scholarly journals Understanding the predisposing risk factors of young suicide

2020 ◽  
Vol 8 (12) ◽  
pp. 4530
Author(s):  
Rashmi Wardhan ◽  
Padmshree Mudgal
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Suicide Risk ◽  
Suicide Ideation ◽  
Aminobutyric Acid ◽  
Economic Factors ◽  
Gamma Aminobutyric Acid ◽  
Insight Into ◽  
Socio Economic Factors

Suicide is an unfortunate multifactorial problem impacting families and communities. Many young lives are lost every year due to suicide. There is an urgent need to understand the multifactorial risk factor mechanisms providing vulnerability to suicidal behavior for early detection of impending incidents, monitoring, and prevention. This review aims to give an insight into the various biochemical and genetic markers along with the associated socio-economic factors and mental disorders which contribute to increased suicide risk. The role of different neurotransmitter-associated pathways such as serotonin, gamma aminobutyric acid (GABA), and norepinephrine pathway, and pathways involving the hypothalamic-pituitary-adrenal (HPA) axis, lipid metabolism, and neuroinflammation in suicide ideation and risk have been explored. Understanding of these predisposing factors and associated pathways could help identify the risk and lead to the development of drugs/ treatment to prevent suicides.

Stress, Cortisol and Suicide Risk

2019 ◽  
Author(s):  
Daryl Brian O'Connor
Keyword(s):  
Risk Factors ◽  
Suicidal Behavior ◽  
Suicide Risk ◽  
Stressful Events ◽  
Additional Risk ◽  
Global Health Issue ◽  
History Of ◽  
Hpa Axis Activity ◽  
The Impact

Suicide is a global health issue accounting for at least 800,000 deaths per annum. Numerous models have been proposed that differ in their emphasis on the role of psychological, social, psychiatric and neurobiological factors in explaining suicide risk. Central to many models is a stress-diathesis component which states that suicidal behavior is the result of an interaction between acutely stressful events and a susceptibility to suicidal behavior (a diathesis). This article presents an overview of studies that demonstrate that stress and dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity, as measured by cortisol levels, are important additional risk factors for suicide. Evidence for other putative stress-related suicide risk factors including childhood trauma, impaired executive function, impulsivity and disrupted sleep are considered together with the impact of family history of suicide, perinatal and epigenetic influences on suicide risk.

Changes in gamma-aminobutyric acid and somatostatin in epileptic cortex associated with low-grade gliomas

1992 ◽  
Vol 77 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Michael M. Haglund ◽  
Mitchel S. Berger ◽  
Dennis D. Kunkel ◽  
JoAnn E. Franck ◽  
Saadi Ghatan ◽  
...  
Keyword(s):  
Epileptiform Activity ◽  
Aminobutyric Acid ◽  
Low Grade ◽  
Tumor Infiltration ◽  
Gamma Aminobutyric Acid ◽  
Content Type ◽  
Low Grade Gliomas ◽  
Neuronal Populations ◽  
Significant Difference

✓ The role of specific neuronal populations in epileptic foci was studied by comparing epileptic and nonepileptic cortex removed from patients with low-grade gliomas. Epileptic and nearby (within 1 to 2 cm) nonepileptic temporal lobe neocortex was identified using electrocorticography. Cortical specimens taken from four patients identified as epileptic and nonepileptic were all void of tumor infiltration. Somatostatin- and γ-aminobutyric acid (GABAergic)-immunoreactive neurons were identified and counted. Although there was no significant difference in the overall cell count, the authors found a significant decrease in both somatostatin- and GABAergic-immunoreactive neurons (74% and 51 %, respectively) in the epileptic cortex compared to that in nonepileptic cortex from the same patient. It is suggested that these findings demonstrate changes in neuronal subpopulations that may account for the onset and propagation of epileptiform activity in patients with low-grade gliomas.

scholarly journals The effect of sexual abuse and dissociation on suicide attempt

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Silje Støle Brokke ◽  
Thomas Bjerregaard Bertelsen ◽  
Nils Inge Landrø ◽  
Vegard Øksendal Haaland
Keyword(s):  
Sexual Abuse ◽  
Risk Factor ◽  
Suicide Attempt ◽  
Indirect Effects ◽  
Suicide Ideation ◽  
Suicide Attempts ◽  
Suicidal Thoughts ◽  
Dissociative Experiences ◽  
Self Harm

Abstract Background Suicide attempt is the most predictive risk factor of suicide. Trauma – especially sexual abuse – is a risk factor for suicide attempt and suicide. A common reaction to sexual abuse is dissociation. Higher levels of dissociation are linked to self-harm, suicide ideation, and suicide attempt, but the role of dissociation in suicidal behavior is unclear. Methods In this naturalistic study, ninety-seven acute psychiatric patients with suicidal ideation, of whom 32 had experienced sexual abuse, were included. Suicidal behaviour was assessed with The Columbia suicide history form (CSHF). The Brief trauma questionnaire (BTQ) was used to identify sexual abuse. Dissociative symptoms were assessed with Dissociative experiences scale (DES). Results Patients who had experienced sexual abuse reported higher levels of dissociation and were younger at onset of suicidal thoughts, more likely to self-harm, and more likely to have attempted suicide; and they had made more suicide attempts. Mediation analysis found dissociative experiences to significantly mediate a substantive proportion of the relationship between sexual abuse and number of suicide attempts (indirect effects = 0.17, 95% CI = 0.05, 0.28, proportion mediated = 68%). Dissociative experiences significantly mediated the role of sexual abuse as a predictor of being in the patient group with more than four suicide attempts (indirect effects = 0.11, 95% CI = 0.02, 0.19, proportion mediated = 34%). Conclusion The results illustrate the importance of assessment and treatment of sexual abuse and trauma-related symptoms such as dissociation in suicide prevention. Dissociation can be a contributing factor to why some people act on their suicidal thoughts.

Depression: An insight into Heterocyclic and Cyclic Hydrocarbon Compounds inspired from Natural Sources

2021 ◽  
Vol 19 ◽  
Author(s):  
Abdul Jalil Shah ◽  
Reyaz Hassan Mir ◽  
Roohi Mohi-ud-din ◽  
Faheem Hyder Pottoo ◽  
Mubashir Hussain Masoodi ◽  
...  
Keyword(s):  
Gaba Receptors ◽  
Herbal Medicines ◽  
Aminobutyric Acid ◽  
Cyclic Hydrocarbon ◽  
Natural Sources ◽  
Drug Candidates ◽  
Signalling Molecules ◽  
Symptoms Of Depression ◽  
Insight Into

: Depression, a well know mental disorder has global prevalence, nearly affecting 17% of population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main source for new drug candidates in depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this review is to revisit the role of signalling molecules in depression and highlight the use of plant-derived natural compounds to counter depression in the CNS.

Technology and culture

2011 ◽  
pp. 273-285 ◽  
Author(s):  
Alev M. Efendioglu ◽  
Vincent F. Yip
Keyword(s):  
Local Environment ◽  
The Internet ◽  
Economic Factors ◽  
Technology And Culture ◽  
Internet Users ◽  
The World ◽  
Different Characteristics ◽  
The Impact ◽  
Socio Economic Factors

The number of Internet users around the world has been steadily growing and this growth has provided the impetus and the opportunities for global and regional e-commerce. However, as with the Internet, different characteristics (infrastructure and socio-economic) of the local environment have created a significant level of variation in the acceptance and growth of e-commerce in different regions of the world. Our research focuses on the impact of these infrastructure and socio-economic factors on e-commerce development in China and the findings provide insights into the role of culture in e-commerce, and the factors that may impact a broader acceptance and development of e-commerce in China. In this chapter, we present and discuss our findings, and propose some strategies for success for e-commerce in China.

Role of Hospital Medicine in Management of Intracranial Brain Tumors

2019 ◽  
pp. 57-73
Author(s):  
Donald Y. Ye ◽  
Thana Theofanis ◽  
Tomas Garzon-Muvdi ◽  
James J. Evans
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Postoperative Complications ◽  
Brain Tumors ◽  
Management Strategies ◽  
Hospital Medicine ◽  
Intracranial Tumors ◽  
Medical Oncologists ◽  
Insight Into

Intracranial tumors reflect a broad range of benign and malignant processes that are often managed by neurosurgeons and medical oncologists. Patients presenting with new brain tumors will undergo biopsies or resection for tissue diagnosis and resolution of neurological symptoms. These patients have significant perioperative risk factors that must be addressed to ensure the best possible outcomes. Hospitalists play a pivotal role in identifying these risk factors and offering management strategies prior to the development of an operative plan. This chapter provides insight into the range of preoperative considerations and postoperative complications that a hospitalist may face when managing brain tumor patients.

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