scholarly journals Herpes febrilis и herpes genitalis

2020 ◽  
Vol 22 (2) ◽  
pp. 248-249
Author(s):  
Y. Pechnikov
Keyword(s):  
Human Skin ◽  
Experimental Infection ◽  
Skin Lesions ◽  
Herpes Genitalis ◽  
Clinical Observations ◽  
Causative Agents ◽  
The Difference

It is still unclear whether the causative agents of both of these diseases are identical or different. Lipschutz (Arch. F. Derm. U. Sypb., 1925, Bd. 149) indicates the difference between them on the basis of: 1) his own observations during experimental infection of human skin with a virus of both forms: 2) different duration of evolution of keratitis in a rabbit after vaccination of both viruses and 3) is different in histological skin lesions. A comparison of a number of clinical observations also indicates a difference in the etiological moment for both herpes species.

Pemphigus foliaceus in Arabian oryx (Oryx leucoryx)

2021 ◽  
pp. 030098582110305
Author(s):  
Jeffrey B. Curtiss ◽  
Michelle Lewis ◽  
Emily P. Mitchell
Keyword(s):  
Medical Records ◽  
Skin Lesions ◽  
Domestic Animals ◽  
Histological Evaluation ◽  
Pemphigus Foliaceus ◽  
Arid Environments ◽  
Zoological Garden ◽  
Causative Agents ◽  
Arabian Oryx ◽  
Tail Tip

Pemphigus foliaceus (PF) is an autoimmune acantholytic skin disease described in humans, dogs, cats, horses, goats, and sheep. From 2003 to 2016, six Arabian oryx ( Oryx leucoryx) at the National Zoological Garden in Pretoria, South Africa, developed progressive, bilaterally symmetrical, hyperkeratotic skin lesions and pustules consistent with PF. Lesions were similar to those observed in domestic animals and primarily affected the pinnae, face and nasal planum, distal legs, and tail tip. Histological evaluation of suspect PF skin lesions in affected animals, evaluation of medical records for treatments received, causative agents in the diet and environment, and special stains for infectious organisms yielded no consistent inciting cause. The Arabian oryx is a species highly adapted to arid environments of the desert and has recently survived from a severe genetic bottleneck; both of these factors may have contributed to the development of PF in these animals.

The influence of dietary carbohydrates on experimental infection withTrichuris suisin pigs

Parasitology ◽  
2005 ◽  
Vol 132 (6) ◽  
pp. 857-865 ◽  
Author(s):  
L. E. THOMSEN ◽  
S. PETKEVIČIUS ◽  
K. E. BACH KNUDSEN ◽  
A. ROEPSTORFF
Keyword(s):  
Sugar Beet ◽  
Experimental Infection ◽  
Diet Group ◽  
The Other ◽  
Post Inoculation ◽  
Dietary Carbohydrates ◽  
Barley Flour ◽  
Faecal Egg Counts ◽  
The Difference ◽  
Fermentable Carbohydrates

Two experiments (Exps 1 and 2) were carried out to study the effect of dietary carbohydrates on the establishment ofTrichuris suisin pigs. Two experimental diets based on barley flour were used; Diet 1 was supplemented with non-fermentable carbohydrates from oat hull meal, while Diet 2 was supplemented with fermentable carbohydrates from sugar beet fibre and inulin. In Exp. 1, thirty-two pigs were allocated randomly into 4 groups. Two groups were fed Diet 1 and 2 groups were fed Diet 2. Pigs from one of each diet group were inoculated with 2000 infectiveT. suiseggs each and the other two groups were uninfected controls. All pigs were slaughtered 8 weeks post-inoculation (p.i.). In Exp. 2, twenty-four pigs were allocated randomly into 2 groups and fed Diet 1 or Diet 2, respectively. All the pigs were inoculated with 2000 infectiveT. suiseggs. Six pigs from each group were slaughtered 8 weeks p.i. and the remaining 6 pigs from each group were slaughtered 12 weeks p.i. Infections were followed by faecal egg counts and worm burdens were assessed at necropsy. Pigs fed Diet 2 had lower egg counts in both experiments; in Exp. 2 the difference was significant (P<0·05). No differences were found in worm burdens 8 weeks p.i. in both experiments, however, worms from pigs on Diet 2 were significantly shorter (P<0·0001). Pigs fed Diet 2 and slaughtered 12 weeks p.i. had significantly lower worm counts (P<0·01) compared to pigs fed Diet 1. The results indicate that fermentable carbohydrates do not affect the establishment ofT. suisin naïve pigs, but result in earlier expulsion and reduced growth of the established worms. Thus, diets with highly fermentable carbohydrates may be used in the control ofT. suis.

The value of cyclooxygenase-2 expression in differentiating between early melanomas and histopathologically difficult types of benign human skin lesions

2012 ◽  
Vol 22 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Łukasz Kuźbicki ◽  
Dariusz Lange ◽  
Anita Strączyńska-Niemiec ◽  
Barbara W. Chwirot
Keyword(s):  
Human Skin ◽  
Skin Lesions ◽  
Cyclooxygenase 2

scholarly journals Impact of valganciclovir therapy on severe IRIS-Kaposi Sarcoma mortality: an open-label, parallel, randomized controlled trial.

2021 ◽  
Author(s):  
Patricia Volkow ◽  
Leslie Chavez-Galan ◽  
Lucero Ramon-Luing ◽  
Judith Cruz-Velazquez ◽  
Patricia Cornejo-Juarez ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Kaposi Sarcoma ◽  
Pulmonary Involvement ◽  
Skin Lesions ◽  
Attributable Mortality ◽  
Control Group ◽  
Open Label ◽  
Parallel Group ◽  
Pulmonary Lymph Node ◽  
The Difference

High HHV-8 viral load (VL) in Kaposi Sarcoma (KS) has been associated with severe Immune reconstitution inflammatory syndrome (S-IRIS-KS), which can occur after initiating cART, and is linked with high mortality particularly in patients with pulmonary involvement. We investigate if valganciclovir initiated before cART decreases HHV-8 VL and assess if it reduces the incidence of S-IRIS-KS and its attributable mortality. Methods: Open-label parallel-group randomized clinical trial in AIDS cART naive patients with disseminated KS (DKS) as defined by at least two of the following: pulmonary, lymph-node or gastrointestinal involvement, lymphedema, or equal or more 30 skin lesions. In the experimental group (EG), patients were randomized to valganciclovir 900 mg BID four weeks before cART and continued until week-48; in the control group (CG), cART was initiated on week-0. Non-severe-IRIS-KS was defined as: increase in the number of lesions plus equal or more than one log10 HIV-VL decrease or equal or more than 50 cells/mm3 increase or equal or more than 2-fold rise in baseline CD4+ cells. S-IRIS-KS was defined as abrupt clinical worsening of KS lesions and/or fever after ruling out another infection following cART initiation, and at least three of the following: thrombocytopenia, anemia, hyponatremia, or hypoalbuminemia. Results: 40 patients were randomized and 37 completed the study. In the ITT analysis, the overall mortality did not differ between groups. In the per-protocol analyses, the difference showed a trend for higher S-IRIS-KS mortality in the CG 3/19 (15.7%), compared to EG 0/18 (p=0.07). The incidence of S-IRIS KS was significantly lower in the EG; two patients, one each had S-IRIS-KS episode (0.038 per 100 patient-days) compared to CG group, four patients developed 12 S-IRIS-KS episodes (0.21 per 100 patient-days); incidence rate of 0.09 (95% CI 0.02-0.5 p=0.006). Mortality in patients with pulmonary KS was significantly lower in EG, 3/4 in CG vs 0/5 in EG. S-IRIS-KS was associated with higher HHV-8-VL; IL6 and CRP; valganciclovir was protective. Of survivors at week 48, 82% achieved more than 80% remission. No difference was found between groups in the number of non-S-IRIS-KS events. Conclusions: Valganciclovir significantly reduced the episodes of S-IRIS-KS although attributable KS mortality was lower in the EG the difference was not significant (p=0.07). Mortality was significantly lower in EG patients with pulmonary KS.

scholarly journals Clinical Observation of Zhuang Medicine Crystal Sugar Ye’An Decoction in Treating Senile Skin Pruritus and Its Effects on Serum IgE

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yun Zhang ◽  
Yuying Lan
Keyword(s):  
Adverse Reactions ◽  
Clinical Observation ◽  
Skin Lesions ◽  
Effective Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Observation Group ◽  
Serum Ige ◽  
The Difference ◽  
Lesion Severity

Objective: To discuss the specific application of Zhuang Medicine Crystal Sugar Ye’An Decoction in senile skin pruritus and its effects on serum IgE detection level. Methods: 90 patients with senile skin pruritus admitted to our hospital from February 2019 to April 2020 were randomly grouped. The general treatment effect, itching, secondary skin lesion severity, serum IL-6, IgE level and adverse reactions between 45 patients treated with Chlorcyclizine Hydrochloride Tablets (The control group) and 45 patients treated with Crystal Sugar Ye’An Decoction were compared. Results: The total effective rate of the treatment in the observation group was 93.33%, much higher than that in the control group, 75.56%. The difference was verified and statistically significant (P<0.05). Before the treatment, the itching area, frequency, duration and severity of secondary skin lesions were at the same level (P>0.05). After the treatment, the above data were all reduced, and the reduction of the observation group was more significant than that of the control group, indicating the difference was statistically significant (P<0.05). Before the treatment, there was no difference in serum IL-6 and IgE test data between the two groups (P>0.05). After the treatment, the tendency all declined, and that of the observation group was more obvious, indicating the difference was statistically significant (P<0.05). During the experiment, no obvious adverse reactions were observed in both groups. Conclusion: In the treatment of patients with senile pruritus, the application of Zhuang Medicine Crystal Sugar Ye’An Decoction is not only safe and reliable, but can promote the improvement of patients’ symptoms, adjust the level of inflammatory factors, and enhance clinical efficacy.

Imaging of human skin lesions with the multispectral dermoscope

2010 ◽  
Author(s):  
Dimitrios Kapsokalyvas ◽  
Nicola Bruscino ◽  
Domenico Alfieri ◽  
Vincenzo de Giorgi ◽  
Giovanni Cannarozzo ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Lesions

scholarly journals IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

2016 ◽  
Vol 213 (10) ◽  
pp. 2147-2166 ◽  
Author(s):  
Juhan Yoon ◽  
Juan Manuel Leyva-Castillo ◽  
Guoxing Wang ◽  
Claire Galand ◽  
Michiko K. Oyoshi ◽  
...  
Keyword(s):  
T Cells ◽  
Human Skin ◽  
Cd4 T Cells ◽  
Mouse Skin ◽  
Skin Inflammation ◽  
Serum Levels ◽  
Skin Lesions ◽  
Tape Stripping ◽  
Keratinocyte Proliferation ◽  
Th22 Cells

Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD skin lesions. We show that application of antigen to mouse skin subjected to tape stripping, a surrogate for scratching, induces an IL-22 response that drives epidermal hyperplasia and keratinocyte proliferation in a mouse model of skin inflammation that shares many features of AD. DC-derived IL-23 is known to act on CD4+ T cells to induce IL-22 production. However, the mechanisms that drive IL-23 production by skin DCs in response to cutaneous sensitization are not well understood. We demonstrate that IL-23 released by keratinocytes in response to endogenous TLR4 ligands causes skin DCs, which selectively express IL-23R, to up-regulate their endogenous IL-23 production and drive an IL-22 response in naive CD4+ T cells that mediates epidermal thickening. We also show that IL-23 is released in human skin after scratching and polarizes human skin DCs to drive an IL-22 response, supporting the utility of IL-23 and IL-22 blockade in AD.

EXPERIMENTAL INFECTION OF THE SKIN IN THE HAMSTER SIMULATING HUMAN IMPETIGO

PEDIATRICS ◽  
1971 ◽  
Vol 48 (1) ◽  
pp. 83-90
Author(s):  
Adnan S. Dajani ◽  
Patty Lee Hill ◽  
Lewis W. Wannamaker
Keyword(s):  
Animal Model ◽  
Experimental Animal ◽  
Topical Application ◽  
Experimental Infection ◽  
Skin Lesions ◽  
Experimental Animal Model ◽  
Benzathine Penicillin ◽  
Procaine Penicillin ◽  
Prophylactic Administration ◽  
Delayed Healing

The efficacy of various therapeutic regimens for the treatment of impetigo was assessed in an experimental animal model. The topical application of gentamicin or bacitracin and removal of scabs were ineffectual. PHisoHex scrubbing delayed healing significantly and resulted in the development of satellite lesions. Healing was significantly promoted by the administration of penicillin, the benzathine variety being more effective than procaine penicillin. Benzathine penicillin was similarly effective in pure streptococcal lesions and in mixed lesions containing penicillin-sensitive or penicillin-resistant staphylococci in addition to streptococci. The development of skin lesions was markedly reduced following prophylactic administration of benzathine penicillin.

scholarly journals First detection and molecular characterisation of pseudocowpox virus in a cattle herd in Zambia

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Maureen Wakwamba Ziba ◽  
Chanda Chitala ◽  
Tirumala Bharani K. Settypalli ◽  
Malama Mumba ◽  
Giovanni Cattoli ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Laboratory Diagnosis ◽  
Skin Lesions ◽  
Cattle Herd ◽  
High Morbidity ◽  
B2l Gene ◽  
Comparative Sequence ◽  
Pseudocowpox Virus ◽  
Field Investigations ◽  
Causative Agents

Abstract Background Pseudocowpox virus (PCPV) of the genus Parapoxvirus in the family Poxviridae causes pseudocowpox in cattle worldwide and presents a zoonotic concern. Most poxviruses produce diseases of similar clinical signs in affected animals, which are impossible to differentiate clinically or by serology. It is, therefore, vital to use molecular assays to rapidly identify the causative agents of poxvirus infections. This study aimed to detect, diagnose, and characterize the causative agent of pox-like skin lesions in a cattle herd in Zambia, initially suspected to be infected with Lumpy Skin Disease virus. Methods We used a High-Resolution Melting (HRM) analysis assay to detect the PCPV genome and sequenced the major envelope protein (B2L gene) for comparative sequence and phylogenetic analysis. Results Our field investigations showed cattle presenting atypical skin lesions and high morbidity within the herd. The laboratory diagnosis, based on the HRM assay revealed PCPV DNA in the samples. Phylogenetic and comparative sequence analyses confirmed PCPV in the samples and revealed genomic differences between samples collected in 2017 and 2018 from the same farm. Conclusion Our work is the first documented report of PCPV in Zambia. It shows the strength of molecular methods to diagnose pox-like infections in cattle and discriminate between diseases causing similar clinical signs. This rapid and accurate diagnosis improves the response time for more accurate veterinary interventions.

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