scholarly journals A prospective study on the role of Hysterolaparoscopy in the evaluation of infertility

2019 ◽  
Vol 8 (12) ◽  
pp. 4766
Author(s):  
Pandeeswari B. ◽  
Shalini Mahana Valecha
Keyword(s):  
Age Groups ◽  
Female Infertility ◽  
Reproductive Age ◽  
Current Evidence ◽  
Secondary Infertility ◽  
Ovulatory Period ◽  
A Prospective Study ◽  
Work Up ◽  
Ovarian Syndrome

Background: Infertility affects about 10-15% of couples of reproductive age groups. The current evidence indicates a 9% prevalence of infertility with 56% of couples seeking medical care. Hysterolaparoscopy provides a comprehensive investigative procedure in which various factors causing female infertility can be assessed at one sitting.Methods: A total 100 infertile women between 20-40 years of age including primary and secondary infertility were evaluated. Patients would be investigated thoroughly for infertility and in preparation for anaesthesia. Tests include follicular study, Ultrasound pelvis. Hysterolaparoscopy was performed in the pre ovulatory period between days 6-10 of the cycle for infertility evaluation.Results: In the present study out of 100 cases for infertility evaluated, primary infertility were 57(57%) and secondary infertility were 43(43%). In our study out of 100 patients, Hysterolaparoscopy showed tuberculosis in 24 (24%) patients, remaining were endometriosis, polycystic ovarian syndrome, congestion, intra-pelvic adhesions, hydro-salpinx.Conclusions: It is concluded that while treating the causes of female infertility combined simultaneous diagnostic laparoscopy and hysteroscopy should be performed in all infertile patients as” seeing is believing” and if any pathologies found to be operable the gynaecologist can perform operative hystero-laparoscopy at that time, hence anticipating the pathologies after pre-operative work up is very important.

Role of genetic and environmental factors in the development of polycystic ovary syndrome

2013 ◽  
Vol 154 (17) ◽  
pp. 650-657
Author(s):  
László Ságodi ◽  
Emőke Kiss-Tóth ◽  
László Barkai
Keyword(s):  
Environmental Factors ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Current Evidence ◽  
Ovary Syndrome ◽  
Genetic And Environmental Factors ◽  
Endocrine Abnormality ◽  
Ovarian Syndrome

Polycystic ovary syndrome is the most common heterogeneous endocrine abnormality in women in the reproductive age. The syndrome remains an enigmatic disorder because the aetiology is still unclear. Familial aggreagation is relatively common among patients with polycystic ovary syndrome suggesting a significant genetic component, although the way of inheritance has not been established firmly. The authors review the relevant medical literature and suggest that genetic and environmental factors play a role in the development of polycystic ovary syndrome. To date, no gene has been identified that causes or contributes substantially to the development of a polycystic ovary syndrome phenotype. Polycystic ovarian syndrome is considered to be an oligogenic disorder in which the interaction of a number of genetic and environmental factors determines the heterogeneous clinical and biochemical phenotype. To summarize current evidence the authors conclude, that when we are able to identify and then modify environmental determinants, then we will be able to safeguard better the health of those patients who are predisposed to disease development due to genotype or previous environmental effects. Orv. Hetil., 2013, 154, 650–657.

scholarly journals Role of Diagnostic Hysterolaparoscopy in the Evaluation of Infertility - A Prospective Study from Telangana, India

2021 ◽  
Vol 10 (32) ◽  
pp. 2640-2644
Author(s):  
Arjumand Bano ◽  
Parvathapuram Sneha
Keyword(s):  
Comprehensive Evaluation ◽  
Economic Consequences ◽  
Reproductive Age ◽  
Medical Sciences ◽  
Male Factor ◽  
Secondary Infertility ◽  
Uterine Malformation ◽  
Uterine Septum ◽  
A Prospective Study

BACKGROUND Infertility is a multidimensional health problem with social and economic consequences. Infertility affects about 10 - 15 % of reproductive age couples. 1 Hysterolaparoscopy is safe and effective method to diagnose infertility. The purpose of this study was to determine the role of diagnostic hysterolaparoscopy in the evaluation of infertility in Chalmeda Anand Rao Institute of Medical Sciences. METHODS A prospective hospital-based study was carried out in Chalmeda Anand Rao Institute of Medical Sciences over a period of 1 year from August 2019 to July 2020. Hysterolaparoscopy was done in 100 patients. Women aged 20 - 40 years with normal hormone profile without male factor infertility were included. RESULTS 100 patients with infertility were undertaken, 70 (70 %) women had primary infertility and the remaining 30 (30 %) had secondary infertility. Ovarian pathology (30 %), endometriosis (23 %), tubal pathology (14 %) and pelvic adhesion (14 %) were the most well-known anomalies recognized in laparoscopy in both primary and secondary infertility. Uterine septum was major intrauterine pathology seen in two gatherings. Out of 12 patients having uterine malformations, most regular uterine malformation in both the gatherings was 9 uterine septum and 2 unicornuate and 1 was hypoplastic uterus. CONCLUSIONS Combined hysterolaparoscopy is a safe, effective, and reliable method in comprehensive evaluation of infertility. It helps in the diagnosis of pelvic pathology which is missed by routine pelvic examinations and basic investigations done for evaluation of infertility. Hysterolaparoscopy gives the added advantage of doing a therapeutic procedure in the same sitting. Thus, hysterolaparoscopy may be considered as gold standard and definitive investigative day-care procedure for evaluation of female infertility. KEY WORDS Hysteroscopy, Infertility, Laparoscopy

scholarly journals Role of diagnostic hysterolaparoscopy in the evaluation of female infertility

2019 ◽  
Vol 7 (5) ◽  
pp. 1531
Author(s):  
Madhuri N. ◽  
Rashmi H. S. ◽  
Sujatha M. S. ◽  
Dhanyata G.
Keyword(s):  
Tertiary Care ◽  
Female Infertility ◽  
Reproductive Age ◽  
Common Finding ◽  
Care Hospital ◽  
Male Factor ◽  
Secondary Infertility ◽  
Unprotected Sexual Intercourse ◽  
Primary Infertility

Background: Infertility is defined by WHO as a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. The prevalence of infertility is about 10%-15% of reproductive age couples. Female factor is responsible for 40-45% of etiology of infertility. Aim of the study was to evaluate the role of diagnostic hysterolaparoscopy in female infertility at a tertiary care centre.Methods: This is a retrospective hospital based study done at a tertiary care hospital attached to JSS Medical College, Mysuru between January 2017 and December 2018. Infertile women with primary or secondary infertility in the 18-40 years age group, with normal hormonal profile and no known male factor were included.Results: In our study, primary infertility was found in 77% of the 96 patients and secondary infertility was found in 23% of patients. In primary infertility, ovarian pathology was the most common finding while Endometriosis was the most common finding in secondary infertility group. 77 % patients were found to have bilaterally patent tubes while remaining had unilateral or bilateral blockage. On hysteroscopy, endometrial polyps were the commonest hysteroscopic finding in both groups.Conclusions: Combined hystero-laparoscopy is a safe, effective and reliable method in comprehensive evaluation of infertility. It helps in the diagnosis of pelvic pathology which may have been missed by routine examination and thereby helps in optimal management of female infertility.

scholarly journals Role of diagnostic hysterolaparoscopy in evaluation of female infertility

2017 ◽  
Vol 6 (9) ◽  
pp. 4048
Author(s):  
Mariyam S. Ahmed ◽  
Anand N. Bhalerao
Keyword(s):  
Prospective Study ◽  
Diagnostic Procedures ◽  
Female Infertility ◽  
Reproductive Age ◽  
Pelvic Examination ◽  
Therapeutic Procedures ◽  
Uterine Septum ◽  
The Common ◽  
A Prospective Study

Background: Infertility affects 10-15% of reproductive age couples. Routine pelvic examination and usual diagnostic procedures can miss majority of the pelvic pathologies. Hysterolaparoscopy is an effective tool for diagnosing these pathologies and additionally therapeutic procedures, like polypectomy, myomectomy, septal resection and adhesiolysis, can be done in the same sitting. Objective of present study was to determine the role of diagnostic hysterolaparoscopy for evaluating the causes of infertility.Methods: It was a prospective study conducted at the Department of OBGY from September 2015 to August 2016. Patients aged 20-40 years with infertility were included in the study. The prevalence of different lesions was analysed.Results: Out of the 30 patients studied, most had primary infertility. Laparoscopic abnormalities (56.6%) were more common than hysteroscopic abnormalities (36.6%). Adnexal adhesions (26.6%) was the most common abnormality detected on laparoscopy, while the common intra-uterine pathologies were uterine septum and synechiae.Conclusions: Hysterolaparoscopy may be recommended as the procedure of choice for evaluation of female infertility, which are usually missed by imaging modalities.

scholarly journals Role of Ultrasound in the Assessment of Female Infertility

2014 ◽  
Vol 8 (2) ◽  
pp. 184-200
Author(s):  
Maria Sheikh
Keyword(s):  
Obstet Gynecol ◽  
Color Doppler ◽  
3D Ultrasound ◽  
Vital Role ◽  
Female Infertility ◽  
Luteal Phase Defect ◽  
Ovarian Syndrome ◽  
Luteinized Unruptured Follicle ◽  
Ovarian Cycles

ABSTRACT Ultrasound has made significant advancements in reproductive medicine, especially infertility of a female cause. It is a useful tool in the diagnosis and management of various disorders. Transvaginal ultrasonography in particular plays a vital role in infertility treatment as it allows for evaluation of normal and stimulated ovarian cycles, aspiration of follicles, and subsequent transfer of embryos. The use of color Doppler permits visualization of endometrial and intraovarian vessels, facilitating an understanding of normal and abnormal physiology of the uterus and ovaries. This article reviews a variety of case scenarios regarding female infertility that may be encountered in the practice of reproductive endocrinology. Ovarian causes such as polycystic ovarian syndrome, luteinized unruptured follicle, luteal phase defect, premature ovarian failure, and endometriosis, are discussed together with tubal and uterine causes of infertility. By using illustrative images, the reader will be able to correlate findings on B-mode, color Doppler and 3D ultrasound with various causes of female infertility. How to cite this article Sheikh M, Kupesic Plavsic S. Role of Ultrasound in the Assessment of Female Infertility. Donald School J Ultrasound Obstet Gynecol 2014;8(2):184-200.

scholarly journals Role of oral inositol supplementation in women with polycystic ovarian syndrome

2021 ◽  
Vol 10 (12) ◽  
pp. 4493
Author(s):  
Najma Malik ◽  
Navneet Dubey
Keyword(s):  
Insulin Resistance ◽  
Prospective Observational Study ◽  
Oocyte Quality ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Medical College ◽  
Good Medicine ◽  
Ovarian Syndrome ◽  
Rotterdam Criteria

Background: PCOS is one of the most common endocrine disorder in women of reproductive age, it affects about 5-10% of women of reproductive age. It is characterized by chronic anovulation, hyperandrogenism, and insulin resistance. 30-40% of PCOS women have impaired glucose tolerance.Methods: This was prospective observational study carried out on 100 patients of PCOS visiting outpatient Department of Obstetrics and Gynecology, BRD Medical College, Gorakhpur from 1st July 2018 to 30th June 2019. Patients were diagnosed as PCOS on basis of Rotterdam criteria. In these 100 patients, oral inositol 2 gm twice daily was given for 3 months to 6 months depending upon the response of the patient and patients were examined every 4 week for menstrual regularity, acne improvement, hirsutism, spontaneous ovulation and pregnancy.Results: With inositol supplementation, menstrual abnormality corrected in 80% cases, 45% cases having acne improved. Ovulation occurred in 75.5% cases and 66.6% cases conceived with inositol supplementation.Conclusions: Insulin resistance is the basic pathophysiology for PCOS hence inositol supplementation is supposed to be very good medicine for management of PCOS to improve insulin sensitivity. Inositol leads to improvement in regularity of menstrual cycle, insulin resistance, hyperandrogenic features like hirsutism, acne, restores ovulation and improves oocyte quality.

Studying Cytotoxic T-lymphocyte- Associated Antigen-4 (CTLA-4) gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

2019 ◽  
pp. 1-6
Keyword(s):  
Gene Polymorphism ◽  
Polycystic Ovarian Syndrome ◽  
Cytotoxic T Lymphocyte ◽  
Reproductive Age ◽  
Amplification Refractory Mutation System ◽  
Low Grade ◽  
Metabolic Disturbances ◽  
Mutation System ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) considers as the most common disorder among women during reproductive age. Its common features involve hyperandrogenism, chronic anovulation, and weight gain. Till now, the pathogenesis of PCOS stay unknown, and there is evidence considered PCOS as a low-grade inflammatory disease. Polycystic ovarian syndrome is associated with a variety of endocrine and metabolic disturbances. The present study was designed to detect the role of (CTLA-4) gene polymorphism (rs733618) with PCOS. A total of 60 PCOS patients and 30 healthy women, matching in average age and body mass index (BMI), were enrolled in this study. Patients with PCOS were attend to AL - Nahrain University High Institute for Infertility Assisted Reproductive Technology, in Baghdad between Septembers to December/2018. Blood samples were aspirated from both groups to detection (CTLA-4) gene polymorphism (rs733618) by tetra-primer amplification-refractory mutation system based on real time polymerase chain reaction (ARMS-qPCR). The obtained results revealed normal genotyping for both groups. The result of current study confirms that there is no role of (CTLA-4) gene polymorphism (rs 733618) in PCOS.

Prevalence of polycystic ovarian syndrome among adolescent girls: a prospective study

2018 ◽  
Vol 7 (11) ◽  
pp. 4375 ◽  
Author(s):  
Archana Singh ◽  
K. Vijaya ◽  
Kaparati Sai Laxmi
Keyword(s):  
Prospective Study ◽  
Adolescent Girls ◽  
Polycystic Ovary ◽  
Maternity Hospital ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Medical College ◽  
A Prospective Study ◽  
Ovarian Syndrome

Background: PCOS is a complex   endocrine   disorder which is most common in women of reproductive age. PCOS may first present in adolescence, but the incidence of PCOS in adolescence is not known, as diagnostic criteria for PCOS in the adolescent age-group is still not defined, PCOS symptoms tend to overlap with normal pubertal changes making the diagnosis even more challenging. The objective is to study prevalence and symptomatology of polycystic ovary syndrome (PCOS) in adolescent girls.Methods: Prospective study between November 2017 and March 2018. 117 adolescent girls aged 15 to19 years attending OPD with oligomenorrhea and/or hirsutism were advised for biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS on the basis of Rotterdam’s criteria at the Department of Obstetrics and Gynaecology, Government Maternity Hospital, Osmania Medical College, Hyderabad.Results: Prevalence of PCOS in the study was 11.96% in the study group.Conclusions: PCOS is increasingly encountered during adolescence, although the overall prevalence is low and evaluation of PCOS in adolescents is challenging. At this age, life style modification is imperative to prevent long-term metabolic and reproductive complications.

scholarly journals Role of diagnostic hystero-laparoscopy in the evaluation of female infertility

2019 ◽  
Vol 8 (8) ◽  
pp. 3156
Author(s):  
Deepa Shanmugham ◽  
Nambala Divya Sahitya ◽  
Sindhu Natarajan ◽  
Deepak Kannan Saravanany
Keyword(s):  
Tertiary Care ◽  
Reproductive Age ◽  
Polycystic Ovaries ◽  
Tertiary Care Centre ◽  
Male Factor ◽  
Acute Pelvic Inflammatory Disease ◽  
Tubal Factor ◽  
The Mean ◽  
A Prospective Study

Background: Infertility affects about 10-15% of reproductive age couples. The main causes of infertility include male factor, ovulatory disorders, tubal factor and endometriosis. This study was conducted to determine the role of Diagnostic hystero-laparoscopy (DHL) in the evaluation of female infertility.Methods: This study was a prospective study done in a tertiary care centre over a period of 1 year on all infertile couples. The exclusion criteria: male factor infertility, hypothyroidism, hyperprolactinemia, acute pelvic inflammatory disease. Diagnostic hysterolaparoscopy was performed in all study patients in pre ovulatory phase, under general anaesthesia. The findings were then documented and analysed.Results: A total number of 90 patients were recruited for the study. The mean age of the patients was 28±3 years. The mean BMI of the study patients was 25±4 kg/m2. The mean duration of infertility was 5.4 years. On laparoscopy, 28 patients had polycystic ovaries (31.1%), 4 patients had pelvic adhesions (4.4%), 2 patients had endometriosis (2.2%) and tubal block was identified in 10 patients (11.11%). 10 patients had abnormal findings on hysteroscopy.Conclusions: Hystero laparoscopy is an effective diagnostic tool in the evaluation of infertility and has to be included in basic diagnostic workup.

Dicarbonyl stress and glyoxalases in ovarian function

2014 ◽  
Vol 42 (2) ◽  
pp. 433-438 ◽  
Author(s):  
Carla Tatone ◽  
Ursula Eichenlaub-Ritter ◽  
Fernanda Amicarelli
Keyword(s):  
Ovarian Function ◽  
Reproductive Age ◽  
Oocyte Competence ◽  
Reproductive Age Women ◽  
Glycation End Products ◽  
Lower Fertility ◽  
Main Regulator ◽  
Ovarian Syndrome ◽  
New Strategies

The ovary is the main regulator of female fertility. Changes in maternal health and physiology can disrupt intraovarian homoeostasis thereby compromising oocyte competence and fertility. Research has only recently devoted attention to the involvement of dicarbonyl stress in ovarian function. On this basis, the present review focuses on clinical and experimental research supporting the role of dicarbonyl overload and AGEs (advanced glycation end-products) as key contributors to perturbations of the ovarian microenvironment leading to lower fertility. Particular emphasis has been given to oocyte susceptibility to methylglyoxal, a powerful glycating agent, whose levels are known to increase during aging and metabolic disorders. According to the literature, the ovary and the oocyte itself can rely on the glyoxalase system to counteract the possible dicarbonyl overload such as that which may occur in reproductive-age women and patients with PCOS (polycystic ovarian syndrome) or diabetes. Overall, although biochemical methods for proper evaluation of dicarbonyl stress in oocytes and the ovarian microenvironment need to be established, AGEs can be proposed as predictive markers and/or therapeutic targets in new strategies for improving reproductive counselling and infertility therapies.

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