Nefrectomia e Cistectomia Parcial no Tratamento de Carcinoma em Bexiga de Cão

O carcinoma de células transicionais (CCT) é considerado a neoplasia mais comum da vesícula urinária do cão. Sua etiologia é multifatorial, porém foi sugerido que fêmeas idosas são mais suscetíveis para desenvolvimento da doença. As manifestações clínicas mais comuns que ocorrem com os animais acometidos são consistentes com hematúria, estrangúria e polaquiúria que podem estar presentes por semanas a meses antes do diagnóstico. O diagnóstico definitivo é realizado através de análise histopatológica, entretanto, através do exame de ultrassonografia podemos detectar anormalidades da bexiga, onde as neoplasias são uma suspeita. Várias terapias têm sido propostas para o tratamento do carcinoma de células transicionais, incluindo cirurgia, radioterapia, quimioterapia, cuidados médicos e paliativos. A excisão cirúrgica em canídeos com CCT pode ser indicada para a obtenção de amostras para biopsia, remoção do carcinoma e para manter ou restaurar o fluxo urinário. O tratamento médico é indicado quando não é possível a ressecção cirúrgica do carcinoma e quando existem metástases, consistindo no uso de quimioterápicos, inibidores COX e a combinação destes dois tipos de tratamento. Objetiva-se com este trabalho relatar o caso de um canino, fêmea, da raça Bloodhound, de sete anos, com carcinoma de células transicionais que foi submetido ao tratamento cirúrgico. Neste caso a nefrectomia associada a cistectomia parcial mesmo com envolvimento de região de trígono e ureter apresentou tratamento curativo durante o período de avaliação do animal, que em sua última avaliação demonstrou-se com doze meses de remissão, assim aumentando a longevidade e melhorando a qualidade de vida do mesmo. Palavras-chave: Canino. Células Transicionais. Cirurgia. Rim. Trígono Vesical. Abstract Transitional cell carcinoma (TCC) is the most common neoplasm of the urinary vesicle in dogs. Its etiology is multifactorial; however, it has been suggested that elderly female dogs appear more susceptible to disease development. Clinically, the affected animals frequently demonstrate hematuria, strangury, and polaquiuria. These symptoms may be present for weeks to months prior to diagnosis. Definitive diagnosis is made through histopathological analysis; however, ultrasound examination enables detection of bladder abnormalities, where neoplasms often occur. Several therapies are used to treat, including surgery, radiation therapy, chemotherapy, and medical and palliative care. Surgical excision in dogs with TCC can be indicated to obtain samples for biopsy, carcinoma removal and to maintain or restore urinary flow. Medical treatment is indicated when surgical resection of the carcinoma is not possible and when there are metastasis, consisting of the use of chemotherapy, COX inhibitors and the combination of these two types of treatment. The objective of this study was to report a case of a seven-year-old female Bloodhound dog with TCC who underwent surgical treatment. In this case, nephrectomy associated with partial cystectomy, even with involvement of the trigone and ureter region, presented curative treatment during the evaluation period of the animal, which in its last evaluation was demonstrated with twelve months of remission, thus increasing longevity and improving quality life. Keywords: Canine. Kidney. Surgery. Transitional cell. Vesical trigone.

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Multiple Koenen Tumors, a Rare Entity: Combination Treatment with 1% Topical Sirolimus Electrofulguration and Excision

Skin Appendage Disorders ◽

10.1159/000511743 ◽

2020 ◽

Vol 7 (1) ◽

pp. 66-70

Author(s):

Vishalakshi Viswanath ◽

Jay D. Gupte ◽

Niharika Prabhu ◽

Nilima L. Gour

Keyword(s):

Tuberous Sclerosis ◽

Combination Treatment ◽

Tumor Regression ◽

Surgical Excision ◽

Tumor Formation ◽

Rare Entity ◽

Rare Presentation ◽

Cutaneous Manifestations ◽

Elderly Female

Introduction: Koenen tumors are benign, cutaneous manifestations of tuberous sclerosis. These are disfiguring, painful, and challenging to treat as they frequently recur. We report a case of long-standing, multiple Koenen tumors affecting all twenty nails in an elderly female who was successfully treated with a combination of topical sirolimus 1%, surgical excision, and electrofulguration. Case Report: A 57-year-old lady presented with multiple, asymptomatic periungual, and subungual tumors affecting all twenty nails since 27 years. Cutaneous examination revealed confetti macules, ash-leaf macule, and shagreen patch over trunk. Nail biopsy was compatible with Koenen’s tumor. Computerized tomography of brain showed diffuse patchy sclerosis. The tumors were treated with topical sirolimus 1% ointment for 10 months with excellent regression. Electrofulguration for both great toenails and surgical excision of right thumbnail periungual fibroma was done. 1% sirolimus was advised after the surgical treatment. There were no adverse effects or recurrence of tumors over a 2-year follow-up. Discussion: Topical sirolimus 1% was effective in tumor regression and preventing new tumor formation. Larger tumors that interfered in daily chores were treated with excision and electrofulguration. Thus, a combination treatment for this rare presentation of tuberous sclerosis provided optimum results.

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Basal Cell Carcinoma of the Head and Neck Region in Ethnic Chinese

International Journal of Surgical Oncology ◽

10.1155/2011/890908 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Velda Ling Yu Chow ◽

Jimmy Yu Wai Chan ◽

Richie Chiu Lung Chan ◽

Joseph Hon Ping Chung ◽

William Ignace Wei

Keyword(s):

Neck Region ◽

Surgical Excision ◽

Chinese Patients ◽

Skin Closure ◽

Recurrence Rates ◽

Tumour Control ◽

Female Patients ◽

Ethnic Chinese ◽

Elderly Female ◽

Tertiary Centre

Objectives.This study aims to report our experience in the management of HNBCC in ethnic Chinese over a 10-year period.Methods.A retrospective review of all ethnic Chinese patients with HNBCC treated in a tertiary centre from 1999 to 2009.Results.From 1999 to 2009, 225 patients underwent surgical excision for HNBCC. Majority were elderly female patients. Commonest presentation was a pigmented (76.2%) ulcer (64.8%) over the nose (31.6%). Median skin margin taken on tumour excision was 2.0 mm; primary skin closure was achieved in 51.8%. Postresection skin margin was clear in 75.4%. Of those with inadequate skin margins, 56.7% opted for further treatment, 43.4% for observation. Recurrence rates were 2.6% and 13.8%, respectively (). Overall recurrence rate was 5.5%.Conclusions.HNBCC commonly presented as pigmented ulcers over the nose of elderly female patients in our locality. Adequate tumour excision ± reconstruction offered the best chance of cure. Reexcision of those with inadequate skin margins improved local tumour control.

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Cutaneous lymphoma in a cow - a case report

Veterinarski glasnik ◽

10.2298/vetgl180904004k ◽

2019 ◽

Vol 73 (1) ◽

pp. 50-56

Author(s):

Branislav Kureljusic ◽

Slobodan Maksimovic ◽

Slobodan Vujinovic ◽

Bozidar Savic ◽

Vesna Milicevic ◽

...

Keyword(s):

Disease Virus ◽

Skin Disease ◽

Mononuclear Cells ◽

Subcutaneous Tissue ◽

Leukemia Virus ◽

Surgical Excision ◽

Cutaneous Lymphoma ◽

Histopathological Analysis ◽

Lumpy Skin Disease ◽

Lumpy Skin Disease Virus

In this paper the case of a 2.5-year-old Simmental cow, with suspicion of lumpy skin disease in mid-2017 in Serbia will be presented. Clinical examination revealed numerous nodules of varied size from a few millimeters to approximately 10 centimeters disseminated predominantly on the skin of the udder and the perineum, some of which were coalescing and exulcerated. The general condition of the affected animal was unchanged. According to the results of laboratory analysis, the cow was negative for the presence of antibodies against the bovine leukemia virus, showed a negative reaction in tuberculinization and was vaccinated against lumpy skin disease virus. After the surgical excision of one skin node, the sample tested negative for the genome of lumpy skin disease virus. In order to establish the morphology of the skin lesion, a histopathological analysis was performed. Histopathological analysis showed the infiltration of the corium and subcutaneous tissue by numerous mononuclear cells showing cellular atypia. Suspicion of cutaneous lymphoma was established. Furthermore, the immunohistochemical examination confirmed that the infiltrate contained exclusively CD3-immunopositive cells, suggesting a T-cell origin nonepitheliotropic lymphoma.

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Myxoid liposarcoma of small bowel presenting with intussusception and obstruction: A case report

Indian Journal of Case Reports ◽

10.32677/ijcr.v7i12.3171 ◽

2022 ◽

pp. 519-521

Author(s):

Mohd Monis ◽

Divyashree Koppal ◽

Aiman Ibbrahim ◽

Zeeshan Nahid

Keyword(s):

Small Bowel ◽

Intestinal Obstruction ◽

Leading Edge ◽

Surgical Excision ◽

Myxoid Liposarcoma ◽

Histopathological Analysis ◽

Contrast Enhanced ◽

Well Differentiated ◽

Enhanced Computed Tomography

Gastrointestinal liposarcomas are extremely rare with the most common reported morphological subtype being dedifferentiated liposarcoma and well-differentiated liposarcoma. These tumors are rarely diagnosed preoperatively and diagnosis is only confirmed on histopathological analysis. Treatment of gastrointestinal liposarcomas consists of surgical excision with widely negative margins followed by post-operative irradiation and close follow-up. We report an exceedingly rare case of myxoid liposarcoma of the small bowel (ileum) presenting with an unusual presentation with intussusception and intestinal obstruction. A 42-year-old male presented to the emergency department with features of intestinal obstruction. Contrast-enhanced computed tomography abdomen revealed ileo-ileal intussusception with an endoluminal soft-tissue lesion at the leading edge. The patient was taken for surgical intervention and the involved segment of the bowel along with the lesion was resected and re-anastomosis done. Histological sections of the mass along with immunohistochemistry suggested the pathological diagnosis of myxoid liposarcoma.

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Right Elbow Angioleiomyoma: A Case Report & Review of the Literature

10.33140/ijor.02.01.02 ◽

2019 ◽

Vol 2 (1) ◽

Keyword(s):

Corticosteroid Injection ◽

Standard Of Care ◽

Surgical Excision ◽

Upper Extremities ◽

Histopathological Analysis ◽

Current Standard ◽

Smooth Muscle Tumors ◽

Mass Size ◽

Case Basis ◽

Postoperative Observation

Angioleiomyoma are typically benign vascular smooth muscle tumors. These tumors are rarely seen in males as well as the upper extremities. A 49-year-old patient presented with a painful, fluctuant right elbow mass after a 5-6-year latency. In this case, aspiration as well as corticosteroid injection did not diminish mass size or pain caused by it. After exhausting conservative management, the patient opted for surgical excision, debridement, and histopathological analysis for diagnosis and showed the hallmark variable veins within muscular walls. Current standard of care consists of surgical resection and subsequent postoperative observation for local recurrence. Due to its rarity in location and non-specific findings, diagnosis is often unclear. In the context of existing literature, the optimal treatment for these patients should be determined on a case-by-case basis.

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DIAGNOSTIC PROBLEMS ACCOMPANYING BRANHYOGENIC CANCER – A CLINICAL CASE

Wiadomości Lekarskie ◽

10.36740/wlek202003140 ◽

2020 ◽

Vol 73 (3) ◽

pp. 614-618

Author(s):

Uliana D. Matolych ◽

Svetlana V. Ushtan ◽

Victoria V. Pankevych ◽

Kateryna V. Horytska

Keyword(s):

Head And Neck ◽

Morphological Analysis ◽

Clinical Case ◽

Ultrasound Examination ◽

Transitional Cell ◽

Final Diagnosis ◽

Surgical Removal ◽

Invasive Squamous Cell Carcinoma ◽

Bronchial Cancer ◽

Neck Vessels

Tumours and tumorous lesions of head and neck account for 10% of all oncological pathologies. Branhyogenic cancer is found in 4.5% of patients with lateral cysts in the neck. The article highlights the results of research the clinical case of branhyogenic cancer, provide its clinical and morphological analysis. The aim of our work was to study the clinical case of bronchial cancer, providing clinical and pathomorphological analysis. Examination and treatment was conducted in accordance with the clinical protocol using the diagnostic criteria necessary for management of patients diagnosed with tumours and tumorous lesions in a particular clinical case. We applied ultrasound examination of the locus, angiography of head and neck vessels with tomohexol and with 3D reconstruction, histological examination of surgical specimens (macroscopy and microscopy). On the basis of clinical investigaton, ultrasound examination, angiography clinical diagnosis was formulated – lateral cyst on the left side of the neck. A radical surgical removal of the mass was conducted. Histopathological conclusion: there is a proliferation of cystic transitional cell epithelium with the locus of invasive squamous cell carcinoma in the cystic wall that suggests malignant transformation of bronchogenic cyst. Final diagnosis: branhyogenic cancer. Thorough examination and analysis of a clinical case demonstrates that the development of branhyogenic cancer, is histo-genetically associated with lateral cysts in the neck. Complexity of diagnosing and high percentage of malignancy induces to more early discovery and removal of lateral cysts in the neck .

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Laryngeal Langerhans Cell Histiocytosis: A Case Report and Literature Review

Annals of Otology Rhinology & Laryngology ◽

10.1177/0003489420954883 ◽

2020 ◽

pp. 000348942095488

Author(s):

Allen S. Zhou ◽

Lei Li ◽

Thomas L. Carroll

Keyword(s):

Literature Review ◽

Langerhans Cell Histiocytosis ◽

Medical Center ◽

Tertiary Care ◽

Rare Condition ◽

Surgical Excision ◽

Langerhans Cell ◽

Histopathological Analysis ◽

Current Case ◽

Tertiary Care Medical Center

Objective: To describe a case of laryngeal Langerhans cell histiocytosis, discuss its characteristic features and management, and provide a review of the available literature. Methods: A patient presenting to a tertiary care medical center with dyspnea and hoarseness is described. A literature review of laryngeal Langerhans cell histiocytosis cases was performed through a search of articles indexed in the National Institutes of Health PubMed system. Results: We report a case of a 69-year old male, who presented with a laryngeal mass highly suspicious for laryngeal squamous cell carcinoma, was treated with laser excision, and was subsequently found to have laryngeal Langerhans cell histiocytosis upon histological analysis. Including our current case, we found six prior reported cases of laryngeal Langerhans cell histiocytosis in the literature. Of the six cases, four were in adults, while two were in children. Dyspnea is a common presenting complaint present in all cases. Smoking may be a potential risk factor. Conclusions: Laryngeal Langerhans cell histiocytosis is a rare condition and an important consideration in the differential diagnosis of patients presenting with a laryngeal mass and symptoms of dyspnea or hoarseness. Biopsy and histopathological analysis are key to the diagnosis. Surgical excision and radiotherapy are successful treatments used in clinical practice.

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Myofibroma of the cervical spine presenting as brachialgia

Journal of Neurosurgery Spine ◽

10.3171/2014.8.spine131194 ◽

2014 ◽

Vol 21 (6) ◽

pp. 916-918 ◽

Cited By ~ 2

Author(s):

Benjamin M. Davies ◽

Daniel du Plessis ◽

Kanna K. Gnanalingham

Keyword(s):

Soft Tissue ◽

Facet Joint ◽

Surgical Excision ◽

En Bloc Resection ◽

Bloc Resection ◽

Benign Tumors ◽

Histopathological Analysis ◽

En Bloc ◽

Left Posterior ◽

Midline Approach

Myofibromas are rare, benign tumors of myofibroblasts. Their occurrence in adults, involving bone outside of the head and neck, is especially uncommon. The authors report the case of a 34-year-old woman who presented with left-sided brachialgia. Magnetic resonance imaging identified an expansile soft-tissue lesion of the C6–7 facet joint. En bloc resection via a left posterior midline approach was undertaken. Histopathological analysis confirmed the lesion to be a myofibroma. Brachialgia resolved following surgery and there is no evidence of recurrence at 20 months follow-up. Myofibroma is a rare cause of primary soft-tissue tumor of the spine. Surgical excision remains the mainstay of treatment.

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Aberrant Pancreatic Tissue in a Mediastinal Enteric Duplication Cyst: A Rarity with Review of Literature

Case Reports in Gastrointestinal Medicine ◽

10.1155/2017/7294896 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Meha Mansi ◽

Nidhi Mahajan ◽

Sonam Mahana ◽

C. R. Gupta ◽

Anup Mohta

Keyword(s):

Respiratory Distress ◽

Surgical Excision ◽

Mass Effect ◽

Posterior Mediastinum ◽

Duplication Cyst ◽

Pancreatic Tissue ◽

Histopathological Analysis ◽

Early Presentation ◽

Enteric Duplication Cyst ◽

Enteric Duplication

Mediastinal enteric duplication cysts are a rare congenital malformation encountered mainly in neonates and infants. It is a distinct entity within the family of foregut duplication cysts. It can present with respiratory distress due to mass effect and hence surgical excision is the preferred treatment. Histologically, it is characterised by a double layered smooth muscle wall with intestinal lining epithelium. We report a case of mediastinal enteric duplication cyst with aberrant pancreatic tissue in a neonate due to its rarity and early presentation. A neonate presented with respiratory distress and a cystic mass in the right posterior mediastinum. The lesion was excised and on histopathological analysis the diagnosis of mediastinal enteric duplication cyst was made. Also, aberrant pancreatic tissue which has been reported rarely was noted in this case. We discuss this case and review similar cases reported in literature.

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Clinical and Immunohistochemical Features of Oral Angioleiomyoma: A Comprehensive Review of the Literature and Report of a Case in a Young Patient

Case Reports in Dentistry ◽

10.1155/2019/2498353 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9

Author(s):

Amerigo Giudice ◽

Francesco Bennardo ◽

Caterina Buffone ◽

Ylenia Brancaccio ◽

Francesca Maria Plutino ◽

...

Keyword(s):

English Language ◽

Immunohistochemical Analysis ◽

Surgical Excision ◽

Clinical Aspects ◽

Histopathological Analysis ◽

Histopathological Diagnosis ◽

Presumptive Diagnosis ◽

Female Ratio ◽

S 100 ◽

Male To Female

Angioleiomyoma (AL) is an uncommon benign soft tissue neoplasia arising from the tunica media of the smooth muscle cells. AL appears as a solitary and slow-growing mass and seldom is observed in oral tissues. We reported a rare case of AL involving the cheek of a 17-year-old young woman. A review of the English-language literature was performed entering the keywords “angioleiomyoma” and “oral” in the search fields of PubMed. 70 results were identified. Excluded were cases that were not in the oral cavity or not compatible with the AL diagnosis or report lacking immunohistochemical analysis. According to the exclusion criteria, we selected 30 studies that included 63 cases of AL. The results of the review showed an average age of 42.97 years with a prevalence between the fourth and fifth decade of life with a male-to-female ratio of 1.95 : 1. The most affected sites were palate, buccal mucosa of the cheek, lip, tongue, and gingiva. Surgical excision was the treatment of choice, and diagnosis was possible through histopathological and immunohistochemical analysis. SMA, vimentin, CD34, desmin, and S-100 were the most common markers to guide the histopathological diagnosis of oral AL. In conclusion, oral AL is a rare entity, especially in adolescence as in the reported case of AL of the cheek in a 17-year-old woman. The clinical aspects of AL did not allow clinicians to make a correct presumptive diagnosis. A scrupulous histopathological analysis and immunohistochemical examinations are fundamental to differentiate AL from other lesions.

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