Chronicle

1934 ◽  
Vol 30 (2) ◽  
pp. 365-370
Keyword(s):  
Connective Tissue ◽  
The Body ◽  
Protective Reaction ◽  
Fight Against Cancer

The fight against cancer that has already appeared in the body should be aimed not only at destroying the tumor itself, but also at strengthening the protective reaction of the connective tissue.

Current Scientific Considerations in Regard to Defining a “Silicone Syndrome”/Disease and the Formation of Silica from Silicone

1998 ◽  
Vol 17 (4) ◽  
pp. 449-463 ◽  
Author(s):  
John A. Todhunter ◽  
Michael G. Farrow
Keyword(s):  
Connective Tissue ◽  
Patient Population ◽  
Breast Implant ◽  
Connective Tissue Diseases ◽  
The Body ◽  
Silicone Implants ◽  
Augmentation Mammoplasty ◽  
Patient Case ◽  
Increased Risk ◽  
Epidemiology Studies

Whether the constellation of various symptoms reported in various case-study reports on some patients who have had augmentation mammoplasty with silicone implants reflects a distinct, novel “silicone syndrome”or disease is important to settingproper endpoints for the epidemiological study of this patient population. To date, epidemiology studies on breast implant patients have focused on end-points which are typical of connective tissue disease, rheumatoid disease, and/ or autoimmune disorders. The consensus at this time, as was recently stated in a paper authored by Food and Drug Administration (FDA) personnel, is that the weight of the evidence from existing epidemiology studies is that silicone breast implants do not appreciably, if at all, increase the risk of these types of diseases. Critics of the epidemiology database have countered that had the analysis of association in these studies been done for a “silicone syndrome,” as opposed to the disease types which were analyzed, an association between silicone breast implantation and increased risk of “silicone syndrome” would have been observed. In the present analysis, this question is approached from two directions: First, the available single or multi-patient case reports available in the open literature were evaluated. The objective was to define those symptoms/ complaints that were reported in all studies or in at least 50% of the patients reported and to assign frequency distributions to individual symptoms or complaints reported in breast implant patients presenting for various complaints. By definition, if a “silicone syndrome” exists, then it can only be characterized by those symptoms or complaints which appear with regular frequency in patients so afflicted. Second, the symptoms or complaints which were used as criteria in the existing epidemiology studies were correlated with their frequency of occurrence among single or multi-patient case-reported breast implant patients. The working hypothesis in this present study is that if the number of “silicone syndrome” symptoms or complaints that also are symptoms of the existing epidemiology endpoints is large, then a distinct “silicone syndrome” is not likely to exist, and it can be concluded that existing epidemiology studies have adequately addressed the relevant issues. Also, to the extent that the frequency of symptom occurrence in “silicone syndrome” is similar to the distribution seen for known connective tissue, rheumatoid, and/ or autoimmune diseases, this will then add to the weight of evidence that no distinct “silicone syndrome” needs be postulated. Conversely, if a different set of symptoms or complaints occurs in silicone breast-implanted patients than is seen in patients with connective tissue diseases, this will argue that a distinct syndrome may exist. In the present study, the more recent suggestion that silicone may be broken down to silica in the body, and evidence for and against this suggestion are also discussed. The present analysis does not support the contention that a distinct “silicone syndrome” exists, but does support the contention that the disease endpoints used in existing epidemiology studies are adequate for examining the patient population. Also, consideration of the chemistry of silicone and its potential hydrolysis or oxidative cleavage indicates that if such reactions occur in the body at any significant rate, the product will be silicic acid, a normal and necessary constituent of the body, and not silica (i.e., silicon dioxide).

HISTOLOGICAL EFFECTS OF 3-TRIFLUORMETHYL-4-NITROPHENOL (TFM) ON LARVAL LAMPREY AND TROUT

1963 ◽  
Vol 41 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Ronald M. Christie ◽  
Helen I. Battle
Keyword(s):  
Connective Tissue ◽  
Prolonged Exposure ◽  
Periodic Acid ◽  
Secretory Activity ◽  
The Body ◽  
Salmo Gairdneri ◽  
Periodic Acid Schiff ◽  
Sinusoidal Dilatation ◽  
Gill Filaments ◽  
Red Coloration

Larvae of the lamprey, Entosphenus lamottei (Le Sueur), and rainbow trout, Salmo gairdneri Richardson, were exposed to the sodium salt of 3-trifluormethyl-4-nitrophenol (TFM) in concentrations of 0.75 p.p.m., 3.00 p.p.m., and 6.00 p.p.m. Microscopic examination of changes induced in the gills, liver, cloacal region, and musculature were made on 7-micron sections stained with Harris' haematoxylin and Bowie's eosin, and in the gill region with periodic acid Schiff reagent. A comparison of the degree of the effects in the two species was made by planimetry of the vascular, cellular, and edematous areas from enlarged drawings of sections.Upon exposure to lethal concentrations of TFM, the body of the larval lamprey becomes distended at the pharyngeal level and heavy cords of mucus emerge from the external gill clefts. A deep red coloration is evident in the pharyngeal region consequent upon vasodilatation of the arterioles and capillaries of the gill filaments. Trout exhibit a similar vasodilatation of the gills together with increased mucous secretion. Edema in the connective tissue between the respiratory epithelium and the vascular endothelium is induced in both species. After prolonged exposure to TFM, the mucous cells in the lining of the branchial chamber and covering the tips of the gill filaments are actively discharging their secretions or completely spent.Certain effects induced by TFM in the larval lamprey are not evident in the trout. The cloacal region takes on a deep red coloration due to dilatation of the venous sinuses and the liver becomes reddish because of sinusoidal dilatation. Extensive edema of the fibrous connective tissue of the skeletal musculature is characteristically present. A slightly increased secretory activity of mucous-secreting cells may occur in the epidermis.With the techniques employed in this study, there was no evidence in either species of cytological or histological changes in the nervous tissue, cardiac musculature, notochord, alimentary canal (including the haemopoietic typhlosole of the lamprey), or mesonephros.

scholarly journals Collagen drinks for functional nutrition

2018 ◽  
Vol 80 (3) ◽  
pp. 97-103
Author(s):  
L. V. Antipova ◽  
S. A. Storublevtsev ◽  
A. A. Getmanova
Keyword(s):  
Connective Tissue ◽  
Main Part ◽  
Jerusalem Artichoke ◽  
The Body ◽  
Whole Body ◽  
Energy Functions ◽  
Preventive Actions ◽  
Prevention And Treatment ◽  
Experimental Laboratory

In the process of life of the body continuously consumed nutrients that perform plastic and energy functions. The source of nutrients is a variety of foods, consisting of a complex of proteins, fats and carbohydrates, which in the process of digestion are converted into digestible substances. Collagen is the basis of connective tissue and binds the cells in the tissues, creates the frame of the whole body. The gastrointestinal tract, as a system of organs, is no exception and is designed process and extract nutrients from food. Most organs consist of connective tissue, accounting for 60–90% of their mass, which confirms its importance and the role of collagen in this regard can not be estimated. Collagen functions in the body are diverse, one of the main - part in digestion, the violation of which is the cause of diseases such as gastritis and ulcers. For the prevention and treatment of such diseases are very useful liquid collagen-containing food in the form of functional drinks. Developed and obtained in the experimental laboratory a variety of drinks on a collagen basis, with the use of additional broth with sea buckthorn pulp, tincture of dried chicory root powder and broth with the flesh of Jerusalem artichoke. An invaluable contribution to the therapeutic and preventive actions of all these components is proved not only scientifically, but also time-tested.

scholarly journals Morphofunctional and immunohistochemical characteristics of the large omentum in ovarian cancer

2020 ◽  
Vol 9 (3) ◽  
pp. 64-71
Author(s):  
N. N. Shevlyuk ◽  
L. V. Khalikova ◽  
A. A. Khalikov
Keyword(s):  
Ovarian Cancer ◽  
Connective Tissue ◽  
Protein Expression ◽  
Blood Vessels ◽  
Lymphoid Tissue ◽  
P53 Protein ◽  
Individual Variability ◽  
The Body ◽  
Great Omentum ◽  
Low Grade

The aim of the study was to establish morphofunctional and immunohistochemical characteristics of large omentum in women with ovarian cancer.Material and methods. The large omenta of 48 women with ovarian cancer (low-grade differentiated seropapillary adenocarcinoma of high-grade malignancy) of II stage (n=20) and III stage (n=28) were studied. Histological sections were stained with overview histological and immunohistochemical methods (to reveal ki67, P53, CD34, CD7, CD4, CD8, CD61 proteins expression). Results. In patients, the size of the large omentum was characterized by high individual variability; in the presence of metastasis, the size of the omentum was reduced. Intensive development of blood vessels in the organ was noted, but in the presence of metastases stasis of blood corpuscles, leucocytic infiltration, and moderate edema of connective tissue were observed in the organ’s vessels. Areas of lymphoid tissue, both small lymphatic follicles and diffusely located lymphoid tissue, were revealed in the omentum. In most follicles, reactive centers were not marked, and the number of follicles was reduced in the presence of metastases in the omentum. The analysis of CD34+ cells distribution showed that they were identified both in the tumor and in the areas of the omentum adjacent to the tumor, which indicates a pronounced angiogenesis. An irregular distribution of CD7+ and CD8+ and CD4+ cells was revealed in the tumor tissues, as well as in the surroundings. Simultaneously with the expression of P53 protein, ki67 protein expression is revealed in the significant number of tumor cells (including endothelial cells of tumor blood vessels). The proportion of ki67+ cells in the tumor cell population was 60.1±3.3%. The presence of a large number of ki67+cells in the presence of P53 protein expression in them indicates the aggressiveness of the tumor, as well as a disturbance of apoptosis regulatory mechanisms in the cells. Ki67 expression was low in the omentum areas unaffected by metastases, and it was revealed in the certain areas of connective tissue in fibroblastic programmed differentiation cells. Conclusion. The results obtained indicate significant plasticity and reactivity of great omentum in the presence of tumor process in the body and confirm the important role of great omentum in protective reactions.

To the doctrine of the intravital coloration of the reticuloendothelial system in experimental animals

1930 ◽  
Vol 26 (4) ◽  
pp. 438-438
Author(s):  
L. I. Vilensky
Keyword(s):  
Connective Tissue ◽  
Reticuloendothelial System ◽  
The Body ◽  
Experimental Animals ◽  
White Rats ◽  
Medical Societies ◽  
Physiological Properties ◽  
Reticulo Endothelial System

Meetings of medical societies. Society of Physicians at Kazan University. General Sessions Session 4 March 1930 L.I. Vilensky. Towards the doctrine of the intravital coloration of the reticuloendothelial system in experimental animals. On the basis of a study of 267 animals of various species (rabbits, rats, pigs, white mice, white rats and dogs) the vivo coloring of trypanblau, pyrrholblau, carmine and collargol, the author comes to the following conclusions: 1) All active cellular elements of the indifferent connective tissue that has retained the embryonic properties of the mesenchyme. 2) Teaching-Aschoff's, in the light of intravital coloration, should be expanded, as the teaching of an active mesenchyme, scattered throughout the body, but united by common physiological properties. 3) The process of gradual absorption of colloidal paint in individual elements of the reticulo-endothelial system has a certain pattern, which is exactly the same in different animals.

A fluid-driven soft robotic fish inspired by fish muscle architecture

2022 ◽  
Author(s):  
Sijia Liu ◽  
Yingjie Wang ◽  
Zhennan Li ◽  
Miao Jin ◽  
Lei Ren ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Structural Design ◽  
Muscle Fibers ◽  
The Body ◽  
Optimum Frequency ◽  
Muscle System ◽  
Key Innovation ◽  
Biological Studies ◽  
Passive Deformation ◽  
Red Muscle

Abstract Artificial fish-like robots developed to date often focus on the external morphology of fish and have rarely addressed the contribution of the structure and morphology of biological muscle. However, biological studies have proven that fish utilize the contraction of muscle fibers to drive the protective flexible connective tissue to swim. This paper introduces a pneumatic silicone structure prototype inspired by the red muscle system of fish and applies it to the fish-like robot named Flexi-Tuna. The key innovation is to make the fluid-driven units simulate the red muscle fiber bundles of fish and embed them into a flexible tuna-like matrix. The driving units act as muscle fibers to generate active contraction force, and the flexible matrix as connective tissue to generate passive deformation. Applying alternant pressure to the driving units can produce a bending moment, causing the tail to swing. As a result, the structural design of Flexi-Tuna has excellent bearing capacity compared with the traditional cavity-type and keeps the body smooth. On this basis, a general method is proposed for modeling the fish-like robot based on the independent analysis of the active and passive body, providing a foundation for Flexi-Tuna’s size design. Followed by the robot’s static and underwater dynamic tests, we used finite element static analysis and fluid numerical simulation to compare the results. The experimental results showed that the maximum swing angle of the tuna-like robot reached 20°, and the maximum thrust reached 0.185 N at the optimum frequency of 3.5 Hz. In this study, we designed a unique system that matches the functional level of biological muscles. As a result, we realized the application of fluid-driven artificial muscle to bionic fish and expanded new ideas for the structural design of flexible bionic fish.

Roles of Secreted Phospholipases A2 in the Mammalian Immune System

2014 ◽  
Vol 21 (12) ◽  
pp. 1201-1208
Author(s):  
Igor Krizaj
Keyword(s):  
Immune System ◽  
Acute Inflammation ◽  
The Body ◽  
Innate Immune ◽  
Future Research ◽  
Biological Processes ◽  
Phospholipases A2 ◽  
Protective Reaction ◽  
Severe Pathology ◽  
Mammalian Immune System

Secreted phospholipase A2 (sPLA2) molecules constitute a family of proteins that are involved functionally in many biological processes. In particular, they participate in diverse pathophysiological settings as enzymes that release free fatty acids and lysophospholipids from phospholipids in biological membranes, or as ligands for various cellular receptors. In this review the confirmed or expected functions of sPLA2s in the mammalian immune system are surveyed. Some of the twelve mammalian sPLA2 molecules constitute part of the so-called innate immune system by virtue of their antibacterial, antiviral and antifungal activities. They are also involved in acute inflammation, a protective reaction of the body to infection or injury. The acute inflammation sometimes escapes regulation, becomes chronic and can evolve into a severe pathology. One or more types of sPLA2 are involved in asthma, rheumatoid arthritis, sepsis, atherosclerosis, myocardial infarction, Crohn’s disease, ulcerative colitis and cancer. sPLA2s are thus important therapeutic targets as well as biotherapeutic molecules. Improving the selectivity of inhibitors of sPLA2s to be able to target a particular sPLA2 could therefore be one of the most important tasks for future research.

Abdominal wall hernias

2018 ◽  
pp. 529-540
Author(s):  
Abdullah Jibawi ◽  
Mohamed Baguneid ◽  
Arnab Bhowmick
Keyword(s):  
Connective Tissue ◽  
Abdominal Wall ◽  
Chronic Cough ◽  
Incidental Finding ◽  
Clinical History ◽  
The Body ◽  
Abdominal Pressure ◽  
Ehlers Danlos Syndrome ◽  
Danlos Syndrome ◽  
Groin Hernias

Hernias are abnormal protrusion of an organ through a weakness/defect in the body wall that contains it. Classifications include groin hernias, ventral abdominal wall hernias (umbilical, femoral), incisional, Spigelian, and lumbar hernias. Inguinal hernias are the commonest types of abdominal wall hernias (~75%). Male are affected 15-times more frequently. Hernias are more common in smokers, patients with underlying connective tissue disorders (Ehlers Danlos Syndrome, Marfan syndrome), and patients with increased intra-abdominal pressure (obesity, heavy lifting, chronic cough, and chronic straining during defecation and urination). Hernias present as incidental finding on imaging, asymptomatic lumps, painful lumps, or incarcerated or strangulated hernias. Clinical history and examination are the mainstay of diagnosis. Most hernias are treated with surgical repair (open or laparoscopic). Conservative wait and watch policy is indicated in some cases.

On the structure of corpuscular proprioceptive endings in sharks

1976 ◽  
Vol 56 (4) ◽  
pp. 925-928 ◽  
Author(s):  
Q. Bone ◽  
A. D. Chubb
Keyword(s):  
Connective Tissue ◽  
Muscle Spindles ◽  
Second Order ◽  
The Body ◽  
Sensory Endings

Proprioceptive endings associated with the locomotor musculature are apparently extremely uncommon in fishes. Muscle spindles are absent, and only in elasmobranchs have sensory endings of two types been recognized as proprioceptive. One of these, found in sharks, is the coiled corpuscular ending first observed by Wunderer (1908) at the bases of the fins in various species. This type of ending also occurs sub-cutaneously along the body, superficial to the myocommata (Bone, 1964). Lowenstein (1956) examined the responses of the endings associated with the fin bases, and showed that they were slowly adapting mechanoreceptors, functioning as second order proprioceptors since as the fin was bent, so the connective tissue amongst which the endings lie was stretched or compressed, and the receptor discharged.

Autoimmune connective tissue diseases

2013 ◽  
Vol 6 (3) ◽  
pp. 159-171
Author(s):  
Ishita Patel ◽  
Alia Ahmed
Keyword(s):  
Primary Care ◽  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
The Body ◽  
Diverse Group ◽  
Connective Tissues

Connective tissue diseases are a rare and diverse group of disorders that result in pathology of the connective tissues of the body. This article focuses on the systemic autoimmune connective tissue diseases, and aims to provide a practical overview of these conditions for use in primary care.

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