Biological activity and flavonoid profile of five species of the Bursera genus

Background: The genus Bursera Jacq. ex. L. concentrates its diversity in Mexico. Among the secondary metabolites that can be isolated from organic its extracts are flavonoids and lignans. Research question: Do the biological activity of the hydroalcoholic extracts from five Bursera species studied depend on their flavonoid content? Study site: Oaxaca, Mexico. Methods: The extracts of B. aptera Ramírez, B. fagaroides (Kunth) Engl., B. schlechtendalii Engl., B. galeottiana Engl., B. morelensis Ramírez were analyzed by High Resolution Liquid Chromatography (HPLC) to determine their flavonoid composition. The antiradical DPPH, anti-inflammatory, antibacterial and antifungal activities of the extracts were determined. Results: Phlorizin and quercetin were conserved in both stems and leaves of the five species studied. The phloretin was present only in the leaves of B. aptera. The highest antibacterial activity was observed against Staphylococcus epidermidis and Salmonella typhimurium by the extracts of leaves of B. aptera (MIC 0.002 mg/mL) and the stems of B. fagaroides (MIC 0.015 mg/mL). The extract of stems of B. morelensis against Fusarium boothii presented the highest antifungal effect (lower than 50 ?g/mL). The anti-inflammatory activity of B. fagaroides was 51.24 % edema inhibition (1 mg/ear) compare to 78.76 % of indomethacin (0.358 mg/ear). Conclusion: The presence of flavonoids in five species studied suggests the richness of these compounds in Bursera genus. The biological activities studied indicated the potential medicinal use of these species and the role that the flavonoids play in plant physiology.

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Effect of Extraction Methods on Polyphenols, Flavonoids, Mineral Elements, and Biological Activities of Essential Oil and Extracts of Mentha pulegium L.

Molecules ◽

10.3390/molecules27010011 ◽

2021 ◽

Vol 27 (1) ◽

pp. 11

Author(s):

Mohammed Messaoudi ◽

Abdelkrim Rebiai ◽

Barbara Sawicka ◽

Maria Atanassova ◽

Hamza Ouakouak ◽

...

Keyword(s):

Candida Albicans ◽

Essential Oil ◽

Biological Activities ◽

Emission Spectrometry ◽

Mentha Pulegium ◽

Antifungal Activities ◽

Antibacterial And Antifungal Activities ◽

Pharmaceutical Industries ◽

Anti Inflammatory ◽

Antibacterial And Antifungal

Our study evaluated the in vitro antioxidant properties, antibacterial and antifungal activities, anti-inflammatory properties, and chemical composition of the essential oils (EOs), total phenol, and total flavonoid of wild Mentha pulegium L. This study also determined the mineral (nutritional and toxic) elements in the plant. The EOs were extracted using three techniques—hydro distillation (HD), steam distillation (SD), and microwave-assisted distillation (MAD)—and were analyzed using chromatography coupled with flame ionization (GC-FID) and gas chromatography attached with mass spectrometry detector (GC-MS). The antioxidant effects of the EOs were tested with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), while the antibacterial and antifungal activities of the EO and methanolic extract were tested using Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. Twenty-six compounds were identified in the essential oil, representing 97.73% of the total oil, with 0.202% yield. The major components were pulegone (74.81%), menthone (13.01%) and piperitone (3.82%). Twenty-one elements, including macro- and micro-elements (Ba, Br, Ca, Cl, Co, Cr, Cs, Eu, Fe, K, Mg, Mn, Mo, Na, Rb, Sb, Sc, Sr, Th, U and Zn), were detected using neutron activation analysis (INAA) and inductively coupled plasma optical emission spectrometry (ICP-OES), with the concentration of mineral element close to the FAO recommendation. The results show that the EOs and extracts from Mentha pulegium L. had significant antimicrobial activities against the microorganisms, including five human pathogenic bacteria, one yeast (Candida albicans), and one phytopathogenic fungi. The in vivo anti-inflammatory activities of the leaf extracts were confirmed. The results indicate that the EOs and extracts from Mentha pulegium L. have promising applications in the pharmaceutical industries, clinical applications, and in medical research.

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Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

10.31221/osf.io/g7mx8 ◽

2019 ◽

Author(s):

Chem Int

Keyword(s):

Nalidixic Acid ◽

Copper Complexes ◽

Biological Activities ◽

Bidentate Coordination ◽

Antibacterial And Antifungal Activities ◽

Elemental Analyses ◽

Oxadiazole Derivatives ◽

Antibacterial And Antifungal ◽

Derivatives Of ◽

Substituted 1

A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.

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Synthesis of a Series of Novel 2-Amino-5-Substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole Derivatives as Potential Anticancer, Antifungal and Antibacterial Agents

Medicinal Chemistry ◽

10.2174/1573406417666210803170637 ◽

2021 ◽

Vol 17 ◽

Author(s):

Em Canh Pham ◽

Tuyen Ngoc Truong ◽

Nguyen Hanh Dong ◽

Duy Duc Vo ◽

Tuoi Thi Hong Do

Keyword(s):

Cell Line ◽

Biological Activities ◽

Chemical Properties ◽

Diffusion Method ◽

Anticancer Activities ◽

Molecular Docking Study ◽

Antifungal Activities ◽

Antibacterial And Antifungal Activities ◽

Thiadiazole Derivatives ◽

Antibacterial And Antifungal

Background: Many compounds containing a five-membered heterocyclic ring display exceptional chemical properties and versatile biological activities. Objective: The objective of the present study was the desire to prepare the 5-substituted 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole derivatives and evaluate their potential anticancer, antibacterial and antifungal activities. Methods: Twenty-seven derivatives were synthesized by iodine-mediated cyclization of semicarbazones or thiosemicarbazones obtained from condensation of semicarbazide or thiosemicarbazide and aldehydes. The structures were confirmed by 1H-NMR, 13C-NMR and MS spectra. The antibacterial and antifungal activities were evaluated by diffusion method and the anticancer activities were evaluated by MTT assay. Results: Twenty-seven derivatives have been synthesized in moderate to good yields. A number of derivatives exhibited potential antibacterial, antifungal and anticancer activities. Conclusion: Compounds (1b, 1e and 1g) showed antibacterial activity against Streptococcus faecalis, MSSA and MRSA with MIC ranging between 4 to 64 µg/mL. Compound (2g) showed antifungal activity against Candida albicans (8 µg/mL) and Aspergillus niger (64 µg/mL). Compound (1o) exhibited high cytotoxic activity against HepG2 cell line (IC50 value 8.6 µM), which is comparable to the activity of paclitaxel, and is non-toxic on LLC-PK1 normal cell line. The structure activity relationship and molecular docking study of the synthesized compounds are also reported.

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Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

Molecules ◽

10.3390/molecules23082013 ◽

2018 ◽

Vol 23 (8) ◽

pp. 2013 ◽

Cited By ~ 16

Author(s):

Ricardo Murcia ◽

Sandra Leal ◽

Martha Roa ◽

Edgar Nagles ◽

Alvaro Muñoz-Castro ◽

...

Keyword(s):

Electrical Conductivity ◽

Biological Activity ◽

Melting Point ◽

Inhibitory Concentration ◽

Vero Cells ◽

Visible Spectroscopy ◽

Antifungal Activities ◽

Antibacterial And Antifungal Activities ◽

Antibacterial And Antifungal ◽

New Compounds

In this work, six complexes (2–7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3–7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL−1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.

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AN UPDATE ON THE SYNTHESIS OF BENZOXAZOLES

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i10.19457 ◽

2017 ◽

Vol 10 (10) ◽

pp. 48 ◽

Cited By ~ 2

Author(s):

Jyothi M ◽

Ramchander Merugu

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Biological Activity ◽

Biological Activities ◽

Starting Material ◽

Bioactive Molecules ◽

Living Systems ◽

Inflammatory Activity ◽

Anti Inflammatory

Benzoxazoles being structurally similar to bases adenine and guanine interact with biomolecules present in living systems. These compounds possess antimicrobial, central nervous system activities, antihyperglycemic potentiating activity, analgesic, and anti-inflammatory activity. It can also be used as starting material for other bioactive molecules. Modifications in structure and the biological profiles of new generations of benzoxazoles were found to be more potent with enhanced biological activity. Considering all these, we have prepared this review and discussed the synthesis and biological activities of benzoxazoles.

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Synthesis and investigation of 3,5-bis-linear and macrocyclic tripeptidopyridine candidates by using l-valine, N,N′-(3,5-pyridinediyldicarbonyl)bis-dimethyl ester as synthon

Zeitschrift für Naturforschung B ◽

10.1515/znb-2019-0006 ◽

2019 ◽

Vol 74 (6) ◽

pp. 473-478 ◽

Cited By ~ 2

Author(s):

Abd El-Galil E. Amr ◽

Ahmed M. Naglah ◽

Nermien M. Sabry ◽

Alhussein A. Ibrahim ◽

Elsayed A. Elsayed ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Candida Albicans ◽

Organic Molecules ◽

Biological Activities ◽

Dimethyl Ester ◽

Antimicrobial Activities ◽

Current Work ◽

Antifungal Activities ◽

Antibacterial And Antifungal Activities ◽

Antibacterial And Antifungal

AbstractInterest in the synthesis of heterocyclic organic molecules with peptide moieties has gained attention due to their potential biological activities. The current work aimed at synthesizing new macrocyclic tripeptide imides and evaluating their possible antimicrobial activities. A series of 11 derivatives were prepared from dimethyl 3,5-pyridinevalinyl ester either by NaOH or NH2NH2 treatment, followed by cyclization and further reaction with NaOH or NH2NH2. The majority of synthesized derivatives showed promising antibacterial and antifungal activities in comparison to standard known antibiotics. Compounds 5a and 7b showed the most potential antibacterial against Staphylococcus aureus and antifungal activities against Candida albicans, respectively.

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Dittrichia Viscosa L. Greuter: Phytochemistry and Biological Activity

Natural Product Communications ◽

10.1177/1934578x0800301110 ◽

2008 ◽

Vol 3 (11) ◽

pp. 1934578X0800301

Author(s):

Alejandro F. Barrero ◽

M. Mar Herrador ◽

Pilar Arteaga ◽

Julieta V. Catalán

Keyword(s):

Biological Activity ◽

Mediterranean Region ◽

Biological Activities ◽

Dittrichia Viscosa ◽

The Mediterranean ◽

Anti Inflammatory

Dittrichia viscosa is a plant widely distributed in the Mediterranean region. This species and its components present a broad range of biological activities (for example, anti-inflammatory, antifungal, antiulcer, antiviral, antiparasitic), which are reviewed. Extracts of the species are particularly rich in terpenoids, in particular eudesmane acids, notably ilicic acid (45) and α-costic acid (44). Flavonoids are also abundant, especially during flowering.

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SYNTHESIS, CHARACTERIZATION AND IN VITRO STUDY OF ANTIBACTERIAL, ANTIFUNGAL ACTIVITIES OF SOME NOVEL DIHYDROPYRIMIDINTHIONE DERIVATIVES

Latin American Applied Research - An international journal ◽

10.52292/j.laar.2014.454 ◽

2014 ◽

Vol 44 (4) ◽

pp. 289-293

Author(s):

S. BALUJA ◽

S. CHANDA ◽

R. BHALODIA ◽

R. TALAVIYA

Keyword(s):

Biological Activities ◽

Wide Spectrum ◽

In Vitro Study ◽

Dimethyl Formamide ◽

Mass Spectral Data ◽

Antifungal Activities ◽

Mass Spectral ◽

Antibacterial And Antifungal Activities ◽

Antibacterial And Antifungal

Dihydropyrimidinthione is an important class of heterocyclic compounds which exhibits wide spectrum of biological activities. In the present study, some bio-active dihydropyrimidinthione derivatives have been synthesized and their characterization was done by IR, NMR and mass spectral data. The antibacterial and antifungal activities of synthesized compounds have also been studied in N,N-dimethyl formamide and Dimethyl sulfoxide.

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Synthesis, Characterization and Study of Antimicrobial Activities of Mannich Bases Incorporating 1,2,4-Triazole Nucleus

Amrit Research Journal ◽

10.3126/arj.v2i01.39894 ◽

2021 ◽

Vol 2 (01) ◽

pp. 19-27

Author(s):

Rhambus Rawat ◽

Prem Shankar Deo ◽

Bhushan Shakya

Keyword(s):

Schiff Base ◽

Heterocyclic Compounds ◽

Environmental Science ◽

Biological Activities ◽

Antimicrobial Activities ◽

Mannich Bases ◽

New Drugs ◽

Spectroscopic Techniques ◽

Antibacterial And Antifungal Activities ◽

Antibacterial And Antifungal

Heterocyclic compounds containing triazole moiety have great importance in the field of medicine, pharmaceuticals, biochemistry, biology, therapeutics, environmental science, and industry. Triazoles and their derivatives have been extensively used in the development of new drugs. Biological activities of Schiff bases are highly investigated, but Mannich bases are on the verge of their development, and they are being synthesized in large number nowadays. In this work, Mannich bases are synthesized by incorporation 1,2,4-triazole moiety through Schiff base using different amines. Mannich bases are found to exhibit highly effective antibacterial and antifungal activities. The formation of synthesized compounds - 1,2,4-triazole-5-thione, Schiff base (4) and Mannich bases (5a and 5b) - are confirmed and characterized by spectroscopic techniques like UV, FTIR 1H-NMR and 13C-NMR. The activity of the synthesized compounds was tested against bacterial and fungal strain.

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A Review: Therapeutic and Biological Activity of Benzothiazole Derivatives

International Journal of Recent Advances in Science and Technology ◽

10.30750/ijrast.432 ◽

2017 ◽

Vol 4 (3) ◽

Cited By ~ 2

Author(s):

Suresh Choudhary ◽

G Jeyabalan ◽

Naresh Kalra

Keyword(s):

Biological Activity ◽

Biological Activities ◽

New Products ◽

Therapeutic Agents ◽

Present Review ◽

Benzothiazole Derivatives ◽

Anti Inflammatory

The Benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess interesting biological activities, such as antitumor, antimicrobial, anthelmintic, antileishmanial, anticonvulsant and anti-inflammatory. The present review focuses on the benzothiazoles with potential activities that are now in development. The synthesized benzothiazole derivatives could be considered as lead molecule for the development of therapeutic agents.

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