scholarly journals A study on effect of neoadjuvant chemotherapy on peri operative complications and outcome in patients under-going radical cystectomy for muscle invasive bladder cancer

2018 ◽  
Vol 6 (10) ◽  
pp. 3281
Author(s):  
Ranjit Kumar Das ◽  
Vishnu Agrawal ◽  
Dawood Khan ◽  
Ranjan Kumar Dey ◽  
Imran Ahmad Khan ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Radical Cystectomy ◽  
Profile Analysis ◽  
Perioperative Complications ◽  
Perioperative Morbidity ◽  
Operative Outcomes ◽  
Significant Difference ◽  
Operative Complications ◽  
Group 2 ◽  
Group 1

Background: To compare the peri-operative complications, related to radical cystectomy and to compare peri operative outcomes between patients receiving neoadjuvant chemotherapy and those treated with radical cystectomy alone.Methods: This was prospective observational study. The study was conducted at ‘The Department of Urosurgery, R. G. Kar Medical College and Hospital, Kolkata’. Study period was between March 2016 to March 2018. Total 36 patients were included in present study. Patients after clinical diagnosis and risk factor profile analysis were divided into two groups: (1) radical cystectomy alone (n=24) (2) patients received neoadjuvant chemotherapy (gemcitabine and cisplatin regime) followed by radical cystectomy (n=12). Different parameters were compared.Results: Total 36 patients were underwent radical cystectomy. In group 1, 96% (n=23) were having T2 stage while 4% (n=1) were having T3stage. In group 2 25% (n=3) patients were having T2stage while 75% (n=9) were having T3 stage as per CECT staging. There were no significant difference noted in perioperative complications in both groups except perioperative adhesions (group 2, 47% vs group 1, 8.3%). There was significant time delay in radical cystectomy in group 2 (patients received neoadjuvant chemotherapy).Conclusions: We found there were no significant increase in perioperative morbidity and mortality with Neoadjuvant Chemotherapy. Most of the complications were comparable to previous studies.

scholarly journals Comparison of Complications from Radical Cystectomy between Old-Old versus Oldest-Old Patients

2014 ◽  
Vol 94 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Evi Comploj ◽  
Jeremy West ◽  
Michael Mian ◽  
Luis Alex Kluth ◽  
Alexander Karl ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Radical Cystectomy ◽  
Medical Center ◽  
Oldest Old ◽  
Age Group ◽  
Cancer Specific Survival ◽  
Old Patients ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

Introduction: The purpose of this study was to evaluate and compare complications after radical cystectomy in patients aged ≥75 years. Materials and Methods: 251 patients aged 75-95 years (median 79) underwent radical cystectomy between 2000 and 2012 at four institutions. The patients were divided into two groups: ≥75-84 years of age (group 1) versus ≥85 years of age (group 2). Comorbidities, body mass index, and complications were obtained retrospectively, except at the Central Hospital of Bolzano and Weill Cornell Medical Center, which collected data prospectively. Cancer-specific survival, overall mortality, hospital stay, clinical outcome and complications were assessed. Complications were categorized using the Clavien-Dindo classification reporting system. The mean follow-up was 21 months. Results: The median hospital stay was 17 (2-91) days. Perioperative Clavien-Dindo grade ≥III complications were seen in 24.1% (48/199) of group 1 patients and 19.2% (10/52) of group 2 patients (p = 0.045). 30- and 90-day mortality was 4.5 and 13.5% in group 1 and 6.5 and 32.3% in group 2, respectively. Only the 90-day mortality rate was statistically significant (p < 0.05) between the two groups. The 3-year overall survival was 40% in group 1 and 34% in group 2. The 3-year cancer-specific survival was 52% in group 1 and 50% in group 2. Conclusions: We evaluated a large series of elderly (≥75 years) patients undergoing radical cystectomy at four institutions. Comparing patients aged ≥75-84 and ≥85 years revealed no significant difference in complications, 30-day mortality, overall and cancer-specific survival rates. Only 90-day mortality rates were significantly higher in the ≥85-year-old patients.

scholarly journals Comparative study between open and laparoscopic lymphadenectomy (pelvic and para-aortic) in gynecological malignancies

2018 ◽  
Vol 5 (5) ◽  
pp. 1657
Author(s):  
Hytham R. Yassin ◽  
Soliman ALShakhs ◽  
Mohammed Hamed ◽  
Adel Karam ◽  
Mohammed Mouneer
Keyword(s):  
Comparative Study ◽  
Radical Surgery ◽  
Safe Procedure ◽  
Gynecological Malignancies ◽  
Number Of Patients ◽  
Significant Difference ◽  
Operative Complications ◽  
Group 2 ◽  
Group 1

Background: Objective of present study was to compare the results of lymphaenectomy (pelvic and para-aortic) between laparoscopy and laparotomy in gynecological malignancies.Methods: Authors analyze the results of 30 patients suffering from gynecological malignancies (Enometrial, Ovarian and cervical) submitted to surgery as apart of treatment. Patients were classified in Two Groups Group (1) included15 patients were submitted to open radical surgery and group (2) included 15 patients Were submitted to laparoscopic radical surgery between May 2016 and October 2017.Results: In present comparative study, there was significant difference regarding intra operative blood loss, operative time and post operative hospital stay (P<0.001) and there was no significant difference regarding intra-operative complications, post-operative complications, total number of lymph node harvested, number of positive lymphnodes (P>0.05).Conclusions: Laparoscopic lymphadenectomy is a technically feasible and safe procedure. Authors recommend further study in large number of patients with longer duration and follow up period for assessment of oncological out-come.

scholarly journals Early Oncological and Functional Outcomes of Prostate Capsule Sparing Cystectomy Compared with Standard Radical Cystectomy

2019 ◽  
Vol 13 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Ahmed Y. Abdelaziz ◽  
Hossam Shaker ◽  
Mohamed Seifelnasr ◽  
Hossam Elfol ◽  
Mohamed Nazim ◽  
...  
Keyword(s):  
Radical Cystectomy ◽  
Randomized Study ◽  
Transitional Cell ◽  
Specific Antigen ◽  
Urinary Continence ◽  
Oncological Outcomes ◽  
Significant Difference ◽  
Group 2 ◽  
Prostate Capsule ◽  
Group 1

Introduction and Objectives: A comparative study of standard radical cystectomy and prostate capsule sparing radical cystectomy regarding functional and oncological outcomes. Materials and Methods: A randomized study of 96 patients with transitional cell carcinoma of the bladder (December 2014 - June 2016) was done. We excluded cases with preoperative T4 staging, lymphadenopathy, prostatic specific antigen > 4 ng/dl, and cases with positive biopsies from the bladder neck, trigone, and/or prostatic urethra. Patients were divided into 2 groups, Group 1: standard radical cystectomy with orthotopic diversion (n = 51), Group 2: prostate capsule sparing cystectomy with orthotopic diversion (n = 45). Preoperative transrectal ultrasound and prostatic biopsies were done in Group 2 to exclude prostate cancer. We compared the urinary continence and erectile function in both groups after 6 months, 1, and 2 years. Results: There was no significant difference between the groups regarding preoperative demographic data, tumor stage, grade, site by cystoscopy, and biopsy. Intraoperative monitoring showed no significant differences regarding blood loss, surgical complications, or operative time (2.5 ± 0.48 vs. 2.4 ± 0.45 h). There was a significantly higher percentage of continence and potency in Group 2 than in Group 1. Sixteen cases (35.6%) in Group 2 but only 4 cases (7.8%) in Group 1 developed large post-voiding residual urine and needed intermittent self-catheterization cleaning (p = 0.001). The tumor recurrence rate was not significantly different between the groups after 2 years (p = 0.3). Conclusion: Prostate capsule sparing cystectomy is a good option in selected cases with better continence and potency and without compromising oncological outcomes after 2 years.

Does induction chemoradiotherapy compromise subsequent radical cystectomy? A single-institutional comparative study on perioperative complications according to the Clavien-Dindo classification.

2011 ◽  
Vol 29 (7_suppl) ◽  
pp. 284-284
Author(s):  
A. Iwai ◽  
F. Koga ◽  
S. Kawakami ◽  
Y. Fujii ◽  
H. Masuda ◽  
...  
Keyword(s):  
Radical Cystectomy ◽  
Perioperative Complications ◽  
University Hospital ◽  
Control Group ◽  
Bladder Preservation ◽  
Perioperative Morbidity ◽  
Major Complications ◽  
Significant Difference ◽  
Bladder Sparing ◽  
The Impact

284 Background: Recently, bladder-sparing protocols incorporating TUR + chemoradiotherapy (CRT) have been developed. Patients who achieve CR after CRT are subjects for bladder preservation treatment and those who with non-CR undergo radical cystectomy (RC). However, early studies suggest that RC following pelvic irradiation associates with a higher mortality. To validate the impact of induction CRT on perioperative morbidity of RC, we compared complications of RC in patients treated with or without induction CRT at a single university hospital. Methods: Records of consecutive 193 patients who underwent RC for bladder cancer between April 1989 and May 2010 were reviewed. Induction CRT consists of radiation at 40 Gy to the small pelvis and 2 cycles of concurrent cisplatin at 20 mg/d for 5 days. Any complications occurred within 30 days after RC were graded according to the Clavien-Dindo classification system. Complications of grade I or II were classified as minor and complications of grade III or greater were classified as major. Results: Eighty-seven patients underwent induction CRT (CRT group) while 106 did not (control group). Patients of CRT group had significantly more advanced disease. No patient died within 90 days. Twenty one (11%) patients experienced at least one major complications; there was no significant difference in the incidence of major complications between CRT and control group (14% vs. 8%, p = 0.26). The details were as follows; infectious (3.5% vs. 3.8%, p = 1.0), gastrointestinal (4.6% vs. 0.9%, p = 0.18), surgical (6.9% vs. 3.8%, p = 0.35), cardiovascular (1.2% vs. 0.9%, p = 1.0). There was no significant difference between the incidence of minor complications (61% vs. 51%, p = 0.19). Conclusions: Induction CRT at 40 Gy is unlikely to compromise subsequent RC. No significant financial relationships to disclose.

scholarly journals Clinical and surgical outcomes of 3 cycles versus 6 cycles of neoadjuvant chemotherapy in advanced ovarian carcinoma

2019 ◽  
Vol 8 (12) ◽  
pp. 4985
Author(s):  
Monika Thakur ◽  
Archana Kumari ◽  
S. C. Saha
Keyword(s):  
Ovarian Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Perioperative Complications ◽  
High Risk Group ◽  
Surgical Morbidity ◽  
Epithelial Cancers ◽  
Significant Difference ◽  
Duration Of Surgery ◽  
Group 2

Background: Epithelial cancers are the most common ovarian malignancy accounting for 90% of all type of ovarian cancer. Objective of this study was to evaluate the surgical morbidity and to study clinical outcomes of 3 cycles versus 6 cycles of neoadjuvant chemotherapy.Methods: A total 30 women with diagnosis of advanced epithelial ovarian cancer were randomly divided equally to receive either 3 cycles (Group 1) or 6 cycles (Group 2) of neoadjuvant chemotherapy. End points noted were duration of surgery, extent of surgery, perioperative complications and length of stay.Results: Both groups had comparable demographic profile. Surgery was more difficult in early IDS group with lesser percentage of patients achieving minimum intended surgery in early IDS (61.53% versus 80. 47%) peri-operative complications were seen more commonly in early IDS group compared to late IDS group (26.66% versus 69.2%). However mean duration of surgery was similar in both groups. Mean duration of stay in hospital was 5.4 days in late IDS group and 7.6 days in early IDS group. The mean follow-up period in late IDS was 7 months and in early IDS was 5 months. Survival in both groups when patients were followed up till the end of study period (12 months) was similar (p=0.186).Conclusions: Authors conclude that late IDS may be used as a treatment option in the high-risk group of patients. Though there was no significant difference at 6 months follow up, higher percent of women were disease free in late IDS.

Who should be performed perioperative chemotherapy in upper-tract urothelial cancer? Risk classification for selecting candidate using preoperative factors.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 328-328
Author(s):  
Kazuhiro Nagao ◽  
Ryo Inoue ◽  
Teruo Inamoto ◽  
Kiyoshi Takahara ◽  
Hiroaki Matsumoto ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Neoadjuvant Chemotherapy ◽  
Predictive Factors ◽  
Perioperative Chemotherapy ◽  
Cancer Death ◽  
Upper Tract ◽  
Significant Difference ◽  
Group 2 ◽  
Preoperative Factors ◽  
Group 1

328 Background: The patients with advanced upper tract urothelial carcinoma (UTUC) have poor prognosis. Previous reports have not shown that neoadjuvant chemotherapy for UTUC improves patient survival and it is difficult to select appropriate candidates for neoadjuvant chemotherapy. We aimed to predict appropriate candidates for neoadjuvant chemotherapy. Methods: We reviewed the data of 536 patients with UTUC undergone total nephroureterctomy in the cohort of Yamaguchi Uro-Oncology Group (Group 1) and 150 cases in the cohort of Osaka Medical College (Group 2). We performed a multivariate analysis to the Group 1 to decide independent predictive factors and validated them in another cohort (Group 2). We evaluated the clinical significance of the predictive factors in cancer-specific survival (CSS) and overall survival (OS) between the cohort with and without perioperataive chemotherapy. Results: Multivariate analysis showed ≥cT3, cN+ and elevated CRP (≥0.31mg/dl) could become independent prognostic factors in Group 1, which showed 0.70 of AUC in predicting cancer death. We validated these factors in Group 2 and confirmed that they also showed 0.78 of AUC in predicting cancer death. Then, we divided the patients into 4 risk groups based on the number of the predictive factors: score 0 (202 cases), score 1 (152 cases), scores 2 (51 cases) and scores 3 (30 cases). Kaplan-Meier Curve showed that 5 year CSS in score 0, 1, 2, and 3 were 84.7%, 67.7%, 32.2% and 22.0%, respectively. Finally, we analyzed the difference in CSS and OS between the 138 cases with and 296 cases without perioperative chemotherapy. A significant difference in CSS and OS between the cases with and without perioperative chemotherapy was shown only in the cases with all the predictive factors: score 3. Additionally, fraction of patients with lymphovascular invasion of the surgical specimen were significantly increased with score advance. Conclusions: Survival in the patients with UTUC was predictable by preoperative factors. The patients with all the predictive factors, ≥cT3, cN+ and elevated CRP, were supposed to be the best candidates for neoadjuvant chemotherapy against UTUC.

scholarly journals Safety and efficacy of Holmium laser enucleation of the prostate (HoLEP) in patients with previous transperineal biopsy (TPB): outcomes from a dual-centre case-control study

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chris Bell ◽  
Sacha L. Moore ◽  
Amarit Gill ◽  
Obinna Obi-Njoku ◽  
Stephen F. Hughes ◽  
...  
Keyword(s):  
Holmium Laser ◽  
Operative Outcomes ◽  
Significant Difference ◽  
Laser Enucleation ◽  
Baseline Characteristics ◽  
Group 2 ◽  
Transperineal Biopsy ◽  
Holmium Laser Enucleation ◽  
Control Study ◽  
Group 1

Abstract Background We investigated the surgical feasibility, safety and effectiveness of 50 W (low power) Holmium Laser enucleation of the prostate (HoLEP) in patients who have undergone previous template biopsy of the prostate (TPB). Methods Data encompassing pre-operative baseline characteristics, intra-operative measures and post-operative outcomes was collected for 109 patients undergoing HoLEP across two UK centres. Patients were stratified into two groups; group 1 (n = 24) had undergone previous TPB were compared with ‘controls’ (no previous TPB) in group 2 (n = 85). The primary outcome was successful HoLEP. Results There were no statistically significant differences in either key baseline characteristics or mass of prostate enucleated between groups 1 and 2. There was no statistically significant difference in enucleation or morcellation times parameters between the two groups other than enucleation efficiency in favour of group 1 (p = 0.024). Functional outcomes improved, without any statistically significant difference, in both groups. Conclusions In patients with a previous TPB, HoLEP is surgically feasible, safe and effective. TPB should not be considered a contraindication to HoLEP. Our work provides a strong foundation for further research in this area.

In-vivo evaluation of the effect of cyanoacrylate on prosthetic vascular graft infection – does cyanoacrylate increase the severity of infection?

VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 281-284
Author(s):  
Atıf Yolgosteren ◽  
Gencehan Kumtepe ◽  
Melda Payaslioglu ◽  
Cuneyt Ozakin
Keyword(s):  
Vascular Graft ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Prosthetic Vascular Graft Infection ◽  
Group 1

Summary. Background: Prosthetic vascular graft infection (PVGI) is a complication with high mortality. Cyanoacrylate (CA) is an adhesive which has been used in a number of surgical procedures. In this in-vivo study, we aimed to evaluate the relationship between PVGI and CA. Materials and methods: Thirty-two rats were equally divided into four groups. Pouch was formed on back of rats until deep fascia. In group 1, vascular graft with polyethyleneterephthalate (PET) was placed into pouch. In group 2, MRSA strain with a density of 1 ml 0.5 MacFarland was injected into pouch. In group 3, 1 cm 2 vascular graft with PET piece was placed into pouch and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. In group 4, 1 cm 2 vascular graft with PET piece impregnated with N-butyl cyanoacrylate-based adhesive was placed and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. All rats were scarified in 96th hour, culture samples were taken where intervention was performed and were evaluated microbiologically. Bacteria reproducing in each group were numerically evaluated based on colony-forming unit (CFU/ml) and compared by taking their average. Results: MRSA reproduction of 0 CFU/ml in group 1, of 1410 CFU/ml in group 2, of 180 200 CFU/ml in group 3 and of 625 300 CFU/ml in group 4 was present. A statistically significant difference was present between group 1 and group 4 (p < 0.01), between group 2 and group 4 (p < 0.01), between group 3 and group 4 (p < 0.05). In terms of reproduction, no statistically significant difference was found in group 1, group 2, group 3 in themselves. Conclusions: We observed that the rate of infection increased in the cyanoacyrylate group where cyanoacrylate was used. We think that surgeon should be more careful in using CA in vascular surgery.

Tuberculosis of the meninges and central nervous system. Experience of clinical diagnostics in St. Petersburg for 50 years

MedAlliance ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 14-24
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Medical Errors ◽  
Clinical Diagnostics ◽  
Lethal Outcome ◽  
Significant Difference ◽  
Group 2 ◽  
Allergic Vasculitis ◽  
Tuberculosis Meningitis ◽  
Group 1

The clinic and diagnostics of tuberculosis meningitis (TM) in 926 patients treated in St. Petersburg hospitals in 1965–1994 (group 1) and in 1995–2018 (group 2) is presented. The TM clinic is demonstrated to be determined by the form of tuberculosis and its characteristic generalization nature in the presence of repeated waves of bacteremia and allergic vasculitis of greater or lesser severity. There is clinical peculiarity of TM in primary pulmonary tuberculosis and its early large-focal and late miliar generalization, as well as in hematogenous tuberculosis. In patients of the 1st and 2nd groups the TM clinic shows in some respects a noticeable similarity, in others — a significant difference. Despite the typical symptoms, early diagnosis of TM took place in less than 20% of patients. Clinical examples illustrating the unusual development of TM, contrasting with its usual course, are given. A number of objective and subjective factors contributing to the adverse evolution of TM and its lethal outcome are discussed. These include the peculiarity of modern tuberculosis, especially when associated with HIV infection, as well as medical errors associated with ignorance of the pathogenesis of tuberculosis and failure to comply with the minimum examination for tuberculosis.

Two Adhesive Systems-effect on Adhesion to Tooth Structure

2019 ◽  
Vol 70 (7) ◽  
pp. 2608-2613
Author(s):  
Larisa Simona Deac ◽  
Kamel Earar ◽  
Adela Loredana Colceriu Burtea ◽  
Alexandra Stefania Berghe ◽  
Aurora Antoniac ◽  
...  
Keyword(s):  
Adhesive Systems ◽  
Hybrid Layer ◽  
Tooth Structure ◽  
Selective Etch ◽  
Etch And Rinse ◽  
Significant Difference ◽  
Wisdom Teeth ◽  
Group 2 ◽  
Self Etch ◽  
Group 1

This study evaluates and compares by dye penetration method and SEM photomicrographs the sealing obtained using two different classes of adhesive systems (etch-and-rinse and self-etch with selective etching) with SDR (Dentsply) bulk fill composite. 84 class V cavities were prepared on oral and vestibular face of 42 intact, freshly extracted wisdom teeth. The cavities were randomly divided in two groups and restored: Group 1 with prime &bond one select (Dentsply) and SDR (Dentsply) and Group 2 with prime&bond one Etch&Rinse (Dentsply) and SDR (Dentsply). Prime&bond one Select (Dentsply) is a single component adhesive and can be used in self etch mode, in selective enamel etch mode, or in etch-and-rinse mode. We chosen for this study the selective etch of the enamel mode. Prime&bond one Etch Rinse (Dentsply) is a universal etch-and-rinse one-bottle dental adhesive, designed to be used in two steps. The bulk fill composites are commonly used in modern dentistry due to their properties of low polymerization shrinkage and curing in layer of 4 mm depth, offering the practitioner a fast clinical procedure with good results. The results showed a good sealing at enamel and dentin margins with no statistically significant difference between adhesives, even though the mean of enamel infiltration was smaller for Group1. Furthermore the results show that there were differences between the two groups, for the infiltrations at the enamel, the values of microleakage being arithmetically higher for Group 1, but with no statistically difference between the two groups.SEM images showed for both groups a good adhesion surface with the tooth, but the hybrid layer of the total-etch adhesives is different from the hybrid layer formed by self etch adhesives, in terms of thickness, uniformity. In conclusion both adhesive systems have equivalent sealing qualities and can be successfully used with SDR.

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