medicine for the treatment of diabetes has been done over the years. Several medicinal plants and their preparations demonstrated to act in key points of glucidic metabolism. The most common mechanisms of action found include the inhibition of &alpha;-glucosidase and of AGE formation, the increase of GLUT-4 and PPARs expression and the antioxidant activity.Despite the large amount of literature available, the actual clinical effectiveness of medicinal plants in controlling diabetes related symptoms is still controversial and there is a crucial need for stronger evidence-based data. In this review, an overview of the medicinal plants, which use in the management of diabetes is supported by authoritative monograph, is provided. References to some species which are currently under growing clinical investigation are also reported.


Author(s):  
Paolo Governa ◽  
Giulia Baini ◽  
Vittoria Borgonetti ◽  
Giulia Cettolin ◽  
Daniela Giachetti ◽  
...  

Phytotherapy has long been a source of medicinal products and many attempts to use herbal medicine for the treatment of diabetes has been done over the years. Several medicinal plants and their preparations demonstrated to act in key points of glucidic metabolism. The most common mechanisms of action found include the inhibition of &alpha;-glucosidase and of AGE formation, the increase of GLUT-4 and PPARs expression and the antioxidant activity. Despite the large amount of literature available, the actual clinical effectiveness of medicinal plants in controlling diabetes related symptoms is still controversial and there is a crucial need for stronger evidence-based data. In this review, an overview of the medicinal plants, which use in the management of diabetes is supported by authoritative monograph, is provided. References to some species which are currently under growing clinical investigation are also reported.


2018 ◽  
pp. 48-53 ◽  
Author(s):  
B. M. Belik ◽  
A. N. Kovalev ◽  
A. L. Khatlamadzhiyan

OBJECTIVES OF RESEARCH. To assess the clinical effectiveness of phlebotrophic drug Detralex (Micronized purifiedflavonoid fraction (MPFF)) during complex treatment of patients with acute hemorrhoids. MATERIALS AND METHODS. A comparative analysis of treatment outcomes of 293 patients with acute hemorrhoids was conducted. All patients were divided into two groups for further clinical observations. Standard drug therapy was performedfor 145 patients (group I). For 148 patients (group II), in addition to the standard treatment, phlebotrophic drug Detralex was additionally initiated. Research program included detection of content of acute inflammatory phase reactants and pro-inflammatory cytokines in blood plasma, evaluation of pain syndrome severity (VRS) and quality of life parameters (SF-36 questionnaire). RESULTS. Initiation of MPFF with complex treatment of patients with acute hemorrhoids was found to be contributed to faster elimination of edema and inflammation, a decrease in severity of hemorrhoids thrombosis, relief of pain syndrome and improvement in patients'quality of life, along withwell-marked regression of laboratory markers of inflammatory reaction This allows to increase the number of good outcomes of acute hemorrhoids treatment from 66,2% to 89,9%, that is by 23,7% and to reduce the number of unsatisfactory outcomes from 4,2% to 1,3%, that is by 2,9%. CONCLUSION. Inclusion of Detralex into program of acute hemorrhoids treatment contributes to a faster elimination of clinical and laboratory manifestations of the disease and allows improving the results of treatment for this category of patients.


2011 ◽  
Vol 138 (1) ◽  
pp. 26-32
Author(s):  
Yusuke Furukawa ◽  
Nobuya Hiraoka ◽  
Taeko Wada ◽  
Jiro Kikuchi ◽  
Yasuhiko Kano

2012 ◽  
Vol 93 (1) ◽  
pp. 72-76
Author(s):  
V E Radzinskiy ◽  
Yu A Petrov ◽  
M L Polina

Aim. To evaluate the clinical effectiveness of impulse electrotherapy in the complex treatment of patients with different variants of chronic endometritis based on the evaluation of adaptive reactions and immune status. Methods. Conducted was a clinical and laboratory examination of 550 women with early reproductive losses, who were divided into three groups. Studied was the efficacy of electro-impulse therapy with high-amplitude short-wavelength low-frequency electrical signals using the apparatus «SKENAR» (SKENAR-therapy) in the complex treatment of 269 women with chronic endometritis (first group). The second group included 67 women with similar variants of chronic endometritis, who were treated without the physiotherapy component. 54 patients refused the proposed rehabilitation activities (third group). Results. New data has been obtained on the adaptive reactions of the female body before and after treatment during different types of chronic endometritis. The frequency of disadaptation was highest during the hypoplastic form of chronic endometritis. Shown was the high efficiency of electro-impulse therapy, using the apparatus «SKENAR» in the complex treatment of chronic endometritis due to the normalization of parameters of immunoreactivity. It was established that SKENAR-therapy of chronic endometritis promotes early normalization of adaptive reactions in comparison to conventional methods of treatment. Conclusion. Rehabilitation treatment of chronic endometritis in combination with electro-impulse therapy with high-amplitude short-wavelength low-frequency electrical signals contributes to the recovery of immunoreactivity and to the formation of favorable adaptation reactions.


2015 ◽  
Vol 84 (4) ◽  
pp. 218-222
Author(s):  
Marta Holeyko ◽  
Volodymyr Zubachyk

Introduction. Chronic combined periodontal and periapical lesions have a negative impact on the human organism, since they are a source of intoxication and sensitization causing progression of infection, development of focal sequelae and secondary immunodeficiency. Problem of successful treatment of apical and marginal periodontitis is associated with a significant prevalence of these diseases, a complexity of medical procedures, a substantial proportion of failures and complications, and with a lack of long-term stability of gained results.Aim. The aim of this work was to investigate clinical effectiveness of drug formulation with thiotriazoline and chloramphenicol in the integrated treatment of combined apical and marginal periodontitis.Meterial and methods. The condition of oral cavity of the 65 patients with combined lesions of periodontal and endodontic tissues before and after treatment was studied. Outcomes measured were X-ray examination, probing depth, OHI-S, PMA, PI, SBI indices. The complex treatment has been worked out in the patients of main group and the ointment with thiotriazoline and chloramphenicol was introduced in the scheme of periodontal treatment Results and conclusions. Results of applied treatment indicated to the acceleration of healing process, reduction of exudation period and decrease of exacerbations frequency in the patients of main group. Clinical experience also demonstrated positive dynamic in changes of periodontal indices after the conducted treatment.


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