scholarly journals A study of the neuroprotective role of Punica granatum and rosuvastatin in scopolamine induced cognitive deficit in rats

2017 ◽  
Vol 6 (7) ◽  
pp. 1773
Author(s):  
Fariha Fatima ◽  
Dilshad A. Rizvi ◽  
Afroz Abidi ◽  
Ali Ahmad ◽  
Pooja Shukla ◽  
...  
Keyword(s):  
Standard Treatment ◽  
Neuroprotective Effect ◽  
Memory Function ◽  
Acetylcholinesterase Inhibitor ◽  
Punica Granatum ◽  
Protective Role ◽  
Experimental Models ◽  
Anticholinergic Agent ◽  
Model Of Alzheimer’S Disease

Background: The present work has been planned to find out the effect of Punica granatum and Rosuvastatin on learning and memory in Scopolamine induced cognitive deficits in rats. Scopolamine being an anticholinergic agent is used fervently in experimental models for memory deficits and has been widely implicated for the screening of cognitive dysfunction. Punica granatum (Pomegranate) has shown to suppress tumor neuronal cells, hence it can be a potential agent in providing neuroprotection for preventing the development and progression of AD. There are conflicting reports indicating the role of statins as a neuroprotective agent. This contradiction led us to investigate the effect of the role of Rosuvastatin on memory. The test agents were further compared to the standard treatment group acetylcholinesterase inhibitor i.e. Donepezil.Methods: Male wistar rats 150-200gms were divided into 4 groups of 6 rats each. Amnesia was induced by scopolamine 3mg/kg ip at day 5 in all the groups. Group1 (amnesic control) given distilled water; group 2(standard treatment i.e. Donepezil 0.5mg/kg orally); group 3(Rosuvastatin group10mg/kg orally); group 4 (Punica granatum juice 500mg/kg orally) The methods for validating cognition deficits were behavioural tests like Cook’s pole response and Passive Avoidance response.Results: It was evident from our research that the Punica granatum juice and Rosuvastatin effectively antagonized the scopolamine induced cognitive impairment in the paradigms studied. The neuroprotective effect of Punica granatum juice was better as compared to the Rosuvastatin group and the effects of the former were comparable with the standard treatment i.e. Donepezil group.Conclusions: Punica granatum has a remarkable protective role in memory function, learning, cognition and behavior in Scopolamine induced amnesia model of Alzheimer’s disease which was better than Rosuvastatin treatment.

A Preliminary Clinical Study of Cyclophosphamide with Reduced Glutathione Asc Uroprotector

1989 ◽  
Vol 75 (3) ◽  
pp. 257-258 ◽  
Author(s):  
Maria Teresa Nobile ◽  
Maria Giuseppina Vidili ◽  
Marco Benasso ◽  
Marco Venturini ◽  
Michele Tedeschi ◽  
...  
Keyword(s):  
Clinical Study ◽  
Reduced Glutathione ◽  
Protective Role ◽  
Experimental Models ◽  
Microscopic Hematuria ◽  
Clinical Use ◽  
Thiol Compound ◽  
Preliminary Results

Reduced glutathione (GSH) has been reported to be an effective protector against cyclophosphamide-induced urotoxicity in experimental models, providing protection comparable to that of mesna. This paper describes our preliminary results of the clinical use of GSH in combination with cyclophosphamide. GSH was administered i.v. in two divided doses of 2.5 g, 15 min before and 30 min after escalating doses of cyclophosphamide ranging from 1.2 up to 1.6 g/m2 (1-h infusion). GSH was well tolerated and did not produce unexpected toxicity. The lack of bladder damage, including microscopic hematuria, supports the protective role of this thiol compound.

scholarly journals Sex differences in obesity-induced hypertension and vascular dysfunction: a protective role for estrogen in adipose tissue inflammation?

2016 ◽  
Vol 311 (4) ◽  
pp. R714-R720 ◽  
Author(s):  
Lia E. Taylor ◽  
Jennifer C. Sullivan
Keyword(s):  
Energy Homeostasis ◽  
Cell Activation ◽  
Immune Cell ◽  
Vascular Dysfunction ◽  
Protective Role ◽  
Experimental Models ◽  
Immune Cell Activation ◽  
The Subject ◽  
Associated Risk Factors

Obesity is a potent predictor of cardiovascular disease and associated risk factors, including hypertension. Systemic inflammation has been suggested by a number of studies to be an important link between excess adiposity and hypertension, yet the majority of the studies have been conducted exclusively in males. This is problematic since women represent ∼53% of hypertensive cases and are more likely than men to be obese. There is a growing body of literature supporting a central role for immune cell activation in numerous experimental models of hypertension, and both the sex of the subject and the sex of the T cell have been shown to impact blood pressure (BP) responses to hypertensive stimuli. Moreover, sex steroid hormones play an important role in energy homeostasis, as well as in the regulation of immune responses; estrogen, in particular, has a well-known impact on both cardiovascular and metabolic disorders. Therefore, the purpose of this review is to examine whether sex or sex hormones regulate the role of the immune system in the development of hypertension and related vascular dysfunction in response to metabolic changes and stimuli, including a high-fat diet.

Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats

2010 ◽  
Vol 45 (4) ◽  
pp. 581-585 ◽  
Author(s):  
Osama Y. Althunibat ◽  
Ahmed H. Al-Mustafa ◽  
Khaled Tarawneh ◽  
Khaled M. Khleifat ◽  
B.H. Ridzwan ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Punica Granatum ◽  
Protective Role ◽  
Diabetic Rats ◽  
Punica Granatum L ◽  
Peel Extract

The protective role of pomegranate (Punica granatum) juice against reproductive induced toxicity by 2,4- Dichlorophenoxyacetic in male rats

2019 ◽  
Vol 88 ◽  
pp. 27
Author(s):  
Rachid Mosbah ◽  
Aziez Chetoum ◽  
Zouhir Djerrou ◽  
Karim Hamidat Hamza ◽  
Alberto Mantovani
Keyword(s):  
Punica Granatum ◽  
Protective Role ◽  
Male Rats

Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats

2013 ◽  
Vol 141 (3) ◽  
pp. 1587-1596 ◽  
Author(s):  
Nadia Z. Shaban ◽  
Mohamed A.L. El-Kersh ◽  
Fatma H. El-Rashidy ◽  
Noha H. Habashy
Keyword(s):  
Hepatic Injury ◽  
Seed Oil ◽  
Punica Granatum ◽  
Protective Role ◽  
Male Rats ◽  
Pomegranate Peel

Loss of clusterin expression worsens renal ischemia-reperfusion injury

2010 ◽  
Vol 298 (3) ◽  
pp. F568-F578 ◽  
Author(s):  
Wenjun Zhou ◽  
Qiunong Guan ◽  
Chris C. H. Kwan ◽  
Huifang Chen ◽  
Martin E. Gleave ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Clinical Care ◽  
Kidney Injury ◽  
Protective Role ◽  
Experimental Models ◽  
Novel Therapy ◽  
Clusterin Expression

Prevention of ischemia-reperfusion injury (IRI) is a challenge in clinical care of the patients with kidney transplants or acute kidney injury, and understanding of the intrinsic mechanisms of resistance to injury in the kidney will lead to a novel therapy. Clusterin, a secreted glycoprotein, is an antiapoptotic protein in cancer cells. Our study is to investigate the role of clusterin in renal IRI. Renal IRI in mice was induced by clamping renal vein and artery for 45 or 50 min at 32°C. Apoptosis of renal tubular epithelial cells (TECs) was determined by FACS analysis. Clusterin expression was examined by Western blot or immunohistochemistry. Here, we showed that clusterin protein was induced in TECs following IRI, and more tubules expressed clusterin in the kidneys following ischemia at higher temperatures. In human proximal TEC HKC-8 cultures, clusterin was upregulated by removal of serum and growth factors in medium and was downregulated by TNF-α-IFN-γ mixture. The levels of clusterin were positively correlated with cell survival in these conditions. Knockdown or knockout of clusterin expression enhanced the sensitivity of TECs to apoptosis. In experimental models of renal IRI, deficiency in clusterin expression worsened the injury, as indicated by a significant increase in renal tissue damage with higher levels of serum creatinine and blood urea nitrogen and by a poorer recovery from the injury in clusterin-deficient mice compared with wild-type mice. Our data indicate that the reduction of inducible expression of clusterin results in an increase in TEC apoptosis in the cultures and renders mice susceptibility to IRI, implying a protective role of clusterin in kidney injury.

scholarly journals Melatonin and Ischemic Stroke: Mechanistic Roles and Action

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Syed Suhail Andrabi ◽  
Suhel Parvez ◽  
Heena Tabassum
Keyword(s):  
Ischemic Stroke ◽  
Brain Injury ◽  
Neurological Diseases ◽  
Neuroprotective Effect ◽  
Economic Loss ◽  
Protective Role ◽  
Physiological Processes ◽  
Cord Injury ◽  
The Brain

Stroke is one of the most devastating neurological disabilities and brain’s vulnerability towards it proves to be fatal and socio-economic loss of millions of people worldwide. Ischemic stroke remains at the center stage of it, because of its prevalence amongst the several other types attacking the brain. The various cascades of events that have been associated with stroke involve oxidative stress, excitotoxicity, mitochondrial dysfunction, upregulation of Ca2+level, and so forth. Melatonin is a neurohormone secreted by pineal and extra pineal tissues responsible for various physiological processes like sleep and mood behaviour. Melatonin has been implicated in various neurological diseases because of its antioxidative, antiapoptotic, and anti-inflammatory properties. We have previously reviewed the neuroprotective effect of melatonin in various models of brain injury like traumatic brain injury and spinal cord injury. In this review, we have put together the various causes and consequence of stroke and protective role of melatonin in ischemic stroke.

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