scholarly journals Neurological aspects of diagnosis and treatment of chronic prostatitis

2017 ◽  
Vol 7 (3) ◽  
pp. 22-27
Author(s):  
Valentin N Krupin ◽  
Yakov Ya Makhmudov ◽  
Liudmila A Makhmudova ◽  
Alexey V Krupin ◽  
Vladimir D Troshin
Keyword(s):  
Chronic Prostatitis ◽  
High Efficiency ◽  
Diagnosis And Treatment ◽  
Complex Treatment ◽  
Neurological Manifestations ◽  
Neurogenic Disorders ◽  
Neurological Pathology

In this study were analyzed the results of examination and treatment of patients with chronic prostatitis and vertebral neurogenic prostatopathy. Inclusion in the complex treatment of methods of correction of neurogenic disorders (segmental therapy, therapeutic gymnastics, psychotherapy, pharmacotherapy) showed high efficiency. Correction of the revealed neurological pathology and vertebral pathology as well, in most patients led to the elimination of not only neurological manifestations, but also symptoms of chronic prostatitis. (For citation: Krupin VN, Makhmudov IYa, Makhmudova LA, et al. Neurological aspects of diagnosis and treatment of chronic prostatitis. Urologicheskie vedomosti. 2017;7(3):22-27. doi: 10.17816/uroved7322-27).

POSSIBILITIES OF ANTIOXIDANT PROTECTION IN PATIENTS WITH SUPERIOR HYPERPLASIA OF THE PEDESTAL GLAND AND ACCOMPANYING CHRONIC POSTATITIS

2020 ◽  
pp. 8-11
Author(s):  
Павел Георгиевич Осипов ◽  
Андрей Александрович Береш ◽  
Юрий Сергеевич Ханин ◽  
Олеся Игоревна Некрылова
Keyword(s):  
Lipid Peroxidation ◽  
Chronic Prostatitis ◽  
Antioxidant Defense ◽  
Prostate Gland ◽  
Antioxidant Defense System ◽  
Complex Treatment ◽  
Traditional Treatment ◽  
Important Place ◽  
Antioxidant Defense Systems ◽  
Benign Hyperplasia

Несмотря на достигнутые успехи в диагностике и лечении, на сегодняшний день проблема хронического простатита у пациентов с доброкачественной гиперплазией простаты продолжает оставаться актуальной. Тем временем, выздоровление или же стойкая ремиссия хронического простатита наступает только у 30-35% больных, которые получают традиционное лечение. В патогенезе хронического простатита важное место занимают мембранопатологические процессы, которые обусловлены активацией перекисного окисления липидов и нарушением состояния антиоксидантной системы защиты. У больных с хроническим простатитом и доброкачественной гиперплазией простаты наблюдается существенное усиление процессов липопероксидации на фоне сниженной функциональной способности антиоксидантных систем защиты организма. Поэтому равновесие в оксидантно-антиоксидантной системе является важным звеном в поддержании гомеостаза и, в частности, при патологии предстательной железы, предопределяет включение в комплексное лечение средств антиоксидантного действия. Перспективным можно считать применение препаратов с высоким содержанием биофлавоноидов и антиоксидантных витаминов. Включение в комплексное лечение таких пациентов препарата Кверцетина приводит к сокращению сроков нормализации клинико-лабораторных проявлений заболевания благодаря восстановлению равновесия между перекисным окислением липидов и состоянием антиоксидантной системы защиты Despite the successes achieved in the diagnosis and treatment, to date, the problem of chronic progression in patients with benign hyperplasia of the growth continues to remain relevant. Meanwhile, recovery or persistent remission of chronic prostatitis occurs only in 30-35% of patients who receive traditional treatment. In the pathogenesis of chronic prostatitis, membrane-pathological processes take an important place, which are caused by the activation of lipid peroxidation and impaired state of the antioxidant defense system. In patients with chronic prostate and benign hyperplasia, a significant increase in lipoperoxidation processes is observed against the background of a reduced functional ability of antioxidant defense systems. Therefore, the equilibrium in the oxidant-antioxidant system is an important link in the maintenance of homeostasis and, in particular, with the pathology of the prostate gland, allows the inclusion of antioxidant drugs in the complex treatment. The use of drugs with a high content of bioflavonoids and antioxidant vitamins can be considered promising. The inclusion of such patients in the complex treatment of the drug Quercetin leads to a reduction in the normalization period of the clinical and laboratory manifestations of the disease due to the restoration of the equilibrium between the peroxidation of the lipid peroxidation system and the state of lipid peroxidation

EFFICIENCY OF NEW HEMOSORBENT IN ACUTE AMITRIPTYLINE AND CYCLODOL POISONING

2020 ◽  
pp. 14-18
Author(s):  
A. M. Fomin
Keyword(s):  
Clinical Effect ◽  
High Efficiency ◽  
Initial Level ◽  
Synthetic Polymer ◽  
Complex Treatment ◽  
Direct Hemoperfusion ◽  
Selective Sorption ◽  
Positive Clinical Effect ◽  
Before And After

A complex treatment of a patient with acute amitriptyline and cyclodol poisoning using enterosorption, intestinal lavage and hemosorption on a new column with a synthetic sorbent is presented. A two-layer synthetic polymer column developed for the selective sorption of cytokines by direct hemoperfusion was used for hemosorption. Quantitative determinations of amitriptyline and cyclodol levels before and after the column, as well as before and after hemosorption have showed high efficiency of the sorbent to remove the toxicant from the blood. The use of 6-hour hemosorption allowed to reduce the level of amitriptyline from the initial level by more than 4 times and the level of cyclodol - by more than 3 times to therapeutic levels and to obtain a pronounced positive clinical effect in the complex treatment of a patient with severe poisoning.

The relationship between detrusor state and tone of the large intestine and their sphincter apparatus in women with hyperactive urinary bladder

2017 ◽  
pp. 32-34
Author(s):  
S.A. Vozianov ◽  
◽  
M.P. Zakharash ◽  
Yu.M. Zakharash ◽  
N.A. Sevast'yanova ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Bladder ◽  
Large Intestine ◽  
Lower Urinary Tract ◽  
High Efficiency ◽  
Clinical Manifestations ◽  
Distal Colon ◽  
Neurogenic Disorders ◽  
Neurogenic Dysfunction ◽  
Lower Urinary

The objective: increase the effectiveness of diagnosis and treatment of women with a hyperactive bladder, combined neurogenic pathology of the lower urinary tract and distal colon. Patients and methods. The study included 73 women. In assessing the symptoms of clinical manifestations and EMG and UFS data, two groups of patients were identified: the first group – women with increased tone of the neuro-muscular structures of the hyperkinetic type; the second group - women with an increased tone of the neuromuscular structures of the hypokinetic type. In the first group, 37 women were examined, whose mean age was 44.5±2.3 years, and the duration of the disease was 16.7±1.6 months. The second group included 36 women, whose average age was 43.4±2.1 years, and the average duration of the disease was 19.7±1.5 months. Results. The performed treatment showed clinically high efficiency of electrostimulation application depending on the state of the tone of the neuromuscular structures of the lower urinary tract and the distal part of the large intestine, which is confirmed by the data of UFS and EMG. Conclusion. The obtained data allowed to develop and optimize methods of treatment of women with hyperactive urinary bladder with a combined neurogenic pathology of the lower urinary tract and distal division of the large intestine. Key words: neurogenic disorders in urination, intestine neurogenic dysfunction, detrusor, uroflowmetry, electromyography.

scholarly journals Argentine Registry of neurological manifestations due to coronavirus-19 (COVID-19)

2021 ◽  
Author(s):  
Mariana Bendersky ◽  
Lucas Alessandro ◽  
Franco Appiani ◽  
Brenda Borrego Guerrero ◽  
Patricia Cairola ◽  
...  
Keyword(s):  
Demographic Variables ◽  
Neurological Symptoms ◽  
Neurological Manifestations ◽  
Cns Involvement ◽  
Term Care ◽  
Cerebrovascular Complications ◽  
Guillain Barré ◽  
Neurological Pathology ◽  
Degree Of Severity

COVID-19 disease has spread around the world since December 2019. Neurological symptoms are part of its clinical spectrum. Objective: To know the neurological manifestations in patients infected by COVID-19 in Argentina. Methods: Multicenter study conducted in adults, from May 2020 to January 2021, with confirmed COVID-19 and neurological symptoms. Demographic variables, existence of systemic or neurological comorbidities, the form of onset of the infection, alteration in complementary studies and the degree of severity of neurological symptoms were recorded. Results: 817 patients from all over the country were included, 52% male, mean age 38 years, most of them without comorbidities or previous neurological pathology. The first symptom of the infection was neurological in 56.2% of the cases, predominantly headache (69%), then anosmia / ageusia (66%). Myalgias (52%), allodynia / hyperalgesia (18%), and asthenia (6%) were also reported. 3.2% showed diffuse CNS involvement such as encephalopathy or seizures. 1.7% had cerebrovascular complications. Sleep disorders were observed in 3.2%. 6 patients were reported with Guillain Barre (GBS), peripheral neuropathy (3.4%), tongue paresthesia (0.6%), hearing loss (0.4%), plexopathy (0.3%). The severity of neurological symptoms was correlated with age and the existence of comorbidities. Conclusions: Our results, similar to those of other countries, show two types of neurological symptoms associated with COVID-19: some potentially disabling or fatal such as GBS or encephalitis, and others less devastating, but more frequent such as headache or anosmia that demand increasingly long-term care.

An enzyme cascade fluorescence-based assay for quantification of phenylalanine in serum

The Analyst ◽  
2022 ◽  
Author(s):  
Leilei Meng ◽  
Rui Hu ◽  
Jinping Chen ◽  
Tianjun Yu ◽  
Xiaopin Cai ◽  
...  
Keyword(s):  
High Efficiency ◽  
Diagnosis And Treatment ◽  
Enzyme Cascade

Quantification of phenylalanine in clinic samples is essential to diagnosis and treatment of phenylketonuria in neonates. In this report, an enzyme cascade strategy was proposed and a high efficiency fluorescence...

Application of Graphene and its Derivatives in Cancer Diagnosis and Treatment

Drug Research ◽  
2017 ◽  
Vol 67 (12) ◽  
pp. 681-687 ◽  
Author(s):  
S. Ghanbarzadeh ◽  
H. Hamishehkar
Keyword(s):  
Cancer Diagnosis ◽  
Targeted Drug Delivery ◽  
High Selectivity ◽  
High Efficiency ◽  
Volume Ratio ◽  
Biological Properties ◽  
Diagnosis And Treatment ◽  
Therapeutic Effects ◽  
Pharmaceutical Sciences ◽  
Small Molecule Drugs

AbstractAlthough chemotherapies are successful in some cases, systemic toxicity could be simultaneously observed due to the lack of drugs selectivity to cancerous tissues, leading to the failure of the chemotherapies. Furthermore, the therapeutic effects will be significantly improved if the anticancer drugs could be delivered to cancer cells with high selectivity. In recent years, there have been many advances in the field of diagnosis and treatment of cancer as a result of the development of novel materials with noticeable and often unique properties. Nanoparticles have unique biological properties, owing to their small size and large surface area-to-volume ratio, which allow them to bind, absorb, and carry compounds such as small molecule drugs, DNA, RNA, proteins, and probes with high efficiency. In the course of the last decade, Graphene and its derivatives have attracted growing interest in medicinal and pharmaceutical sciences, and many studies have focused on the potential of Graphene and its derivatives as carriers for targeted drug delivery intended for cancer diagnosis and therapies. In the present study, we will review the characteistics and application of Graphene and its different derivatives and finally discuss the opportunities, limitations, and challenges in this encouraging field.

Evaluation of the Efficacy and Performance of a New Nano-Drug Carrier in the Treatment of Recurrent Oral Ulcerper

2021 ◽  
Vol 21 (2) ◽  
pp. 1107-1117
Author(s):  
Yuqi He ◽  
Zhiqiang Xu ◽  
Zhuwen Qiu ◽  
Dechun Zheng ◽  
Liting Xie
Keyword(s):  
High Efficiency ◽  
Drug Carrier ◽  
Rapid Development ◽  
Drug Carriers ◽  
Surface Proteins ◽  
Diagnosis And Treatment ◽  
Research Progress ◽  
Hydrophobic Core ◽  
Polymer Micelle ◽  
Oral Ulcers

Recurrent oral ulcer is a common oral mucosal disease. Due to its periodic and recurrent characteristics, the onset of burning pain is unbearable, which brings great inconvenience to the patient’s life and seriously affects the patient’s quality of life. There are certain limitations to conventional drug therapy. With the rapid development of nanotechnology, the obvious advantages of nanotechnology such as targeting, controlled release, biocompatibility is obviously shown. The combination of nanotechnology and medical research has led to the emergence of polymer nanoparticles and ligands. Nano-drugs for gene therapy, and many other new nano-drug carriers, polymer micelle is a new type of nano drug carrier that has appeared in recent years. It has both a hydrophilic shell and a hydrophobic core, and has a variety of excellent properties, such as higher stability in vivo and in vitro, and poorly soluble drugs. In this paper, a new method for treating recurrent oral ulcers based on a new nano-drug carrier was studied. Because of the hydrophilicity and biocompatibility of oral cell surface proteins, the research progress of nanopharmaceutical carrier in the treatment of recurrent oral ulcers is reviewed. The experimental results show that the method has good reproducibility and high efficiency in the treatment of recurrent oral ulcers. It is used to explore the application and progress of nanotechnology in the diagnosis and treatment of recurrent oral ulcers, and to provide new ideas for the clinical diagnosis and treatment of recurrent oral ulcers. This new technical method has wide practical application value.

scholarly journals Autoimmune encephalitis: a review of diagnosis and treatment

2018 ◽  
Vol 76 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Lívia Almeida Dutra ◽  
Fabiano Abrantes ◽  
Fabio Fieni Toso ◽  
José Luiz Pedroso ◽  
Orlando Graziani Povoas Barsottini ◽  
...  
Keyword(s):  
Movement Disorders ◽  
Psychiatric Symptoms ◽  
Clinical Manifestations ◽  
Autoimmune Encephalitis ◽  
Diagnosis And Treatment ◽  
Diagnostic Approach ◽  
Neurological Manifestations ◽  
Common Causes ◽  
Autonomic Disturbances

ABSTRACT Autoimmune encephalitis (AIE) is one of the most common causes of noninfectious encephalitis. It can be triggered by tumors, infections, or it may be cryptogenic. The neurological manifestations can be either acute or subacute and usually develop within six weeks. There are a variety of clinical manifestations including behavioral and psychiatric symptoms, autonomic disturbances, movement disorders, and seizures. We reviewed common forms of AIE and discuss their diagnostic approach and treatment.

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