scholarly journals Do we need more than ultrasound endometrial thickness to predict malignancy?

2018 ◽  
Vol 7 (3) ◽  
pp. 766
Author(s):  
Adly N. Al Fattah ◽  
Tricia D. Anggraeni ◽  
Bella Aprilia ◽  
Muhammad Ikhsan
Keyword(s):  
Prediction Accuracy ◽  
Endometrial Thickness ◽  
Volume Ratio ◽  
High Sensitivity ◽  
3D Ultrasound ◽  
Ultrasound Measurement ◽  
Clinical Parameters ◽  
Endometrial Volume ◽  
Ultrasound Parameters ◽  
Histopathology Examination

Endometrial thickness (ET) ultrasound measurement has high diagnostic performance for detection of endometrial cancer in symptomatic postmenopausal women. Identified clinical risk factors, Doppler or 3D ultrasound parameters to predict endometrial malignancy had been proposed in several studies. We compared the accuracy of ultrasound endometrial thickness with scoring system/index involving both of clinical and ultrasound parameters to predict endometrial malignancy. Eight eligible diagnostic studies were appraised to assess the accuracy of ultrasound ET and/or ultrasound-based index to predict malignancy. The incidence of endometrial malignancy confirmed by histopathology examination was ranging from 10.5 to 58% from 8 studies. Ultrasound-based index to predict endometrial malignancy had good accuracy (AUC 75% - 98%). The addition of endometrial volume/uterine corpus volume ratio (EV/UCV) and Doppler to clinical parameters had increased the prediction accuracy of the index. While ultrasound ET alone has also high sensitivity, respectively 90.6% and 96.9% using the cut-off 4 mm and 3 mm with low accuracy. Ultrasound-based index to predict endometrial malignancy had better accuracy compared to ultrasound ET alone. Combination of ultrasound including Doppler parameters and clinical parameters had increased the prediction accuracy of the endometrial malignancy prediction index.

scholarly journals Continuous Endometrial Volumetric Analysis for Endometrial Receptivity Assessment on Assisted Reproductive Technology Cycles

2020 ◽  
Author(s):  
Renato Martins ◽  
Antonio Helio Oliani ◽  
Denise Vaz Oliani ◽  
Jose Martinez de Oliveira
Keyword(s):  
Assisted Reproductive Technology ◽  
Endometrial Thickness ◽  
Transvaginal Ultrasound ◽  
Research Question ◽  
Continuous Process ◽  
Volume Ratio ◽  
Volumetric Analysis ◽  
Reproductive Technology ◽  
Endometrial Receptivity ◽  
Endometrial Volume

Abstract Research Question: Human implantation is a complex process requiring synchrony between a healthy embryo and a functionally competent or receptive endometrium. In order to assess endometrial receptivity in Assisted Reproductive Technology (ART) cycles continuous evaluation of endometrial volumetric analysis may have a predictive value on a positive outcome.Design: Serial 3D transvaginal ultrasound performed in women on ART cycle to evaluate a pattern that better predicts implantation rates. 169 subjects on a prospective case control study were assessed. Endometrial pattern, endometrial thickness, endometrial volume and adjusted endometrial volume (ratio between endometrial volume and uterine volume) was performed to all subjects on a continuous process from baseline (prior to ovarian controlled stimulation), day 6, 8 and 10 of controlled ovarian stimulation, trigger day with human chorionic gonadotropin hormone (hCG) and at embryo transfer day.Results: No statistical difference was noted between the two groups in terms of demographics and ART procedures and scores. Endometrium morphology also didn’t show any difference between the two groups. Endometrial volume and adjusted endometrial volume was significantly higher in the positive group as soon as day 6 of ovarian controlled stimulation.Conclusions: Continuous serial 3D endometrial volume and adjusted endometrial volumes may be a useful tool for clinicians in predicting endometrial receptivity enhancing elective embryo transfers in fresh ART cycle, and thus providing a non-invasive continuous technique for endometrial receptivity assessment that reflects endometrial changes during ART procedures.

scholarly journals 2D and 3D Power Doppler Ultrasound of Endometrium as Implantation Marker

2008 ◽  
Vol 2 (2) ◽  
pp. 1-11 ◽  
Author(s):  
Santiago Bau ◽  
Luis T Mercé ◽  
María J Barco
Keyword(s):  
Sagittal Plane ◽  
Endometrial Thickness ◽  
Power Doppler ◽  
3D Ultrasound ◽  
Single Measurement ◽  
3D Power Doppler ◽  
Endometrial Pattern ◽  
Reproductive Techniques ◽  
Endometrial Volume ◽  
2D And 3D

Abstract Transvaginal ultrasonography has an important role in assessing the endometrium. With 2DUS, a single measurement of endometrial thickness in the sagittal plane is widely used in assisted reproductive technology and in pregnancy prediction. Endometrial volume, measured with 3DUS, has been studied as a potentially more accurate parameter. The endometrial pattern was related to the likelihood of implantation. This pattern correlated in a positive fashion with subsequent implantation. 3D ultrasound and 3D power Doppler parameters have been applied to assisted reproductive techniques as outcome predictors, although studies are still scarce, they show very promising results.

scholarly journals Continuous Endometrial Volumetric Analysis for Endometrial Receptivity Assessment on Assisted Reproductive Technology Cycles

2020 ◽  
Author(s):  
Renato Martins ◽  
Antonio Helio Oliani ◽  
Denise Vaz Oliani ◽  
Jose Martinez de Oliveira
Keyword(s):  
Assisted Reproductive Technology ◽  
Endometrial Thickness ◽  
Transvaginal Ultrasound ◽  
Continuous Process ◽  
Volume Ratio ◽  
Positive Outcome ◽  
Volumetric Analysis ◽  
Reproductive Technology ◽  
Endometrial Receptivity ◽  
Endometrial Volume

Abstract Background: Human implantation is a complex process requiring synchrony between a healthy embryo and a functionally competent or receptive endometrium. In order to assess endometrial receptivity in Assisted Reproductive Technology (ART) cycles continuous evaluation of endometrial biophysical markers may have a predictive value on a positive outcome.Design: Serial 3D transvaginal ultrasound performed in women on ART cycle to evaluate a pattern that better predicts implantation rates. 169 subjects on a prospective case control study were assessed. Endometrial pattern, endometrial thickness, endometrial volume and adjusted endometrial volume (ratio between endometrial volume and uterine volume) was performed to all subjects on a continuous process from baseline (prior to ovarian controlled stimulation), day 6, 8 and 10 of controlled ovarian stimulation, trigger day with human chorionic gonadotropin hormone (hCG) and at embryo transfer day.Results: No statistical difference was noted between the two groups in terms of demographics and ART procedures and scores. Endometrium morphology also didn’t show any difference between the two groups. Endometrial volume and adjusted endometrial volume was significantly higher in the positive group as soon as day 6 of ovarian controlled stimulation.Conclusions: Continuous serial 3D endometrial volume and adjusted endometrial volumes may be a useful tool for clinicians in predicting endometrial receptivity enhancing elective embryo transfers in fresh ART cycle, and thus providing a non-invasive continuous technique for endometrial receptivity assessment that reflects endometrial changes during ART procedures.

scholarly journals Endometrial Volume Measured by VOCAL Compared to Office Hysteroscopy for Diagnosis of Endometrial Polyps in Premenopausal Women with Abnormal Uterine Bleeding

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Mohamed Laban ◽  
Sherif H. Hussain ◽  
Alaa S. Hassanin ◽  
Waleed M. Khalaf ◽  
Mohamed K. Etman ◽  
...  
Keyword(s):  
Endometrial Thickness ◽  
Transvaginal Ultrasound ◽  
Premenopausal Women ◽  
Abnormal Uterine Bleeding ◽  
Final Analysis ◽  
Uterine Bleeding ◽  
Endometrial Polyps ◽  
Predictive Values ◽  
Endometrial Volume ◽  
Sensitivity Specificity

The aim is to compare hysteroscopy, two-dimensional transvaginal ultrasound (2D TVUS), and three-dimensional (3D) Virtual Organ Computer-aided AnaLysis™ (VOCAL) to detect endometrial polyps (EPs) in premenopausal women with abnormal uterine bleeding (AUB). This prospective study was done at Ain Shams Maternity Hospital, Egypt, from March 5, 2015, to December 30, 2015, enrolling 118 premenopausal women with AUB. 2D TVUS, 3D VOCAL, and hysteroscopy were done. 109 patients reached final analysis. 36 women (33%) were diagnosed with EP by 2D TVUS. 50 (45.9%) had EP by hysteroscopy. Endometrial thickness was 10.1 mm by 2D TVUS and endometrial volume was 4.92 mL by VOCAL in women with EP by hysteroscopy compared to 9.9 mm and 3.50 mL in women with no EP, respectively (P=0.223;P=0.06). 2D TVUS has sensitivity, specificity, and positive and negative predictive values of 54%, 84.7%, 75%, and 68.5%, respectively. Endometrial thickness of >7.5 mm has sensitivity, specificity, positive and negative predictive values, and overall accuracy of 82%, 37.3%, 52.6%, 71%, and 57.8%, respectively. Endometrial volume of >1.2 mL has sensitivity, specificity, positive and negative predictive values, and overall accuracy of 90%, 42.4%, 57%, 83.3%, and 64.2%, respectively. 3D VOCAL may be used as a noninvasive method for the diagnosis of EP in premenopausal women with AUB.

scholarly journals Using snowflake surface-area-to-volume ratio to model and interpret snowfall triple-frequency radar signatures

2017 ◽  
Vol 17 (19) ◽  
pp. 12011-12030 ◽  
Author(s):  
Mathias Gergely ◽  
Steven J. Cooper ◽  
Timothy J. Garrett
Keyword(s):  
Surface Area ◽  
Cross Sections ◽  
Volume Ratio ◽  
High Sensitivity ◽  
Maximum Size ◽  
Strong Impact ◽  
Triple Frequency ◽  
Bounding Volume ◽  
Wide Range ◽  
Radar Signatures

Abstract. The snowflake microstructure determines the microwave scattering properties of individual snowflakes and has a strong impact on snowfall radar signatures. In this study, individual snowflakes are represented by collections of randomly distributed ice spheres where the size and number of the constituent ice spheres are specified by the snowflake mass and surface-area-to-volume ratio (SAV) and the bounding volume of each ice sphere collection is given by the snowflake maximum dimension. Radar backscatter cross sections for the ice sphere collections are calculated at X-, Ku-, Ka-, and W-band frequencies and then used to model triple-frequency radar signatures for exponential snowflake size distributions (SSDs). Additionally, snowflake complexity values obtained from high-resolution multi-view snowflake images are used as an indicator of snowflake SAV to derive snowfall triple-frequency radar signatures. The modeled snowfall triple-frequency radar signatures cover a wide range of triple-frequency signatures that were previously determined from radar reflectivity measurements and illustrate characteristic differences related to snow type, quantified through snowflake SAV, and snowflake size. The results show high sensitivity to snowflake SAV and SSD maximum size but are generally less affected by uncertainties in the parameterization of snowflake mass, indicating the importance of snowflake SAV for the interpretation of snowfall triple-frequency radar signatures.

scholarly journals Prediction of Arteriovenous Fistula Clinical Maturation from Postoperative Ultrasound Measurements: Findings from the Hemodialysis Fistula Maturation Study

2018 ◽  
Vol 29 (11) ◽  
pp. 2735-2744 ◽  
Author(s):  
Michelle L. Robbin ◽  
Tom Greene ◽  
Michael Allon ◽  
Laura M. Dember ◽  
Peter B. Imrey ◽  
...  
Keyword(s):  
Blood Flow ◽  
Arteriovenous Fistula ◽  
Characteristic Curve ◽  
Ultrasound Measurement ◽  
Case Mix ◽  
Elimination Algorithm ◽  
Clinical Center ◽  
Ultrasound Measurements ◽  
Before And After ◽  
Ultrasound Parameters

BackgroundThe utility of early postoperative ultrasound measurements in predicting arteriovenous fistula (AVF) clinical maturation is uncertain.MethodsWe investigated the relationships of ultrasound parameters with AVF clinical maturation in newly created AVF, measured at 1 day and 2 and 6 weeks, in 602 participants of a multicenter, observational cohort study. A backward elimination algorithm identified ultrasound measurements that independently predicted unassisted and overall AVF maturation. Candidate variables included AVF blood flow, diameter, and depth, upper arm arterial diameter, presence of stenosis, presence of accessory veins, seven case-mix factors (age, sex, black race, AVF location, diabetes, dialysis status, and body mass index), and clinical center. We evaluated the accuracy of the resulting models for clinical prediction.ResultsAt each ultrasound measurement time, AVF blood flow, diameter, and depth each predicted in a statistically significant manner both unassisted and overall clinical maturation. Moreover, neither the remaining ultrasound parameters nor case-mix factors were associated with clinical AVF maturation after accounting for blood flow, diameter, and depth, although maturation probabilities differed among clinical centers before and after accounting for these parameters. The crossvalidated area under the receiver operating characteristic curve for models constructed using these three ultrasound parameters was 0.69, 0.74, and 0.79 at 1 day and 2 and 6 weeks, respectively, for unassisted AVF clinical maturation and 0.69, 0.71, and 0.76, respectively, for overall AVF maturation.ConclusionsAVF blood flow, diameter, and depth moderately predicted unassisted and overall AVF clinical maturation. The other factors considered did not further improve AVF maturation prediction.

scholarly journals NGAL Correlates with Femoral and Carotid Plaque Volume Assessed by Sonographic 3D Plaque Volumetry

2020 ◽  
Vol 9 (9) ◽  
pp. 2811
Author(s):  
Michael Schreinlechner ◽  
Maria Noflatscher ◽  
Daniela Lener ◽  
Axel Bauer ◽  
Rudolf Kirchmair ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Interleukin 1 ◽  
High Sensitivity ◽  
3D Ultrasound ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Asymptomatic Patients ◽  
Single Center Study ◽  
Hs Crp ◽  
Plaque Destabilization ◽  
Neutrophil Gelatinase

Background/Objectives: Inflammation represents a cornerstone in the development of atherosclerosis and early detection is essential to avoid cardiovascular events. Biomarkers like interleukin-1 beta, interleukin-6, or high sensitivity CRP (hs-CRP) have been investigated intensively in this field. Since they have several limitations, additional biomarkers are needed for cardiovascular risk stratification. The acute phase protein, neutrophil gelatinase-associated lipocalin (NGAL), modulates inflammation and is elevated in cardiovascular disease (CVD). Moreover, it contributes to plaque destabilization. Methods: In this prospective, single-center study, we included 323 asymptomatic patients with at least one cardiovascular risk factor or established CVD. NGAL levels were measured in plasma samples using a commercially available ELISA. Carotid, femoral, and total atherosclerotic plaque volumes (PV) were measured using a 3D ultrasound system (Philips iU22). Patients were separated into a low (n = 243) and high (n = 80) total PV group. Results: NGAL was significantly higher in patients with high total PV versus patients with low total PV. The NGAL amplitude for the prediction of high total PV was significantly higher when compared with hs-CRP. A high predictive value could also be observed for patients without established CVD. Conclusion: NGAL seems to be a promising biomarker for the identification of asymptomatic patients with atherosclerotic disease.

Ultrasound parameters of pelvic organs and their age-related changes in a cohort of asymptomatic postmenopausal women: A community-based study

2020 ◽  
Vol 26 (3) ◽  
pp. 147-154
Author(s):  
Thiran D Dias ◽  
Thilina S Palihawadana ◽  
Malitha Patabendige ◽  
Mary BC Motha ◽  
Hithanadura J de Silva
Keyword(s):  
Postmenopausal Women ◽  
Endometrial Thickness ◽  
Hormone Replacement ◽  
Sri Lankan ◽  
Community Based ◽  
Pelvic Organs ◽  
Age Related ◽  
Pelvic Ultrasonography ◽  
Ultrasound Parameters ◽  
Age Related Changes

Objective To describe the ultrasound parameters of pelvic organs and their age-related changes in a cohort of asymptomatic postmenopausal women and to describe the prevalence of ultrasound-detected pathologies in a Sri Lankan population. Study design A large community-based longitudinal study using a randomly selected sample of postmenopausal women who have never used hormone replacement therapy. Main outcome measures Uterine, endometrial and ovarian measurements at pelvic ultrasonography as described by the International Endometrial Tumor Analysis and the International Ovarian Tumor Analysis groups. Results A total of 815 postmenopausal women were approached and all volunteered to participate. This included women between the ages of 45 and 74 years with a median (interquartile range (IQR)) of 62.0 (10.0) years. The median (IQR) uterine volume was 18.1 (17) ml, while the median (IQR) of right and left ovarian volumes were 17.3 (22.9) ml and 18.2 (21.5) ml. Both uterine and ovarian volumes showed an age-related decline (p < 0.01). Furthermore, the ovarian volumes demonstrated an increase in size with a higher body mass index (p < 0.03 for left and p < 0.01 for right, respectively). Median (IQR) endometrial thickness among the population was 3.0 (1.0) mm and there was no age-related change observed. Sixty-one women had an ultrasound-detected gynaecological pathology with a prevalence of 7.5% (95% confidence interval (CI) 5.6–9.5). Conclusions This study aimed at describing ultrasound parameters of pelvic organs among postmenopausal women of Sri Lanka was able to provide the reference values for uterine and ovarian volume among asymptomatic postmenopausal women. Both uterine and ovarian volumes demonstrated an age-related decline, whereas the endometrial thickness does not seem to relate to the age.

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