scholarly journals LIPOSOMES AS A TARGETED DELIVERY SYSTEM OF DRUGS (REVIEW)

2021 ◽  
Vol 20 (1) ◽  
pp. 33-41
Author(s):  
V. S. Gorbik ◽  
Z. S. Shprakh ◽  
Z. M. Kozlova ◽  
V. G. Salova
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Malignant Neoplasms ◽  
Target Tissue ◽  
Advantages And Disadvantages ◽  
Physicochemical Factors ◽  
Targeted Drug ◽  
Main Component ◽  
Preclinical And Clinical Studies

Liposomal targeted drug delivery makes it possible to achieve effective concentration in the target cell under various pathological conditions. The main advantage of liposomal particles is their biodegradability and immunological neutrality, which improves the safety profile of drugs. The review provides information on the composition of liposomes: the main component of the liposomal membrane is phospholipids, which provide its strength and protect from mechanical impacts. Liposomal particles are distinguished by the size and number of bilayer membranes, also secreted liposomes with a non‑lamellar organization. The composition and size of liposomes are selected depending on the purpose, including excipients in the membrane that affect the properties and functions of liposomes, including the rate of release of the components, the affinity of liposomes for the target tissue, etc. The review considers the main methods for obtaining liposomes and the features of their use, advantages and disadvantages. The creation of liposomes that are sensitive to various external or internal physicochemical factors makes it possible to realize drugs effects, localize the site of its action and reduce the number and severity of side effects. Currently, liposome‑based drugs are successfully used in various fields of medicine – dermatology, cardiology, oncology, neurology, etc. The most active condact preclinical and clinical studies of liposomal drugs for the treatment of malignant neoplasms. Particular attention is paid to the work of Russian researchers in the field of targeted drug delivery. It is shown that today liposomes are an open for study and improvement system for targeted drug delivery.

Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System

2020 ◽  
Vol 17 (10) ◽  
pp. 911-924
Author(s):  
Rohitas Deshmukh
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Therapeutic Agent ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Target Tissue ◽  
Polymer Carriers

Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective drug delivery system. The delivery systems employing the use of polymers, such as chitosan and pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an increased amount of the drug to reach the target tissue or cells. In this systematic review of published literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the use of chitosan and pectin in colon targeted drug delivery systems.

scholarly journals Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents

2015 ◽  
Vol 6 (8) ◽  
pp. 1286-1299 ◽  
Author(s):  
D. D. Lane ◽  
D. Y. Chiu ◽  
F. Y. Su ◽  
S. Srinivasan ◽  
H. B. Kern ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Raft Polymerization ◽  
Chemotherapeutic Agents ◽  
Polymer Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Targeted Drug

Second generation polymeric brushes with molecular weights in excess of 106 Da were synthesize via RAFT polymerization for use as antibody targeted drug delivery vehicles.

Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

2022 ◽  
Author(s):  
Nafeesa Khatoon ◽  
Zefei Zhang ◽  
Chunhui Zhou ◽  
Maoquan Chu
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Systemic Toxicity ◽  
Coated Nanoparticles ◽  
Biomimetic Approach ◽  
Targeted Drug ◽  
Macrophage Membrane

The enhanced and targeted drug delivery with low systemic toxicity and subsequent release of drugs is the major concern among researchers and pharmaceutics. Inspite of greater advancement and discoveries in...

scholarly journals Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Gels ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 6 ◽  
Author(s):  
Filippo Pinelli ◽  
Giuseppe Perale ◽  
Filippo Rossi
Keyword(s):  
Drug Delivery ◽  
Surface Functionalization ◽  
Targeted Drug Delivery ◽  
Delivery Systems ◽  
Research Field ◽  
Colloidal Systems ◽  
Advantages And Disadvantages ◽  
Targeted Drug ◽  
Final System ◽  
Targeted Drug Delivery Systems

Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be adopted in order to modify the selectivity of the nanoparticles in the delivery process and obtain a final system with great targeted drug delivery ability. We also highlight the most important fields of application of these kinds of delivery systems and we propose a comparison between the advantages and disadvantages of the described functionalization strategies.

scholarly journals Alginate-Based Platforms for Cancer-Targeted Drug Delivery

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Lili He ◽  
Zhenghui Shang ◽  
Hongmei Liu ◽  
Zhi-xiang Yuan
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Delivery Systems ◽  
Cancer Targeting ◽  
Innovative Strategies ◽  
General Chemical ◽  
Different Types ◽  
Targeted Drug ◽  
Potential Use

As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and biodegradable. A significant number of studies have confirmed the potential use of alginate-based platforms as effective vehicles for drug delivery for cancer-targeted treatment. In this review, the focus is on the formation of alginate-based cancer-targeted delivery systems. Specifically, some general chemical and physical properties of alginate and different types of alginate-based delivery systems are discussed, and various kinds of alginate-based carriers are introduced. Finally, recent innovative strategies to functionalize alginate-based vehicles for cancer targeting are described to highlight research towards the optimization of alginate.

Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles

2020 ◽  
Vol 66 (6) ◽  
pp. 464-468
Author(s):  
L.V. Kostryukova ◽  
Y.A. Tereshkina ◽  
E.I. Korotkevich ◽  
V.N. Prozorovsky ◽  
T.I. Torkhovskaya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Breast Adenocarcinoma ◽  
Control Line ◽  
Phospholipid Nanoparticles ◽  
Significant Difference ◽  
Targeted Drug ◽  
Cd13 Receptor

Doxorubicin is one of the widely known and frequently used chemotherapy drugs for the treatment of various types of cancer, the use of which is difficult due to its high cardiotoxicity. Targeted drug delivery systems are being developed to reduce side effects. One of the promising components as vector molecules (ligands) are NGR-containing peptides that are affinity for the CD13 receptor, which is expressed on the surface of many tumor cells and tumor blood vessels. Previously, a method was developed for preparing a composition of doxorubicin embedded in phospholipid nanoparticles with a targeted fragment in the form of an ultrafine emulsion. The resulting composition was characterized by a small particle size (less than 40 nm) and a high degree of incorporation of doxorubicin (about 93%) into transport nanoparticles. When assessing the penetrating ability and the degree of binding to the surface of fibrosarcoma cells (HT-1080), it was shown that when the composition with the targeted fragment was added to the cells, the level of doxorubicin was almost 2 times higher than that of the liposomal form of doxorubicin, i.e. the drug in the system with the targeted peptide penetrated the cell better. At the same time, on the control line of breast adenocarcinoma cells (MCF-7), which do not express the CD13 receptor on the surface, there was not significant difference in the level of doxorubicin in the cells. The data obtained allow us to draw preliminary conclusions about the prospects of targeted delivery of doxorubicin to tumor cells when using a peptide conjugate containing an NGR motif and the further need for its comprehensive study.

scholarly journals Abstract P-34: Cryo-EM Study of Submicrocapsules with a Shell of Nanoparticle Heteroaggregates and Polyelectrolyte Layers

2021 ◽  
Vol 11 (Suppl_1) ◽  
pp. S26-S27
Author(s):  
Anastasiya Kostenko ◽  
Konstantin Palamarchuk ◽  
Yury Chesnokov ◽  
Konstantin Plokhikh ◽  
Tatyana Bukreeva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Colloidal Particles ◽  
Electron Tomography ◽  
Physical Adsorption ◽  
Sio2 Nanoparticles ◽  
Silicon Dioxide Nanoparticles ◽  
Liquid Form ◽  
Targeted Drug

Background: Currently, different approaches of active and passive targeted drug delivery are being developed. One of the most promising methods of targeted drug delivery is the use of capsules. For instance, colloidosomes—capsules consisting of the shell formed by colloidal particles at the interface of the emulsion—can be used for targeted delivery of antitumor drugs or any other drugs in liquid form. Here we present results of cryo-EM study of submicrocapsules with the soybean oil core and with the shell consisting of SiO2 nanoparticles and detonation nanodiamonds (DNDs) stabilized with chitosan and alginate. Methods: Сryo-electron tomography (Cryo-ET) was used to identify the morphological features of the submicrocapsules. Preliminary screening of samples and cryo-ET data collection were performed using Titan Krios cryo-EM (ThermoFisher Scientific, US) equipped with Falcon 2 direct electron detector. The restoration of the tomographic series was carried out using IMOD software. Eman2 was used for segmentation and UCSF Chimera was used for visualization of the 3D model. Submicron capsules were obtained by stabilizing oil droplets with a mixture of SiO2 nanoparticles and DNDs. To form a stable shell, an additional layer of silica particles and polyelectrolyte layers of alginate/chitosan were applied to the droplets of the dispersed phase of the emulsion by physical adsorption. Results: Cryo-EM data showed the presence of submicrocapsules with a diameter in the range of 200-900 nm. Although a significant fraction of submicrocapsules was found to be partially destroyed, results of cryo-ET study of intact capsules demonstrated that silicon dioxide nanoparticles form a net, while DNDs form clusters. Conclusion: Here we demonstrate the results of the study of submicron capsules with a shell of silica nanoparticles and DNDs. It was found that a uniform distribution of DNDs is not a prerequisite for the creation of submicron capsules that contradicts the theoretical model.

scholarly journals Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

2014 ◽  
Vol 5 ◽  
pp. 937-945 ◽  
Author(s):  
Amanee D Salaam ◽  
Patrick Hwang ◽  
Roberus McIntosh ◽  
Hadiyah N Green ◽  
Ho-Wook Jun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cell Death ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Treatment Regimens ◽  
Targeted Drug ◽  
Prostate Cancers

The field of nanomedicine has emerged as an approach to enhance the specificity and efficacy of cancer treatments as stand-alone therapies and in combination with standard chemotherapeutic treatment regimens. The current standard of care for metastatic cancer, doxorubicin (DOX), is presented with challenges, namely toxicity due to a lack of specificity and targeted delivery. Nano-enabled targeted drug delivery systems can provide an avenue to overcome these issues. Nanodiamonds (ND), in particular, have been researched over the past five years for use in various drug delivery systems but minimal work has been done that incorporates targeting capability. In this study, a novel targeted drug delivery system for bone metastatic prostate cancer was developed, characterized, and evaluated in vitro. NDs were conjugated with the Asp–Gly–Glu–Ala (DGEA) peptide to target α2β1 integrins over-expressed in prostate cancers during metastasis. To facilitate drug delivery, DOX was adsorbed to the surface of the ND-DGEA conjugates. Successful preparation of the ND-DGEA conjugates and the ND-DGEA+DOX system was confirmed with transmission electron microscopy, hydrodynamic size, and zeta potential measurements. Since traditional DOX treatment regimens lack specificity and increased toxicity to normal tissues, the ND-DGEA conjugates were designed to distinguish between cells that overexpress α2β1 integrin, bone metastatic prostate cancers cells (PC3), and cells that do not, human mesenchymal stem cells (hMSC). Utilizing the ND-DGEA+DOX system, the efficacy of 1 µg/mL and 2 µg/mL DOX doses increased from 2.5% to 12% cell death and 11% to 34% cell death, respectively. These studies confirmed that the delivery and efficacy of DOX were enhanced by ND-DGEA conjugates. Thus, the targeted ND-DGEA+DOX system provides a novel approach for decreasing toxicity and drug doses.

scholarly journals TARGETED DRUG DELIVERY SYSTEMS IN BREAST CANCER CHEMOTHERAPY

2021 ◽  
Vol 77 (1) ◽  
pp. 12-16
Author(s):  
A.H. Al-Humairi ◽  
◽  
O.V. Ostrovsky ◽  
E.V. Zykova ◽  
D.L. Speransky ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Breast Cancer Chemotherapy ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

The article presents a review, systematizing the state and directions of development in the fabrication of targeted drug delivery systems in relation to the treatment of breast cancer. Drug delivery systems constructed on the basis of natural and artificial liposomes, nanoparticles of various nature, polymers, and dendrimer structures are consistently considered. For each class of platforms, information is provided on the features of the structure and functional properties of carriers, on successful examples of their use for the treatment of breast cancer at various stages of preclinical and clinical trials. The most probable directions to achieve a progress in the development of new systems for targeted delivery of antitumor drugs are shown.

scholarly journals Primary and Novel Approaches in Colon Targeted Drug Delivery System: A Review

2015 ◽  
Vol 3 (02) ◽  
pp. 37-57
Author(s):  
Komal . ◽  
Ujjwal Nautiyal ◽  
Ramandeep , Anita Devi Singh ◽  
Anita Devi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Local Treatment ◽  
Systemic Delivery ◽  
Colonic Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoeabiasis , colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). The colon specific drug delivery system (CDDS) should be capable of protecting the drug en route to the colon i.e. drug release and absorption should not occur in the stomach as well as the small intestine, and neither the bioactive agent should be degraded in either of the dissolution sites but only released and absorbed once the system reaches the colon. Different approaches are designed based on prodrug formulation, pHsensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes for colon targeting. The efficiency of drug delivery system is evaluated using different in vitro and in vivo release studies. This review article discusses, in brief, introduction to targeted drug delivery system, anatomy and physiology of the colon and approaches utilized in the colon targeted drug delivery system.

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