scholarly journals Aggressive angiomyxoma of broad ligament: an uncommon mesenchymal tumor

2019 ◽  
Vol 8 (7) ◽  
pp. 2913
Author(s):  
Sunil Vitthalrao Jagtap ◽  
Nitesh Nasre ◽  
Nitin S. Kshirsagar ◽  
Shubham S. Jagtap
Keyword(s):  
Soft Tissue Mass ◽  
Histopathological Examination ◽  
Broad Ligament ◽  
Mesenchymal Tumor ◽  
Aggressive Angiomyxoma ◽  
Recurrent Pain ◽  
Lower Abdomen ◽  
Radiological Findings ◽  
Tissue Mass ◽  
History Of

Aggressive angiomyxoma is a rare mesenchymal tumor occurring predominantly in the pelviperineal region. Authors present a case of a 70 years female presented with history of distention of lower abdomen with recurrent pain since 6 months. On clinical examination there was suspicion of fibroid. On USG it was reported as huge fleshy, soft tissue mass measuring 20x10x9 cm in lower abdominal flanks and pelvis with vascular pedicle attached to right parametrium. Pan-hysterectomy was performed. Right broad ligament showed mass measuring 18.5x10x6 cm. On histopathological examination it was diagnosed as a case of Aggressive angiomyxoma of broad ligament. We are presenting this case for its extreme rarity, clinicohisto-pathological and radiological findings.

scholarly journals Nevus lipomatosus cutaneous superficialis presenting as papilloma: A case report

2021 ◽  
Vol 7 (4) ◽  
pp. 367-369
Author(s):  
Shagufta Tahir Mufti ◽  
Shreya Mehdiratta ◽  
Salim Tahir ◽  
M.M.A. Faridi
Keyword(s):  
Adipose Tissue ◽  
Rare Case ◽  
Soft Tissue Mass ◽  
Histopathological Examination ◽  
Review Of Literature ◽  
Tissue Mass ◽  
Dermal Collagen ◽  
History Of ◽  
Smooth Skin ◽  
The Right

Nevus Lipomatosus Cutaneous Superficialis (NLCS) is an uncommon hamartomatous lesion of the skin. NLCS is classified into two clinical forms classic and solitary. Some authors consider this lesion as a type of connective tissue nevus. We report a rare case of solitary NLCS in a 69 year old male with a long history of pedunculated swelling in the right gluteal cleft with review of literature. On gross appearance the lesion was a grey brown, exophytic, cerebriform, smooth skin covered soft tissue mass measuring 4.5 cms in the largest dimension with a broad peduncle attached. On histopathological examination the lesion showed superficial and deep dermal infiltration of the adipose tissue with distortion of the dermal collagen.

scholarly journals Thymoma in an aged backyard Leghorn chicken, with reviews of a database and literature

2021 ◽  
Vol 33 (2) ◽  
pp. 336-339
Author(s):  
Julia Blakey ◽  
Carmen Jerry ◽  
Ana da Silva ◽  
Simone Stoute
Keyword(s):  
Soft Tissue Mass ◽  
Animal Health ◽  
Postmortem Examination ◽  
Cervical Region ◽  
Laboratory System ◽  
Unexpected Death ◽  
Tissue Mass ◽  
Microscopic Features ◽  
History Of ◽  
Backyard Chickens

A 7-y-old backyard Leghorn chicken ( Gallus domesticus) was submitted to the California Animal Health and Food Safety Laboratory System (CAHFS)–Turlock branch for postmortem examination, with a history of unexpected death. At postmortem examination, a hemorrhagic soft tissue mass was observed in the cervical region. Microscopically, a densely cellular neoplasm of polygonal epithelial cells and small lymphocytes was observed. The microscopic features of the neoplasm in combination with positive immunohistochemistry for pancytokeratin and CD3 were used to classify the lesion as a thymoma. Thymoma was diagnosed in only 5 birds submitted to CAHFS from 1990 to 2019. Thymoma has been described only rarely in birds, and is an unusual diagnosis in backyard chickens.

scholarly journals Soft Tissue Tumor Leg - A Rare Presentation of Cutaneous Rhinosporidiosis

2020 ◽  
pp. 1-2
Author(s):  
R. Chithra ◽  
B Sai Dhandapani ◽  
R King Gandhi ◽  
R. Chithra
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Soft Tissue Mass ◽  
Radiological Findings ◽  
Rare Presentation ◽  
Diagnostic Dilemma ◽  
Tissue Mass ◽  
Tissue Tumor ◽  
Typical History ◽  
Polypoidal Growth

Rhinosporidiosis presents commonly as polypoidal growth in nose, but presentation in other sites including skin, genitourinary tract is documented. Cutaneous presentation is rare, which may present as pedunculated swelling or cutaneous ulceration, but presenting as soft tissue tumor is extremely rare. The multifaceted presentation of the disease causes diagnostic dilemma to an unsuspecting physician. Clinical and radiological findings may mislead, but usually typical history helps, and typical histology clinches the diagnosis. We are presenting a case of disseminated cutaneous rhinosporidiosis presented as soft tissue mass lesion in the leg causing diagnostic difficulty due to the rare presentation.

Vulval myxoid liposarcoma

2001 ◽  
Vol 11 (4) ◽  
pp. 321-322 ◽  
Author(s):  
R. Donnellan ◽  
M. Moodley
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Lymph Nodes ◽  
Soft Tissue Mass ◽  
Myxoid Liposarcoma ◽  
Complete Resection ◽  
Tissue Mass ◽  
History Of ◽  
Labium Majus ◽  
Draining Lymph Nodes

Abstract.Donnellan R, Moodley M. Vulval myxoid liposarcoma.A 26 year old woman presented with a 4-year history of a gradually enlarging fluctuant mass on the left labium majus. Histologic examination following excision revealed myxoid liposarcoma. Following the diagnosis, further surgery was performed to ensure complete resection. Routine excision of draining lymph nodes is not advocated. Although rare, myxoid liposarcoma should be considered in the differential diagnosis of a vulval soft tissue mass.

scholarly journals Novel HMGA2-YAP1 fusion gene in aggressive angiomyxoma

2019 ◽  
Vol 12 (5) ◽  
pp. e227475 ◽  
Author(s):  
Mee-young Lee ◽  
Brandon da Silva ◽  
Daniel C Ramirez ◽  
Robert G Maki
Keyword(s):  
Fusion Gene ◽  
Soft Tissue Mass ◽  
Locally Advanced ◽  
High Mobility ◽  
Aggressive Angiomyxoma ◽  
Tissue Mass ◽  
Persistent Disease ◽  
Gonadotropin Releasing Hormone Agonist ◽  
Definitive Operation ◽  
Oestrogen Antagonism

We describe a case of a 44-year-old woman with locally advanced aggressive angiomyxoma with a novel translocation high-mobility group AT-hook 2–yes-associated protein 1 (HMGA2-YAP1) fusion, implying a t(11;12)(q22.1;q14.3) translocation. She was started on gonadotropin-releasing hormone agonist injection and an aromatase inhibitor for persistent disease, which responded to treatment; she was subsequently treated with radiation before a more definitive operation was conducted. This case report indicates that HGMA2-YAP1–translocated aggressive angiomyxoma is responsive to oestrogen antagonism and hopefully will allow for the development of diagnostics useful for this rare but often morbid neoplasm. This case also highlights the importance of appropriate workup of a soft tissue mass.

Unusual cause of a painless soft tissue mass of the scalp: a rare presentation of primary intracranial neuroendocrine neoplasm

2021 ◽  
Vol 14 (2) ◽  
pp. e236856
Author(s):  
Susruta Manivannan ◽  
Feras Sharouf ◽  
George Lammie ◽  
Paul Leach
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Neuroendocrine Tumour ◽  
Clinical Findings ◽  
Neuroendocrine Neoplasm ◽  
Tumour Resection ◽  
Rare Presentation ◽  
Tissue Mass ◽  
Left Hand ◽  
History Of

Incidental soft tissue lumps in the scalp are a common presenting complaint in clinical practice. However, they may signify more sinister underlying pathologies. Our report examines a 63-year-old man presenting with impaired co-ordination in his left hand following a 3-month history of a painless left retroauricular scalp lump. MRI revealed a large left occipital soft tissue mass eroding through the underlying skull with infiltration into the underlying cerebellum and temporal lobe. Open biopsy confirmed a diagnosis of high-grade intracranial neuroendocrine tumour (NET). At approximately 5 months following successful tumour resection and adjuvant chemotherapy, he developed tumour recurrence and was subsequently palliated, and died at 1 year post diagnosis. Herein, we review other cases of primary intracranial NET, clinical findings, histopathological features and prognosis.

scholarly journals Aggressive Angiomyxoma with Perineal Herniation

2014 ◽  
Vol 4 ◽  
pp. 23 ◽  
Author(s):  
Seema Narang ◽  
Supreethi Kohli ◽  
Vinod Kumar ◽  
Raj Chandoke
Keyword(s):  
Surgical Planning ◽  
Soft Tissue Mass ◽  
Aggressive Angiomyxoma ◽  
Radiological Evaluation ◽  
Perianal Region ◽  
Tissue Mass ◽  
The Third ◽  
Fourth Decade ◽  
Perineal Herniation ◽  
Perineal Region

Aggressive angiomyxoma is a rare mesenchymal tumor involving the pelvic-perineal region. It occurs during the third and fourth decade of life and is predominantly seen in females. It presents clinically as a soft tissue mass in variable locations such as vulva, perianal region, buttock, or pelvis. Assessment of extent of the tumor by radiological evaluation is crucial for surgical planning; however, biopsy is essential to establish diagnosis. We present the radiological and pathological features seen in a 43-year-old female diagnosed with abdominal angiomyxoma with an unusual extension to the perineum.

Olfactory ganglioneuroblastoma in a dog: case report and literature review

2021 ◽  
pp. 104063872110228
Author(s):  
Ashley M. Romano ◽  
Chad B. Frank
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Ganglion Cells ◽  
Soft Tissue Mass ◽  
Neoplastic Cell ◽  
Cell Populations ◽  
Intact Male ◽  
Tissue Mass ◽  
Immunohistochemical Markers ◽  
History Of

A 7-y-old, intact male Alaskan Malamute was presented with a 3-mo history of stertor and epistaxis. Computed tomography of the skull revealed generalized loss of gas throughout both nasal passages with replacement by a soft tissue mass that traversed the cribriform plate. Histopathology revealed neoplastic neuroblast cells arranged in anastomosing cords, as well as separately located aggregates of ganglion cells. Both neoplastic cell populations demonstrated immunoreactivity to MAP-2, TuJ-1, and synaptophysin. Neuroblastic cells additionally exhibited punctate immunoreactivity to MCK and CK8/18. We document here both the positive neural immunohistochemical markers for this neoplasm, as well as propose possible histomorphologic variants.

Schwannoma with Psammoma Body

2021 ◽  
Vol 111 (1) ◽  
Author(s):  
Lindsay M. Hummel ◽  
Susan Gamble ◽  
Robert Krouse ◽  
Darshana Jhala ◽  
Sharvari Dalal ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Carney Complex ◽  
Psammoma Body ◽  
Psammoma Bodies ◽  
Tissue Mass ◽  
Pathologic Evaluation ◽  
History Of ◽  
Male Veteran

We present a case of a 59-year-old male veteran with a chronic history of right foot soft-tissue mass that was causing pain in his shoes, but not functional or neurologic symptoms. Excision of the mass and pathologic evaluation resulted in multidisciplinary involvement and evaluation. In this example, the mass was found to be either an unusual schwannoma that happens to be psammoma body–rich or an unusual psammomatous melanocytic schwannoma that deviates from conventional examples, as a diagnostic consensus was unable to be reached. Schwannomas are an uncommon finding in the foot, and even more uncommon are those that contain psammoma bodies. Although rare, these tumors can be concerning for more systemic, life-altering diseases such as Carney complex, for which our patient refused genetic testing.

Extraskeletal mesenchymal chondrosarcoma mimicking a thrombosed venous aneurysm with femoral vein involvement: A case report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S25-S25
Author(s):  
J Muldoon ◽  
L Warmke
Keyword(s):  
Case Report ◽  
Gene Fusion ◽  
Soft Tissue Mass ◽  
Femoral Vein ◽  
Mesenchymal Chondrosarcoma ◽  
Venous Aneurysm ◽  
Tissue Mass ◽  
Common Femoral Vein ◽  
Extraskeletal Mesenchymal Chondrosarcoma ◽  
History Of

Abstract Introduction/Objective Mesenchymal chondrosarcoma is a high-grade primitive mesenchymal tumor, which accounts for <5% of all chondrosarcomas and commonly affects young adults (peak incidence in second to third decade of life). The tumor has a widespread anatomic distribution, frequently involving the craniofacial bones as well as extraskeletal sites. The clinical presentation of an inguinal mass mimicking a thrombosed venous aneurysm is unusual and represents a potential diagnostic pitfall. Methods/Case Report A 42-year-old female with hypertension and obesity initially presented with a two-week history of left lower leg swelling. Venous doppler revealed presumed venous thrombosis, and she was prescribed apixaban while no history of coagulopathy, immobility, or recent surgery was noted. Two months later, she had residual swelling. Follow-up CT scan favored a large, peripherally thrombosed venous aneurysm arising from the left common femoral vein, while MRI showed a lobulated, inguinal soft tissue mass abutting the vein. Biopsy of the mass demonstrated a spindle cell mesenchymal neoplasm; subsequent resection revealed a pink-to-tan, well-circumscribed, and encapsulated mass (5.2 cm) with focal left common femoral vein invasion. Microscopically, the lesion demonstrated poorly-differentiated, oval-to-spindle cells with prominent staghorn vasculature interspersed were focal areas of well-differentiated hyaline cartilage. Immunohistochemical stains showed that the lesional cells were negative for cytokeratin cocktail, EMA, SMA, desmin, S100 protein, SOX10, STAT6, MUC4, MDM2, and ER. Next-generation sequencing (NGS) revealed a HEY1-NCOA2 gene fusion, confirming the diagnosis of extraskeletal mesenchymal chondrosarcoma. Results (if a Case Study enter NA) N/A Conclusion Extraskeletal mesenchymal chondrosarcoma can rarely present as an inguinal soft tissue mass with vascular invasion, mimicking a thrombosed venous aneurysm. Molecular confirmation of HEY1-NCOA2 gene fusion can help confirm the diagnosis in unusual clinical presentations.

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