Microwave Assisted Synthesis of Novel N-(Benzo[d]Thiazol-2-yl)-2-((2,4'-Dioxospiro[Indoline-3,2'-Thiazolidin]-3'-yl)Amino)Acetamide Derivatives as Potent Antibacterial Agents
2015 ◽
Vol 53
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pp. 122-129
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Keyword(s):
As part of continuing studies in emerging new antibacterial agent, a novel series of N-(benzo[d] thiazol-2-yl)-2-((2,4’-dioxospiro[indoline-3, 2’-thiazolidin]-3'-yl)amino)acetamide derivatives were synthesized by sequencing reaction of 2-aminobenzothiazole with chloroacetyl chloride, hydrazine hydrate, isatin and Thioglycolic acid. The novel heterocycles were characterized by elemental analyses and various spectroscopic techniques. The synthesized compounds were tested in-vitro antibacterial activity against two Gram-positive and two Gram-negative bacteria. Bacteriological results showed that compound 5c possessed a broad spectrum of antibacterial activity against the tested microorganisms.
2015 ◽
Vol 53
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pp. 114-121
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2014 ◽
Vol 38
(5)
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pp. 300-303
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2009 ◽
Vol 4
(7)
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pp. 1934578X0900400
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2019 ◽
2019 ◽
Vol 16
(3)
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pp. 284-290
1998 ◽
Vol 42
(4)
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pp. 911-915
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1977 ◽
Vol 3
(5)
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pp. 403-410
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1996 ◽
Vol 4
(8)
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pp. 1307-1315
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