The influence of mother's diseases and complications of pregnancy on the development of allergic reactions in neonates and infants

The article reviews the materials dealing with the role of mothers diseases, complications of pregnancy, and unfavorable environmental factors in formation of immunological reactions in neonates. The author emphasizes the role of disturbances of afterbirth state in case of gestosis, infections, mothers smoking.Peculiarities of immune mechanisms of neonates compared with those of elder children determine their reactivity and early development of allergic diseases.

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The interplay of genotype and environment in the development of fear and anxiety

e-Neuroforum ◽

10.1007/s13295-013-0045-1 ◽

2013 ◽

Vol 19 (3) ◽

Author(s):

N. Sachser ◽

K.-P. Lesch

Keyword(s):

Individual Differences ◽

Environmental Factors ◽

Anxiety Disorders ◽

Candidate Gene ◽

Early Development ◽

Genetic Variants ◽

External Influences ◽

Postnatal Environment ◽

Fear And Anxiety

AbstractIndividual differences in fear, anxiety, and the etiology of anxiety disorders develop during ontogeny. They are due to both genetic and environmental factors. With regard to the role of the environment, the organism is most susceptible to external influences during early development. Accordingly, stressors that impinge on the maternal organism during pregnancy evoke high levels of anxiety in the offspring later in life, as does an adverse early postnatal environment. However, anxiety-related circuits in the central nervous system retain their plasticity in adulthood, i.e., levels of anxiety can also be modified by experience across the entire successive lifespan. Notably, the effects of external stressors on the individual’s level of anxiety are modulated by genotype. Such genotype-by-environment interactions are particularly well studied in relation to genetic variants that modulate the function of the serotonin transporter. Thus, this review focuses on this candidate gene to elucidate the interplay of genotype and environment in the development of fear and anxiety.

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Molecular Targets of Fatty Acid Ethanolamides in Asthma

Medicina ◽

10.3390/medicina55040087 ◽

2019 ◽

Vol 55 (4) ◽

pp. 87 ◽

Cited By ~ 4

Author(s):

Oxana Kytikova ◽

Tatyana Novgorodtseva ◽

Marina Antonyuk ◽

Yulia Denisenko ◽

Tatyana Gvozdenko

Keyword(s):

Nervous System ◽

Fatty Acid ◽

Clinical Symptoms ◽

Allergic Airway Inflammation ◽

Molecular Targets ◽

Allergic Diseases ◽

Allergic Reactions ◽

Fatty Acid Ethanolamides ◽

System Physiology

Asthma is a common allergic pathology of the respiratory tract that requires the study of mechanisms underlying it, due to severe forms of the disease, which are refractory to therapy. The review is devoted to the search for molecular targets of fatty acid ethanolamides in asthma, in particular palmitoylethanolamide (PEA), which has been successfully used in the treatment of chronic inflammatory and neurodegenerative diseases, in the pathogenesis of which the nervous and immune systems are involved. Recently, the potentially important role of neuro-immune interactions in the development of allergic reactions has been established. Many of the clinical symptoms accompanying allergic airway inflammation are the result of the activation of neurons in the airways, so the attention of researchers is currently focused on neuro-immune interactions, which can play an important role in asthma pathophysiology. A growing number of scientific works confirm that the key molecule in the implementation of these inter-systemic interactions is nerve growth factor (NGF). In addition to its classic role in nervous system physiology, NGF is considered as an important factor associated with the pathogenesis of allergic diseases, particularly asthma, by regulating of mast cell differentiation. In this regard, NGF can be one of the targets of PEA in asthma therapy. PEA has a biological effect on the nervous system, and affects the activation and the degranulation of mast cells.

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Chitin and chitinases in allergic reactions

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja1015 ◽

2009 ◽

Vol 6 (1) ◽

pp. 18-23

Author(s):

S N Kulikov ◽

Yu A Tyurin ◽

D A Dolbin ◽

R S Fassakhov ◽

S N Kulikov ◽

...

Keyword(s):

Cell Wall ◽

Structural Component ◽

Potential Role ◽

Allergic Diseases ◽

Allergic Reactions ◽

T Helper ◽

Disease Pathogenesis ◽

Fungal Cell ◽

T Helper 2

Chitin - the structural component of fungal cell wall, arthropodal exoskeleton, microfilarial sheat and egg of helminths. Allergens of this organisms cause allergic diseases. The potential role of chitin in allergic reactions has been discussed. Other studies have suggested that chitin preparations may skew immunity away from T-helper-2-mediated allergic responses. Chitinases, enzymes that can degrade chitin polymer, and chitinase-like proteins might also play an important role in allergic disease pathogenesis.

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The role of educational work in educational institutions in order to prevent the influence of harmful factors on the human body

ScienceRise Pedagogical Education ◽

10.15587/2519-4984.2021.249006 ◽

2021 ◽

pp. 35-39

Author(s):

Allа Shlianina ◽

Iryna Shelyuk ◽

Svitlana Mulenko ◽

Olena Shemet

Keyword(s):

Healthy Lifestyle ◽

Allergic Diseases ◽

Allergic Reactions ◽

Toxic Substances ◽

Educational Work ◽

Daily Work ◽

Treatment And Prevention ◽

The World ◽

Allergic Manifestations

The growing number of allergic diseases among people is a global problem. The article considers the role of educational work among students as an important component of knowledge formation about the causes of allergic diseases, prevention methods and maintaining a healthy lifestyle. It is established, that this problem is relevant in the world and requires the introduction of a system of measures to overcome it. The prevalence of allergic diseases has tripled in the last 10 years and to date allergies have reached pandemic proportions. The stages of allergic reactions and possible causes of allergic diseases (genetic, environmental, social) are indicated. The result of immunodeficiency as a result of allergies is the development of various complications or chronic diseases that can lead to disability and even death. The complex epidemiological situation in the world with a large increase in the number of allergic diseases requires constant monitoring to understand current trends. It is taken into account, that there are no statistical data on the level of prevalence of allergic diseases among the population of Ukraine, the study of epidemiological and preventive areas is relevant. The problem of allergic manifestations was considered among the applicants for education of Zhytomyr Pharmaceutical Basic Vocational College. It has been found, that students of the college already have certain professional competencies: demonstrate knowledge and understanding of the concept of "allergy", the manifestation of allergies, treat the causes and ways of the disease, methods of diagnosing allergens, are informed about historical aspects of disease recognition. It has been proven, that issues, related to allergies, worry students because of the causes of their allergic reactions and diseases. It has been found, that students want to continue to receive and deepen modern knowledge on prevention, causes and types of allergic manifestations and ways to eliminate them. As a result of the analysis the actual questions of students and the necessary answer to them, teachers and specialists-allergists have been revealed. The importance of information work among applicants for pharmaceutical education, which in their daily work will constantly use toxic substances, drugs and cosmetics that contain substances – allergens, has been traced. Substantiation of the need to develop effective systems of actions for prevention, diagnosis and provision of treatment and prevention care to the population has been presented

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The Role of Environmental Factors in the Early Development of Egyptian Stone Architecture

Cambridge Archaeological Journal ◽

10.1017/s0959774320000232 ◽

2020 ◽

pp. 1-13

Author(s):

Jun Yi Wong

Keyword(s):

Environmental Factors ◽

Early Development ◽

Climatic Conditions ◽

Short Term ◽

Old Kingdom ◽

Private Realm ◽

Early Dynastic ◽

First Dynasty ◽

Socio Economic Factors

Much detail regarding the early development of stone architecture in Egypt remains unclear. Prevailing studies tend to focus on the contribution of religious and socio-economic factors, but the role of environmental elements should not be understated. For much of the First Dynasty, innovation in stone architecture was driven by developments in the private realm, a result of favourable geology in Lower Egypt. Meanwhile, multiple strands of evidence suggest that Egypt experienced wetter climatic conditions during the Early Dynastic period and the Old Kingdom. This would have had major implications on both the production of mudbrick and the short-term durability of mudbrick structures. It is argued that these environmental factors played a key role in facilitating and accelerating the rise of stone architecture in Egypt.

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Questions on the role of biofilms for the adaptation of microorganisms to unfavorable environmental factors by the example of P. aeruginosa

Hygiene and Sanitation ◽

10.33029/0016-9900-2020-99-4-379-383 ◽

2020 ◽

Vol 99 (4) ◽

pp. 379-383

Author(s):

Vasily N. Afonyushkin ◽

N. A. Donchenko ◽

Ju. N. Kozlova ◽

N. A. Davidova ◽

V. Yu. Koptev ◽

...

Keyword(s):

Antibiotic Resistance ◽

Environmental Factors ◽

Barrier Function ◽

Infectious Agent ◽

Antagonistic Activity ◽

The Body ◽

Main Function ◽

Pathogenic Potential ◽

The Face

Pseudomonas aeruginosa is a widely represented species of bacteria possessing of a pathogenic potential. This infectious agent is causing wound infections, fibrotic cystitis, fibrosing pneumonia, bacterial sepsis, etc. The microorganism is highly resistant to antiseptics, disinfectants, immune system responses of the body. The responses of a quorum sense of this kind of bacteria ensure the inclusion of many pathogenicity factors. The analysis of the scientific literature made it possible to formulate four questions concerning the role of biofilms for the adaptation of P. aeruginosa to adverse environmental factors: Is another person appears to be predominantly of a source an etiological agent or the source of P. aeruginosa infection in the environment? Does the formation of biofilms influence on the antibiotic resistance? How the antagonistic activity of microorganisms is realized in biofilm form? What is the main function of biofilms in the functioning of bacteria? A hypothesis has been put forward the effect of biofilms on the increase of antibiotic resistance of bacteria and, in particular, P. aeruginosa to be secondary in charcter. It is more likely a biofilmboth to fulfill the function of storing nutrients and provide topical competition in the face of food scarcity. In connection with the incompatibility of the molecular radii of most antibiotics and pores in biofilm, biofilm is doubtful to be capable of performing a barrier function for protecting against antibiotics. However, with respect to antibodies and immunocompetent cells, the barrier function is beyond doubt. The biofilm is more likely to fulfill the function of storing nutrients and providing topical competition in conditions of scarcity of food resources.

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Role of environmental factors in the etiology of hepatocellular carcinoma

Orvosi Hetilap ◽

10.1556/oh.2010.28913 ◽

2010 ◽

Vol 151 (28) ◽

pp. 1132-1136 ◽

Cited By ~ 7

Author(s):

István Tornai

Keyword(s):

Hepatocellular Carcinoma ◽

Hepatitis B Virus ◽

Environmental Factors ◽

Hepatitis B ◽

Hepatitis A ◽

Virus Hepatitis ◽

B Virus

A krónikus vírushepatitisek jelentik ma a legismertebb okokat a hepatocellularis carcinoma (HCC) kialakulásában. A krónikus B- és C-vírus-hepatitis a májrákok körülbelül 40-50%-át okozza. A nyugati típusú társadalmakban a HCC előfordulása folyamatosan növekvő tendenciát mutat. Az alkohol számít a környezeti tényezők közül a legfontosabbnak, bár az alkoholfogyasztás a legtöbb országban csökken. Ez aláhúzza az egyéb környezeti tényezők fontosságát is. Az elfogyasztott alkoholmennyiséggel egyenes arányban növekszik a cirrhosis és a következményes HCC gyakorisága nőkben és férfiakban egyaránt. A kémiai anyagok közül a legismertebb a Kínában és Afrikában elterjedt aflatoxin, amely a gabonaféléket szennyező mycotoxin. Hasonló területeken endémiás, mint a hepatitis B-vírus, együtt szinergista hatást fejtenek ki. A dohányzás is egyértelműen bizonyított hepatocarcinogen hatással rendelkezik. Ez is jelentősen fokozódik, ha alkoholfogyasztással vagy vírushepatitisszel társul. Társadalmilag talán a legfontosabb az elhízás, a következményes nem alkoholos zsírmáj, illetve steatohepatitis és a 2-es típusú cukorbetegség, amelyek prevalenciája egyre fokozódik. Feltehetően ezek állnak a növekvő HCC-gyakoriság hátterében. Az inzulinrezisztencia és az oxidatív stressz képezik a legfontosabb patogenetikai lépéseket a májsejtkárosodásban. További fontos rizikótényező az orális fogamzásgátlók elterjedt használata. Egyes foglalkozások esetén a tartós szervesoldószer-expozíció is növeli a HCC rizikóját. Védelmet jelenthetnek az antioxidánsok, a szelén, a gyógyszerek közül a statinok és a feketekávé-fogyasztás.

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