scholarly journals A clinical case of central cancer of the lung and infiltrative tuberculosis

2020 ◽  
Vol 101 (4) ◽  
pp. 574-578
Author(s):  
A G Naumov ◽  
A V Pavlunin ◽  
A Yu Golova ◽  
N A Nikolskaya ◽  
K V Mansurskaya ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Case ◽  
Delayed Diagnosis ◽  
Simultaneous Occurrence ◽  
Healthcare Network ◽  
Specific Pathogen ◽  
Long Time ◽  
Low Incidence ◽  
Scientific Challenge ◽  
Cancer Of The Lung

The scientific challenge of combining the tuberculosis process and lung cancer has not been fully disclosed in modern literature. This primarily involves the low incidence of these two pathologies at the same time. This may contribute to difficulties in the qualitative and timely diagnosis of these diseases. Tuberculosis hides the radiological manifestations of a malignant tumor for a long time that contributing to its progression and the development of high mortality among patients. Lung cancer facilitates hemato- and lymphogenous spread of a specific pathogen. As an example, a clinical case of simultaneous occurrence of pulmonary tuberculosis and lung cancer which was observed in the patient admitted to the Department for patients with respiratory tuberculosis of Nizhny Novgorod regional clinical tuberculosis dispensary, was presented. We concluded that compliance with the algorithm of the mandatory diagnostic minimum when patients admitted to the general healthcare network, as well as compliance with the rules for population screening, especially among people over 45, will minimize the risks of delayed diagnosis in case of coexistence of respiratory tuberculosis and lung cancer.

scholarly journals A clinical case of bronchoscopic detection and removal of a foreign body from the upper lobar bronchus on the right mimicking lung cancer

2020 ◽  
Vol 98 (8) ◽  
pp. 58-62
Author(s):  
L. V. Telegina ◽  
S. S. Pirogov ◽  
T. I.-A. Tazabaev ◽  
V. E. Khoronenko ◽  
A. S. Vodoleev ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Foreign Body ◽  
Clinical Case ◽  
Foreign Bodies ◽  
Clinical Manifestations ◽  
Cigarette Filter ◽  
X Ray ◽  
Lobar Bronchus ◽  
Long Time ◽  
The Right

Foreign bodies in the respiratory tract are rare in adults. Clinical manifestations include hemoptysis among other signs which requires the examination to detect tuberculosis and lung cancer. The article describes a clinical case that demonstrates the possibilities of endoscopic diagnostics and treatment in the patient with an X-ray negative foreign body (a cigarette filter) that has been in the lumen of the upper lobar bronchus of the right lung for a long time which caused inflammation in the blocked lobe and mimicking endoscopically central lung cancer.

Cancer of the Lung, Larynx, and Pleura

2018 ◽  
Author(s):  
Jyoti Malhotra ◽  
Paolo Boffetta ◽  
Lorelei Mucci
Keyword(s):  
Lung Cancer ◽  
Secondhand Smoke ◽  
Lung Cancer Risk ◽  
Occupational Exposures ◽  
Men And Women ◽  
Established Risk Factor ◽  
Former Smokers ◽  
Never Smokers ◽  
Exposure To Secondhand Smoke ◽  
Cancer Of The Lung

Lung cancer is the most commonly diagnosed cancer among men in most countries, and is the primary cause of cancer death in men and women. Its epidemic increase in incidence began in the first half of the twentieth century, paralleling the uptake of cigarette smoking that occurred 20 years before. A series of landmark studies beginning in 1950 established tobacco as the primary cause of lung cancer. Current smokers have a 10- to 20-fold higher lung cancer risk compared to never smokers. Important for prevention, former smokers substantially reduce this excess risk 5 years after smoking cessation. Exposure to secondhand smoke, a well-established risk factor for lung cancer, has a 20%–25% higher risk for those exposed. There are several occupational exposures associated with lung cancer, including asbestos. Despite the success in defining lung cancer’s etiology, this highly preventable disease remains among the most common and most lethal cancers globally.

Cancer as a Scottish Problem

1968 ◽  
Vol 13 (10) ◽  
pp. 338-348
Author(s):  
A. J. Haddow
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Cause Of Death ◽  
Cancer Mortality ◽  
Time Lag ◽  
Age Distribution ◽  
Lung Cancer Mortality ◽  
Cervix Uteri ◽  
Hospital Treatment ◽  
Cancer Of The Lung

Cancer, responsible for about 1 death in 5 in Scotland, cost over £1 per head of population in 1965 and led to bed occupation of almost 2,000 bed years. Time lag (symptoms-doctor-hospital-treatment) is usuallv small. Age distribution is as in other European countries. Excluding accidents, cancer is the second most important cause of death in children. In relation to other countries Scotland's position is very poor and the lung cancer mortality in both sexes is the highest known. Lung cancer is the most important in males, breast cancer in females. Alimentary cancers come second in both sexes. In this century alimentary cancers increased till the thirties or forties and then declined. Cancers of pancreas, cervix uteri, ovary, prostate, kidney and bladder, together with leukaemia, have all increased. Cancer of the lung has increased elevenfold in women and fiftyfold in men. It now accounts for 9 to 12 per cent of all male deaths in cities and large towns

scholarly journals Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers? A Brief Overview

2021 ◽  
Vol 22 (8) ◽  
pp. 3822
Author(s):  
Riccardo Di Fiore ◽  
Sherif Suleiman ◽  
Francesca Pentimalli ◽  
Sharon A. O’Toole ◽  
John J. O’Leary ◽  
...  
Keyword(s):  
Female Genital Tract ◽  
Germ Cell Tumors ◽  
Delayed Diagnosis ◽  
Public Health Issue ◽  
Gene Promoters ◽  
Gynecological Cancers ◽  
High Incidence ◽  
Low Incidence ◽  
Diagnosis Therapy ◽  
Malignant Germ Cell Tumors

Gynecological cancers pose an important public health issue, with a high incidence among women of all ages. Gynecological cancers such as malignant germ-cell tumors, sex-cord-stromal tumors, uterine sarcomas and carcinosarcomas, gestational trophoblastic neoplasia, vulvar carcinoma and melanoma of the female genital tract, are defined as rare with an annual incidence of <6 per 100,000 women. Rare gynecological cancers (RGCs) are associated with poor prognosis, and given the low incidence of each entity, there is the risk of delayed diagnosis due to clinical inexperience and limited therapeutic options. There has been a growing interest in the field of microRNAs (miRNAs), a class of small non-coding RNAs of ∼22 nucleotides in length, because of their potential to regulate diverse biological processes. miRNAs usually induce mRNA degradation and translational repression by interacting with the 3′ untranslated region (3′-UTR) of target mRNAs, as well as other regions and gene promoters, as well as activating translation or regulating transcription under certain conditions. Recent research has revealed the enormous promise of miRNAs for improving the diagnosis, therapy and prognosis of all major gynecological cancers. However, to date, only a few studies have been performed on RGCs. In this review, we summarize the data currently available regarding RGCs.

Pulmonary Tuberculosis Mimicking Lung Cancer and Metastasis Radiologically- A Case Report

2020 ◽  
Author(s):  
Harveen Kaur
Keyword(s):  
Lung Cancer ◽  
Pulmonary Tuberculosis ◽  
Diagnostic Procedures ◽  
Mediastinal Lymphadenopathy ◽  
Presumptive Diagnosis ◽  
Clinical Presentations ◽  
High Incidence ◽  
Pulmonary Infiltration ◽  
Low Incidence ◽  
Clinical Conditions

Tuberculosis (TB) is known to mimic several clinical conditions, especially malignancy. Pulmonary TB can present with pulmonary infiltration with or without mediastinal lymphadenopathy. TB often gets misdiagnosed in the countries having a low incidence of TB with a high incidence of lung cancer and varying clinical presentations, which results in delay in treatment initiation and unnecessary diagnostic procedures. We present a case of a 52-year old female, with a presumptive diagnosis of malignancy, which was subsequently proved as pulmonary tuberculosis with no evidence of malignancy instead.

Imperforate hymen mimicking acute appendicitis in an adolescent woman: a rare presentation

2021 ◽  
Vol 14 (3) ◽  
pp. e238547
Author(s):  
Victoria Rose Russell ◽  
Mohamed Ibrahim ◽  
Georgina Phillips ◽  
Tom Setchell ◽  
Sanjay Purkayastha
Keyword(s):  
Abdominal Pain ◽  
Acute Appendicitis ◽  
Iliac Fossa ◽  
Female Genital Tract ◽  
Delayed Diagnosis ◽  
Rare Presentation ◽  
Left Iliac Fossa ◽  
Imperforate Hymen ◽  
Retrograde Menstruation ◽  
Low Incidence

Imperforate hymen is a rare congenital malformation of the female genital tract. The condition poses several diagnostic challenges owing to its low incidence and often atypical presentation. Classical symptoms include amenorrhoea and cyclical abdominal pain. Delayed diagnosis leads to potentially irreversible and lifechanging sequelae including infertility, endometriosis and renal failure. A premenarchal 13-year-old girl with a background of chronic constipation presented with symptoms mimicking acute appendicitis. The underlying cause was imperforate hymen and retrograde menstruation. The diagnosis was made during diagnostic laparoscopy. As with this patient, pre-existing symptoms are often troublesome long before the true diagnosis is made. This case report highlights the importance of recognising imperforate hymen as a potential cause of acute abdominal pain in premenarchal adolescent girls. The clinical picture may present as right or left iliac fossa pain. Early identification reduces the risk of adverse complications and avoids unnecessary and potentially harmful interventions.

scholarly journals P2.11-21 Factors Predicting Attrition in Community-Based Healthcare Network Lung Cancer Screening Programs

2018 ◽  
Vol 13 (10) ◽  
pp. S786-S787
Author(s):  
K. Spiegel ◽  
J. Rayburn ◽  
C. Wilshire ◽  
E. Rauch ◽  
J. Handy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
Lung Cancer Screening ◽  
Community Based ◽  
Screening Programs ◽  
Healthcare Network

scholarly journals Monosomy 12 and deletion of 13q34 in a case of chronic lymphocytic leukemia with concomitant lung cancer

2010 ◽  
Vol 67 (10) ◽  
pp. 864-866 ◽  
Author(s):  
Darko Antic ◽  
Marija Dencic-Fekete ◽  
Dragica Tomin ◽  
Irena Djunic
Keyword(s):  
Lung Cancer ◽  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Lung Carcinoma ◽  
Prognostic Significance ◽  
Specific Treatment ◽  
Lymphocytic Leukemia ◽  
Simultaneous Occurrence ◽  
Hybridization Technique

Background. We described a patient with chronic lymphocytic leukemia (CLL) and lung cancer and unusual chromosomal aberrations. Case report. At the same time with the diagnosis of B-cell CLL, squamocellular lung carcinoma diagnosis was established. Using interphase fluoresecence in situ hybridization technique (FISH) we detected monosomy 12 and deletion of 13q34 occured in the same clone. One month after the beginning of examination the patient died unexpectedly during sleep immediately before we applied a specific treatment for CLL or lung carcinoma. Conclusion. Simultaneous occurrence of monosomy 12 and deletion of 13q34 in a patient with B-cell CLL has been described only once before, but as a part of a complex karyotype. The prognostic significance of these abnormalities remains uncertain.

scholarly journals Delayed Diagnosis of Unilateral Mandibular Condylar Fracture in a Posterior Edentulous Patient

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Sahani Anupama ◽  
Pilana Vithanage Kalani Shihanika Hettiarachchi
Keyword(s):  
Early Diagnosis ◽  
Clinical Case ◽  
Delayed Diagnosis ◽  
Mandibular Fractures ◽  
Edentulous Patient ◽  
Condylar Fracture ◽  
Physical Finding ◽  
Case Presentation ◽  
Edentulous Patients ◽  
Condylar Fractures

Background. Fractures of the mandible are common in elderly patients, and among them, condylar fractures are the most frequent type. A change in occlusion is the most common physical finding in patients with fractures of the mandible. Therefore, it is challenging to identify mandibular fractures in posterior edentulous patients due to the lack of posterior occlusal contacts. It is crucial to do radiological investigations in such patients to exclude fractures. Case Presentation. This article describes a case of delayed diagnosis of a unilateral mandibular condylar fracture for a week’s duration and treating the condition as temporomandibular pathology in a posterior edentulous, 52-year-old patient. Conclusion. This clinical case highlights the importance of radiological investigations and occlusal analysis for early diagnosis of condylar fractures, particularly in posterior edentulous patients, lacking posterior occlusal contacts.

scholarly journals Clinical case of the treatment of metastatic luminal breast cancer

2021 ◽  
pp. 160-166
Author(s):  
A. F. Nasretdinov ◽  
A. V. Sultanbaev ◽  
K. V. Menshikov ◽  
Sh. I. Musin ◽  
N. I. Sultanbaeva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Hormone Therapy ◽  
Hormone Receptor ◽  
Clinical Case ◽  
Luminal Breast Cancer ◽  
Hormone Receptor Positive ◽  
Long Time ◽  
Visceral Metastases

Hormone therapy currently open up the prospect of long-term, comfortable and relatively low-toxic treatment for patients with hormone receptor – positive advanced breast cancer. For a long time, the presence of visceral metastases prompted oncologists to abandon hormone therapy in favor of cytostatic agents. Now days, even in the presence of visceral metastases, clinical guidelines allow use of modern hormonal therapy in the absence of a visceral crisis. In particular, the so-called CDK 4/6 inhibitors, presented on the Russian market by drugs: palbociclib, ribociclib and abemacyclib, became the drugs that significantly improved the  results of  hormone therapy. Each of  them has demonstrated its effectiveness in  clinical trials; moreover, there are lots of clinical cases demonstrating the benefits of this therapy in real clinical practice. The article presents a clinical case of treatment of advanced hormone receptor-positive breast cancer. The effectiveness of treatment with CDK 4/6 inhibitors has been demonstrated, a comparatively analysed with the data obtained in the course of clinical trials. The analysis of the tactics of treatment of cytomegalovirus infection of the cornea during therapy with ribociclib was carried out. 

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