scholarly journals Clinical, histopathological and immunofluorescent study of vesicobullous lesions of skin

2019 ◽  
Vol 7 (4) ◽  
pp. 1288
Author(s):  
Seeram Satish Kumar ◽  
Bhagyalakshmi Atla ◽  
Guru Prasad Patnala ◽  
Kukkala Saraswati Sarat Srinivas ◽  
Saraswathi Samantra ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Histopathological Examination ◽  
Pemphigus Vulgaris ◽  
Direct Immunofluorescence ◽  
Pemphigus Foliaceus ◽  
Female Ratio ◽  
Medical College ◽  
Intensive Investigation ◽  
Male To Female

Background: Vesiculobullous diseases have been the focus of intensive investigation in recent years. However, these disorders are still associated with substantial morbidity, considerable mortality and impaired quality of life. Accurate diagnosis of vesiculobullous lesions of skin entails evaluation of clinical, histopathologic and immunofluorescence findings.Methods: Hospital based prospective study for a period of 24 months from August 2014 to July 2016 in the Department of Pathology at Andhra Medical College, Visakhapatnam, India. Total of 50 patients aged 3-70 years with vesiculobullous lesions of both sexes attending the Department of Dermatology were selected and analysed clinically, histopathological examination and direct immunofluorescence (DIF).Results: In the present study, majority of patients presented between 51-60 yrs of age (32%) with male to female ratio of 1.08:1 and mean age of 46.02 years. Pemphigus vulgaris constituted the most common vesiculobullous disorder (32%) followed by bullous pemphigoid and pemphigus foliaceous, 18% each. Bullae were located intra epidermally in 68% and sub epidermally in 32% of the patients. DIF was positive in 80% of the cases. Overall clinicopathological correlation was established in 74%. Overall histopathological and direct immunofluorescence correlation was established in 78%. Out of 50 cases, 35 cases (70%) correlated clinically and histo-pathologically with direct immunofluorescence.Conclusions: In the present study, on histopathological examination alone pemphigus foliaceus and pemphigus vulgaris could be differentiated. Direct immunofluorescence was useful in differentiating epidermolysis bullosa acquisita from bullous pemphigoid which have similar histopathological picture. This study proves that direct immunofluorescence is confirmatory as well as diagnostic for vesiculobullous disorders.

scholarly journals Clinicopathological study of sinonasal masses

1970 ◽  
Vol 16 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Abu HenaMohammad Parvez Humayun ◽  
AHM Zahurul Huq ◽  
SM Tarequddin Ahmed ◽  
Md Shah Kamal ◽  
Kyaw Khin U ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Malignant Lesion ◽  
Malignant Tumour ◽  
Neck Surgery ◽  
Female Ratio ◽  
Medical College ◽  
Male To Female ◽  
Study Setting ◽  
Head Neck Surgery ◽  
Head Neck

Objective: To observe the incidence, clinical presentation and to perform comparative studyof different sinonasal masses. Study design: Prospective study. Setting: Department ofotolaryngology and Head-Neck Surgery & ENT OPD of Chittagong Medical College Hospital.Patients & methods: 50 patients are included in this study (39 male & 11 female) between theages of 3 years and 80 years who were treated between August 2006 to January 2007. Studybased on history, clinical, radiological, laboratory and histopathological examination. Results:Mean age for male was 35.12 years and for female was 22.63 years. Male to female ratio was3.5:1. Highest frequency was noted in second decade. Most of patient (78%) were from poorclass. Frequency of inflammatory nasal masses were more in second decade, benign tumourin fourth and fifth decade, malignant tumour in second decade (OAN & NHL) and fifth andsecond decades (others). Rhinosporidiosis were most frequent inflammatory nasal masses.Nasal obstruction was the commonest and orbitus symptoms were less frequent symptoms.But orbital symptoms were more prevalent in malignant lesion. Conclusion: sinonasal massesare found in all age group. Rhinosporidiosis are appearing to be the commonest nasal masses.The prevalence of nasal polyp is also high. Among the malignant sinonasal masses thepercentage of squamous cell carcinoma is high.DOI: 10.3329/bjo.v16i1.5776Bangladesh J Otorhinolaryngol 2010; 16(1): 15-22

scholarly journals A Clinical Profile and Co-morbidities of Pemphigus Vulgaris Patients: A Study of 35 Cases

KYAMC Journal ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 106-109
Author(s):  
Md Abdur Razzaque ◽  
Zulfikar Ali ◽  
Kazi Shihab Uddin ◽  
Md Imtiajul Islam ◽  
Sajib Kumar Nath
Keyword(s):  
Pemphigus Vulgaris ◽  
Skin Lesions ◽  
Cutaneous Lesions ◽  
Female Ratio ◽  
Medical College ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease ◽  
High Index Of Suspicion ◽  
Male To Female ◽  
Sixth Decade

Background: Pemphigus vulgaris (PV), an autoimmune blistering disease involving the skin and mucosa. PV frequently begins with oral lesions and progresses to skin lesions. Autoimmune bullous skin disorders are associated with IgG or IgA auto- antibodies against distinct adhesion molecules of the epidermis and dermal epidermal basement membrane zone, respectively. These auto- antibodies lead to a loss of skin adhesion which shows up clinically as the formation of blisters or erosions. Objectives: To characterize the clinical parameters and co-morbidities of PV patients from a single tertiary medical centre in Bangladesh. Material and Methods: This observational study was done including 35 PV patients attending in the department of Dermatology and Venereology, Khwaja Yunus Ali Medical College Khawja Eunus Ali Medical College from 2010 to 2014. Thirty patients of pemphigus diagnosed clinically confirmed and treated over a 4-year period (2010-2014). Results: Majority of the patients 45.7% belongs to age group 41-50 years. Mean age 47.12±11.13. The male to female ratio in our study sample was 1:1.5. The youngest patient was 17 years old and the oldest 68. For both genders, the risk of onset peaked during the fifth and sixth decade of life. Out of 35 patients, 15(42.9%) was presented with mucosal lesions only, while 13 patients 37.1% had mucocutaneous lesions and 7 patients 20% had only cutaneous lesions. The most common comorbidies were hypertension 20.0%, osteoporosis 17.1%, and diabetes 8.6%, thyroid disease 8.6%, psoriasis 5.7%, rheumatoid arthritis 2.7%, rheumatic fever 2.9%, autoimmune hepatitis 2.9%, and myasthenia gravis 2.9%. Conclusion: The associated comorbidities of PV emphasize the need for dermatologists to keep a high index of suspicion and actively evaluate patients to determine their presence. KYAMC Journal Vol. 10, No.-2, July 2019, Page 106-109

scholarly journals Histopathological study of nasal lesions: 2 years study

2018 ◽  
Vol 6 (4) ◽  
pp. 1217
Author(s):  
Nisha Jayantilal Parmar ◽  
Deepa P. Jethwani ◽  
Gauravi A. Dhruva
Keyword(s):  
Histopathological Examination ◽  
Advanced Age ◽  
Histopathological Study ◽  
Age Group ◽  
Female Ratio ◽  
Nasal Mass ◽  
Medical College ◽  
Histopathological Lesions ◽  
Neoplastic Lesions ◽  
Male To Female

ackground: Majority of the nasal lesions are polypoid. It is difficult to comment upon the nature of the nasal lesion- whether neoplastic or non-neoplastic. Hence histopathological examination is essential for both ENT surgeons as well as pathologists. Aim to study the incidence of different nasal lesion. Also, to find out frequency of inflammatory, benign and malignant conditions of nasal lesions and to compare various histopathological lesions of nasal mass in relation to age, sex and site distribution.Methods: The present study was undertaken in histopathology laboratory of Department of Pathology, P.D.U. medical college and hospital, Rajkot for period of 2 years from October 2013 to September 2015. A histopathological study of total 100 cases of nasal lesions was done. Tissue were processed and studied.Results: Out of 100 cases, 59 were males and 41 were females. Male to Female ratio was 1.44:1. Maximum numbers of nasal lesions were detected in age group of 11-20 years with 24 (24.00%) cases. Out of these 100 cases, 80 (80.00%) were non neoplastic and 20 (20.00%) were of neoplastic origin. In neoplastic lesions, 12(12.00%) were benign, 1 (1.00%) was borderline and 7 (7.00%) were malignant nasal lesions. Non neoplastic lesions were composed of the majority of cases followed by benign neoplastic lesions.Conclusions: Most of malignant neoplastic lesions were occurs after 40 years of age. Incidence of malignant neoplastic lesions was increase with advanced age.

scholarly journals Management of Adult Renal Tumours: Review of Nine (9) Years Experience

2020 ◽  
Vol 2 (5) ◽  
Author(s):  
Ngwobia Peter Agwu ◽  
Abdullahi Khalid ◽  
Uzodimma Ejike Onwuasoanya ◽  
Abdullahi Abdulwahab-Ahmed ◽  
Abubakar Sadiq Muhammad ◽  
...  
Keyword(s):  
Late Presentation ◽  
Molecular Therapy ◽  
Female Ratio ◽  
Review Period ◽  
Urological Malignancies ◽  
Clinical Presentations ◽  
Renal Tumours ◽  
Male To Female ◽  
Management Challenge

Background: Renal tumours appear to be relatively uncommon in our routine urological practice compared to other urological malignancies of bladder and prostate origins. Their presentations are often late despite increasing availability and affordability of routine imaging modalities for early detection. This therefore poses management challenge in our environment. This study aims to review our 9-year experience with the management of renal tumours at the Urology Unit of a tertiary health facility in North-western Nigeria Methodology: A retrospective review of 20 patients managed for renal tumour at our facility from September 2009 to August 2017. Data of all adult patients managed for renal tumours was retrieved and analyzed using SPSS 20.0 version for windows. The results were presented in percentages and mean ± SD as well as charts. Results: Twenty (20) patients were managed for renal tumours during the review period. The mean age of patients was 39.94 ± 12.19 years with median of 35 years and male to female ratio of 1:2. Nineteen (19) patient (95%) and 1(5%) had malignant and benign renal tumours respectively. Clinical presentations were flank mass seen in 18 patients (90%), flank pain 16 (80%), haematuria 10(50%), cough 2(10%), and pleural effusion 2(10%). Only clinical stages III and IV tumour were seen. 70% were clear cell variety while 5% was angiomyolipoma. Sixteen (80%) of patients had radical nephrectomy and two (10%) with inoperable tumour benefited from targeted molecular therapy preoperatively using Sorafenib. Conclusion: Late presentation of patients with renal tumours to our facility despite the availability of imaging facilities such as ultrasound scanning is still the norm. This makes surgery which offers best chance of survival and quality of life difficult and challenging. Targeted therapy using sorafenib, if available and affordable in our environment will be useful in management of patients with inoperable tumours.

scholarly journals Dengue Fever : Study of 100 Cases in a Tertiary Care Hospital in Dhaka City

2015 ◽  
Vol 24 (Number 1) ◽  
pp. 3-7
Author(s):  
A H M Karnal ◽  
K H Mollah ◽  
A Begum ◽  
K Khoda ◽  
S Tanzeem ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Tertiary Care ◽  
Hemorrhagic Fever ◽  
Viral Disease ◽  
Care Hospital ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Male To Female ◽  
Body Ache

Dengue is a rapidly spreading mosquito-borne viral disease worldwide. The endemicity in Bangladesh is also increasing gradually. The study was a prospective observational one, documented the presenting features and outcome of management. It was carried out in Department of Medicine in Holy Family Red Crescent Medical College Hospital, Dhaka from June 2013 to December 2013. Total 100 admitted cases of both sera positive and sera-negative were included in this study. Detailed history was taken, clinical examination and relevant investigations were done. Out of 100 patients 54 (54%) were male and 46 (46%) were female. So male to female ratio was 1.7:1. The age of the patients ranged from 12-75 years. Among them 20-40 years age group was highest 63%. Patients of higher socio-economic group were (69%) more affected. Out of 100 cases 54 had classical dengue fever (DF), 46 had dengue hemorrhagic fever (DHF). Antibody was positive in 81% cases. All patients presented with high fever, headache in 90%, retro-orbital pain in 45%, body ache in 56%, and backache in 48%. Leucopenia found in 60, platelet count <100x1091L was in 57, HCT- normal 17, <20% rise in 48%, ?20% rise in 28%. With proper management all patients were recovered.

scholarly journals The Significance of Scalp Involvement in Pemphigus: A Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Marta Sar-Pomian ◽  
Lidia Rudnicka ◽  
Malgorzata Olszewska
Keyword(s):  
Web Of Science ◽  
Clinical Manifestations ◽  
Pemphigus Vulgaris ◽  
Hair Follicles ◽  
Response To Treatment ◽  
Direct Immunofluorescence ◽  
Pemphigus Foliaceus ◽  
Medical Databases ◽  
Scalp Lesions ◽  
Reliable Diagnostic Method

Scalp is a unique location for pemphigus because of the abundance of desmogleins localized in hair follicles. Scalp involvement is observed in up to 60% of patients in the course of pemphigus. The lesions may occasionally lead to alopecia. Unforced removal of anagen hairs in a pull test is a sign of high disease activity. Direct immunofluorescence of plucked hair bulbs is considered a reliable diagnostic method in patients with pemphigus. Follicular acantholysis is a characteristic histopathological feature of pemphigus lesions localized on the scalp. Trichoscopy may serve as a supplementary method in the diagnosis of pemphigus. This review summarizes the most recent data concerning scalp involvement in pemphigus vulgaris and pemphigus foliaceus. A systematic literature search was conducted in three medical databases: PubMed, Embase, and Web of Science. The analysis included literature data about desmoglein distribution in hair follicles, as well as information about clinical manifestations, histopathology, immunopathology, and trichoscopy of scalp lesions in pemphigus and their response to treatment.

scholarly journals Correlation between Clinical Symptoms of Various Colorectal Diseases and Colonoscopic Findings

2019 ◽  
Vol 17 (1) ◽  
pp. 16-19
Author(s):  
Roman Kidwai ◽  
Anup Sharma
Keyword(s):  
Diagnostic Accuracy ◽  
Clinical Symptoms ◽  
Colorectal Polyps ◽  
Bowel Habit ◽  
Female Ratio ◽  
Medical College ◽  
Inflammatory Conditions ◽  
The Mean ◽  
Colorectal Diseases ◽  
Male To Female

Background: About 30% of patients presenting to surgical outpatient department has lower gastrointestinal (LGI) symptoms. Colonoscopy is a low risk and at the same time investigation of choice in these patients which allows visualization of the entire colon and the terminal portion of ileum. This study was done to find out the diagnostic accuracy of colonoscopy in relation to the clinical symptoms of the disease.  Methods: This was a prospective, hospital based study from February 2014 to March 2019 carried out at Nepalgunj Medical College and Teaching Hospital. The colonoscopy diagnosis was compared with the clinical symptoms and further confirmed with histological examination.  Results: 341 patients underwent colonoscopy. There were 234 (68.62%) males and 107 (31.37%) females with the male to female ratio of 2.18: 1. The age ranged from 16 to 81 with the mean age of 59.63±10.37. The most common presenting symptom was per rectal bleeding (40.34%) the after were alteration in bowel habit (17.30%), constipation (12.90%), hematochezia (11.43%). The least common indication for colonoscopy was unexplained anemia. Haemorrhoids were the most common findings consisting 32.55%. In 19.94% it was normal. Majority had various inflammatory conditions, among them 10.85% had proctocolitis, 2.34% were suspected to have ulcerative colitis. There were 17(4.98%) patients with colonic and 13(3.18%)with rectal carcinoma. 10.55% had colorectal polyps. Out of 111 patients suspected to have hemorrhoids clinically 102 had same findings on colonoscopy. Similarly 34 patients presenting with chronic diarrhea with bleeding and 59 with alteration in bowel habit where inflammatory conditions were suspected had similar findings on colonoscopy in 29 and 34 patients respectively. Similarly the suspicion of malignancy on clinical basis was also correlated on colonoscopy. The inflammatory conditions diagnosed on colonoscopy were confirmed in 85.04 % by histology. Similarly malignancy and the presence of polyps diagnosed on colonoscopy were confirmed by histology in 97.05% and in 97.22% cases respectively. Conclusion: Colonoscopy is a safe and effective investigation to diagnose various colorectal conditions. There was a correlation between the clinical symptoms and the colonoscopicdiagnosis especially in conditions like inflammatory and neoplastic colorectal diseases. When combined with histology the diagnostic accuracy can be near 100% in conditions like inflammatory and benign or malignant diseases.

scholarly journals 176 Measuring quality of life with the EQ-5D in patients with pemphigus vulgaris and pemphigus foliaceus

2019 ◽  
Vol 139 (9) ◽  
pp. S244
Author(s):  
B. Tamasi ◽  
V. Brodszky ◽  
M. Pentek ◽  
L. Gulacsi ◽  
K. Hajdu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pemphigus Vulgaris ◽  
Pemphigus Foliaceus

scholarly journals Accuracy of GRK-2200T Auto-refkeratometer in Subjective Acceptance for Refractive Errors

2019 ◽  
Vol 4 (1) ◽  
pp. 645-648
Author(s):  
Bishwa Nath Adhikari ◽  
Pramod Sharma Gautam ◽  
Shishu Upadhyay ◽  
Uday Chandra Prakash
Keyword(s):  
Refractive Errors ◽  
Spherical Equivalent ◽  
Female Ratio ◽  
Medical College ◽  
Spherical Component ◽  
Number Of Patients ◽  
Prospective Comparative Study ◽  
The Mean ◽  
Male To Female ◽  
Day By Day

Introduction: Globally, the most common cause for diminution of vision is refractive errors and the number of patients with refractive errors is increasing day by day. The Auto-refraction (AR) is quick and patient friendly procedure as compared to retinoscopy and subjective refraction in finding out refractive errors. Hence, the accuracy of Auto-refractometer in terms of subjective acceptance (SA) should be taken into account before prescribing optical correction based on findings of that particular model of Auto-refractometer. So, this study is directed towards analysis of the accuracy of GRK-2200T Auto-retieratometer in terms of acceptance by comparing findings of AR with that of SC. Objectives: The aim of this study was to assess the refractive status of patient's eyes using auto refractometer (GRK-2200T auto-retierato meter) and to estimate the agreement of it in terms of accuracy in acceptance of subjective correction by the patient. Methodology: A hospital based prospective comparative study conducted on 226 eyes of 113 patients who visited out-patient department (OPD) of Ophthalmology at Nobel Medical College and Teaching Hospital (NoMCTH), Biratnagar diagnosed with Myopia, Hyperopia and Astigmatism. Duration of study was 4 months from 2nd October, 2018 to 2nd February, 2019. All data thus collected was subjected to statistical analysis by using SPSS version 22. Result The mean age of the study subjects was 26.91±7.79 years with male to female ratio of 0.47. When spherical power, cylindrical power and the axis are taken into consideration together, only 13.3% of the total tested eyes subjectively accepted the AR values unchanged. On subjective correction, 32.7% of the tested eyes accepted spherical power while 46.5% accepted cylindrical power and 50.9% accepted axis of AR unchanged. About 52.2% of the total eyes examined fall within the deviation of spherical equivalent (SE) of ±o.25D and up to 67.3% of them fall within the deviation of ±o.50D. Conclusion The auto refraction by GRK-2200T auto-retieratometer was found to be satisfactory for a preliminary refraction but not satisfactory as substitutes for conventional subjective refraction. However, auto refraction values obtained by GRK-2200T auto-retieratometer could be important in order to accurately prescribe the cylindrical power as well as its axis than the spherical component.

scholarly journals Congenital Anomalies Presenting as Head-Neck Swellings: A Study of 50 Cases

2020 ◽  
Vol 23 (2) ◽  
pp. 171-179
Author(s):  
Md Zahidul Islam ◽  
Md Abdur Rahman ◽  
Md Sirajul Islam Mahfuz
Keyword(s):  
Dermoid Cyst ◽  
Branchial Arch ◽  
Medical College Hospital ◽  
Sex Distribution ◽  
Thyroglossal Cyst ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Male To Female ◽  
Head Neck

Purpose: To analyse the prevalence, distribution and presentation of different congenital head-neck lesions with their age, sex, site and side predilection. Methods: 50 patients of head-neck congenital swelling was selected from january/2013 upto december/2013 in the OPD of otorhino-laryngology, head and neck deptt. of Dhaka medical college hospital under a specific prospective study protocol. Results: The most frequent swelling was thyroglossal cyst(42%), followed by branchial arch anomalies (18%),dermoid cyst(14%),pre-auricular sinus(14%),lymphangioma(8%) and haemangioma(4%).Amongst the cervical swellings the sequential preponderence was thyroglossal cyst(52%),branchial arch anomalies(23%),dermoid cyst(13%), lymphangioma(10%) and haemangioma (2%).The majority of branchial arch anomalies(100%) were of second arch. The majority of patients were of first(52%) and second(30%) decade and the male to female ratio for thyroglossal cysts was 1:1.1.The majority of lesions were painless swelling and all were surgically excised. Conclusion: The overall frequency and age-sex distribution of congenital head-neck swellings as well as site, nature and type specific predominance of some of them in OPD of Dhaka medical college hospital are almost similar to international findings. Bangladesh J Otorhinolaryngol; October 2017; 23(2): 171-179

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