scholarly journals A comparative study of the antidepressant effect of ondansetron and granisetron on Albino mice

2017 ◽  
Vol 6 (12) ◽  
pp. 2922
Author(s):  
Mansi J. Shah ◽  
Geetha M. ◽  
Rahul H. D. ◽  
Shashikala G. H.
Keyword(s):  
Animal Studies ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Experimental Models ◽  
Antidepressant Effect ◽  
Test Model ◽  
Potential Candidate ◽  
Test Drug ◽  
Standard Drug

Background: Ondansetron and granisetron are selective 5-HT receptor antagonists used as antiemetics. The present study as aimed at comparing the antidepressant activity of ondansetron and granisetron in animal experimental models.Methods: The study was done after obtaining approval from the institutional animal ethical committee of JJM Medical college, Davangere and CPCSEA. A total of 24 mice of either sex and of weight between 20-40g were included in the study. The antidepressant activity of ondansetron and granisetron was evaluated in mice using forced swim test model (FST) and tail suspension test model (TST). In both the experimental models animals were divided into 4 groups and received the following drugs- Group 1 (control) - normal saline 10mg/kg i.p, Group 2 (standard)-fluoxetine 10mg/kg i.p, Group 3(test drug 1), ondansetron 2mg/kg i.p, Group 4 (test drug 2)- granisetron 0.5mg/kg i.p. The duration of immobility was noted and compared amongst the 4 groups in both the models 60 min after drug administration. The observations were analysed using ANOVA (one way) and post hoc Tukey’s test.Results: The test drugs showed significant reduction in duration of immobility in both the models. In FST and TST models, granisetron (0.5mg/kg i.p) showed a significant reduction in immobility period of 10.33 sec and 67 secs respectively when compared to ondansetron (2mg/kg i.p) and the standard drug fluoxetine (10mg/kg i.p).Conclusions: The results of study suggest that granisetron may be useful as a potential candidate for treatment of depression. Hence further animal studies with different model for depression and clinical studies should be conducted in order to choose the better drug for treatment PONV which is often associated with depression.

scholarly journals The effect of docosahexaenoic acid (DHA) supplementation on experimental depression in mice

2018 ◽  
Vol 7 (2) ◽  
pp. 288 ◽  
Author(s):  
Tulika Singhal ◽  
Saroj Kothari
Keyword(s):  
Side Effects ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
World Population ◽  
Omega 3 ◽  
Standard Drug ◽  
Gum Acacia ◽  
Group I

Background: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. Many drugs which are available as effective antidepressants produce various side effects like sedation weight gain postural hypotension etc., so there is need to develop novel compounds with minimized side effects. Hence this study was aimed to investigate the antidepressant activity of DHA, an omega-3 polyunsaturated fatty acid in albino mice.Methods: Animals were divided into four groups, consisting six mice in each group. Out of these, group I served as control (2% gum acacia), group II and III received test drug in two different doses 200mg/kg and 300mg/kg respectively and group IV received fluoxetine (20mg/kg) as standard drug. To determine the antidepressant-like activity, we used forced swim test and tail suspension test in mice. These methods are based on the observation that a mouse show alternating agitation and immobility; the immobility is indicative of a state of depression.Results: DHA produced significant antidepressant effect at all the doses, as indicated by reduction in immobility times as compared to control in both FST and TST. (P˂0.05) The efficacy of DHA at dose of 300 mg/kg was comparable with that of fluoxetine. DHA at 200mg/kg dose showed significantly less antidepressant activity compared to fluoxetine. (P˂0.05).Conclusions: The result specifies that compared to two doses of DHA (200mg/kg and 300mg/kg), higher dose of DHA found as an effective dose for treating depression produced due to stress.

scholarly journals EXPERIMENTAL EVALUATION OF ANTIDEPRESSANT AND ANTIANXIETY ACTIVITIES OF AQUEOUS LEAF EXTRACTS OF SENNA ALATA (L.) ROXB. USING IN VITRO ANIMAL MODELS

2016 ◽  
Vol 8 (4) ◽  
pp. 60
Author(s):  
Archana Pamulaparthi ◽  
Vamshi Ramana Prathap ◽  
Mahitha Banala ◽  
Rama Swamy Nanna
Keyword(s):  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Control Group ◽  
Test Drug ◽  
Leaf Extracts ◽  
Standard Drug ◽  
The Mean ◽  
Senna Alata

Objective: In the present investigation antidepressant and antianxiety activities of aqueous leaf extracts of Senna alata (200 mg/Kg) were carried out to establish the species as a potent natural antidepressant and anxiolytic drug.Methods: Antidepressant activity was carried out using forced swim test and tail suspension test. In both these tests, the animals were subjected to external stress that results in alteration of the behavior of animal due to fear.The antianxiety activity of aqueous leaf extracts of S. alata has been studied by the elevated plus-maze test in rats. The mean number of entries and the time spent in the open arm after 45 min of the administration of test drug was noted to determine the antianxiety effect of the test drug.Results: For antidepressant activity administration of test drug (200 mg/Kg) showed a significant decrease in the time spent by the animal in state of depression in both the assays which clearly indicates that the aqueous leaf extracts of S. alata exhibited a strong antidepressant activity similar to that of the control drug (Imipramine).In the antianxiety activity, administration of aqueous leaf extract (200 mg/Kg) of S. alata significantly increased the mean number of entries (2.25±0.98) in the open arm and the time spent in open arm (2.23±0.04) compared to the control group. The activity of the extract was slightly greater than standard drug Diazepam.Conclusion: From the above-presented results, it can be concluded that administration of Senna alata aqueous leaf extracts (200 mg/Kg) showed a considerable decrease in both antidepressant and antianxiety activities in all the test animals and can be used in the replacement of commercially available synthetic drugs in the near future.

scholarly journals Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

2017 ◽  
Vol 6 (3) ◽  
pp. 695
Author(s):  
Chiranjeevi Bonda ◽  
Sudhir Pawar ◽  
Jaisen Lokhande
Keyword(s):  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Group I ◽  
Immobility Time ◽  
Suspension Test

Background: The aim of the study was to evaluate the antidepressant effect of opioid analgesic tramadol using forced swim test and tail suspension test models.Methods: The antidepressant effect was assessed by recording the immobility time in Forced swim test (FST) and Tail suspension test (TST). The mice were randomly divided into five groups. Mice belonging to group I was given normal saline (0.1ml/kg) which acted as control. Group II received imipramine (15mg/kg) considered as the standard drug tramadol was given in graded dose (10, 20 and 40 mg/kg) to mice of groups III, IV, V respectively. All drugs were administered intraperitoneally for seven successive days; test was done on 7th day.Results: Tramadol and Imipramine showed antidepressant activity when compared to control. There is dose dependent increase in antidepressant activity of tramadol. The antidepressant activity of imipramine was significantly (P<0.05) more than tramadol at dose 10 and 20 mg/kg but antidepressant activity with tramadol 40mg/kg was comparable to imipramine treated mice.Conclusions: The results of this study indicated the presence of antidepressant activity of tramadol at 40mg/kg.

scholarly journals EVALUATION OF ANTIDEPRESSANT ACTIVITY OF TAPENTADOL IN SWISS ALBINO MICE

2017 ◽  
Vol 10 (8) ◽  
pp. 103
Author(s):  
Pradeep Be ◽  
Narendranath S ◽  
Shruthi Ks ◽  
Shashikala Gh ◽  
Krishnagouda Patil ◽  
...  
Keyword(s):  
Animal Studies ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Experimental Models ◽  
Control Group ◽  
Swiss Albino Mice ◽  
Group I ◽  
Antidepressant Efficacy ◽  
Albino Mice ◽  
Post Hoc

Objective: The aim of this study is to evaluate the antidepressant activity of tapentadol using forced swimming test (FST) and tail suspension test (TST) experimental models.Methods: A total of 36 Swiss albino mice (18 for each experimental model) were divided into 3 groups of 6 animals each. In both the experimental models, Group I received normal saline – 10 ml/kg (Control group), Groups II and III given tapentadol 20 mg/kg and tapentadol 40 mg/kg, respectively, for 7 days, intraperitoneally. On day 7, the drugs were given 40 minutes before conducting the experiment. The duration of immobility was noted and compared among all the 3 groups. The observations were analyzed using analysis of variance and Tukey’s post-hoc test.Results: The duration of immobility was significantly decreased in both the experimental models. Tapentadol groups when compared to control group showed statistically significant values, and better results were obtained with tapentadol 20 mg/kg groups in both the models. The mean duration of Immobility was 34.67 seconds in FST model and 101.00 seconds in TST model when treated with tapentadol 20 mg/kg compared to 102.33 seconds in FST control and 141 seconds in TST control groups. FST model demonstrates greater antidepressant efficacy of tapentadol (p<0.00) than with TST model (p<0.04).Conclusion: Tapentadol showed significant antidepressant activity at the dose of 20 mg/kg. The results should be further confirmed by animal studies with different experimental models for the evaluation of depression and by human clinical studies, and if found effective, tapentadol can be preferred for patients with chronic pain, such as cancer pain.

scholarly journals Antidepressant effect of atypical antipsychotic ziprasidone in albino rats

2017 ◽  
Vol 6 (3) ◽  
pp. 528
Author(s):  
Rajiv Kumar ◽  
Hansraj Kumar ◽  
U. S. P. Keshri ◽  
Manju Gari
Keyword(s):  
Normal Saline ◽  
Depressive Disorders ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
Albino Rats ◽  
Potential Candidate ◽  
Tail Suspension ◽  
Albino Rat ◽  
Suspension Test

Background: Depression is a common psychiatric illness but conventional antidepressants are often shows unpredictable response. Pharmacological profiles of many atypical antipsychotics have potential antidepressant effect. Ziprasidone is an atypical antidepressant with 5HT1A agonistic activity and 5HT1D, 5HT2A and D2 receptors antagonistic activity. It’s a potential candidate for evaluating possible antidepressant activity.Methods: Behavioural despair test are widely used for evaluation of potential antidepressant molecule. Tail suspension test is a variant of behavioural despair test. Healthy male Wistar albino rat 18 in number and weighing between of 150-200 grams were divided in 3 groups with 6 rats in each group. Group A was treated with 0.9% Normal Saline, Group B with Fluoxetine and Group C with Ziprasidone for 28 days. Tail suspension test was done on day 0, 7, 14, 21 and 28 days.Results: In comparison to Normal saline both the drugs shows significant antidepressant activity after 28 days of treatment. While antidepressant activity of fluoxetine started to appear from day 7; that of ziprasidone started to appear from 14th day.Conclusions: Ziprasidone can be suitable candidate for clinical trials of Major Depressive Disorders not responding to conventional antidepressant. 

scholarly journals Antidepressant activity of Trigonella foenum leaves in Wistar albino rats

2019 ◽  
Vol 8 (5) ◽  
pp. 963
Author(s):  
Roopa P. Nayak ◽  
Prabhakar Adake ◽  
Hafis T. K.
Keyword(s):  
Drug Administration ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Experimental Models ◽  
Albino Rats ◽  
Study Results ◽  
Immobility Time ◽  
Wistar Albino Rats

Background: To evaluate antidepressant activity of ethanolic extract of Trigonella foenum in animal models.Methods: A total of 60 healthy male Wistar albino rats weighing 220-250 grams were used and they were divided into 10 groups of 6 rats in each. First five groups (1st -5th) were evaluated by Forced Swim Test (FST) and remaining by Tail Suspension Test (TST). 1st group (control) received normal saline 10 mg/kg, 2nd group (standard) Imipramine 10 mg/kg and 3rd, 4th and 5th groups (test) respectively received Trigonella foenum leaf ethanolic extract [TFEE] in different doses 100 mg, 200 mg, and 400 mg/kg per orally for 14 days. They were evaluated for antidepressant activity using FST after 60 minutes of drug administration on 14th day. Similarly, remaining five groups (6th to 10th) received the same drugs and evaluated using TST after 60 minutes of drug administration. Duration of immobility was noted for six minutes for each rat.Results: One way ANOVA and Tukey Krammer test were used for statistical analysis. The immobility periods were expressed in mean±SD. The immobility period in FST were 207.16±28.7, 50.08±2.9, 46.14±1.2, 40.5±3.4 and 40.0±3.6 seconds respectively for control, standard and three test groups of TFEE (100/200/400 mg/kg). Similarly, immobility periods of 163.11±31.9, 125.03±11.2, 138.81±16.44, 138.16±12.65, 127.58±4.3 seconds were noted for TST for remaining six groups. It was found that TFEE possess statistically significant (p<0.05) antidepressant activity, as evidenced by decrease in the immobility time in both the tests when compared to control group.Conclusions: Present study results demonstrated that TFEE possess antidepressant property in experimental models of depression.

scholarly journals Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation

2019 ◽  
Vol 7 (1) ◽  
pp. 63-73
Author(s):  
Rinki Kumar ◽  
K. Ilango ◽  
G.P.I. Singh ◽  
G.P. Dubey
Keyword(s):  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Control Group ◽  
Potential Candidate ◽  
Standard Drug ◽  
In Vivo Test ◽  
Polyherbal Formulation ◽  
Immobility Time ◽  
Model Control

The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same.

scholarly journals Evaluation of antidepressant effect of aqueous extract of Psidium guajava leaves on Wistar albino rats

2019 ◽  
Vol 8 (2) ◽  
pp. 280
Author(s):  
Chaitra S. R. ◽  
Roopa P. Nayak ◽  
Uttara Krishna
Keyword(s):  
Aqueous Extract ◽  
Forced Swim Test ◽  
Common Mental Disorder ◽  
Herbal Medicines ◽  
Antidepressant Activity ◽  
Psidium Guajava ◽  
Antidepressant Effect ◽  
Albino Rats ◽  
Standard Drug ◽  
Wistar Albino Rats

Background: Depression is one of the common mental disorder prevalent worldwide. Use of herbal medicines in the treatment of depression is becoming popular because of adverse effects of existing non herbal drugs. In this study Psidium guajava leaf aqueous extract is screened for antidepressant activity in Wistar albino rats.Methods: Wistar albino rats of both sex were used. After performing acute toxicity study, dose of test drug was fixed to 100mg/kg and 200mg/kg. Test and standard drugs were administered for 10 days orally. Standard drug used was Imipramine. Antidepressant activity was assessed using forced swim test and tail suspension test.Results: Statistical analysis was done by one way ANOVA followed by Tukey Kramer. Aqueous extract of Psidium guajava leaves showed significant antidepressant activity. Both Psidium guajava aqueous extract (PGAE)-100mg/kg and 200mg/kg showed antidepressant effect but compared to 100mg/kg dose of PGAE, 200mg/kg showed significant antidepressant activity.Conclusions: From this study it can be concluded that aqueous extract of Psidium guajava leaves has antidepressant activity.

scholarly journals EVALUATION OF INVOLVEMENT OF NEURO-CHEMICAL MECHANISM IN VALERIANA WALLICHII INDUCED ANTIDEPRESSANT EFFECT IN MICE

2021 ◽  
pp. 11-17
Author(s):  
HARSAHAY MEENA ◽  
V. K. JOSHI ◽  
MADHU BALA
Keyword(s):  
Locomotor Activity ◽  
Receptor Antagonist ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Chemical Mechanism ◽  
Antidepressant Effect ◽  
Acute Administration ◽  
Synthesis Inhibitor ◽  
Antidepressant Effects

Objective: Valeriana (V) wallichii DC is found among the ground flora of Himalayan regions and used as herbal medicine for CNS disorders in Indian systems of medicine. In the study, aimed to investigation of involvement of neuro-chemical-systems in V. wallichii induced antidepressant effects in mice. Methods: The antidepressant activity of aqueous alcoholic extracts of V. wallichii was measured by using Forced Swim Test and Tail Suspension Test in mice, whereas locomotor activity was observed by Actophotometer. Involvement of adrenergic, dopaminergic and serotonergic receptors in V. wallichii induced antidepressant effects in mice were also observed. Results: Sub-acute administration of V. wallichii in mice showed significant (P<0.05) increase in the antidepressant activity similar to the Imipramine, but did not show at lower doses in FST. Whereas, pretreatment of adrenergic receptor antagonist, dopaminergic receptor antagonist and serotonin synthesis inhibitor prevented V. wallichii induce anti-depressant effect in mice. Lower doses of hydoalcoholic extract of V. wallichii did not interfering the locomotor activity in mice during the sub-acute administration, but at a higher dose significantly (P<0.05) decreases the locomotor activity. Conclusion: Hence, it is concluded that the antidepressant effect of V. wallichii in mice may mediate via adrenergic, dopaminergic and serotonergic systems.

scholarly journals Antidepressant Activity of Methanolic Extract of Vitis vinifera

2018 ◽  
Vol 6 (02) ◽  
pp. 01-04
Author(s):  
Jyoti Singh ◽  
Bishnu Kumar
Keyword(s):  
Vitis Vinifera ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Standard Drug ◽  
Swim Test ◽  
Forced Swim ◽  
Immobility Time ◽  
Suspension Test

The present study was determined to evaluate the effect of methnolic extract of Vitis vinifera (MEVV) as well as its interaction with conventional antidepressant drug using tail suspension test (TST) and forced swim test (FST) and to evaluate the possible mechanisms involved in its actions. The extract was found to reduce the explorative tendencies of the rats in the tail suspension test and forced swim test the extract caused a significant reduction in immobility time and increased swimming time. The leaf of the plant were collected and authenticated. The methnolic extract of Vitis vinifera (MEVV) showed the significant antidepressant activity comparable to the standard drug. The oral administration of methnolic extract of Vitis vinifera (MEVV) at 100, 200 and 400 mg/kg respectively as compared to the control treated group showed an antidepressant activity comparable to that of standard drug. The antidepressant effects of methnolic extract of Vitis vinifera (MEVV) having a particular quality to be mainly associated with the activation of dopamineergic system and possess potential antidepressant activities.

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