scholarly journals Comparative analysis of efficacy and tolerability of tramadol versus diclofenac in treatment of knee osteoarthritis

2021 ◽  
Vol 10 (10) ◽  
pp. 1186
Author(s):  
Rima Kanjiya ◽  
Ravi Kotadia
Keyword(s):  
Knee Joint ◽  
Diclofenac Sodium ◽  
Tertiary Care ◽  
Womac Score ◽  
Primary Objective ◽  
Knee Oa ◽  
Randomized Clinical Study ◽  
Care Institute ◽  
Joint Tenderness ◽  
Traditional Drug

Background: Present study was conducted on patients of osteoarthritis (OA) treated with the traditional drug diclofenac sodium and compares it with tramadol, with the primary objective for determining effectiveness and tolerability based on WOMAC scores.Methods: The study was conducted as a randomized clinical study of the effectiveness and tolerability of tramadol versus diclofenac in the treatment of knee OA, at Tertiary care institute of Gujarat in the department of orthopedics. Consecutive patients were allotted serially in two groups; tramadol group (n=75) One tablet orally twice daily for 8 weeks. Diclofenac group (n75) patients received 75 mg oral dose of diclofenac 2 times daily for a period of 8 weeks. Overall improvement was evaluated through various parameters.Results: About 33% decrease in the scoring of stiffness domain of the WOMAC OA index questionnaire in the tramadol group and a 21% decline in the diclofenac group was observed. There was a 65% decrease in the scoring of knee joint tenderness questionnaire in the tramadol group and a 44% reduction in the diclofenac group. Tramadol was found to be more effective in improving the WOMAC OA index. WOMAC score (overall) and knee joint tenderness scores were also improved by tramadol than diclofenac.Conclusions: There was a significant improvement in the standard of life in patients suffering from knee OA when treated with tramadol. Tolerability was better with tramadol than diclofenac.

scholarly journals A randomized clinical study to compare pre-emptive analgesic efficacy of clonidine and diclofenac sodium in patients undergoing major surgeries at a tertiary care hospital

2020 ◽  
Vol 10 (1) ◽  
pp. 44
Author(s):  
Prachi Jain ◽  
Uma Bhosale ◽  
Shashank Desai
Keyword(s):  
Clinical Study ◽  
Literature Review ◽  
Rating Scale ◽  
Diclofenac Sodium ◽  
Tertiary Care ◽  
Analgesic Efficacy ◽  
Care Hospital ◽  
Pain Scores ◽  
Randomized Clinical Study ◽  
Study Results

Background: Pre-emptive analgesia is a method to achieve analgesia even before exposure to a noxious stimulus The purpose of pre-emptive analgesia is to reduce pain caused due to surgical incision triggered inflammatory mechanism activation; and to ensure a good post-operative pain control so that there is no development of chronic pain. Clonidine is an α2 adrenergic agonist thus it decreases the sympathetic outflow, while Diclofenac is a non-steroidal anti-inflammatory agent. Our literature review showed that both clonidine (150 μg) and diclofenac are efficacious pre-emptive analgesics. Literature review also revealed that there is no study available to compare pre-emptive analgesic efficacy as well as safety of oral clonidine with diclofenac, therefore present study was designed to compare pre emptive analgesic efficacy of these two drugs.Methods: This randomized clinical study included 100 patients from surgical departments, of either sex, between 18 to 70 years age and of American society of anesthesiologists (ASA) I/II grade. Patients were randomly allocated to two groups and received either of the treatments 30 minutes prior to induction of anesthesia. Pain scores were recorded using visual analog scale, facial rating scale and behavioral rating scale at awakening and at 1, 2, 4, 6 and 24 hours. Postoperative analgesic requirement over 24 hours was recorded. Data were analyzed using OpenEpi statistical softwares.Results: Significantly lower pain scores were observed in clonidine group as compared to Diclofenac at 4 and 6 hours (p<0.05) on all the pain scales. Clonidine group also required less postoperative analgesic as compared to diclofenac (p<0.05).Conclusions: Study results are strongly suggestive of greater pre-emptive analgesic efficacy of clonidine over diclofenac in major surgeries done under spinal anesthesia.

Evaluation of patients with psoriatic arthropathy attending tertiary care institute

2019 ◽  
Vol 11 (1) ◽  
pp. 40-45
Author(s):  
Nagesh Vyenktesh Gaddam ◽  
◽  
Smita Maharudrappa Chakote ◽  
Ajay Govindrao Ovhal ◽  
◽  
...  
Keyword(s):  
Tertiary Care ◽  
Psoriatic Arthropathy ◽  
Care Institute

scholarly journals Clinical profile and outcomes of semi-permanent pacing in a tertiary care institute in Southern India

2020 ◽  
Vol 72 ◽  
pp. S39
Author(s):  
Karthik Raghuram ◽  
Krishna Kumar Mohanan Nair ◽  
Narayanan Namboodiri ◽  
Mukund A. Prabhu ◽  
Ajitkumar Valaparambil
Keyword(s):  
Tertiary Care ◽  
Clinical Profile ◽  
Southern India ◽  
Permanent Pacing ◽  
Care Institute

scholarly journals Medial knee joint contact force in the intact limb during walking in recently ambulatory service members with unilateral limb loss: a cross-sectional study

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e2960 ◽  
Author(s):  
Ross H. Miller ◽  
Rebecca L. Krupenevich ◽  
Alison L. Pruziner ◽  
Erik J. Wolf ◽  
Barri L. Schnall
Keyword(s):  
Knee Joint ◽  
Limb Loss ◽  
Service Members ◽  
Model Parameters ◽  
Joint Loading ◽  
Cross Sectional ◽  
Medial Knee ◽  
Knee Oa ◽  
Joint Contact ◽  
Intact Limb

BackgroundIndividuals with unilateral lower limb amputation have a high risk of developing knee osteoarthritis (OA) in their intact limb as they age. This risk may be related to joint loading experienced earlier in life. We hypothesized that loading during walking would be greater in the intact limb of young US military service members with limb loss than in controls with no limb loss.MethodsCross-sectional instrumented gait analysis at self-selected walking speeds with a limb loss group (N = 10, age 27 ± 5 years, 170 ± 36 days since last surgery) including five service members with transtibial limb loss and five with transfemoral limb loss, all walking independently with their first prosthesis for approximately two months. Controls (N = 10, age 30 ± 4 years) were service members with no overt demographical risk factors for knee OA. 3D inverse dynamics modeling was performed to calculate joint moments and medial knee joint contact forces (JCF) were calculated using a reduction-based musculoskeletal modeling method and expressed relative to body weight (BW).ResultsPeak JCF and maximum JCF loading rate were significantly greater in limb loss (184% BW, 2,469% BW/s) vs. controls (157% BW, 1,985% BW/s), with large effect sizes. Results were robust to probabilistic perturbations to the knee model parameters.DiscussionAssuming these data are reflective of joint loading experienced in daily life, they support a “mechanical overloading” hypothesis for the risk of developing knee OA in the intact limb of limb loss subjects. Examination of the evolution of gait mechanics, joint loading, and joint health over time, as well as interventions to reduce load or strengthen the ability of the joint to withstand loads, is warranted.

AB0917 Pulmonary Manifestations in Patients with IGG4-Related Disease at A Tertiary Care Institute: Table 1.

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 1215.3-1215
Author(s):  
R. Banka ◽  
Y. Gc ◽  
C. Balakrishnan ◽  
R. Samant ◽  
L. Pinto ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Care Institute ◽  
Pulmonary Manifestations

90 Lung ultrasound in pediatric asthma patients: A pilot study characterizing findings at baseline stat

2021 ◽  
Vol 26 (Supplement_1) ◽  
pp. e65-e66
Author(s):  
Noah Marzook ◽  
Alexander Dubrovsky
Keyword(s):  
Pediatric Patients ◽  
Lung Ultrasound ◽  
Demographic Data ◽  
Tertiary Care ◽  
Challenge Test ◽  
Primary Objective ◽  
Upper Respiratory Tract ◽  
The Past ◽  
Asthma Patients ◽  
B Lines

Abstract Primary Subject area Emergency Medicine - Paediatric Background Unlike the lung ultrasound (LU) findings of pneumonia, bronchiolitis, pleural effusions and pneumothorax, which have all been well described, the sonographic pattern of asthma remains unclear. Previous pediatric studies have shown that pediatric patients with acute asthma exacerbations had positive LU findings. It is also unclear whether these findings were the result of acute infections associated with the exacerbation or if the findings would be present at baseline, outside an exacerbation in an asthmatic patient. Objectives The primary objective of this study is to characterize lung ultrasound (LU) findings in stable asthma pediatric patients presenting in a tertiary care asthma or respiratory clinic. Design/Methods Eligible patients &gt;6 years of age, underwent a LU by the study sonographer between December 19, 2017 to June 25, 2019, during their regular follow up visit at the pulmonology clinic or scheduled pulmonary function test. Patients were defined as asthmatic if they had a positive methacholine challenge test (MCT) or spirometry at the day of the visit or in the past. Patients were excluded if they had an upper respiratory tract infection in the past 4 weeks, or had any other known pulmonary diseases. Baseline demographic and asthma severity (ISAAC score, ACQ-7) questionnaires were filled out by the patients, following which they underwent a LU by a novice sonographer using a 6-zone protocol. A blinded expert sonographer interpreted the images offline. A positive LU was defined as presence of more than 3 B-lines, consolidation (&lt;1cm or &gt;1cm), absent lung slide, and/or presence of pleural fluid. Results Fifty-two patients were enrolled in the study and 19.2% (CI 8.31-30.15) of the asthma patients had positive LU findings. The positive LU findings were diverse including B-lines (80%), small consolidation (80%), pleural line anomalies (10%). Positive LU findings were not correlated to any demographic value. Conclusion In our study, 19.2% of asthma patients at baseline have a positive LU. Lung consolidations larger than 1 cm were rarely seen. There were no significant differences between demographic data in asthmatic patients with positive compared to those with negative LUS. This positive LU scan rate is in keeping with a prior study on LU in pediatrics.

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