scholarly journals Antidepressant activity of Trigonella foenum leaves in Wistar albino rats

2019 ◽  
Vol 8 (5) ◽  
pp. 963
Author(s):  
Roopa P. Nayak ◽  
Prabhakar Adake ◽  
Hafis T. K.
Keyword(s):  
Drug Administration ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Experimental Models ◽  
Albino Rats ◽  
Study Results ◽  
Immobility Time ◽  
Wistar Albino Rats

Background: To evaluate antidepressant activity of ethanolic extract of Trigonella foenum in animal models.Methods: A total of 60 healthy male Wistar albino rats weighing 220-250 grams were used and they were divided into 10 groups of 6 rats in each. First five groups (1st -5th) were evaluated by Forced Swim Test (FST) and remaining by Tail Suspension Test (TST). 1st group (control) received normal saline 10 mg/kg, 2nd group (standard) Imipramine 10 mg/kg and 3rd, 4th and 5th groups (test) respectively received Trigonella foenum leaf ethanolic extract [TFEE] in different doses 100 mg, 200 mg, and 400 mg/kg per orally for 14 days. They were evaluated for antidepressant activity using FST after 60 minutes of drug administration on 14th day. Similarly, remaining five groups (6th to 10th) received the same drugs and evaluated using TST after 60 minutes of drug administration. Duration of immobility was noted for six minutes for each rat.Results: One way ANOVA and Tukey Krammer test were used for statistical analysis. The immobility periods were expressed in mean±SD. The immobility period in FST were 207.16±28.7, 50.08±2.9, 46.14±1.2, 40.5±3.4 and 40.0±3.6 seconds respectively for control, standard and three test groups of TFEE (100/200/400 mg/kg). Similarly, immobility periods of 163.11±31.9, 125.03±11.2, 138.81±16.44, 138.16±12.65, 127.58±4.3 seconds were noted for TST for remaining six groups. It was found that TFEE possess statistically significant (p<0.05) antidepressant activity, as evidenced by decrease in the immobility time in both the tests when compared to control group.Conclusions: Present study results demonstrated that TFEE possess antidepressant property in experimental models of depression.

scholarly journals Study of Antidepressant Activity of Garcinia indica(Kokum) Fruit Rind in Wistar Albino Rats

2021 ◽  
Vol 10 (36) ◽  
pp. 3077-3082
Author(s):  
Bhagyashree Ajjakana ◽  
Roopa Prasad Nayak
Keyword(s):  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Albino Rats ◽  
Tail Suspension ◽  
Garcinia Indica ◽  
Swim Test ◽  
Wistar Albino Rats ◽  
Suspension Test

BACKGROUND Depression is a mental disorder which is treatable but detected less often in primary healthcare settings. Therefore, there is a need for an effective treatment strategy for the management of depression. Garcinia indica (Thouars) Choisy is a slender evergreen tree. An invitro animal study has shown that its phytochemical constituent, hydroxy citric acid has the ability to increase serotonin levels in the brain. Hence, the objective of the study was to evaluate the antidepressant activity of ethanolic extract of Garcinia indica fruit rind in animal models of depression and compare it with control and standard drugs, imipramine, and fluoxetine. METHODS The study was conducted on Wistar albino rats of either sex. The animals were grouped into five, containing six animals in each group. Control (0.1 % carboxymethylcellulose, 10ml/kg), ethanolic extract of Garcinia indica (GIEE1) – 250mg/kg, ethanolic extract of Garcinia indica (GIEE2) – 500mg/kg, Standard1 - Imipramine – 10mg/kg ( Forced Swim test only) and Standard2 - Fluoxetine – 20mg/kg (Tail suspension test only). Drugs were administered for 14 days and antidepressant activity was evaluated on the 14th day after one hour of drug administration using two models - Forced swim test and tail suspension test. Results were tabulated as mean ± SEM (standard error of mean). One-way analysis of variance (ANOVA) followed by Tukey Kramer test was used to interpret the statistical significance. RESULTS The period of immobility was obtained as 21.83 ± 1.44 and14.66 ± 2.74 in forced swim test and 36.8 ± 1.01 and 14.3 ± 0.954 in tail suspension test in GIEE1 and GIEE2 treated groups respectively, which was significantly less compared to control. CONCLUSIONS Garcinia indica has significant antidepressant activity compared to the control. KEY WORDS Antidepressant, Garcinia indica, Fruit Rind, Wistar Albino Rats

scholarly journals Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

2017 ◽  
Vol 6 (3) ◽  
pp. 695
Author(s):  
Chiranjeevi Bonda ◽  
Sudhir Pawar ◽  
Jaisen Lokhande
Keyword(s):  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Group I ◽  
Immobility Time ◽  
Suspension Test

Background: The aim of the study was to evaluate the antidepressant effect of opioid analgesic tramadol using forced swim test and tail suspension test models.Methods: The antidepressant effect was assessed by recording the immobility time in Forced swim test (FST) and Tail suspension test (TST). The mice were randomly divided into five groups. Mice belonging to group I was given normal saline (0.1ml/kg) which acted as control. Group II received imipramine (15mg/kg) considered as the standard drug tramadol was given in graded dose (10, 20 and 40 mg/kg) to mice of groups III, IV, V respectively. All drugs were administered intraperitoneally for seven successive days; test was done on 7th day.Results: Tramadol and Imipramine showed antidepressant activity when compared to control. There is dose dependent increase in antidepressant activity of tramadol. The antidepressant activity of imipramine was significantly (P<0.05) more than tramadol at dose 10 and 20 mg/kg but antidepressant activity with tramadol 40mg/kg was comparable to imipramine treated mice.Conclusions: The results of this study indicated the presence of antidepressant activity of tramadol at 40mg/kg.

scholarly journals Evaluation of Antidepressant Activity of Ethanolic Extract of Abies webbiana and Berberis aristata in Laboratory Animals

2019 ◽  
Vol 9 (1) ◽  
pp. 244-247 ◽  
Author(s):  
Sucheta Gautam ◽  
Neetu Sachan ◽  
Alankar Shrivastav ◽  
Dilipkumar Pal
Keyword(s):  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Laboratory Animals ◽  
Control Group ◽  
Standard Group ◽  
Therapeutic Effects ◽  
Conventional Drug ◽  
Immobility Time ◽  
Swimming Test

Abstract Objective: Abies webbiana and Berberis aristata is an herbal plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated anti-depressant effect of ethanolic extract from Abies webbiana and Berberis aristata by using Forced Swimming Test (FST) and Tail Suspension Test (TST). Methods: Two doses of ethanolic extract of Abies webbiana and berberis aristata (200 mg/kg and 400 mg/kg) was given orally. Immobility time were measured after 30 min after the dosing and compared with control group and Flouxetine (25mg/kg) as a standard group. Results: The ethanolic extract of BA and AW (400 mg/kg) was found to be effective and it exhibited activity similar to that of the conventional drug Flouxetine (25mg/kg) (p<0.001) whereas 200 mg/kg dose showed higher activity with significantly increased swimming time and suspension time and decreased immobility time than 400 mg/kg of ethanolic extracts and Flouxetine (25mg/kg). Conclusion: These results proposed 400 mg/kg of ethanolic extract was showed higher anti-depressant activity as compared to control which is similar to the standard.

scholarly journals A comparative study of the antidepressant effect of ondansetron and granisetron on Albino mice

2017 ◽  
Vol 6 (12) ◽  
pp. 2922
Author(s):  
Mansi J. Shah ◽  
Geetha M. ◽  
Rahul H. D. ◽  
Shashikala G. H.
Keyword(s):  
Animal Studies ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Experimental Models ◽  
Antidepressant Effect ◽  
Test Model ◽  
Potential Candidate ◽  
Test Drug ◽  
Standard Drug

Background: Ondansetron and granisetron are selective 5-HT receptor antagonists used as antiemetics. The present study as aimed at comparing the antidepressant activity of ondansetron and granisetron in animal experimental models.Methods: The study was done after obtaining approval from the institutional animal ethical committee of JJM Medical college, Davangere and CPCSEA. A total of 24 mice of either sex and of weight between 20-40g were included in the study. The antidepressant activity of ondansetron and granisetron was evaluated in mice using forced swim test model (FST) and tail suspension test model (TST). In both the experimental models animals were divided into 4 groups and received the following drugs- Group 1 (control) - normal saline 10mg/kg i.p, Group 2 (standard)-fluoxetine 10mg/kg i.p, Group 3(test drug 1), ondansetron 2mg/kg i.p, Group 4 (test drug 2)- granisetron 0.5mg/kg i.p. The duration of immobility was noted and compared amongst the 4 groups in both the models 60 min after drug administration. The observations were analysed using ANOVA (one way) and post hoc Tukey’s test.Results: The test drugs showed significant reduction in duration of immobility in both the models. In FST and TST models, granisetron (0.5mg/kg i.p) showed a significant reduction in immobility period of 10.33 sec and 67 secs respectively when compared to ondansetron (2mg/kg i.p) and the standard drug fluoxetine (10mg/kg i.p).Conclusions: The results of study suggest that granisetron may be useful as a potential candidate for treatment of depression. Hence further animal studies with different model for depression and clinical studies should be conducted in order to choose the better drug for treatment PONV which is often associated with depression.

scholarly journals EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA ROOT L. ON ACUTE RESTRAINT STRESS-INDUCED ANXIETY AND DEPRESSION IN SWISS ALBINO MICE

2018 ◽  
Vol 11 (10) ◽  
pp. 182 ◽  
Author(s):  
Shashikumara Shashikumara ◽  
Prathima C ◽  
Amrutheswari B
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Phytochemical Analysis ◽  
Mimosa Pudica ◽  
Swiss Albino Mice ◽  
Acute Restraint Stress ◽  
Immobility Time ◽  
Albino Mice

Objective: The present study is undertaken to study the ameliorative effects of ethanolic extract of Mimosa pudica root (EMPR) on stress-induced anxiety and depressive-like behavior in Swiss albino mice.Methods: The animals were subjected to acute restraint stress (ARS) for 7 days, and on the 8th day after drugs administration, the antianxiety effect was evaluated using elevated plus maze (EPM) test. Antidepressant activity was evaluated by animal despair models-forced swim test and tail suspension test. Phytochemical analysis of the extract was also conducted.Results: EMPR (1000 and 2000 mg/kg) and the combined test groups have shown significant antianxiety effects similar to the standard diazepam as indicated by an improved open arm exploratory behavior in EPM model. EMPR also significantly reduced the immobility time in the animal despair models tested.Conclusion: Results suggest that EMPR possesses significant anxiolytic and antidepressant activity in male Swiss albino mice.

scholarly journals The protective effect of L. siceraria against depression using behavioural despair animal models

2018 ◽  
Vol 7 (7) ◽  
pp. 1391
Author(s):  
Karunakar Kota ◽  
Sandhya Sharma ◽  
P. Ragavendra ◽  
Jameela Tahashildar
Keyword(s):  
Animal Models ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Repeated Treatment ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Suspension Test

Background: In recent years, the search for novel pharmacotherapy from medicinal plants for psychiatric illness was significantly progressed. The present study was performed to evaluate the antidepressant activity of ethanolic extract of Lagenaria siceraria in animal models.Methods: The antidepressant activity of ethanolic extract of the fruit of L. siceraria in rats was assessed using forced swim test and tail suspension test. Imipramine at 15 mg/kg was used as standard antidepressant drug.Results: The ethanolic extract of L. siceraria fruit (EELS) was significantly and dose-dependently reduced the duration of immobility after repeated treatment for 7 days in Forced swim test and Tail suspension Test. But combination of L. siceraria (200mg/kg) with Imipramine gave a highly significant result (p<0.001) in reduction of immobility duration and the effect of high dose (400mg/kg) with imipramine (15mg/kg) did not decrease the duration of immobility period in both animal models at end of the study. In this work the dose of 400mg/kg afforded more protection than the imipramine.Conclusions: The results obtained from this study was indicate that the antidepressant activity of L. siseraria.

scholarly journals Antidepressant-like activity of hydroalcoholic extract of Agaricus blazei in stressed and unstressed mice

2019 ◽  
Vol 14 (3) ◽  
pp. 136-143
Author(s):  
Israr Ul Haq ◽  
Muhammad Aslam ◽  
Hammad Ahmed ◽  
Nuzhat Sultana
Keyword(s):  
Tryptophan Hydroxylase ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Agaricus Blazei ◽  
Hydroalcoholic Extract ◽  
Adrenoceptor Antagonist ◽  
Immobility Time ◽  
Plasma Nitrite ◽  
Substantial Change

The aim of this study was to investigate the antidepressant activity of hydroalcoholic extract Agaricus blazei (273 and 819 mg/kg; orally) in stressed and unstressed Swiss albino mice. Mice were immobilized to induce stress. Fluoxetine 20 mg/kg orally was given to stressed and unstressed animals and immobility time was noted by using forced swim test and tail suspension test. The concentration of plasma nitrite was also evaluated in stressed and unstressed mice. The effect of prazosin (α1-adrenoceptor antagonist), p-CPA (parachlorophenylalanine–tryptophan hydroxylase inhibitor) and 7-nitro-indazole (nNOS inhibitor) on the antidepressant activity of A. blazei was also evaluated. A. blazei and fluoxetine significantly decreased the duration of immobility time in stressed and unstressed mice, showing significant antidepressant activity. No substantial change was found in the locomotor activity. However, a significant reduction in the level of plasma nitrite was also noted in stressed mice. Hydroalcoholic extract showed prominent antidepressant activity in mice.

scholarly journals EVALUATION OF ANTI-STRESS ACTIVITY OF ETHANOLIC EXTRACTS OF TERMINALIA CATAPPA L. IN SWISS ALBINO MICE

2018 ◽  
Vol 11 (6) ◽  
pp. 253
Author(s):  
Imtiyaz Ansari ◽  
Rajeshwari Shashikant Sorte
Keyword(s):  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Soxhlet Extraction ◽  
Tail Suspension Test ◽  
Active Role ◽  
Swiss Albino Mice ◽  
Terminalia Catappa ◽  
Immobility Time ◽  
Ethanolic Extracts ◽  
Albino Mice

Objective: The aim of the study was to evaluate the anti-stress activity of ethanolic extract of Terminalia catappa L. in Swiss albino mice. Methods: The extract used in this study was prepared by Soxhlet extraction of fresh dried leaves of T. catappa L. using ethanol as an extraction solvent. Stress is involved in the pathogenesis of a variety of diseases including hypertension, peptic ulcer, immunodepression, reproductive dysfunction, and behavior disorder. Overload of stress increases free radicals, produces damage to neuronal receptors and a variety of tissues. In this experimental research study two models, namely, forced swim test (FST) and tail suspension test (TST) were used for the screening of anti-stress activity. 50, 100, and 200 mg/kg ethanolic extracts of T. catappa L. were given orally, while 2mg/kg of Diazepam which acts as a standard was given intraperitoneally. The data obtained were analyzed by one-way ANOVA, followed by Dunnett’s test. p<0.05 was considered to be significant. Result: The entire three test groups of the ethanolic extract of leaves of T. catappa L. showed decrease in immobility time in both FST (immobility for 42.5±3.5 s and mobility at 197.5±3.5 s) against diazepam (immobility 82.6±4.17 s and mobility at 157.3±4.17 s) and TST (92±2.28 s and mobility at 148±2.28) when compared against control as well as against diazepam (116.3±2.73 s and mobility at 123.6±2.73) which was used as a standard. Conclusion: There is substantial evidence that flavonoids play an active role in providing anti-stress activity. This study is an attempt to find out the alternative medication for treating chronic stress with single medication which was shown a beneficial effect in animal models, may be useful for curing symptoms of stress.

scholarly journals “We are antidepressant also”: aspirin and diclofenac sodium

2020 ◽  
Vol 9 (10) ◽  
pp. 1569
Author(s):  
Meera Sumanth ◽  
Prajwala R. Khapale
Keyword(s):  
Elevated Plus Maze ◽  
Forced Swim Test ◽  
Diclofenac Sodium ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Tnf Α ◽  
Plus Maze ◽  
Immobility Time

Background: Many studies have indicated that inflammation and depression are associated with each other. Present study was taken up to prove antidepressant effect of aspirin and diclofenac sodium.Methods: The present study was divided into 6 phases with 5 groups of animals N=10. In study 1, C57Bl mice were used and in remaining 4 studies swiss albino mice. Amitriptyline was standard drug used. For each study first group of animals was treated with a saline solution 1ml P.O., and second group of animals injected with 0.1 ml of 2% formalin. In group 3, 4, 5 animals depression was produced by stressors and treated with aspirin 14mg/kg P.O., diclofenac sod. 10 mg/kg P.O. and amitriptyline 10 mg/kg P.O., respectively. Antidepressant activity of aspirin and diclofenac sodium was determined by using forced swim test, tail suspension test, elevated plus maze test and light dark box test. Inflammatory mediators (IL-6, TNF-α) and central neurotransmitters (5-HT, NE, Ach) were estimated.Results: In light dark box test, latency of first crossing, time spent in dark area were decreased and no. of crossing increased significantly in the aspirin, diclofenac sod. treated animals. In forced swim test, the immobility time was decreased. Swiss albino mice treated with aspirin, diclofenac sod. showed decreased concentration of IL-6 and TNF-α and increased concentration of serotonin, nor epinephrine and acetylcholine. In elevated plus maze test, no. of open arm, closed arm entries, time spent in open arm increased and time spent in closed arm decreased. In tail suspension test immobility time was decreased.Conclusions: Aspirin and diclofenac sodium has antidepressant activity.

scholarly journals Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.

2019 ◽  
Vol 66 (2) ◽  
pp. 26-31
Author(s):  
H. Sunaryo ◽  
S. Siska ◽  
E. Hanani ◽  
RS. Anindita ◽  
N. Yanti ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Experimental Models ◽  
Albino Rats ◽  
Clinical Settings ◽  
Dependent Manner ◽  
Analgesic Effects ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

Abstract Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats. The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract (100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and clinical settings.

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